Developmental Cognitive Neuroscience最新文献_第10页

Brain-phenotype predictions of language and executive function can survive across diverse real-world data: Dataset shifts in developmental populations 大脑表型对语言和执行功能的预测可以在不同的真实世界数据中存活：发育人群中的数据集转移。

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-10-16 DOI: 10.1016/j.dcn.2024.101464

Brendan D. Adkinson , Matthew Rosenblatt , Javid Dadashkarimi , Link Tejavibulya , Rongtao Jiang , Stephanie Noble , Dustin Scheinost

{"title":"Brain-phenotype predictions of language and executive function can survive across diverse real-world data: Dataset shifts in developmental populations","authors":"Brendan D. Adkinson , Matthew Rosenblatt , Javid Dadashkarimi , Link Tejavibulya , Rongtao Jiang , Stephanie Noble , Dustin Scheinost","doi":"10.1016/j.dcn.2024.101464","DOIUrl":"10.1016/j.dcn.2024.101464","url":null,"abstract":"<div><div>Predictive modeling potentially increases the reproducibility and generalizability of neuroimaging brain-phenotype associations. Yet, the evaluation of a model in another dataset is underutilized. Among studies that undertake external validation, there is a notable lack of attention to generalization across dataset-specific idiosyncrasies (i.e., dataset shifts). Research settings, by design, remove the between-site variations that real-world and, eventually, clinical applications demand. Here, we rigorously test the ability of a range of predictive models to generalize across three diverse, unharmonized developmental samples: the Philadelphia Neurodevelopmental Cohort (n=1291), the Healthy Brain Network (n=1110), and the Human Connectome Project in Development (n=428). These datasets have high inter-dataset heterogeneity, encompassing substantial variations in age distribution, sex, racial and ethnic minority representation, recruitment geography, clinical symptom burdens, fMRI tasks, sequences, and behavioral measures. Through advanced methodological approaches, we demonstrate that reproducible and generalizable brain-behavior associations can be realized across diverse dataset features. Results indicate the potential of functional connectome-based predictive models to be robust despite substantial inter-dataset variability. Notably, for the HCPD and HBN datasets, the best predictions were not from training and testing in the same dataset (i.e., cross-validation) but across datasets. This result suggests that training on diverse data may improve prediction in specific cases. Overall, this work provides a critical foundation for future work evaluating the generalizability of brain-phenotype associations in real-world scenarios and clinical settings.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101464"},"PeriodicalIF":4.6,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging mixed-effects location scale models to assess the ERP mismatch negativity’s psychometric properties and trial-by-trial neural variability in toddler-mother dyads 利用混合效应位置标度模型评估ERP失配负性的心理测量特性和幼儿-母亲二人组的逐次试验神经变异性。

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-10-12 DOI: 10.1016/j.dcn.2024.101459

Serena K. Mon , Brittany L. Manning , Lauren S. Wakschlag , Elizabeth S. Norton

{"title":"Leveraging mixed-effects location scale models to assess the ERP mismatch negativity’s psychometric properties and trial-by-trial neural variability in toddler-mother dyads","authors":"Serena K. Mon , Brittany L. Manning , Lauren S. Wakschlag , Elizabeth S. Norton","doi":"10.1016/j.dcn.2024.101459","DOIUrl":"10.1016/j.dcn.2024.101459","url":null,"abstract":"<div><div>Trial-by-trial neural variability, a measure of neural response stability, has been examined in relation to behavioral indicators using summary measures, but these methods do not characterize meaningful processes underlying variability. Mixed-effects location scale models (MELSMs) overcome these limitations by accounting for predictors and covariates of variability but have been rarely used in developmental studies. Here, we applied MELSMs to the ERP auditory mismatch negativity (MMN), a neural measure often related to language and psychopathology. 84 toddlers and 76 mothers completed a speech-syllable MMN paradigm. We extracted early and late MMN mean amplitudes from trial-level waveforms. We first characterized our sample’s psychometric properties using MELSMs and found a wide range of subject-level internal consistency. Next, we examined the relation between toddler MMNs with theoretically relevant child behavioral and maternal variables. MELSMs offered better model fit than analyses that assumed constant variability. We found significant individual differences in trial-by-trial variability but no significant associations between toddler variability and their language, irritability, or mother variability indices. Overall, we illustrate how MELSMs can characterize psychometric properties and answer questions about individual differences in variability. We provide recommendations and resources as well as example code for analyzing trial-by-trial neural variability in future studies.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101459"},"PeriodicalIF":4.6,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement of emerging neurocognitive and language skills in the HEALthy Brain and Child Development (HBCD) study 在 HEALthy Brain and Child Development (HBCD) 研究中测量新出现的神经认知和语言技能。

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-09-28 DOI: 10.1016/j.dcn.2024.101461

Julie A. Kable , Alexandra S. Potter , Natacha Akshoomoff , Patricia M. Blasco , Stefanie C. Bodison , Lucia Ciciolla , Sherry DeGray , Zoe Hulce , Emily S. Kuschner , Britley Learnard , Monica Luciana , Alexandra Perez , Miriam A. Novack , Tracy Riggins , So Yeon Shin , Sidney Smith , Jennifer Vannest , Eric.H. Zimak , the HBCD Neurocognitive and Language (NCL) Workgroup

{"title":"Measurement of emerging neurocognitive and language skills in the HEALthy Brain and Child Development (HBCD) study","authors":"Julie A. Kable , Alexandra S. Potter , Natacha Akshoomoff , Patricia M. Blasco , Stefanie C. Bodison , Lucia Ciciolla , Sherry DeGray , Zoe Hulce , Emily S. Kuschner , Britley Learnard , Monica Luciana , Alexandra Perez , Miriam A. Novack , Tracy Riggins , So Yeon Shin , Sidney Smith , Jennifer Vannest , Eric.H. Zimak , the HBCD Neurocognitive and Language (NCL) Workgroup","doi":"10.1016/j.dcn.2024.101461","DOIUrl":"10.1016/j.dcn.2024.101461","url":null,"abstract":"<div><div>The HEALthy Brain and Child Development (HBCD) study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The study plans enrolling over 7000 families across 27 sites. This manuscript presents the measures from the Neurocognition and Language Workgroup. Constructs were selected for their importance in normative development, evidence for altered trajectories associated with environmental influences, and predictive validity for child outcomes. Evaluation of measures considered psychometric properties, brevity, and developmental and cultural appropriateness. Both performance measures and caregiver report were used wherever possible. A balance of norm-referenced global measures of development (e.g., Bayley Scales of Infant Development-4) and more specific laboratory measures (e.g., deferred imitation) are included in the HBCD study battery. Domains of assessment include sensory processing, visual-spatial reasoning, expressive and receptive language, executive function, memory, numeracy, adaptive behavior, and neuromotor. Strategies for staff training and quality control procedures, as well as anticipated measures to be added as the cohort ages, are reviewed. The HBCD study presents a unique opportunity to examine early brain and neurodevelopment in young children through a lens that accounts for prenatal exposures, health and socio-economic disparities.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101461"},"PeriodicalIF":4.6,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing the reporting of pediatric EEG data: Tools for estimating reliability, effect size, and data quality metrics 推进儿科脑电图数据的报告工作：估计可靠性、效应大小和数据质量指标的工具

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-09-28 DOI: 10.1016/j.dcn.2024.101458

Wenyi Xu , Alexa D. Monachino , Sarah A. McCormick , Emma T. Margolis , Ana Sobrino , Cara Bosco , Cassandra J. Franke , Lauren Davel , Michal R. Zieff , Kirsten A. Donald , Laurel J. Gabard-Durnam , Santiago Morales

{"title":"Advancing the reporting of pediatric EEG data: Tools for estimating reliability, effect size, and data quality metrics","authors":"Wenyi Xu , Alexa D. Monachino , Sarah A. McCormick , Emma T. Margolis , Ana Sobrino , Cara Bosco , Cassandra J. Franke , Lauren Davel , Michal R. Zieff , Kirsten A. Donald , Laurel J. Gabard-Durnam , Santiago Morales","doi":"10.1016/j.dcn.2024.101458","DOIUrl":"10.1016/j.dcn.2024.101458","url":null,"abstract":"<div><div>EEG studies play a crucial role in enhancing our understanding of brain development across the lifespan. The increasing clinical and policy implications of EEG research underscore the importance of utilizing reliable EEG measures and increasing the reproducibility of EEG studies. However, important data characteristics like reliability, effect sizes, and data quality metrics are often underreported in pediatric EEG studies. This gap in reporting could stem from the lack of accessible computational tools for quantifying these metrics for EEG data. To help address the lack of reporting, we developed a toolbox that facilitates the estimation of internal consistency reliability, effect size, and standardized measurement error with user-friendly software that facilitates both computing and interpreting these measures. In addition, our tool provides subsampled reliability and effect size in increasing numbers of trials. These estimates offer insights into the number of trials needed for detecting significant effects and reliable measures, informing the minimum number of trial thresholds for the inclusion of participants in individual difference analyses and the optimal trial number for future study designs. Importantly, our toolbox is integrated into commonly used preprocessing pipelines to increase the estimation and reporting of data quality metrics in developmental neuroscience.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101458"},"PeriodicalIF":4.6,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive control processes and emotion regulation in adolescence: Examining the impact of affective inhibition and heart-rate-variability on emotion regulation dynamics in daily life 青春期的认知控制过程和情绪调节：研究情感抑制和心率变异对日常生活中情绪调节动态的影响

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-09-26 DOI: 10.1016/j.dcn.2024.101454

Gillian Debra, Nathalie Michels, Matteo Giletta

{"title":"Cognitive control processes and emotion regulation in adolescence: Examining the impact of affective inhibition and heart-rate-variability on emotion regulation dynamics in daily life","authors":"Gillian Debra, Nathalie Michels, Matteo Giletta","doi":"10.1016/j.dcn.2024.101454","DOIUrl":"10.1016/j.dcn.2024.101454","url":null,"abstract":"<div><div>Cognitive control processes likely influence the extent to which adolescents can successfully regulate their emotions. This study examined whether individual differences in affective inhibition and heart rate variability (HRV), as a peripheral index of cognitive control, moderated the association between momentary emotion regulation and negative affect (NA). Ecological Momentary Assessments (EMA) over 14 days were obtained in 235 adolescents (<em>M</em><sub><em>age</em></sub> = 13.48 years; 106 females). At each assessment, participants reported their current NA and the extent to which they used cognitive reappraisal and rumination. Moreover, at three time points (approximately 1 year, 6 months, and just before the EMA), affective inhibition was assessed using an affective go/no-go task and HRV was recorded at rest. Results indicate that adolescents with lower affective inhibition reported lower average levels of daily rumination. However, affective inhibition did not moderate the association between either daily cognitive reappraisal or rumination and momentary NA. Consistent with hypotheses, the association between momentary rumination and NA was weaker in adolescents showing higher levels of resting HRV. Overall, findings may underscore the importance of interventions targeting HRV as a malleable factor for enhancing adolescents’ affective well-being.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101454"},"PeriodicalIF":4.6,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the late maturation of an intrinsic episodic memory network: A resting-state fMRI study 探索内在外显记忆网络的晚期成熟：静息态 fMRI 研究。

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-09-26 DOI: 10.1016/j.dcn.2024.101453

Miguel Ângelo Andrade , Ana Raposo , Alexandre Andrade

{"title":"Exploring the late maturation of an intrinsic episodic memory network: A resting-state fMRI study","authors":"Miguel Ângelo Andrade , Ana Raposo , Alexandre Andrade","doi":"10.1016/j.dcn.2024.101453","DOIUrl":"10.1016/j.dcn.2024.101453","url":null,"abstract":"<div><div>Previous research suggests that episodic memory relies on functional neural networks,which are present even in the absence of an explicit task. The regions that integrate.these networks and the developmental changes in intrinsic functional connectivity.remain elusive. In the present study, we outlined an intrinsic episodic memory network.(iEMN) based on a systematic selection of functional connectivity studies, and.inspected network differences in resting-state fMRI between adolescents (13–17 years.old) and adults (23–27 years old) from the publicly available NKI-Rockland Sample.Through a review of brain regions commonly associated with episodic memory.networks, we identified a potential iEMN composed by 14 bilateral ROIs, distributed.across temporal, frontal and parietal lobes. Within this network, we found an increase.in resting-state connectivity from adolescents to adults between the right temporal pole.and two regions in the right lateral prefrontal cortex. We argue that the coordination of.these brain regions, connecting areas of semantic processing and areas of controlled.retrieval, arises as an important feature towards the full maturation of the episodic.memory system. The findings add to evidence suggesting that adolescence is a key.period in memory development and highlights the role of intrinsic functional.connectivity in such development.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101453"},"PeriodicalIF":4.6,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain structures with stronger genetic associations are not less associated with family- and state-level economic contexts 遗传关联性较强的大脑结构与家庭和州一级的经济环境关联性并不小。

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-09-24 DOI: 10.1016/j.dcn.2024.101455

Camille M. Williams , David G. Weissman , Travis T. Mallard , Katie A. McLaughlin , K. Paige Harden

{"title":"Brain structures with stronger genetic associations are not less associated with family- and state-level economic contexts","authors":"Camille M. Williams , David G. Weissman , Travis T. Mallard , Katie A. McLaughlin , K. Paige Harden","doi":"10.1016/j.dcn.2024.101455","DOIUrl":"10.1016/j.dcn.2024.101455","url":null,"abstract":"<div><div>We investigate whether neural, cognitive, and psychopathology phenotypes that are more strongly related to genetic differences are less strongly associated with family- and state-level economic contexts (N = 5374 individuals with 1KG-EUR-like genotypes with 870 twins, from the Adolescent Behavior and Cognitive Development study). We estimated the twin- and SNP-based heritability of each phenotype, as well as its association with an educational attainment polygenic index (EA PGI). We further examined associations with family socioeconomic status (SES) and tested whether SES-related differences were moderated by state cost of living and social safety net programs (Medicaid expansion and cash assistance). SES was broadly associated with cognition, psychopathology, brain volumes, and cortical surface areas, even after controlling for the EA PGI. Brain phenotypes that were more heritable or more strongly associated with the EA PGI were not, overall, less related to SES, nor were SES-related differences in these phenotypes less moderated by macroeconomic context and policy. Informing a long-running theoretical debate, and contra to widespread lay beliefs, results suggest that aspects of child brain development that are more strongly related to genetic differences are not, in general, less associated with socioeconomic contexts and policies.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101455"},"PeriodicalIF":4.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal two-time point longitudinal models for estimating individual-level change: Asymptotic insights and practical implications 用于估计个体水平变化的最佳两时间点纵向模型：渐近的见解和实际意义

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-09-24 DOI: 10.1016/j.dcn.2024.101450

Andreas M. Brandmaier , Ulman Lindenberger , Ethan M. McCormick

{"title":"Optimal two-time point longitudinal models for estimating individual-level change: Asymptotic insights and practical implications","authors":"Andreas M. Brandmaier , Ulman Lindenberger , Ethan M. McCormick","doi":"10.1016/j.dcn.2024.101450","DOIUrl":"10.1016/j.dcn.2024.101450","url":null,"abstract":"<div><div>Based on findings from a simulation study, Parsons and McCormick (2024) argued that growth models with exactly two time points are poorly-suited to model individual differences in linear slopes in developmental studies. Their argument is based on an empirical investigation of the increase in precision to measure individual differences in linear slopes if studies are progressively extended by adding an extra measurement occasion after one unit of time (e.g., year) has passed. They concluded that two-time point models are inadequate to reliably model change at the individual level and that these models should focus on group-level effects. Here, we show that these limitations can be addressed by deconfounding the influence of study duration and the influence of adding an extra measurement occasion on precision to estimate individual differences in linear slopes. We use asymptotic results to gauge and compare precision of linear change models representing different study designs, and show that it is primarily the longer time span that increases precision, not the extra waves. Further, we show how the asymptotic results can be used to also consider irregularly spaced intervals as well as planned and unplanned missing data. In conclusion, we like to stress that true linear change can indeed be captured well with only two time points if careful study design planning is applied before running a study.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101450"},"PeriodicalIF":4.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics 处于十字路口的精神科神经影像学：精神病遗传学的启示

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-09-23 DOI: 10.1016/j.dcn.2024.101443

Lorenza Dall’Aglio , Saúl Urbina Johanson , Travis Mallard , Sander Lamballais , Scott Delaney , Jordan W. Smoller , Ryan L. Muetzel , Henning Tiemeier

{"title":"Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics","authors":"Lorenza Dall’Aglio , Saúl Urbina Johanson , Travis Mallard , Sander Lamballais , Scott Delaney , Jordan W. Smoller , Ryan L. Muetzel , Henning Tiemeier","doi":"10.1016/j.dcn.2024.101443","DOIUrl":"10.1016/j.dcn.2024.101443","url":null,"abstract":"<div><div>Thanks to methodological advances, large-scale data collections, and longitudinal designs, psychiatric neuroimaging is better equipped than ever to identify the neurobiological underpinnings of youth mental health problems. However, the complexity of such endeavors has become increasingly evident, as the field has been confronted by limited clinical relevance, inconsistent results, and small effect sizes. Some of these challenges parallel those historically encountered by psychiatric genetics. In past genetic research, robust findings were historically undermined by oversimplified biological hypotheses, mistaken assumptions about expectable effect sizes, replication problems, confounding by population structure, and shared biological patterns across disorders. Overcoming these challenges has contributed to current successes in the field. Drawing parallels across psychiatric genetics and neuroimaging, we identify key shared challenges as well as pinpoint relevant insights that could be gained in psychiatric neuroimaging from the transition that occurred from the candidate gene to (post) genome-wide “eras” of psychiatric genetics. Finally, we discuss the prominent developmental component of psychiatric neuroimaging and how that might be informed by epidemiological and <em>omics</em> approaches. The evolution of psychiatric genetic research offers valuable insights that may expedite the resolution of key challenges in psychiatric neuroimaging, thus potentially moving our understanding of psychiatric pathophysiology forward.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101443"},"PeriodicalIF":4.6,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol 量化 HEALthy Brain and Child Development (HBCD) 研究中的大脑发育情况：磁共振成像和光谱分析方案

IF 4.6 2区医学

Developmental Cognitive Neuroscience Pub Date : 2024-09-21 DOI: 10.1016/j.dcn.2024.101452

Douglas C. Dean III , M Dylan Tisdall , Jessica L. Wisnowski , Eric Feczko , Borjan Gagoski , Andrew L. Alexander , Richard A.E. Edden , Wei Gao , Timothy J. Hendrickson , Brittany R. Howell , Hao Huang , Kathryn L. Humphreys , Tracy Riggins , Chad M. Sylvester , Kimberly B. Weldon , Essa Yacoub , Banu Ahtam , Natacha Beck , Suchandrima Banerjee , Sergiy Boroday , Jed T. Elison

{"title":"Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol","authors":"Douglas C. Dean III , M Dylan Tisdall , Jessica L. Wisnowski , Eric Feczko , Borjan Gagoski , Andrew L. Alexander , Richard A.E. Edden , Wei Gao , Timothy J. Hendrickson , Brittany R. Howell , Hao Huang , Kathryn L. Humphreys , Tracy Riggins , Chad M. Sylvester , Kimberly B. Weldon , Essa Yacoub , Banu Ahtam , Natacha Beck , Suchandrima Banerjee , Sergiy Boroday , Jed T. Elison","doi":"10.1016/j.dcn.2024.101452","DOIUrl":"10.1016/j.dcn.2024.101452","url":null,"abstract":"<div><div>The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study’s core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life. Overcoming these challenges requires an innovative and harmonized approach, combining age-appropriate acquisition protocols together with specialized pediatric neuroimaging strategies. The HBCD MRI Working Group aimed to establish a core acquisition protocol for all 27 HBCD Study recruitment sites to measure brain structure, function, microstructure, and metabolites. Acquisition parameters of individual modalities have been matched across MRI scanner platforms for harmonized acquisitions and state-of-the-art technologies are employed to enable faster and motion-robust imaging. Here, we provide an overview of the HBCD MRI protocol, including decisions of individual modalities and preliminary data. The result will be an unparalleled resource for examining early neurodevelopment which enables the larger scientific community to assess normative trajectories from birth through childhood and to examine the genetic, biological, and environmental factors that help shape the developing brain.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101452"},"PeriodicalIF":4.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0