Developmental Cognitive Neuroscience最新文献_第5页

Corrigendum to “Previous institutionalization is associated with elevated functional connectivity between the nucleus accumbens and amygdala during aversive learning” [Dev. Cognit. Neurosci. 76 (2025), 101617] “先前的制度化与厌恶学习期间伏隔核和杏仁核之间的功能连接升高有关”的更正[Dev. Cognit]。神经科学，76(2025),101617。

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.1016/j.dcn.2025.101665

Benjamin M. Rosenberg , João F. Guassi Moreira , Adriana S. Méndez Leal , Natalie M. Saragosa-Harris , Elizabeth Gaines , Wesley J. Meredith , Clare F. McCann , Saché M. Coury , Yael Waizman , Emilia Ninova , Jennifer A. Silvers

引用次数: 0

Longitudinal associations between adolescent adversity, brain development and behavioural and emotional problems 青少年逆境、大脑发育、行为和情感问题之间的纵向联系

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2026-01-01 Epub Date: 2025-11-16 DOI: 10.1016/j.dcn.2025.101646

Ayla Pollmann , Divyangana Rakesh , Delia Fuhrmann

{"title":"Longitudinal associations between adolescent adversity, brain development and behavioural and emotional problems","authors":"Ayla Pollmann , Divyangana Rakesh , Delia Fuhrmann","doi":"10.1016/j.dcn.2025.101646","DOIUrl":"10.1016/j.dcn.2025.101646","url":null,"abstract":"<div><div>Adolescent adversity could have lasting effects on mental health, potentially through neurodevelopmental changes. This study used a random intercept cross-lagged panel model to examine how adverse experiences, brain development, and behavioural and emotional problems are linked over time in the ABCD study (N ≈ 12.000, USA). We found a positive association between family conflict and behavioural and emotional problems: family conflict was related to increased problems at 10 – 12 years (β = 0.06, p = 0.002), and vice versa. At 12 – 14 years, behavioural and emotional problems were also related to increased family conflict (β = 0.20, p < 0.001). Neighbourhood perception was related to behavioural and emotional problems and white matter microstructure. At 10 – 12 years, low neighbourhood safety was related to lower levels of white matter microstructure (β = −0.04, p = 0.041) and vice versa. It was also associated with more behavioural and emotional problems (β = 0.05, p = 0.015) and vice versa. Behavioural and emotional problems were positively associated with neighbourhood perception for adolescents with more friends (χ²(1) = 9.82, p<sub>Bonf.</sub> = 0.02). These findings underscore the need to consider socio-environmental adversity when examining adolescent brain development and mental health.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101646"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking functional brain networks in preterm and term infants using precision mapping 使用精确映射追踪早产儿和足月儿的脑功能网络。

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-10-12 DOI: 10.1016/j.dcn.2025.101629

Diego Derman, Silvina L. Ferradal

{"title":"Tracking functional brain networks in preterm and term infants using precision mapping","authors":"Diego Derman, Silvina L. Ferradal","doi":"10.1016/j.dcn.2025.101629","DOIUrl":"10.1016/j.dcn.2025.101629","url":null,"abstract":"<div><div>Preterm birth is a known risk factor for neurodevelopmental disabilities, but early neurobehavioral assessments and structural imaging often fail to predict long-term outcomes. This limitation underscores the need for alternative biomarkers that reflect early brain organization. Resting-state functional connectivity offers a powerful tool to track functional brain organization by characterizing resting-state networks (RSNs), potentially offering more sensitive biomarkers. However, most fMRI studies in infant populations use group-level analyses that average subject-specific data across several weeks of development, reducing sensitivity to subtle, time-sensitive deviations from typical brain trajectories, particularly in higher-order association networks. Using a recently introduced precision mapping approach, we estimated individual resting-state networks (RSNs) in a large cohort of term and preterm neonates from the developing Human Connectome Project. RSN connectivity strength increased linearly with age at scan, with primary sensory networks maturing earlier and higher-order association networks, including the default mode network (DMN), showing more gradual but pronounced changes, evolving from an immature organization in preterm infants to a more adult-like pattern in term-born infants. Longitudinal data from a subset of preterm infants confirmed ongoing network development shortly after birth. Despite this maturation, preterm infants did not reach the connectivity levels of term-born infants by term-equivalent age. These findings demonstrate that individualized RSN mapping captures heterogeneous developmental trajectories in the neonatal brain and highlights higher-order association networks, particularly the DMN, as promising early markers for monitoring neurodevelopmental outcomes in neonates.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101629"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-09-08 DOI: 10.1016/j.dcn.2025.101611

Aislinn Sandre , Sonya V. Troller-Renfree , Melina Amarante , Amanda M. Dettmer , Jerrold S. Meyer , Kimberly G. Noble

{"title":"Age-related patterns of resting EEG power in infancy: Associations with prenatal socioeconomic disadvantage","authors":"Aislinn Sandre , Sonya V. Troller-Renfree , Melina Amarante , Amanda M. Dettmer , Jerrold S. Meyer , Kimberly G. Noble","doi":"10.1016/j.dcn.2025.101611","DOIUrl":"10.1016/j.dcn.2025.101611","url":null,"abstract":"<div><div>The brain develops rapidly during the prenatal period and first two years of life, making it particularly sensitive to environmental influences. Family socioeconomic disadvantage is one environmental factor that may shape the development of brain function in infancy. However, it is unclear how brain function changes across infancy or whether prenatal family socioeconomic disadvantage is associated with age-related differences in brain function during this period. Here, we examine whether resting electroencephalography (EEG) power (theta, alpha, beta, and gamma) shows linear and/or non-linear age-related patterns across four assessments from 1 to 18 months of age (N = 165), and whether these patterns are moderated by prenatal family socioeconomic disadvantage. We find that lower-frequency (relative theta) and higher-frequency (relative alpha, beta, and gamma) power show non-linear age-related patterns during the first 18 months of life. Prenatal family socioeconomic disadvantage moderates these patterns, such that infants from lower-income families show less steep age-related decreases in lower-frequency (relative theta) power and less steep increases in higher-frequency (relative beta) power. These associations hold when adjusting for other prenatal and postnatal experiences, as well as infant demographic and health-related factors. These data suggest that lower prenatal family income is associated with age-related differences in brain function during infancy.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101611"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Previous institutionalization is associated with elevated functional connectivity between the nucleus accumbens and amygdala during aversive learning 先前的制度化与厌恶学习期间伏隔核和杏仁核之间的功能连接升高有关。

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-09-26 DOI: 10.1016/j.dcn.2025.101617

Benjamin M. Rosenberg , João F. Guassi Moreira , Adriana S. Méndez Leal , Natalie M. Saragosa-Harris , Elizabeth Gaines , Wesley J. Meredith , Clare F. McCann , Saché M. Coury , Yael Waizman , Emilia Ninova , Jennifer A. Silvers

{"title":"Previous institutionalization is associated with elevated functional connectivity between the nucleus accumbens and amygdala during aversive learning","authors":"Benjamin M. Rosenberg , João F. Guassi Moreira , Adriana S. Méndez Leal , Natalie M. Saragosa-Harris , Elizabeth Gaines , Wesley J. Meredith , Clare F. McCann , Saché M. Coury , Yael Waizman , Emilia Ninova , Jennifer A. Silvers","doi":"10.1016/j.dcn.2025.101617","DOIUrl":"10.1016/j.dcn.2025.101617","url":null,"abstract":"<div><div>Institutionalization is a profound form of early adversity that is associated with increased risk for internalizing disorders, which most commonly have their onset during adolescence. Developmental models emphasize how differences in childhood learning contribute to avoidance behaviors, a core pathway linking adversity to internalizing disorders. Yet, little empirical research has tested this theory. 43 previously institutionalized (PI; 12.1–22.8 years) and 47 comparison (9.9–22.9 years) youth completed an aversive learning task while undergoing fMRI. The task involved an escapable stimulus reinforced with an aversive sound (CS+<sub>r</sub>), the same stimulus without reinforcement (CS+<sub>nr</sub>), and an escapable stimulus that was never reinforced (CS-). Internalizing symptoms were measured using the parent-report Revised Child Anxiety and Depression Scales. Functional connectivity between the nucleus accumbens (NAcc) and amygdala was elevated among the PI versus comparison youth across stimuli (<em>p</em> = .036). Exploratory analyses found that NAcc-amygdala connectivity was elevated among the PI youth during early adolescence relative to late adolescence (<em>p</em> = .009). Institutionalization may impact neurodevelopment in ways that increase responsiveness of threat neurocircuitry across threatening and safe stimuli. Differences in NAcc-amygdala functional connectivity may attenuate with age following adoption.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101617"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal habituation and novelty detection neural responses from infancy to early childhood in The Gambia and UK 纵向习惯和新奇检测神经反应从婴儿期到幼儿期在冈比亚和英国。

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1016/j.dcn.2025.101619

Anna Blasi Ribera , Borja Blanco Maniega , Samantha McCann , Ebrima Mbye , Ebou Touray , Maria Rozhko , Bosiljka Milosavljevic , Laura Katus , Mariama Saidykhan , Muhammed Ceesay , Tijan Fadera , Giulia Ghillia , Marta Perapoch Amado , Maria M. Crespo-Llado , Sophie E. Moore , Clare E. Elwell , Sarah Lloyd-Fox , The BRIGHT Project team

{"title":"Longitudinal habituation and novelty detection neural responses from infancy to early childhood in The Gambia and UK","authors":"Anna Blasi Ribera , Borja Blanco Maniega , Samantha McCann , Ebrima Mbye , Ebou Touray , Maria Rozhko , Bosiljka Milosavljevic , Laura Katus , Mariama Saidykhan , Muhammed Ceesay , Tijan Fadera , Giulia Ghillia , Marta Perapoch Amado , Maria M. Crespo-Llado , Sophie E. Moore , Clare E. Elwell , Sarah Lloyd-Fox , The BRIGHT Project team","doi":"10.1016/j.dcn.2025.101619","DOIUrl":"10.1016/j.dcn.2025.101619","url":null,"abstract":"<div><div>As infants and young children learn from and respond to their environment, their development is driven by their ability to filter out irrelevant stimuli and respond to salient stimuli. While sources and types of stimuli vary across cultural contexts, research to understand the neural mechanisms of these behaviors have largely focused on relatively homogeneous populations in high income settings. To address this lack of diverse representation the Brain Imaging for Global health project (BRIGHT) collected longitudinal data in The Gambia (N = 204) and the UK (N = 61). Here we present results of the Habituation and Novelty Detection (HaND) fNIRS neuroimaging task. Gambian infants showed persistent response suppression (Habituation) at all visits (from 5mo to 60mo) while Novelty Detection was only observed once infants reached 18 and 24mo. In the UK, infants only showed persistent habituation from 5 to 12mo, while the response was not evident at 18 and 24mo. Furthermore, in contrast to The Gambia, alongside the habituation patterns observed Uk infants showed novelty detection from 5 to 12mo. This is the first longitudinal description of the HaND response in individuals from different contextual backgrounds across such a broad age range and number of time points, revealing different patterns of specialization in The Gambia and UK.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101619"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking reinforcement learning, working memory, and choice dynamics to age and symptoms of anxiety and depression in adolescence 将强化学习、工作记忆和选择动态与年龄和青春期焦虑和抑郁症状联系起来。

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-10-08 DOI: 10.1016/j.dcn.2025.101626

Erik R. Frogner , Andreas Dahl , Rikka Kjelkenes , Torgeir Moberget , Anne G.E. Collins , Lars T. Westlye , Mads L. Pedersen

{"title":"Linking reinforcement learning, working memory, and choice dynamics to age and symptoms of anxiety and depression in adolescence","authors":"Erik R. Frogner , Andreas Dahl , Rikka Kjelkenes , Torgeir Moberget , Anne G.E. Collins , Lars T. Westlye , Mads L. Pedersen","doi":"10.1016/j.dcn.2025.101626","DOIUrl":"10.1016/j.dcn.2025.101626","url":null,"abstract":"<div><div>Adolescence is a sensitive period characterized by significant neurocognitive development, with important implications for learning and decision-making. Working memory and reinforcement learning are essential for decision making and real-life dynamic adaptation to the environment and are often affected in individuals with anxiety and depression. Using a cognitive computational approach, we investigated associations between working memory, reinforcement learning, age, and symptoms of generalized anxiety and depression in 193 adolescents aged 12–24 years. Participants completed the Reinforcement Learning Working Memory (RLWM) task. To gain insight into the dynamics underlying instrumental learning behavior, we employed a computational model that combines the RLWM model with a Linear Ballistic Accumulator (RLWM-LBA), to quantify processes related to working memory and reinforcement learning, as well as choice dynamics underlying reaction times. We observed an age-related increase in task performance, but no differences depending on symptoms. Bayesian regression models revealed strong evidence for an association between age and the start point variability parameter of the LBA module, suggesting reduced choice stochasticity in older adolescents. In line with the behavioral findings, we found anecdotal to moderate evidence for no associations between RLWM-LBA parameters and symptom sum scores. Lastly, we trained regression models testing the utility of RLWM-LBA parameters for predicting age and symptom burden, yielding poor predictive performance. This study highlights differences in choice dynamics underlying age-related improvements in instrumental learning, while finding that cognitive differences identified in case-control studies did not generalize to symptom variation in this sample from the general adolescent population.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101626"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain functional connectivity, but not neuroanatomy, captures the interrelationship between sex and gender in preadolescents 大脑功能连接，而不是神经解剖学，捕捉了青春期前的性和性别之间的相互关系。

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-10-03 DOI: 10.1016/j.dcn.2025.101624

Athanasia Metoki , Roselyne J. Chauvin , Evan M. Gordon , Timothy O. Laumann , Benjamin P. Kay , Babatunde Adeyemo , Samuel R. Krimmel , Scott Marek , Anxu Wang , Andrew N. Van , Noah J. Baden , Vahdeta Suljic , Kristen M. Scheidter , Julia Monk , Forrest I. Whiting , Nadeshka J. Ramirez-Perez , Deanna M. Barch , Aristeidis Sotiras , Nico U.F. Dosenbach

{"title":"Brain functional connectivity, but not neuroanatomy, captures the interrelationship between sex and gender in preadolescents","authors":"Athanasia Metoki , Roselyne J. Chauvin , Evan M. Gordon , Timothy O. Laumann , Benjamin P. Kay , Babatunde Adeyemo , Samuel R. Krimmel , Scott Marek , Anxu Wang , Andrew N. Van , Noah J. Baden , Vahdeta Suljic , Kristen M. Scheidter , Julia Monk , Forrest I. Whiting , Nadeshka J. Ramirez-Perez , Deanna M. Barch , Aristeidis Sotiras , Nico U.F. Dosenbach","doi":"10.1016/j.dcn.2025.101624","DOIUrl":"10.1016/j.dcn.2025.101624","url":null,"abstract":"<div><div>Understanding sex differences in the adolescent brain is crucial, as they relate to sex-specific neurological and psychiatric conditions. Predicting sex from adolescent brain data may reveal how these differences influence neurodevelopment. Recently, attention has shifted toward socially-identified gender (distinct from sex assigned at birth) recognizing its explanatory power. This study evaluates whether resting-state functional connectivity (rsFC), cortical thickness, or cortical volume better predicts sex and sex/gender alignment (congruence between sex and gender) in preadolescents. Using Adolescent Brain Cognitive Development (ABCD) Study data and machine learning, rsFC predicted sex more accurately (85 %) than cortical thickness (76 %) and cortical volume (70 %). Brain regions most predictive of sex belonged to association (default mode, dorsal attention, parietal memory) and visual networks. The rsFC classifier trained on sex/gender aligned youth classified more accurately unseen youth with sex/gender alignment (<em>n</em> = 2013) than unalignment (<em>n</em> = 1116). The female rsFC sex profile was positively associated with sex/gender alignment, while in males, there was a negative association. However, neither brain modality predicted sex/gender alignment. These findings suggest that while rsFC predicts sex in the adolescent brain more accurately, it does not directly capture sex/gender alignment, underscoring the need for further investigation into the neural underpinnings of gender.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101624"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growing minds, integrating senses: Neural and computational insights into age-related changes in audio-visual and tactile-visual learning in children 心智成长，感官整合：儿童视听和触觉-视觉学习中与年龄相关的变化的神经和计算见解。

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-10-01 DOI: 10.1016/j.dcn.2025.101622

Nina Raduner , Carmen Providoli , Sarah V. Di Pietro , Maya Schneebeli , Iliana I. Karipidis , Ella Casimiro , Saurabh Bedi , Michael von Rhein , Nora M. Raschle , Christian C. Ruff , Silvia Brem

{"title":"Growing minds, integrating senses: Neural and computational insights into age-related changes in audio-visual and tactile-visual learning in children","authors":"Nina Raduner , Carmen Providoli , Sarah V. Di Pietro , Maya Schneebeli , Iliana I. Karipidis , Ella Casimiro , Saurabh Bedi , Michael von Rhein , Nora M. Raschle , Christian C. Ruff , Silvia Brem","doi":"10.1016/j.dcn.2025.101622","DOIUrl":"10.1016/j.dcn.2025.101622","url":null,"abstract":"<div><div>Multisensory processing and learning shape cognitive and language development, influencing how we perceive and interact with the world from an early age. While multisensory processes mature into adolescence, it remains poorly understood how age influences multisensory associative learning. This study investigated age-related effects on multisensory processing and learning during audio-visual and tactile-visual learning in 67 children (5.7–13 years) by integrating behavioural and neuroimaging data with computational methods. A reinforcement-learning drift diffusion model revealed that older children processed information faster and made more efficient decisions on multisensory associations. These age-related increases coincided with higher activity in brain regions associated with cognitive control, multisensory integration, and memory retrieval, specifically during audio-visual learning. Notably, the bilateral anterior insula exhibited heightened activation in response to lower reward prediction errors, indicative of increased sensitivity to negative feedback with development. Finally, reward prediction errors modulated activation in reward processing and cognitive control regions, with this modulation remaining modality-independent and largely stable across age. In conclusion, while children employ similar learning strategies, older children make decisions more efficiently and engage neural resources more strongly. Our findings reflect ongoing maturation of neural networks supporting multisensory learning in middle childhood, enabling more adaptive learning in later childhood.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101622"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age and sex, but not depression or anxiety, predict P3 amplitude during adolescence 年龄和性别，而不是抑郁或焦虑，预测青春期P3振幅

IF 4.9 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-11-01 DOI: 10.1016/j.dcn.2025.101640

Marta Korom , Marco McSweeney , Selin Zeytinoglu , Lucrezia Liuzzi , Daniel S. Pine , Nathan A. Fox , Katharina Kircanski

{"title":"Age and sex, but not depression or anxiety, predict P3 amplitude during adolescence","authors":"Marta Korom , Marco McSweeney , Selin Zeytinoglu , Lucrezia Liuzzi , Daniel S. Pine , Nathan A. Fox , Katharina Kircanski","doi":"10.1016/j.dcn.2025.101640","DOIUrl":"10.1016/j.dcn.2025.101640","url":null,"abstract":"<div><div>Reduced P3 amplitude during selective attention has been linked to depression in cross-sectional studies primarily with adults. Neurodevelopmental research has yet to examine relations between age-related changes in P3 amplitude, assessed across multiple time points, and the emergence of depressive and anxiety symptoms during adolescence, which may vary by sex. The present study addresses this gap by testing the effects of between- and within-person depressive symptoms, age, and sex on P3 amplitude during the Flanker task, across up to three age time points in a sample of adolescents (N = 190, ages ∼12, 15 and 18) at risk for developing internalizing symptoms. When depression was measured continuously without adjusting for age and sex, higher within-person depressive symptoms emerged as a significant predictor of reduced P3 amplitude. However, when age, sex, and depression (continuous or binary diagnostic status) were modeled together, only age and sex, but not depression, remained significant predictors of P3 amplitude. Specifically, P3 amplitude decreased with age, and males consistently exhibited higher P3 amplitudes than females, with stable age-related decrease across sexes. For anxiety, neither between- nor within-person symptoms were significantly associated with P3 amplitude, with or without age and sex included in the model. Similar to the findings for depression, however, age and sex were significant predictors of P3 amplitude. Thus, previous studies involving a single assessment of P3 amplitude and depression symptoms may be influenced by developmental factors.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101640"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0