Developmental Cognitive Neuroscience最新文献

{"title":"Integrating multilevel, multidomain and multimodal neuroimaging factors to predict early alcohol exposure trajectories using explainable AI","authors":"Ana Ferariu ,&nbsp;Hansoo Chang ,&nbsp;Ashni Kumar ,&nbsp;Alexandra Sahl ,&nbsp;Stephanie Gorka ,&nbsp;Lei Wang ,&nbsp;Wesley K. Thompson ,&nbsp;Fengqing Zhang","doi":"10.1016/j.dcn.2025.101597","DOIUrl":"10.1016/j.dcn.2025.101597","url":null,"abstract":"<div><div>Various multilevel, multidomain factors at the individual-, family-, and environmental-level, and changes in neurobiology have been associated with the likelihood of developing alcohol use disorder (AUD) or binge drinking later in life. Prior studies have examined only limited subsets of these factors, typically focusing on cross-sectional associations with alcohol initiation, binge drinking, or AUD rather than exploring longitudinal alcohol use trajectories. Our study addresses these gaps by applying machine learning methods to a comprehensive set of multilevel, multidomain factors and multimodal brain imaging features (including brain structure and functional connectivity) to prospectively predict early alcohol sipping trajectories. Using data from the Adolescent Brain Cognitive Development Study, we identified functional connectivity features and multilevel factors that distinguish youth with an increasing alcohol sipping trajectory from those who initially experimented with alcohol but reduced their consumption over time. Moreover, structural and functional features predicted differences between youth who increasingly sipped over time and those who did not engage in alcohol experimentation. Interactions between age, socioeconomical status and positive attitudes towards drinking could predict a pattern of increasing alcohol sipping over time. These trends could inform how individual, family, environmental and neurobiological factors impact the development of different alcohol sipping trajectories over time.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101597"},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety learning during adolescence facilitates fear regulation in adult mice","authors":"Heidi C. Meyer","doi":"10.1016/j.dcn.2025.101606","DOIUrl":"10.1016/j.dcn.2025.101606","url":null,"abstract":"<div><div>Experiences during sensitive early life developmental periods such as adolescence have a profound influence on brain maturation and long-term affective behavior. While substantial work focuses on early life adversity, emerging evidence suggests that positive affective experiences can also shape trajectories of neurobehavioral development. This study examined how experience with fear conditioning or discriminative conditioning (i.e., safety learning) during either adolescence or adulthood in male and female mice influenced fear behavior and engagement with an anxiogenic environment one month later, when adolescents had aged to adulthood. Prior conditioning (both fear and safety training) at either age, regardless of valence, promoted later fear generalization to a novel cue. In contrast, safety learning during adolescence conferred enduring benefits, leading to reduced fear expression and enhanced extinction memory in adulthood, whereas similar training in adulthood offered limited protective effects. Behavior in the elevated plus maze revealed increased movement in all previously conditioned animals (both Fear-trained and Safety-trained groups), with safety learning decreasing initial freezing in the maze and accelerating initial re-location from the placement arm. Sex differences in this study were modest, showing limited interaction with age and minimal impact on training-related outcomes across experimental phases, suggesting that the effects of conditioning on later affective regulation are robust and broadly conserved across sexes. Overall, these findings highlight adolescence as a sensitive period during which safety learning can shape affective regulation and potentially buffer against later life pathological fear responding. This work offers insight into developmental mechanisms that may inform early interventions for psychiatric conditions like anxiety.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101606"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific relationships between gray matter volume and executive function in young children with and without prenatal alcohol exposure","authors":"Madison Long ,&nbsp;Preeti Kar ,&nbsp;Nils D. Forkert ,&nbsp;Bennett A. Landman ,&nbsp;Gerald F. Giesbrecht ,&nbsp;Deborah Dewey ,&nbsp;W. Ben Gibbard ,&nbsp;Christina Tortorelli ,&nbsp;Carly A. McMorris ,&nbsp;Yuankai Huo ,&nbsp;Catherine Lebel","doi":"10.1016/j.dcn.2025.101608","DOIUrl":"10.1016/j.dcn.2025.101608","url":null,"abstract":"<div><div>Sex differences in brain volume are well established across ages however, limited research has investigated if sex differences in brain structure associate with early cognitive outcomes. Moreover, associations among sex, brain structure, and cognition in individuals with prenatal alcohol exposure (PAE), the most common known cause of developmental delay in North America, are unclear. Here, we investigated associations between executive function (measured by the BRIEF or BRIEF-P Global Executive Composite (GEC) and the Statue subtest of the NEPSY-II) and volumes of 36 gray matter regions in a longitudinal MRI sample of 169 young children (N_PAE=37; 534 total scans) aged 2–8 years. We found significant three-way interactions between sex, alcohol exposure, and executive function in 22 regions for GEC and 6 regions for Statue. Unexposed males showed negative executive function-volume associations, whereas males with PAE showed opposite associations. Unexposed females showed strong positive executive function-volume associations whereas females with PAE showed weak positive associations. We also evaluated reduced models in regions without significant 3-way interactions and found significant two-way interactions of sex and executive function for the GEC in three regions, and for the Statue in 22 regions. Males showed a negative executive function-volume relationship whereas females showed a positive relationship, regardless of exposure status. Our results suggest that males with PAE and unexposed females show relatively more mature volume-executive function relationships than females with PAE and unexposed males. This study highlights the importance of considering sex in investigations of brain and cognition, especially in populations with PAE.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101608"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological activity predicts children's reading ability through orthographic awareness: Evidence from a cross-sectional and longitudinal study","authors":"Man Zhang ,&nbsp;Zeping Liu ,&nbsp;Xuedi Liu ,&nbsp;Pengfei Lu ,&nbsp;Li Liu ,&nbsp;Taomei Guo","doi":"10.1016/j.dcn.2025.101609","DOIUrl":"10.1016/j.dcn.2025.101609","url":null,"abstract":"<div><div>The relationship between brain activity and reading acquisition has been a research focus in recent years. In the current cross-sectional and longitudinal study, we aimed to investigate whether and how resting-state (rs) and task-state brain electrophysiological activity would predict children’s reading ability. Here, we tracked 73 primary school children’ orthographic awareness, reading ability, and EEG signals during both rest and completed a Chinese character recognition task over two consecutive years. Our analyses reveled these neurophysiological measures (rs-EEG power in theta/delta bands and N170 amplitude) significantly predicted orthographic awareness in both cross-sectional and longitudinal analyses. Mediation analysis revealed that these neurophysiological measures influenced reading ability by affecting children's orthographic awareness. Importantly, age moderated these effects: the predictive effect of rs-EEG power was stronger in younger children and decreased with age, whereas the effect of N170 amplitude showed the opposite pattern, becoming more prominent as age increased. Collectively, these findings indicate that children's reading performance is shaped by age-sensitive brain neurophysiological activity, with orthographic processing potentially serving as a key cognitive mechanism.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101609"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological decoding captures the temporal trajectory of face categorization in infants","authors":"Roman Kessler,&nbsp;Michael A. Skeide","doi":"10.1016/j.dcn.2025.101601","DOIUrl":"10.1016/j.dcn.2025.101601","url":null,"abstract":"<div><div>The adult human brain rapidly distinguishes between faces at around 170 ms after stimulus onset. During early brain development, however, face discrimination is thought to require almost twice as much processing time. To re-examine this long-standing assumption, we presented human and nonhuman primate faces to five to thirteen-month-old infants in an event-related electroencephalography experiment. Using time-resolved decoding based on logistic regression we detected above-chance discrimination of human faces from nonhuman faces in a time window already starting at around 200 ms, originating from occipito-temporal electrodes. There was no evidence, however, for above-chance discrimination of individual human or individual nonhuman faces. These results indicate that rapid face categorization emerges already in preverbal infants.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101601"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intellectual ability and cortical homotopy development in children and adolescents","authors":"Li-Zhen Chen ,&nbsp;Xi-Nian Zuo","doi":"10.1016/j.dcn.2025.101596","DOIUrl":"10.1016/j.dcn.2025.101596","url":null,"abstract":"<div><div>Functional homotopy, defined as the similarity between the corresponding regions of the two hemispheres, is a critical feature of interhemispheric communication and cognitive integration. Throughout development, the brain transitions from broadly connected networks in early childhood to more specialized configurations in adolescence, accompanied by increased hemispheric differentiation and integration. Using longitudinal data and a novel metric of functional homotopy, Homotopic Functional Affinity (HFA), we investigated the developmental patterns of functional homotopy and its relationship with intelligence. Our findings indicate a significant decrease in HFA with age, particularly in higher-order association networks. In addition, adolescents demonstrate stronger, predominantly negative correlations between HFA and intelligence, in contrast to younger children. In particular, individuals with superior intellectual ability experience accelerated decreases in HFA, indicating greater neural efficiency based on higher hemispheric specialization and differentiation. These findings provide evidence of the neural mechanisms that underlie cognitive development, emphasizing the dynamic interaction between hemispheric organization and intelligence. Our work may inform customized educational and clinical interventions for individual development.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101596"},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social profiles among youth with attention-deficit/hyperactivity disorder (ADHD): Evidence from the ABCD study","authors":"Rosario Pintos Lobo ,&nbsp;Julio A. Peraza ,&nbsp;Taylor Salo ,&nbsp;Alan Meca ,&nbsp;Donisha D. Smith ,&nbsp;Kathleen E. Feeney ,&nbsp;Katherine M. Schmarder ,&nbsp;Matthew T. Sutherland ,&nbsp;Raul Gonzalez ,&nbsp;Erica D. Musser ,&nbsp;Angela R. Laird","doi":"10.1016/j.dcn.2025.101591","DOIUrl":"10.1016/j.dcn.2025.101591","url":null,"abstract":"<div><div>Social functioning difficulties among youth with attention-deficit/hyperactivity disorder (ADHD) have been examined behaviorally; however, limited research has investigated brain networks associated with social difficulties among youth with ADHD. A growing body of literature supports the utility of the NIMH’s Research Domain Criteria (RDoC) framework, which emphasizes broad neurobiological based dimensions, allowing for the integration of models of both neural circuitry and behavior when examining externalizing behaviors in youth. We hypothesized that an ADHD classification system based on social functioning would better predict real-world psychosocial and academic outcomes compared to traditional Diagnostic and Statistical Manual of Mental Disorders (DSM-5) nosology of ADHD presentations. First, using data from the Adolescent Brain Cognitive Development (ABCD) Study, we identified four distinct profiles of youth with ADHD ranging from low social functioning to high social functioning. These social-data-derived profiles were linked to differential social challenges associated with caregiver income and mental health disorders. Next, our neuroimaging findings initially revealed differential patterns of functional connectivity across profiles involving attention-control, cingulo-opercular, sensorimotor networks. However, these connectivity differences were not consistently replicated, indicating that social functioning alone may not define neurobiologically distinct subgroups. Finally, in comparing our social functioning profiles to existing DSM-5 nosology with respect to real-world psychosocial outcomes, our social profiles demonstrated greater explanatory power for outcomes related to peer relationships, family conflict, and mental health. Overall, these findings emphasize the heterogeneity in social functioning among ADHD youth and suggest that while behavioral profiles are clinically meaningful, future work should integrate additional dimensions, such as executive functioning, to more precisely capture the neurobiological underpinnings of ADHD.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101591"},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental differences in social information use under uncertainty: A neurocomputational approach","authors":"Lieke Hofmans ,&nbsp;Wouter van den Bos","doi":"10.1016/j.dcn.2025.101604","DOIUrl":"10.1016/j.dcn.2025.101604","url":null,"abstract":"<div><div>Adolescence is a period of social re-orientation, with studies suggesting that adolescents may be more sensitive to peer influence than other age groups. A clearer understanding of the dynamics and development of peer influence during adolescence is therefore particularly pertinent. In this study, we compared the cognitive and neural processes underlying social learning in adolescents (12–18 years) and adults (22–45 years), focusing on how uncertainty influences social information use. Participants completed a perceptual decision-making task in which they could revise their initial estimate after viewing a peer's estimate. Uncertainty was manipulated by varying the amount of information provided before their decision and by manipulating the peer's reported confidence. Using a combination of model-free analyses and a Bayesian computational model, we found that while adolescents and adults exhibit similar core decision-making mechanisms, computational modeling revealed that adolescents were less sensitive to variations in their own certainty and peer confidence, reducing the effect on social information use. Functional MRI revealed that adolescents showed a reduced neural response to peer confidence variations compared to adults, but exhibited a stronger initial neural response to variations in their own certainty. However, this heightened response was not present anymore when personal and peer information was to be combined. We discuss how these observations might be explained by ongoing neural development during adolescence, leading to reduced metacognitive abilities which hinder the effective integration of precision signals. Together, these findings deepen our understanding of how adolescents process social information under uncertainty and how this process evolves with age.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101604"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of peer relationship on children's creativity during cooperative and competitive interactions: An fNIRS-based hyperscanning study","authors":"Shujin Zhou ,&nbsp;Yuxuan Zhang ,&nbsp;Mingming Zhang ,&nbsp;Dan Li","doi":"10.1016/j.dcn.2025.101592","DOIUrl":"10.1016/j.dcn.2025.101592","url":null,"abstract":"<div><div>Children are at a critical stage of development for cultivating creativity and are highly sensitive to the influence of peers. This study investigated the impact of peer relationships on children's creativity during both cooperative and competitive interactions, using functional near-infrared spectroscopy (fNIRS)-based hyperscanning techniques. A total of 66 children, including 18 familiar dyads and 15 stranger dyads, were recruited to participate in the cooperative and competitive tangram puzzle tasks. The results showed that familiar dyads demonstrated higher originality and lower appropriateness in cooperative tasks compared to stranger dyads. fNIRS data revealed distinct task-specific neural coupling patterns in the inferior frontal gyrus (IFG) contingent upon peer relationship: familiar dyads exhibited enhanced inter-brain synchronization (IBS) during cooperative tasks, while stranger dyads demonstrated stronger neural alignment during competitive interactions. Additionally, positive feedback during cooperative interactions in familiar dyads was significantly correlated with increased IBS in the IFG. These findings underscore the advantages of familiar peer relationships in fostering cooperative creativity and the benefits of strange relationships in enhancing competitive performance. This study highlights the importance of considering relational and contextual factors in fostering children’s creative potential.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101592"},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeling left out in the Lunchroom: Neural mechanisms of ostracism vary across adolescence","authors":"Cailee M. Nelson ,&nbsp;Rebecca Revilla ,&nbsp;Nicole R. Friedman ,&nbsp;Mengya Xia ,&nbsp;Caitlin M. Hudac","doi":"10.1016/j.dcn.2025.101607","DOIUrl":"10.1016/j.dcn.2025.101607","url":null,"abstract":"<div><div>Ostracism (i.e., being ignored/excluded) can cause intense emotional reactions that detrimentally impact mental and physical health. Adolescents may be particularly susceptible to these negative consequences due to brain maturation and changing social priorities. To better understand how neural mechanisms of ostracism vary across development (i.e., age, puberty), the current study employed a pictorial adaptation of Hudac’s (2019) Lunchroom electroencephalography (EEG) task in a sample of 84 adolescents (aged 10–14 years). Results indicated unique effects across event-related potential amplitudes, including a reversed pattern (greater sensitivity to inclusion) for the P1, the “classic” ostracism effect (greater sensitivity to exclusion) for the N2, and classic effects when modulated by puberty for the P3. Source estimation identified different neural networks that were likely driving sensitivity to exclusion (e.g., amygdala, SCG, and IFG) or inclusion (e.g., ACC, cingulate, fusiform, insula, SPL, STG). Further, sensitivity to exclusion increased over pubertal development for P3 amplitude but over age for amygdala and IFG. Sensitivity to inclusion decreased over age for P1 amplitude and inclusion sensitive regions. The current study emphasizes the utility of using paradigms that isolate neural processes associated with ostracism while controlling for participant involvement.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101607"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}