Cancer Control最新文献

{"title":"Letter to the Editor: Do Nutritional and Inflammatory Indices Predict Response in Geriatric Gastric Cancer Patients Treated With Neoadjuvant FLOT Regimen?","authors":"Aybala Nur Ucgul","doi":"10.1177/10732748251357471","DOIUrl":"10.1177/10732748251357471","url":null,"abstract":"","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251357471"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Biological Role of LRPPRC in Human Cancers.","authors":"Jiaxin Tang, Jing Li, Shiyu Qin, Yu Xiao, Jiaxin Liu, Xian Chen, Yunyuan Zhang","doi":"10.1177/10732748251353077","DOIUrl":"10.1177/10732748251353077","url":null,"abstract":"<p><p>The leucine-rich pentatricopeptide repeat-containing (LRPPRC) protein, a member of the pentatricopeptide repeat (PPR) family, is a mitochondria-associated protein that regulates various biological processes, including cell cycle progression and mitochondrial gene translation. LRPPRC has also been identified as an important causative gene in several mitochondrial diseases. N6-methyladenosine (m6A) is the most prevalent and extensive modification of mRNA in eukaryotes, playing a significant role in cellular proliferation, differentiation, and oncogenesis. As an m6A regulator, LRPPRC has been shown to play an important role in the development of various human metabolic diseases and malignant tumors. This review mainly focuses on summarizing the biological roles of LRPPRC in a variety of human malignant tumors, emphasizing the molecular mechanisms LRPPRC is involved in and its potential impact on tumor prognosis.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251353077"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Outcomes of Acute Myeloid Leukemia Patients Harboring <i>NPM1/FLT3-ITD/DNMT3A</i> Triple Mutations and the Potential Prognostic Value of <i>GNG4</i>.","authors":"Yujie Niu, Xingchun Luo, Xiaoxiao Yang, Yuancheng Guo, Xiao Tang, Long Zhao, Jinli Jian, Bei Liu","doi":"10.1177/10732748251359836","DOIUrl":"10.1177/10732748251359836","url":null,"abstract":"<p><p>IntroductionNucleophosmin 1 (<i>NPM1</i>), FMS-like tyrosine kinase 3-internal tandem duplication (<i>FLT3-ITD</i>), and de novo methyl transferase 3 A (<i>DNMT3A</i>) triple-mutated acute myeloid leukemia (AML) represents a distinct entity with poor outcomes.MethodsWe explored the gene mutation spectrum and clinical characteristics of 165 AML patients retrospectively, particularly comparing patients with <i>NPM1/FLT3-ITD/DNMT3A</i> triple-mutations and those without.ResultsOur results demonstrated significantly elevated white blood cell counts (<i>P</i> < 0.001), bone marrow blast percentages (<i>P</i> = 0.037), and platelet counts (<i>P</i> = 0.007) in the triple-mutated cohort (6.7%) compared to the non-triple-mutated patients. Furthermore, all triple-mutated cases were classified as the M4/M5 subtype of the French-American-British classification (<i>P</i> = 0.017). Although no significant difference in complete remission rates was observed between the groups after initial treatment, the median overall survival for triple-mutated AML patients was only 4 months. Using the Gene Expression Omnibus (GEO) database and bioinformatics, we compared AML^{<i>NPM1</i>mut<i>FLT3-ITD</i>mut<i>DNMT3A</i>mut} and AML^{<i>NPM1</i>mut<i>FLT3-ITD</i>mut<i>DNMT3A</i>wt}. A total of 246 AML patients from the GEO dataset were included to evaluate the expression profiles of differentially expressed genes. The guanine nucleotide-binding protein subunit γ 4 (<i>GNG4</i>) was differentially expressed between AML^{<i>NPM1</i>mut<i>FLT3-ITD</i>mut<i>DNMT3A</i>mut} and AML^{<i>NPM1</i>mut<i>FLT3-ITD</i>mut<i>DNMT3A</i>wt}, which had the most adjacent nodes among hub genes. The prognostic value of <i>GNG4</i> was further validated in AML patient samples through qRT-PCR.ConclusionClinical validation indicated a substantial downregulation of <i>GNG4</i> in AML^{<i>NPM1</i>mut<i>FLT3-ITD</i>mut<i>DNMT3A</i>mut} compared to AML^{<i>NPM1</i>mut<i>FLT3-ITD</i>mut<i>DNMT3A</i>wt} patients. Thus, <i>GNG4</i> may play a role in the low survival rate of AML^{<i>NPM1</i>mut<i>FLT3-ITD</i>mut<i>DNMT3A</i>mut} patients, offering novel insights into the prognosis, therapeutic targets, and prognostic evaluation of AML.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251359836"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Immunotherapy Outcomes in Cancer: Sarcopenia and Systemic Inflammation.","authors":"Erkan Topkan, Nilüfer Kılıç Durankuş, Şükran Şenyürek, Ugur Selek","doi":"10.1177/10732748251318390","DOIUrl":"10.1177/10732748251318390","url":null,"abstract":"","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251318390"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Antibiotic Used During Surgery With the Outcome in Stage I-III Gastric Cancer.","authors":"Lijuan Ding, Mengyu Zhou, Jiahui Yin, Xiaoming Zhang, Qianwen Ye, Niansong Qian","doi":"10.1177/10732748251339261","DOIUrl":"https://doi.org/10.1177/10732748251339261","url":null,"abstract":"<p><p><b>Introduction:</b> The use of antibiotic (Abx) is common in gastric cancer (GC) patients undergoing radical resection; however, the prognostic value of the use of these agents in stage I-III patients remains largely unknown.<b>Methods:</b> Data concerning the use of Abx in GC patients during surgery including the cumulative defined daily dose (cDDD) and types of Abx, were collected retrospectively. Differences in clinical features between cDDD subgroups and type subgroups were compared. Overall survival (OS) differences were tested via the Kaplan-Meier method, and risk factors for survival were validated by a Cox proportional hazards model.<b>Results:</b> Of 162 patients enrolled, 81 were assigned to the low-cDDD and 81 to the high-cDDD group. Among them, 19 patients were assigned to ≤2 types and 143 to ≥3 types. The low- and high-cDDD subgroups of patients presented no significant difference in OS (log rank = 2.21, <i>P</i> = 0.137). Patients receiving ≥3 types presented significantly better OS (log rank = 4.58, <i>P</i> = 0.032) than those receiving ≤2 types. The low- and high-cDDD subgroups (log rank = 3.83, <i>P</i> = 0.050), but not the ≤2 and ≥3 type subgroups (log rank<0.01, <i>P</i> = 0.982), presented a significant difference in OS in patients undergoing total gastrectomy. These differences were maintained in patients without total gastrectomy (cDDD: log rank = 7.92, <i>P</i> = 0.005; types: log rank = 6.52, <i>P</i> = 0.011). The use of multiple Abx types was validated as an independent factor for OS (HR = 0.46, 95% CI: 0.24-0.90; <i>P</i> = 0.024).<b>Conclusions:</b> Abx use during surgery in patients with stage I-III GC may potentially correlate with the prognosis. Patients with ≥3 types of Abx were more likely to have good outcomes, particularly in those without total gastrectomy.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251339261"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Patient-specific Quality Assurance for Automated Segmentation of Organs at Risk in Nasopharyngeal Carcinoma Radiotherapy.","authors":"Yixuan Wang, Jiang Hu, Lixin Chen, Dandan Zhang, Jinhan Zhu","doi":"10.1177/10732748251318387","DOIUrl":"10.1177/10732748251318387","url":null,"abstract":"<p><strong>Introduction: </strong>Precision radiotherapy relies on accurate segmentation of tumor targets and organs at risk (OARs). Clinicians manually review automatically delineated structures on a case-by-case basis, a time-consuming process dependent on reviewer experience and alertness. This study proposes a general process for automated threshold generation for structural evaluation indicators and patient-specific quality assurance (QA) for automated segmentation of nasopharyngeal carcinoma (NPC).</p><p><strong>Methods: </strong>The patient-specific QA process for automated segmentation involves determining the confidence limit and error structure highlight stage. Three expert physicians segmented 17 OARs using computed tomography images of NPC and compared them using the Dice similarity coefficient, the maximum Hausdorff distance, and the mean distance to agreement. For each OAR, the 95% confidence interval was calculated as the confidence limit for each indicator. If two or more evaluation indicators (N2) or one or more evaluation indicators (N1) exceeded the confidence limits, the structure segmentation result was considered abnormal. The quantitative performances of these two methods were compared with those obtained by artificially introducing small/medium and serious errors.</p><p><strong>Results: </strong>The sensitivity, specificity, balanced accuracy, and F-score values for N2 were 0.944 ± 0.052, 0.827 ± 0.149, 0.886 ± 0.076, and 0.936 ± 0.045, respectively, whereas those for N1 were 0.955 ± 0.045, 0.788 ± 0.189, 0.878 ± 0.096, and 0.948 ± 0.035, respectively. N2 and N1 had small/medium error detection rates of 97.67 ± 0.04% and 98.67 ± 0.04%, respectively, with a serious error detection rate of 100%.</p><p><strong>Conclusion: </strong>The proposed automated patient-specific QA process effectively detected segmentation abnormalities, particularly serious errors. These are crucial for enhancing review efficiency and automated segmentation, and for improving physician confidence in automated segmentation.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251318387"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum High-Density Lipoprotein Cholesterol Concentrations in Pancreatic Ductal Adenocarcinoma and Its Association With Histological Grade in a Chinese Population.","authors":"Ying-Ying Cao, Xiao-Jing Lv, Hui Li, Li-Chao Qian, Hai-Peng Si, Yuan Li, Kai Guo, Shuai Ren, Zhong-Qiu Wang","doi":"10.1177/10732748251316602","DOIUrl":"10.1177/10732748251316602","url":null,"abstract":"<p><strong>Background: </strong>Serum high-density lipoprotein cholesterol (HDL-c) may influence cancer development. However, its relationship with the histological grade of pancreatic ductal adenocarcinoma (PDAC) is not well understood. This study aims to explore the potential associations between serum HDL-c levels and different histological grades of PDAC.</p><p><strong>Methods: </strong>This retrospective study included 181 patients with pathologically confirmed PDAC who underwent radical surgery. Clinical data, blood biochemical results, imaging features, and pathological details of the patients were collected, such as age, gender, diabetes, hypertension, tumor grade, tumor size and location, high-density lipoprotein (HDL-c), low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TG), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA).</p><p><strong>Results: </strong>Patients with high-grade PDAC had significantly lower HDL-c levels compared to those with low-grade PDAC across both training and validation cohorts (<i>P</i> < 0.05). Significant associations were found between HDL-c levels and high-grade PDAC in the training (<i>P</i> < 0.001) and validation (<i>P</i> = 0.044) groups. Moreover, HDL-c levels were inversely related to lymph node metastasis in the training (<i>P</i> = 0.001) and validation (<i>P</i> = 0.012) sets.</p><p><strong>Conclusions: </strong>Lower HDL-c levels are associated with high-grade PDAC and lymph node metastasis, suggesting that HDL-c may play a protective role in the progression of PDAC.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251316602"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nomogram for Predicting Cancer-Specific Survival in Patients With Stage I Vulvar Squamous Cell Carcinoma: A Study Based on the SEER Database and External Validation.","authors":"Yingfan Zhu, Tao Zhang, Jiali Xu, Zhuoqun Lin, Fenfen Wang, Xiaodong Cheng","doi":"10.1177/10732748251357144","DOIUrl":"10.1177/10732748251357144","url":null,"abstract":"<p><p>IntroductionVulvar squamous cell carcinoma (VSCC) is a rare but increasingly prevalent gynecological malignancy. This study aimed to identify risk factors for stage I VSCC, which accounts for approximately 70% of VSCC patients, and to develop a nomogram to predict cancer-specific survival (CSS) for this large subgroup.MethodsThis study analyzed the datasets consisting of public training and independent external validation sets of patients diagnosed with stage I VSCC between 2010 and 2019. Prognostic factors were discerned through Cox regression analyses and the least absolute shrinkage and selection operator (LASSO) method. A nomogram for CSS was developed and evaluated using the C-index, Kaplan-Meier curves, and decision curve analysis (DCA) plots.ResultsOur analysis revealed variations in predictors of CSS and overall survival (OS) in stage I VSCC cases from the Surveillance, Epidemiology, and End Results (SEER) database. The multivariate Cox model suggested associations between CSS and age, grade, and number of tumors (NMT), while the LASSO model indicated potential roles for age, stage, invasion depth, NMT, and surgical method. The nomogram showed reasonable discriminative ability in the training (C-index: 0.785) and validation cohorts (C-index: 0.729), with supporting Kaplan-Meier and DCA analyses.ConclusionThis study proposes a prognostic model for CSS in stage I VSCC, identifying exploratory associations with multifocal tumors and surgical extent. Further prospective studies are needed to validate these findings and clarify their clinical implications.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251357144"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights Into Adipokines and the Tumor Microenvironment in Breast Cancer.","authors":"Xin Ma, Shaofeng Yang, Donghai Li","doi":"10.1177/10732748251347917","DOIUrl":"10.1177/10732748251347917","url":null,"abstract":"<p><p>Breast cancer remains the malignant tumor with the highest incidence among female patients globally, and its treatment represents a well-recognized clinical challenge. Recent studies have demonstrated that the tumor microenvironment (TME) exerts a substantial influence on breast cancer progression, whereby alterations in its internal molecular components ultimately impact disease outcomes. Key factors implicated in this process include adipokines and microRNAs (miRNAs). This review provides a detailed description of how different adipocytokines exert specific mechanistic effects on breast cancer cells. By integrating adipokines with miRNAs, the discussion explores their combined roles in the initiation and progression of breast cancer, addressing a previously unaddressed research gap in studies focusing solely on individual adipokines. Furthermore, by examining the interactions between miRNAs and signaling pathways, this analysis offers a holistic perspective on the TME network, thereby fostering new therapeutic insights for breast cancer management.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251347917"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Adults' Consideration of their Future General and Colorectal-Specific Cancer Risk.","authors":"Jackie Knight Wilt, Maria D Thomson","doi":"10.1177/10732748251348537","DOIUrl":"10.1177/10732748251348537","url":null,"abstract":"<p><p>IntroductionColorectal cancer (CRC) has a lengthy cellular mutation period and early onset (EOCRC) is linked to lifestyle-related factors. Primary prevention approaches earlier in the life course are needed. Emerging adulthood (age 18-25) is a critical stage for shaping health trajectories, and future orientation influences health behavior decisions. Little is known about emerging adults' consideration of future cancer risk (CFC-Cancer), or perceived CRC risk. This study characterizes emerging adult CFC-Cancer, perceived CRC risk, and how they relate to EOCRC lifestyle related factors and cancer prevention behaviors.MethodsWe conducted a cross-sectional survey of college students at a public university. Measures included demographics, stress, family cancer history, and CRC knowledge. Previously validated measures for diet, sedentariness, smoking, alcohol consumption, and stress management assessed adherence with lifestyle prevention guidelines. HPV vaccination and skin checks appraised cancer prevention. Outcomes included perceived CRC risk (0%-100%) and CFC-Cancer adapted scale. Adjusted linear regression models examined CFC-Cancer and perceived CRC risk predictability.ResultsThe sample (N = 282) mean age was 20 years, 77% were female, 40% were White, and 67% had family cancer history. CRC knowledge μ = 14, and current stress was moderate. 18% completed both cancer prevention behaviors, and protective lifestyle behavior scores ranged between 2-15, μ = 8. Perceived CRC risk = 28%, and CFC-Cancer was moderate (μ = 61). CFC-Cancer model included significant predictors of GPA, CRC knowledge, and lifestyle health behavior score, while Perceived CRC Risk model included age and being employed.ConclusionEmerging adults overestimate CRC risk but also have moderate CFC-Cancer. Accurate CRC knowledge provided to this age group may help redirect CRC health trajectories through integration of EOCRC protective lifestyle health behaviors and sustaining them into adulthood.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251348537"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}