Developmental Cognitive Neuroscience最新文献

How will developmental neuroimaging contribute to the prediction of neurodevelopmental or psychiatric disorders? Challenges and opportunities.

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-12-12 DOI: 10.1016/j.dcn.2024.101490

Koraly Pérez-Edgar, Mary Dozier, Rebecca Saxe, Katherine E MacDuffie

引用次数: 0

State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project.

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-12-12 DOI: 10.1016/j.dcn.2024.101496

Zhiyong Zhao, Ruolin Li, Yihan Wu, Mingyang Li, Dan Wu

{"title":"State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project.","authors":"Zhiyong Zhao, Ruolin Li, Yihan Wu, Mingyang Li, Dan Wu","doi":"10.1016/j.dcn.2024.101496","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101496","url":null,"abstract":"Although recent studies have consistently reported the emergence of resting-state networks in early infancy, the changes in inter-network functional connectivity with age are controversial and the alterations in its dynamics remain unclear at this stage. This study aimed to investigate dynamic functional network connectivity (dFNC) using resting-state functional MRI in 244 full-term (age: 37-44 weeks) and 36 preterm infants (age: 37-43 weeks) from the dHCP dataset. We evaluated whether early dFNC exhibits age-dependent changes and is influenced by preterm birth. Gestational age (GA) and postnatal age (PNA) showed different effects on variance of FNC change over time during fMRI scan in resting-state networks, especially among high-order association networks. These variances were significantly reduced by preterm birth. Moreover, two states of weakly-connected (State Ⅰ) and strongly-connected (State Ⅱ) FNC were identified. The fraction window and dwell time in State Ⅰ, and the transition from State Ⅱ to State Ⅰ, all showed significantly negative correlations with both GA and PNA. Preterm-born infants spent a longer time in the weakly-connected state compared to term-born infants. These findings suggest a state-dependent development of dynamic FNC across brain networks in the early stages, gradually reconfiguring towards a more flexible and dynamic system with stronger connections.","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"101496"},"PeriodicalIF":4.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-developing sleep-wake and sensory foundations for cognition in the human fetus and newborn. 人类胎儿和新生儿认知的睡眠-觉醒和感官基础的共同发展。

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-12-12 DOI: 10.1016/j.dcn.2024.101487

Kimberley Whitehead

{"title":"Co-developing sleep-wake and sensory foundations for cognition in the human fetus and newborn.","authors":"Kimberley Whitehead","doi":"10.1016/j.dcn.2024.101487","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101487","url":null,"abstract":"In older children and adults, cognition builds upon waking sensory experience which is consolidated during sleep. In the fetus and newborn, sensory input is instead largely experienced during sleep. The nature of these sensory inputs differs within sleep, between active and quiet sleep, as well as versus wakefulness. Here, sleep-wake organisation in the fetus and newborn is reviewed, and then its interaction with sensory inputs discussed with a focus on somatosensory and auditory modalities. Next, these ideas are applied to how neurological insults affect early development, using fetal growth restriction as a test case. Finally, the argument is made that taking account of sleep-wake state during perinatal functional neuroimaging can better index sensorimotor, language, and cognitive brain activities, potentially improving its diagnostic and prognostic value. To sum up, sensory and sleep-wake functions go hand in hand during early human development. Perturbation of these twinned functions by neurological insults may mediate later neurodevelopmental deficits. Perinatal neuroimaging has the potential to track these trajectories, feasibly identifying opportunities to therapeutically intervene.","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"101487"},"PeriodicalIF":4.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience.

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-12-08 DOI: 10.1016/j.dcn.2024.101488

Alexandra F Bonthrone, Manuel Blesa Cábez, A David Edwards, Jo V Hajnal, Serena J Counsell, James P Boardman

{"title":"Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience.","authors":"Alexandra F Bonthrone, Manuel Blesa Cábez, A David Edwards, Jo V Hajnal, Serena J Counsell, James P Boardman","doi":"10.1016/j.dcn.2024.101488","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101488","url":null,"abstract":"Large diffusion-weighted brain MRI (dMRI) studies in neonates are crucial for developmental neuroscience. Our aim was to investigate the utility of ComBat, an empirical Bayes tool for multisite harmonization, in removing site effects from white matter (WM) dMRI measures in healthy infants born at 37 gestational weeks+ 0 days-42 weeks+ 6 days from the Theirworld Edinburgh Birth Cohort (n = 86) and Developing Human Connectome Project (n = 287). Skeletonized fractional anisotropy (FA), mean, axial and radial diffusivity (MD, AD, RD) maps were harmonized. Differences between voxel-wise metrics, skeleton means and histogram widths (5th-95th percentile) were assessed before and after harmonization, as well as variance associated with gestational age at birth and scan. Before harmonization, large cohort differences were observed. Harmonization removed all voxel-wise differences from MD maps and all metric means and histogram widths, however small voxel-wise differences (<1.5 % of voxels) remained in FA, AD and RD. We detected significant relationships between GA at birth and all metrics. When comparing single site and multisite harmonized datasets of equal sample sizes, harmonized data resulted in smaller standardized regression coefficients. ComBat could enable unprecedented sample sizes in developmental neuroscience, offering new horizons for biomarker discovery and validation, understanding typical and atypical brain development, and assessing neuroprotective therapies.","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"101488"},"PeriodicalIF":4.6,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caregiver-child neural synchrony: Magic, mirage, or developmental mechanism?

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-11-29 DOI: 10.1016/j.dcn.2024.101482

Ellen C Roche, Elizabeth Redcay, Rachel R Romeo

{"title":"Caregiver-child neural synchrony: Magic, mirage, or developmental mechanism?","authors":"Ellen C Roche, Elizabeth Redcay, Rachel R Romeo","doi":"10.1016/j.dcn.2024.101482","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101482","url":null,"abstract":"Young children transition in and out of synchronous states with their caregivers across physiology, behavior, and brain activity, but what do these synchronous periods mean? One body of two-brain studies using functional near-infrared spectroscopy (fNIRS) finds that individual, family, and moment-to-moment behavioral and contextual factors are associated with caregiver-child neural synchrony, while another body of literature finds that neural synchrony is associated with positive child outcomes. Taken together, it is tempting to conclude that caregiver-child neural synchrony may act as a foundational developmental mechanism linking children's experiences to their healthy development, but many questions remain. In this review, we synthesize recent findings and open questions from caregiver-child studies using fNIRS, which is uniquely well suited for use with caregivers and children, but also laden with unique constraints. Throughout, we highlight open questions alongside best practices for optimizing two-brain fNIRS to examine hypothesized developmental mechanisms. We particularly emphasize the need to consider immediate and global stressors as context for interpretation of neural synchrony findings, and the need for full inclusion of socioeconomically and racially diverse families in future studies.","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"101482"},"PeriodicalIF":4.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The connecting brain in context: How adolescent plasticity supports learning and development.

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-11-28 DOI: 10.1016/j.dcn.2024.101486

Amanda E Baker, Adriana Galván, Andrew J Fuligni

{"title":"The connecting brain in context: How adolescent plasticity supports learning and development.","authors":"Amanda E Baker, Adriana Galván, Andrew J Fuligni","doi":"10.1016/j.dcn.2024.101486","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101486","url":null,"abstract":"Puberty initiates significant neurobiological changes that amplify adolescents' responsiveness to their environment, facilitating neural adaptation through processes like synaptic pruning, myelination, and neuronal reorganization. This heightened neuroplasticity, combined with their burgeoning social curiosity and appetite for risk, propels adolescents to explore diverse new environments and forge social bonds. Such exploration can accelerate experiential learning and the formation of social networks as adolescents prepare for adult independence. This review examines the complex interplay between adolescent neuroplasticity, environmental influences, and learning processes, synthesizing findings from recent studies that illustrate how factors such as social interactions, school environments, and neighborhood contexts influence both the transient activation and enduring organization of the developing brain. We advocate for incorporating social interaction into adolescent-tailored interventions, leveraging their social plasticity to optimize learning and development during this critical phase. Going forward, we discuss the importance of longitudinal studies that employ multimodal approaches to characterize the dynamic interactions between development and environment, highlighting recent advancements in quantifying environmental impacts in studies of developmental neuroscience. Ultimately, this paper provides an updated synopsis of adolescent neuroplasticity and the environment, underscoring the potential for environmental enrichment programs to support healthy brain development and resilience at this critical development stage.","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"101486"},"PeriodicalIF":4.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social behavior in ASD males: The interplay between cognitive flexibility, working memory, and functional connectivity deviations.

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-11-25 DOI: 10.1016/j.dcn.2024.101483

Shi Yu Chan, Jasmine Si Min Chuah, Pei Huang, Ai Peng Tan

{"title":"Social behavior in ASD males: The interplay between cognitive flexibility, working memory, and functional connectivity deviations.","authors":"Shi Yu Chan, Jasmine Si Min Chuah, Pei Huang, Ai Peng Tan","doi":"10.1016/j.dcn.2024.101483","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101483","url":null,"abstract":"Autism spectrum disorder (ASD) is highly heterogeneous in presentation. While abnormalities in brain functional connectivity are consistently observed in autistic males, the neurobiological basis underlying the different domains of autism symptoms is unclear. In this study, we evaluated whether individual variations in functional connectivity deviations map to social behavior in ASD males. Using neuroimaging data from the Autism Brain Imaging Data Exchange (ABIDE), we modeled normative trajectories of between-network resting-state functional connectivity (rsFC) in non-ASD males across childhood (n = 321). These normative charts were then applied to ASD males (n = 418) to calculate individual deviation scores (z-scores) that reflect the degree of rsFC atypicality. Deviations in rsFC patterns among the default mode network (DMN), ventral attention network (VAN), frontoparietal network (FPN), and somatomotor network (SMN) were associated with distinct dimensions of social behavior. Cognitive flexibility and working memory mediated the association between VANxDMN z-scores and social behavioral problems. Our findings underscore the potential of normative models to identify atypical brain connectivity at an individual level, revealing the neurobiological patterns associated with social behavioral problems in ASD that are critical for precision diagnosis and intervention. Social outcomes in ASD males may be improved by targeting cognitive flexibility and working memory.","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"101483"},"PeriodicalIF":4.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing infant neuroimaging methods to understand the neurodevelopmental impacts of early nutrition and feeding.

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-11-23 DOI: 10.1016/j.dcn.2024.101481

Claudia A Carreno, Megan E Evans, Blakely K Lockhart, Oziomachukwu Chinaka, Benjamin Katz, Martha Ann Bell, Brittany R Howell

{"title":"Optimizing infant neuroimaging methods to understand the neurodevelopmental impacts of early nutrition and feeding.","authors":"Claudia A Carreno, Megan E Evans, Blakely K Lockhart, Oziomachukwu Chinaka, Benjamin Katz, Martha Ann Bell, Brittany R Howell","doi":"10.1016/j.dcn.2024.101481","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101481","url":null,"abstract":"There is strong evidence proper nutrition is imperative for healthy infant neurodevelopment, providing the neural foundations for later cognition and behavior. Over the first years of life infants are supported by unique sources of nutrition (e.g., human milk, alternative milk sources). It is during this time that the brain undergoes its most drastic changes during postnatal development. Past research has examined associations between infant feeding and nutrition and morphological features of the brain, yet there remains a paucity of information on functional characteristics of neural activity during feeding. Within this article, we discuss how neuroimaging modalities can be optimized for researching the impacts of infant feeding and nutrition on brain function. We review past research utilizing EEG and fNIRS and describe our efforts to further develop neuroimaging approaches that allow for measurement of brain activity during active feeding with greater spatial resolution (e.g., fMRI and OPM-MEG). We also discuss current challenges, as well as the scientific and logistical limitations of each method. Once protocols have been optimized, these methods will provide the requisite insight into the underlying mechanisms of nutritional and feeding impacts on neurodevelopment, providing the missing piece in the field's efforts to understand this essential and ubiquitous part of early life.","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"101481"},"PeriodicalIF":4.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of early maternal care on anxiety and threat learning in adolescent nonhuman primates.

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-11-23 DOI: 10.1016/j.dcn.2024.101480

Elyse L Morin, Erin R Siebert, Brittany R Howell, Melinda Higgins, Tanja Jovanovic, Andrew M Kazama, Mar M Sanchez

{"title":"Effects of early maternal care on anxiety and threat learning in adolescent nonhuman primates.","authors":"Elyse L Morin, Erin R Siebert, Brittany R Howell, Melinda Higgins, Tanja Jovanovic, Andrew M Kazama, Mar M Sanchez","doi":"10.1016/j.dcn.2024.101480","DOIUrl":"10.1016/j.dcn.2024.101480","url":null,"abstract":"Early life adverse experiences, including childhood maltreatment, are major risk factors for psychopathology, including anxiety disorders with dysregulated fear responses. Consistent with human studies, maltreatment by the mother (MALT) leads to increased emotional reactivity in rhesus monkey infants. Whether this persists and results in altered emotion regulation, due to enhanced fear learning or impaired utilization of safety signals as shown in human stress-related disorders, is unclear. Here we used a rhesus model of MALT to examine long-term effects on state anxiety and threat/safety learning in 25 adolescents, using a fear conditioning paradigm (AX+/BX-) with acoustic startle amplitude as the peripheral measure. The AX+/BX- paradigm measures baseline startle, fear-potentiated startle, threat/safety cue discrimination, startle attenuation by safety signals, and extinction. Baseline startle was higher in MALT animals, suggesting elevated state anxiety. No differences in threat learning, or threat/safety discrimination were detected. However, MALT animals showed generalized blunted responses to the conditioned threat cue, regardless of the safety cue presence in the transfer test, and took longer to extinguish spontaneously recovered threat. These findings suggest adverse caregiving experiences have long-term impacts on adolescent emotion regulation, including elevated state anxiety and blunted fear conditioning responses, consistent with reports in children with maltreatment exposure.","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"101480"},"PeriodicalIF":4.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactive effects of social media use and puberty on resting-state cortical activity and mental health symptoms

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-11-22 DOI: 10.1016/j.dcn.2024.101479

Nathan M. Petro , Giorgia Picci , Lauren K. Webert , Mikki Schantell , Jake J. Son , Thomas W. Ward , Kellen M. McDonald , Cooper L. Livermore , Abraham D. Killanin , Danielle L. Rice , Grace C. Ende , Anna T. Coutant , Erica L. Steiner , Tony W. Wilson

{"title":"Interactive effects of social media use and puberty on resting-state cortical activity and mental health symptoms","authors":"Nathan M. Petro , Giorgia Picci , Lauren K. Webert , Mikki Schantell , Jake J. Son , Thomas W. Ward , Kellen M. McDonald , Cooper L. Livermore , Abraham D. Killanin , Danielle L. Rice , Grace C. Ende , Anna T. Coutant , Erica L. Steiner , Tony W. Wilson","doi":"10.1016/j.dcn.2024.101479","DOIUrl":"10.1016/j.dcn.2024.101479","url":null,"abstract":"<div><div>Adolescence is a period of profound biopsychosocial development, with pubertally-driven neural reorganization as social demands increase in peer contexts. The explosive increase in social media access has fundamentally changed peer interactions among youth, creating an urgent need to understand its impact on neurobiological development and mental health. Extant literature indicates that using social media promotes social comparison and feedback seeking (SCFS) behaviors in youth, which portend increased risk for mental health disorders, but little is known about its impact on neurobiological development. We assessed social media behaviors, mental health symptoms, and spontaneous cortical activity using magnetoencephalography (MEG) in 80 typically developing youth (8–16 years) and tested how self-reported pubertal stage moderates their relationship. More mature adolescents who engaged in more SCFS showed weaker fusiform/parahippocampal alpha and medial prefrontal beta activity, and increased symptoms of anxiety and attention problems. Engaging in SCFS on social media during adolescence may thus relate to developmental differences in brain regions that undergo considerable development during puberty. These results are consistent with works indicating altered neurodevelopmental trajectories within association cortices surrounding the onset of many mental health disorders. Importantly, later pubertal stages may be most sensitive to the detrimental effects of social media use.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"Article 101479"},"PeriodicalIF":4.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0