Developmental Cognitive Neuroscience最新文献_第10页

Short-term exposure to traffic-related air pollution and dynamic brain connectivity in adolescents 青少年短期暴露于交通相关的空气污染与动态大脑连通性

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-05-27 DOI: 10.1016/j.dcn.2025.101574

Mónica López-Vicente , Michelle S.W. Kusters , Sami Petricola , Henning Tiemeier , Ryan L. Muetzel , Mònica Guxens

{"title":"Short-term exposure to traffic-related air pollution and dynamic brain connectivity in adolescents","authors":"Mónica López-Vicente , Michelle S.W. Kusters , Sami Petricola , Henning Tiemeier , Ryan L. Muetzel , Mònica Guxens","doi":"10.1016/j.dcn.2025.101574","DOIUrl":"10.1016/j.dcn.2025.101574","url":null,"abstract":"<div><div>There is some evidence which suggests short-term effects of traffic-related air pollution on brain function in adults. We aimed to examine these associations at ages 10 and 14 years using dynamic functional brain connectivity. We included participants from a population-based birth cohort with brain connectivity and air pollution data at home (n = 3608) or school (n = 2305) in at least one visit. We used land use regression models to estimate levels of air pollutants, including nitrogen oxides (NO<sub>X</sub>) and particulate matter (PM), during the week before the outcome measurement. Using resting-state functional magnetic resonance imaging data, we generated five connectivity patterns. We calculated the mean time spent in each pattern for each participant and visit. We performed linear mixed effects models adjusted for relevant confounders. The median levels of NO<sub>X</sub> at the two visits and at home and school were between 36 and 47 μg/m<sup>3</sup> and the median levels of PM<sub>2.5</sub> were between 11 and 12 μg/m<sup>3</sup>. We found a weak association between higher air pollution exposure and less time spent in a low modularized connectivity pattern (e.g. coefficient=-0.031 [95 % confidence interval=-0.056; −0.006] per 20 μg/m<sup>3</sup> increase in NO<sub>X</sub> at home). However, this association did not remain after multiple testing correction. Further research that explores these associations at other exposure levels and other age periods is warranted.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101574"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal effects of physical activity and screen time on childhood intelligence via Mendelian randomization: The mediating role of intracranial volume 通过孟德尔随机化，体育活动和屏幕时间对儿童智力的因果影响：颅内容积的中介作用

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-06-20 DOI: 10.1016/j.dcn.2025.101586

Junjiao Feng , Yi Wan , Liang Zhang

{"title":"Causal effects of physical activity and screen time on childhood intelligence via Mendelian randomization: The mediating role of intracranial volume","authors":"Junjiao Feng , Yi Wan , Liang Zhang","doi":"10.1016/j.dcn.2025.101586","DOIUrl":"10.1016/j.dcn.2025.101586","url":null,"abstract":"<div><div>Growing evidence suggests that physical activity and screen time affect intelligence (IQ) during childhood, a critical period for brain development, yet the relationship between these factors remains controversial. Using bidirectional Mendelian randomization (MR), we investigated these associations while accounting for potential reverse causality. Our two-sample MR analysis revealed a positive causal effect of moderate to vigorous physical activity (PA) on childhood IQ (<em>β</em> = 0.42, 95 % confidence interval (CI): [0.12, 0.72], <em>p</em> = 6.26 × 10<sup>−3</sup>), whereas leisure screen time (LST) exhibited a negative causal effect (<em>β</em> = −0.35, 95 % CI: [ −0.60, −0.10], <em>p</em> = 5.59 ×10<sup>−3</sup>). Reverse MR analysis found no evidence of causations. A two-step MR mediation framework further suggested that the intracranial volume (ICV) mediated 21.69 % (95 % CI: [15.25 %, 28.13 %]) of the negative effect of LST on childhood IQ. These MR-derived findings demonstrate that PA positively influences childhood IQ, whereas LST negatively impacts it, partly through reduced ICV. By leveraging genetic instruments, this study strengthens causal inference and highlights the potential of PA promotion and screen time reduction to support cognitive development. Further research is needed to elucidate the mechanisms underlying these associations and their long-term cognitive consequences.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101586"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bayesian Regularized and Annotation-Informed Integrative Analysis of Cognition (BRAINIAC) 基于贝叶斯正则化和标注的认知综合分析（BRAINIAC）

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-06-25 DOI: 10.1016/j.dcn.2025.101569

Rong W. Zablocki , Bohan Xu , Chun-Chieh Fan , Wesley K. Thompson

引用次数: 0

Generalizability of developmental EEG: Demographic reporting, representation, and sample size 发展性脑电图的普遍性：人口统计报告、代表性和样本量

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-05-13 DOI: 10.1016/j.dcn.2025.101567

Santiago Morales , Lauren Oh , Kylie Cox , Ramiro Rodriguez-Sanchez , Gina Nadaya , George A. Buzzell , Sonya V. Troller-Renfree

{"title":"Generalizability of developmental EEG: Demographic reporting, representation, and sample size","authors":"Santiago Morales , Lauren Oh , Kylie Cox , Ramiro Rodriguez-Sanchez , Gina Nadaya , George A. Buzzell , Sonya V. Troller-Renfree","doi":"10.1016/j.dcn.2025.101567","DOIUrl":"10.1016/j.dcn.2025.101567","url":null,"abstract":"<div><div>Electroencephalography (EEG) is one of the main neuroscientific measures used with infants and children to identify potential biomarkers of cognitive and social developmental processes. Given the implications of developmental EEG research within policy, clinical, and educational domains, it is important to ensure that reported results are generalizable and reproducible. In this review, to provide an initial assessment of previous and current practices regarding participant recruitment (sample size and representation) and demographic reporting, we carried out a systematic review of six notable journals for publishing pediatric EEG studies between 2011 and 2023. We identified 700 articles reporting on pediatric EEG. We found that most studies did not provide complete reporting of basic demographic information (e.g., race, ethnicity, socioeconomic status, geographical location). This trend persisted across years of publication, suggesting continued underreporting. However, the reporting of demographic information differed between journals, suggesting solutions for improving reporting practices. Our review also indicated that samples were of modest sample size (Median = 51) and consisted of mostly White participants (78 %) from North America and Western Europe (85 %). Our discussion emphasizes the need for larger, more diverse samples and greater transparency in developmental EEG studies, while providing recommendations to address barriers to representation and reproducibility.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101567"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations among socioeconomic disadvantage, longitudinal changes in within-network connectivity, and academic outcomes in the ABCD study ABCD研究中社会经济劣势、网络内连通性的纵向变化和学术成果之间的关系

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1016/j.dcn.2025.101587

Divyangana Rakesh , Ekaterina Sadikova , Katie A. McLaughlin

{"title":"Associations among socioeconomic disadvantage, longitudinal changes in within-network connectivity, and academic outcomes in the ABCD study","authors":"Divyangana Rakesh , Ekaterina Sadikova , Katie A. McLaughlin","doi":"10.1016/j.dcn.2025.101587","DOIUrl":"10.1016/j.dcn.2025.101587","url":null,"abstract":"<div><div>Lower parental socioeconomic status (SES) is consistently linked to lower academic achievement among adolescents, with early disparities persisting into adulthood. However, the neurobiological mechanisms underlying these associations are not well understood. This preregistered study investigates the associations between household and neighborhood disadvantage—measured by income-to-needs ratio, parental educational attainment, and neighborhood SES—changes in within-network functional connectivity, and school grades, using longitudinal data from the Adolescent Brain Cognitive Development Study (N = 4745; age at baseline = 119.1 ± 7.5 months; age at 2-year follow up = 143.6 ± 7.8 months; age at 3-year follow up = 154.8 ± 7.7 months). Within-network connectivity changed significantly from baseline to follow-up, increasing in most networks (e.g., default mode, fronto-parietal) and decreasing in a few (e.g., salience, ventral attention). After controlling for other SES indicators, parental education and neighborhood disadvantage, but not income, were associated with changes in connectivity across several brain networks, including reduced increases in default mode, cingulo-opercular, and visual network connectivity and greater increases in within-sensorimotor network connectivity. Further, changes in sensorimotor connectivity mediated the relationship between parental educational attainment and academic achievement three years later. These findings highlight the importance of parental education and neighborhood environments in shaping neurodevelopmental trajectories that influence academic outcomes. Understanding the mechanisms that link socioeconomic disadvantage with academic outcomes could inform interventions aimed at reducing persistent achievement gaps.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101587"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in the neural correlates of affective reactivity and regulation in early adolescence 青春期早期情感反应和调节的神经相关的性别差异

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-06-26 DOI: 10.1016/j.dcn.2025.101588

Leah D. Church , Nadia Bounoua , Kavya Bhattiprolu , Julia Merker , Jeffrey M. Spielberg

{"title":"Sex differences in the neural correlates of affective reactivity and regulation in early adolescence","authors":"Leah D. Church , Nadia Bounoua , Kavya Bhattiprolu , Julia Merker , Jeffrey M. Spielberg","doi":"10.1016/j.dcn.2025.101588","DOIUrl":"10.1016/j.dcn.2025.101588","url":null,"abstract":"<div><div>Internalizing disorders are the leading cause of disability worldwide. Despite this public health crisis, borne disproportionately by female adolescents, specific neural mechanisms driving these differences remain unclear. The present study investigated sex differences in the neural circuitry underlying emotion regulation in a community sample of 180 early adolescents (M<sub>age</sub>= 12.03 years; 54.4 % female). Participants were instructed to either <em>react</em> naturally or <em>regulate</em> their affective responses to <em>negative</em> or <em>neutral</em> stimuli. Voxelwise analyses revealed a significant 3-way interaction between sex, regulation (e.g., regulate vs. react), and stimulus valence (e.g., negative vs. neutral) in bilateral middle/medial orbitofrontal cortex (OFC), right middle frontal gyrus (MFG), and right amygdala. Specifically, female adolescents recruited bilateral OFC when asked to <em>regulate</em> their responses to <em>aversive</em> images. Recruitment of left (but not right) OFC was greater for male adolescents than female adolescents when regulating their responses to <em>neutral</em> stimuli. Finally, greater <em>dea</em>ctivation of right MFG was found when female adolescents <em>reacted naturally</em> to <em>aversive</em> stimuli, relative to male adolescents. These regions play critical roles in cognitive processes involved in emotion regulation. Our identification of sex-specific mechanisms supporting affective processes in early adolescents may reflect risk factors that can be intervened upon before the crystallization of internalizing pathology.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101588"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting state EEG classifies developmental status in three-year-old children 静息状态脑电图对三岁儿童的发育状态进行分类

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-05-31 DOI: 10.1016/j.dcn.2025.101575

Dhanya Parameshwaran , Supriya Bhavnani , Debarati Mukherjee , Kamal Kant Sharma , Jennifer Jane Newson , Narayan Puthanmadam Subramaniyam , Gauri Divan , Vikram Patel , Tara C. Thiagarajan

{"title":"Resting state EEG classifies developmental status in three-year-old children","authors":"Dhanya Parameshwaran , Supriya Bhavnani , Debarati Mukherjee , Kamal Kant Sharma , Jennifer Jane Newson , Narayan Puthanmadam Subramaniyam , Gauri Divan , Vikram Patel , Tara C. Thiagarajan","doi":"10.1016/j.dcn.2025.101575","DOIUrl":"10.1016/j.dcn.2025.101575","url":null,"abstract":"<div><div>Monitoring cognitive development in early childhood enables detection of problems for timely intervention. However, currently recommended methods require lengthy evaluations of task performance, and are resource intense. Here we examined whether 3 minutes of resting-state EEG (rs-EEG) recorded in 70 33–40-month-old children using a 14-channel portable EEG device in low-resource households could classify performance on five domains of developmental outcomes (cognition, receptive language, expressive language, fine motor and gross motor coordination) as measured by the Bayley’s Scale of Infant and Toddler Development, 3rd Edition (BSID-III). Applying supervised learning models to a combination of spectral features and novel time-domain features derived from EEG data, we predicted BSID-III domain scores with moderate accuracy (AUCs ranging from 0.70 to 0.84 and F1-scores ranging from 0.58 to 0.76). While spectral frequencies significantly correlated with cognitive and language domain scores, time-domain features describing amplitude variability were more significantly correlated and contributed more substantially to model outcomes. Model performance was reliable even with a subset of 4 channels. Overall, this study provides a first demonstration that rs-EEG from low electrode configuration devices can serve as a quick and reliable indicator of cognitive developmental outcomes and aid in identifying those requiring support during early childhood.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101575"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive interference elicits developmental sex differences in inhibitory control 认知干扰引起抑制控制的发育性别差异

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-06-25 DOI: 10.1016/j.dcn.2025.101590

Jake J. Son , Abraham D. Killanin , Mikki Schantell , Yasra Arif , Thomas W. Ward , Maggie P. Rempe , Grace C. Ende , Hannah J. Okelberry , Danielle L. Rice , Anna T. Coutant , Julia M. Stephen , Yu-Ping Wang , Vince D. Calhoun , Alex I. Wiesman , Tony W. Wilson

{"title":"Cognitive interference elicits developmental sex differences in inhibitory control","authors":"Jake J. Son , Abraham D. Killanin , Mikki Schantell , Yasra Arif , Thomas W. Ward , Maggie P. Rempe , Grace C. Ende , Hannah J. Okelberry , Danielle L. Rice , Anna T. Coutant , Julia M. Stephen , Yu-Ping Wang , Vince D. Calhoun , Alex I. Wiesman , Tony W. Wilson","doi":"10.1016/j.dcn.2025.101590","DOIUrl":"10.1016/j.dcn.2025.101590","url":null,"abstract":"<div><div>Inhibitory control is a key component of cognitive control that enables children and adolescents to develop increasingly complex skills throughout development. These processes are subject to insult via endogenous and environmental stressors (e.g., puberty, trauma) and alterations can lead to significant behavioral impairments that persist into adulthood. Despite this, the normative developmental course of neural oscillatory activity underlying interference control, a critical subcomponent of inhibitory control, and potential sex differences along this course, remain poorly understood. Herein, we utilized high-density magnetoencephalography (MEG) during the Eriksen flanker task to map the developmental sensitivity of neural processes supporting interference control in a large sample of children and adolescents (N = 121). MEG data were transformed into the time-frequency domain and significant oscillatory responses were imaged using a beamformer. Whole-brain analysis of flanker interference maps (i.e., incongruent - congruent trials) revealed age-related decreases in theta power in the supplementary motor area and cerebellum. Furthermore, regions known to be critical for supporting cognitive control, including the prefrontal and parietal cortices, exhibited age-by-sex interactive effects, suggesting modulation of interference control throughout development in a sex-dependent manner. Taken together, these data contribute to the characterization of the electrophysiological mechanisms supporting the development and refinement of interference control.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101590"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in maturational timing of amygdala and prefrontal cortex volumes and white matter tract microstructure 杏仁核和前额叶皮层体积和白质束微观结构成熟时间的性别差异

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-05-13 DOI: 10.1016/j.dcn.2025.101568

Jamie Roeske , Xiangyu Long , Meaghan V Perdue , Madison Long , Bryce Geeraert , Mohammad Ghasoub , Keith Owen Yeates , Catherine Lebel

{"title":"Sex differences in maturational timing of amygdala and prefrontal cortex volumes and white matter tract microstructure","authors":"Jamie Roeske , Xiangyu Long , Meaghan V Perdue , Madison Long , Bryce Geeraert , Mohammad Ghasoub , Keith Owen Yeates , Catherine Lebel","doi":"10.1016/j.dcn.2025.101568","DOIUrl":"10.1016/j.dcn.2025.101568","url":null,"abstract":"<div><div>The developmental mismatch hypothesis (DMH) proposes that a mismatch in maturational timing of the amygdala and prefrontal cortex (PFC) drives adolescent sensation-seeking behaviour. While some studies provide support for the DMH, few have evaluated sex differences or examined both grey and white matter. Here, we used T1-weighted and diffusion-weighted magnetic resonance imaging (MRI) to examine amygdala and PFC macrostructure and amygdala-PFC white matter microstructure development across 606 MRI sessions from 148 typically developing children and adolescents (76 females) aged 1.95–17.71 years. Using generalized additive mixed effects models, we evaluated the maturational timing of amygdala volume, four PFC subregion volumes, and fractional anisotropy and mean diffusivity of the uncinate fasciculus and amygdala-PFC white matter tracts. Amygdala and PFC maturation was consistent with the DMH in males but less so in females. Relative to males, females exhibited less amygdala development and shorter periods of PFC development. In contrast to gray matter volumes, white matter changed continuously from early childhood to late adolescence, but ended earlier in females than in males. Our findings show different amygdala-PFC maturation patterns and that the amygdala-PFC neural system reaches maturity earlier in females than in males. These important differences may underlie sex differences in sensation-seeking behaviour.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101568"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A six-year longitudinal study examining chronicity and timing of maltreatment effects on risk-related functional connectivity change across adolescence 一项为期六年的纵向研究，研究了虐待对青少年风险相关功能连接变化的慢性和时间影响

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1016/j.dcn.2025.101577

Morgan Lindenmuth , Ya-Yun Chen , Tae-Ho Lee , Natalie Melville , Brooks Casas , Jungmeen Kim-Spoon

{"title":"A six-year longitudinal study examining chronicity and timing of maltreatment effects on risk-related functional connectivity change across adolescence","authors":"Morgan Lindenmuth , Ya-Yun Chen , Tae-Ho Lee , Natalie Melville , Brooks Casas , Jungmeen Kim-Spoon","doi":"10.1016/j.dcn.2025.101577","DOIUrl":"10.1016/j.dcn.2025.101577","url":null,"abstract":"<div><div>Childhood adversity is associated with negative mental health outcomes. Research proposes sensitive periods for the effects of adversity on brain development, yet little is known about the developmental timing effects of abuse and neglect on neural mechanisms underlying risk-related decision making. This study examined 1) trajectories of neural connectivity during risk processing, and 2) how abuse and neglect during early childhood, middle childhood, and adolescence are associated with changes in functional connectivity during risk processing. A sample of 167 adolescents were assessed annually for six years (mean age 14–20 years). Adolescents completed a lottery choice task during a functional magnetic resonance imaging scan (fMRI) and reported maltreatment experiences between ages 1 and 18. Generalized psychophysiological interactions (gPPI) was used to examine task-based functional connectivity in the insula and dorsal anterior cingulate cortex (dACC) during risk processing. Growth curve models revealed increases in insula-dACC connectivity strength across adolescence. Chronic abuse statistically predicted weaker insula-dACC connectivity in late adolescence, and no significant sensitive periods emerged. Results suggest abuse may be linked to delayed maturation in salience network connectivity during risk processing and highlight the importance of distinguishing between effects of abuse and neglect on neural connectivity involved in risk-related decision making.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101577"},"PeriodicalIF":4.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0