Developmental Cognitive Neuroscience最新文献

Development of brain metastable dynamics during the equivalent of the third gestational trimester 相当于妊娠晚期的脑亚稳态动力学的发展

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-04-07 DOI: 10.1016/j.dcn.2025.101556

Juliette L.Y. Champaud , Samanta Asite , Lorenzo Fabrizi

{"title":"Development of brain metastable dynamics during the equivalent of the third gestational trimester","authors":"Juliette L.Y. Champaud , Samanta Asite , Lorenzo Fabrizi","doi":"10.1016/j.dcn.2025.101556","DOIUrl":"10.1016/j.dcn.2025.101556","url":null,"abstract":"<div><div>Metastability, a concept from dynamical systems theory, provides a framework for understanding how the brain shifts between various functional states and underpins essential cognitive, behavioural, and social function. While studied in adults, metastability in early brain development has only received recent attention. As the brain undergoes dramatic functional and structural changes over the third gestational trimester, here we review how these are reflected in changes in brain metastable dynamics in preterm, preterm at term-equivalent and full-term neonates.</div><div>We synthesize findings from EEG, fMRI, fUS, and computational models, focusing on the spatial distribution and temporal dynamics of metastable states, which include functional integration and segregation, signal predictability and complexity. Despite fragmented evidence, studies suggest that neonatal metastability develops over the equivalent of the third gestational trimester, with increasing ability for integration-segregation, broader range of metastable states, faster metastable state transitions and greater signal complexity. Preterms at term-equivalent age exhibit immature metastability features compared to full-terms. We explain and interpret these changes in terms of maturation of the brain in a free energy landscape and establishment of cognitive functions.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101556"},"PeriodicalIF":4.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory control development from infancy to early childhood: A longitudinal fNIRS study 抑制控制发展从婴儿期到幼儿期：一项纵向fNIRS研究

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-26 DOI: 10.1016/j.dcn.2025.101557

Abigail Fiske , Alicia Mortimer , Liam Collins-Jones , Carina C J M de Klerk , Sylvia Ulieta Gattas , Henrik Dvergsdal , Gaia Scerif , Karla Holmboe

{"title":"Inhibitory control development from infancy to early childhood: A longitudinal fNIRS study","authors":"Abigail Fiske , Alicia Mortimer , Liam Collins-Jones , Carina C J M de Klerk , Sylvia Ulieta Gattas , Henrik Dvergsdal , Gaia Scerif , Karla Holmboe","doi":"10.1016/j.dcn.2025.101557","DOIUrl":"10.1016/j.dcn.2025.101557","url":null,"abstract":"<div><div>The developmental period from infancy to early childhood is one of substantial change – in advancements in cognitive skills, such as early executive functions, but also in the maturation of the prefrontal and parietal cortices that parallel such advances. The current study aims to investigate the emergence and development of inhibitory control, a core executive function, from infancy to early childhood. We collected longitudinal functional near-infrared spectroscopy (fNIRS) data from the same sample of participants at 10-months, 16-months, and 3½ years of age whilst they completed the <em>Early Childhood Inhibitory Touchscreen Task</em>. In our previous publications, we reported that 10-month-old infants recruited right lateralised regions of the prefrontal and parietal cortex when inhibition was required. Despite no change in response inhibition performance, 16-month-olds recruited broader and bilateral regions of the prefrontal and parietal cortex. Results of the current study found that 3½-year-olds activated regions of the right inferior parietal cortex and the right inferior frontal gyrus when inhibition was required. Response inhibition performance was significantly improved by early childhood, yet there was commonality in the brain regions recruited at 16-months and 3½ years. This could suggest that these brain regions are fundamental neural indices of inhibitory control, even from toddlerhood.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101557"},"PeriodicalIF":4.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-voxel pattern analysis for developmental cognitive neuroscientists 发展认知神经科学家的多体素模式分析

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-25 DOI: 10.1016/j.dcn.2025.101555

João F. Guassi Moreira , Jennifer A. Silvers

{"title":"Multi-voxel pattern analysis for developmental cognitive neuroscientists","authors":"João F. Guassi Moreira , Jennifer A. Silvers","doi":"10.1016/j.dcn.2025.101555","DOIUrl":"10.1016/j.dcn.2025.101555","url":null,"abstract":"<div><div>The current prevailing approaches to analyzing task fMRI data in developmental cognitive neuroscience are brain connectivity and mass univariate task-based analyses, used either in isolation or as part of a broader analytic framework (e.g., BWAS). While these are powerful tools, it is somewhat surprising that multi-voxel pattern analysis (MVPA) is not more common in developmental cognitive neuroscience given its enhanced ability to both probe neural population codes and greater sensitivity relative to the mass univariate approach. Omitting MVPA methods might represent a missed opportunity to leverage a suite of tools that are uniquely poised to reveal mechanisms underlying brain development. The goal of this review is to spur awareness and adoption of MVPA in developmental cognitive neuroscience by providing a practical introduction to foundational MVPA concepts. We begin by defining MVPA and explain why examining multi-voxel patterns of brain activity can aid in understanding the developing human brain. We then survey four different types of MVPA: Decoding, representational similarity analysis (RSA), pattern expression, and voxel-wise encoding models. Each variant of MVPA is presented with a conceptual overview of the method followed by practical considerations and subvariants thereof. We go on to highlight the types of developmental questions that can be answered by MPVA, discuss practical matters in MVPA implementation germane to developmental cognitive neuroscientists, and make recommendations for integrating MVPA with the existing analytic ecosystem in the field.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101555"},"PeriodicalIF":4.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG time-frequency dynamics of early cognitive control development 早期认知控制发展的脑电图时频动态

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-22 DOI: 10.1016/j.dcn.2025.101548

Santiago Morales , George A. Buzzell

{"title":"EEG time-frequency dynamics of early cognitive control development","authors":"Santiago Morales , George A. Buzzell","doi":"10.1016/j.dcn.2025.101548","DOIUrl":"10.1016/j.dcn.2025.101548","url":null,"abstract":"<div><div>Cognitive control is crucial for goal-directed behavior, and essential for other aspects of cognitive and socioemotional development. This review examines when and how the neural dynamics of cognitive control emerge and develop, focusing on electroencephalography measures used to study cognitive control in infants and children. We argue that time-frequency analyses are uniquely able to capture two distinct components of cognitive control: 1) the detection that control is needed, and 2) the instantiation of control. Starting in infancy and increasing across childhood and adolescence, studies suggest the signal strength and consistency of midfrontal theta and delta oscillations are involved in processes that detect the need for control. For control instantiation, there is evidence that theta band connectivity between midfrontal and lateral-frontal cortices is present from early childhood. There is also evidence for the involvement of midfrontal theta power in the instantiation of control in infancy. We further review emerging evidence that indicates individual differences in midfrontal theta are not only proximally related to behavior, but also sensitive to variations in early experience and risk for psychopathology, providing a neural mechanism linking early adversity to future psychopathology. We discuss needed future steps, including novel paradigms, computational models, and aperiodic/periodic modeling of EEG.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101548"},"PeriodicalIF":4.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amygdala subregion volumes and apportionment in preadolescents — Associations with age, sex, and body mass index 青春期前的杏仁核亚区体积和分配——与年龄、性别和体重指数的关系

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-20 DOI: 10.1016/j.dcn.2025.101554

L. Nate Overholtzer , Carinna Torgerson , Jessica Morrel , Hedyeh Ahmadi , J. Michael Tyszka , Megan M. Herting

{"title":"Amygdala subregion volumes and apportionment in preadolescents — Associations with age, sex, and body mass index","authors":"L. Nate Overholtzer , Carinna Torgerson , Jessica Morrel , Hedyeh Ahmadi , J. Michael Tyszka , Megan M. Herting","doi":"10.1016/j.dcn.2025.101554","DOIUrl":"10.1016/j.dcn.2025.101554","url":null,"abstract":"<div><div>The amygdala, a key limbic structure, is critical to emotional, social, and appetitive behaviors that develop throughout adolescence. Composed of a heterogeneous group of nuclei, questions remain about potential differences in the maturation of its subregions during development. In 3953 9- and 10-year-olds from the Adolescent Brain Cognitive Development℠ Study, the <em>CIT168 Atlas</em> was used to segment nine amygdala subregions. Linear mixed-effects models were used to examine the effects of age, sex, pubertal stage, and body mass index z-score (BMIz) on subregion volumes and their relative apportionment within the amygdala. Distinct associations were observed between age, sex, and BMIz with whole amygdala volume, subregion volumes, and subregion apportionment. Pubertal stage was not related to amygdala subregion volumes. Age was associated with near-global expansion of amygdala subregions during this developmental period. Female sex was linked to smaller volumes in most amygdala subregions, with larger relative apportionment in the dorsal subregions and smaller apportionment in the basolateral ventral paralaminar subregion. Higher BMIz was associated with smaller volumes in large basolateral subregions, with increased relative apportionment in smaller subregions. These findings provide a foundational context for understanding how developmental variables influence amygdala structure, with implications for understanding future risk for brain disorders.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101554"},"PeriodicalIF":4.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner 青少年酒精消费在反应抑制和眶额纹状体活动方面以性别特异性的方式产生长期变化

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-19 DOI: 10.1016/j.dcn.2025.101552

Aqilah M. McCane, Lo Kronheim, Bita Moghaddam

{"title":"Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner","authors":"Aqilah M. McCane, Lo Kronheim, Bita Moghaddam","doi":"10.1016/j.dcn.2025.101552","DOIUrl":"10.1016/j.dcn.2025.101552","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) is strongly associated with initiation of drinking during adolescence. Little is known about neural mechanisms that produce the long-term detrimental effects of adolescent drinking. A critical feature of AUD is deficits in response inhibition, or the ability to withhold a reward-seeking response. Here, we sought to determine if adolescent drinking affects response inhibition and encoding of neural events by the orbitofrontal cortex (OFC) and dorsomedial striatum (DMS), two regions critical for expression of response inhibition. Adolescent male and female rats were given access to alcohol for four hours a day for five consecutive days. Then, rats were tested in a cued response inhibition task as adolescents or adults while we recorded concomitantly from the OFC and DMS. Adolescent voluntary alcohol drinking impaired response inhibition and increased alcohol drinking in male but not female rats. Adolescent alcohol drinking was associated with reduced excitation following premature actions in adults and increased OFC-DMS synchrony in male but not female rats. Collectively, these data suggest sex-specific effects of adolescent alcohol drinking on response inhibition and corresponding alterations in cortical-striatal circuitry.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101552"},"PeriodicalIF":4.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intersubject neural similarity reveals the development trajectory of recognition memory in children 主体间神经相似性揭示了儿童识别记忆的发展轨迹

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-18 DOI: 10.1016/j.dcn.2025.101553

Yiwen Li , Chaoqun Wang , Weiyu Hu , Qinfen Zhang , Haitian Mei , Shiyan Ji , Dongwei Li , Yiyang Wang , Yuanjun Kong , Yan Song , Xuan Dong

{"title":"Intersubject neural similarity reveals the development trajectory of recognition memory in children","authors":"Yiwen Li , Chaoqun Wang , Weiyu Hu , Qinfen Zhang , Haitian Mei , Shiyan Ji , Dongwei Li , Yiyang Wang , Yuanjun Kong , Yan Song , Xuan Dong","doi":"10.1016/j.dcn.2025.101553","DOIUrl":"10.1016/j.dcn.2025.101553","url":null,"abstract":"<div><div>Recognition memory improves with child development, but the neural mechanisms underlying such improvement and the developmental variation remain poorly understood. Herein, we investigated how the neural representations during the encoding and retrieval phases of recognition memory change with age, using representational similarity analysis in a sample of children aged 6–13 years (<em>n</em> = 137). Our results indicated that the encoding and retrieval phases have distinct neural patterns of development. Similarly, using a model-free approach, we confirmed that there is a key developmental stage (about 9–10 years old) for the neural representation during the encoding phase, whereas the neural representation during the retrieval phase tends to be stable with child development. Additionally, we identified that the neural similarity between the encoding and retrieval phases in children is primarily located in the left parietal-occipital region. Overall, these findings refine the developmental process underlying memory representation and enhance our understanding of the neural mechanisms of recognition memory.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101553"},"PeriodicalIF":4.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engagement of neural systems varies with level of executive function during late childhood: Evidence from a structural equation modeling approach to data from the adolescent brain cognitive development (ABCD) study 在儿童晚期，神经系统的参与随执行功能的水平而变化：来自青少年大脑认知发展（ABCD）研究数据的结构方程建模方法的证据

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-16 DOI: 10.1016/j.dcn.2025.101549

Brynn A. Paulsen , Naomi P. Friedman , Marie T. Banich

{"title":"Engagement of neural systems varies with level of executive function during late childhood: Evidence from a structural equation modeling approach to data from the adolescent brain cognitive development (ABCD) study","authors":"Brynn A. Paulsen , Naomi P. Friedman , Marie T. Banich","doi":"10.1016/j.dcn.2025.101549","DOIUrl":"10.1016/j.dcn.2025.101549","url":null,"abstract":"<div><div>The present study utilized structural equation models to investigate the association between brain activation and level of executive function in participants in the Adolescent Brain Cognitive Development (ABCD) study at the baseline assessment and the two-year follow-up. The results indicated that increasing levels of a latent factor reflecting activation across multiple regions of the frontoparietal network (FPN) for the contrast of a 2 vs. 0 back condition in the emotional N-back task were significantly associated with higher levels of a latent factor of common executive functioning (cEF) drawn from a variety of behavioral measures, while the opposite was true for a latent factor of activation drawn from somatomotor regions. Moreover, these relationships were specific to cEF as they held even when a latent measure of general intelligence was included. In addition, these effects were observed at each of the two distinct time points 2 years apart. cEF scores at baseline predicted FPN scores at the Year 2 follow-up after controlling for FPN scores at baseline. These results provide for the possibility that increased levels of cEF during late childhood may provide a strong substrate for continued development of the FPN and decreased reliance on somatomotor regions.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101549"},"PeriodicalIF":4.6,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of socioeconomic status in shaping associations between sensory association cortex and prefrontal structure and implications for executive function 社会经济地位在形成感觉联想皮层和前额叶结构之间的联系及其对执行功能的影响中的作用。

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-13 DOI: 10.1016/j.dcn.2025.101550

Maya L. Rosen , Divyangana Rakesh , Rachel R. Romeo

{"title":"The role of socioeconomic status in shaping associations between sensory association cortex and prefrontal structure and implications for executive function","authors":"Maya L. Rosen , Divyangana Rakesh , Rachel R. Romeo","doi":"10.1016/j.dcn.2025.101550","DOIUrl":"10.1016/j.dcn.2025.101550","url":null,"abstract":"<div><div>Socioeconomic status (SES) is associated with widespread differences in structure of temporal, parietal, occipital, and frontal cortices. Development of sensory processing regions—in particular visual association cortex (VAC) and auditory association cortex (AAC)—may scaffold development of the prefrontal cortex (PFC). Experiences that correlate with SES like cognitive stimulation and language may influence VAC and AAC development, in turn allowing the PFC to resolve conflicts between similar stimuli. SES-related differences in these regions may partly explain differences in executive function (EF) skills. Here, we use structural equation modeling of longitudinal data from the Adolescent Brain and Cognitive Development study to test the hypothesis that SES-related differences in AAC and VAC are associated with differences in structure of the PFC and development of the PFC over time, which in turn are associated with development of EF. We found partial support for this model, demonstrating that SES-related differences in PFC structure are mediated by differences in sensory cortex structure, and that SES-related differences in sensory cortex structure mediate the association between SES and EF. These findings highlight the role sensory processing regions play in SES-related differences in PFC development. Future studies should explore proximal environmental factors driving SES-related differences to inform interventions.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101550"},"PeriodicalIF":4.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BrainXcan identifies brain features associated with behavioral and psychiatric traits using large-scale genetic and imaging data BrainXcan通过大规模的基因和成像数据来识别与行为和精神特征相关的大脑特征

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-03-13 DOI: 10.1016/j.dcn.2025.101542

Yanyu Liang , Festus Nyasimi , Owen Melia , Timothy J. Carroll , Thomas Brettin , Andrew Brown , Hae Kyung Im

{"title":"BrainXcan identifies brain features associated with behavioral and psychiatric traits using large-scale genetic and imaging data","authors":"Yanyu Liang , Festus Nyasimi , Owen Melia , Timothy J. Carroll , Thomas Brettin , Andrew Brown , Hae Kyung Im","doi":"10.1016/j.dcn.2025.101542","DOIUrl":"10.1016/j.dcn.2025.101542","url":null,"abstract":"<div><div>Advances in brain MRI have enabled many discoveries in neuroscience. Case-control comparisons of brain MRI features have highlighted potential causes of psychiatric and behavioral disorders. However, due to the cost and difficulty of collecting MRI data, most studies have small sample sizes, limiting their reliability. Furthermore, reverse causality complicates interpretation because many observed brain differences are the result rather than the cause of the disease. Here we propose a method (BrainXcan) that leverages the power of large-scale genome-wide association studies (GWAS) and reference brain MRI data to discover new mechanisms of disease etiology and validate existing ones. BrainXcan tests the association with genetic predictors of brain MRI-derived features and complex traits to pinpoint relevant brain-wide and region-specific features. Requiring only genetic data, BrainXcan allows us to test a host of hypotheses on mental illness, across many MRI modalities, using public data resources. For example, our method shows that reduced axonal density across the brain is associated with schizophrenia risk, consistent with the disconnectivity hypothesis. We also find that the hippocampus volume is associated with schizophrenia risk, highlighting the potential of our approach. Taken together, our results show the promise of BrainXcan to provide insights into the biology of GWAS traits.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"73 ","pages":"Article 101542"},"PeriodicalIF":4.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0