Laura M. Glynn , Sabrina R. Liu , Candice Taylor Lucas , Elysia Poggi Davis
{"title":"Leveraging the science of early life predictability to inform policies promoting child health","authors":"Laura M. Glynn , Sabrina R. Liu , Candice Taylor Lucas , Elysia Poggi Davis","doi":"10.1016/j.dcn.2024.101437","DOIUrl":"10.1016/j.dcn.2024.101437","url":null,"abstract":"<div><p>Addressing the tremendous burden of early-life adversity requires constructive dialogues between scientists and policy makers to improve population health. Whereas dialogues focused on several aspects of early-life adversity have been initiated, discussion of an underrecognized form of adversity that has been observed across multiple contexts and cultures is only now emerging. Here we provide evidence for “why unpredictability?”, including: 1. Evidence that exposures to unpredictability affect child neurodevelopment, with influences that persist into adulthood. 2. The existence of a translational non-human animal model of exposure to early life unpredictability that can be capitalized upon to causally probe neurobiological mechanisms. 3. Evidence that patterns of signals in the early environment promote brain maturation across species. 4. The uneven distribution of unpredictability across demographic populations that illuminates a possible focal point for enhancing health equity. We then outline the potential of unpredictability in terms of the “what”; that is, how might the concept of unpredictability be leveraged to inform policy? We emphasize the importance of interdisciplinary and community partnerships to the success of this work and describe our community-engaged research project. Finally, we highlight opportunities for the science of unpredictability to inform policies in areas such as screening, immigration, criminal justice, education, childcare, child welfare, employment, healthcare and housing.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101437"},"PeriodicalIF":4.6,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000987/pdfft?md5=ef69afead31232bd74b6fd59e283e7a8&pid=1-s2.0-S1878929324000987-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role (and limits) of developmental neuroscience in determining adolescents’ autonomy rights: The case for reproductive and voting rights","authors":"Julie Maslowsky , Emily Buss , Laura Wray-Lake","doi":"10.1016/j.dcn.2024.101435","DOIUrl":"10.1016/j.dcn.2024.101435","url":null,"abstract":"<div><p>Neuroscientific evidence documenting continued neural development throughout adolescence has been leveraged in advocacy for more lenient treatment of adolescents in the criminal justice system. In recent years, developmental science, including neuroscience, has progressed and enabled more nuanced interpretations of what continuing neural development in adolescence likely means functionally for adolescents’ capabilities. However, oversimplified interpretations equating continuing neural development to overall “immaturity” are frequently used to make the case that adolescents should have fewer legal rights to make decisions on their own behalf, including regarding reproductive and voting rights. Here we address ongoing debates about adolescents’ autonomy rights and whether such rights should be expanded or restricted. We review extant neuroscientific and developmental research that can inform these debates. We call for: (1) a more nuanced application of developmental neuroscience to specific rights issues in specific contexts; (2) additional research designed to inform our understanding of the developmental benefits or harms of rights-based policies on young people over time; and (3) the grounding of developmental neuroscientific research on adolescents within a human rights framework. We offer suggestions to developmental and neuroscience scholars on how to discuss the science of adolescent development with those seeking guidance in their design of law and policy.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101435"},"PeriodicalIF":4.6,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000963/pdfft?md5=470da2215774b41fa18cd777bbb3cbf8&pid=1-s2.0-S1878929324000963-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brian Pho , Ryan Andrew Stevenson , Sara Saljoughi , Yalda Mohsenzadeh , Bobby Stojanoski
{"title":"Identifying developmental changes in functional brain connectivity associated with cognitive functioning in children and adolescents with ADHD","authors":"Brian Pho , Ryan Andrew Stevenson , Sara Saljoughi , Yalda Mohsenzadeh , Bobby Stojanoski","doi":"10.1016/j.dcn.2024.101439","DOIUrl":"10.1016/j.dcn.2024.101439","url":null,"abstract":"<div><p>Youth diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) often show deficits in various measures of higher-level cognition, such as, executive functioning. Poorer cognitive functioning in children with ADHD has been associated with differences in functional connectivity across the brain. However, little is known about the developmental changes to the brain’s functional properties linked to different cognitive abilities in this cohort. To characterize these changes, we analyzed fMRI data (ADHD = 373, NT = 106) collected while youth between the ages of 6 and 16 watched a short movie-clip. We applied machine learning models to identify patterns of network connectivity in response to movie-watching that differentially predict cognitive abilities in our cohort. Using out-of-sample cross validation, our models successfully predicted IQ, visual spatial, verbal comprehension, and fluid reasoning in children (ages 6 – 11), but not in adolescents with ADHD (ages 12–16). Connections with the default mode, memory retrieval, and dorsal attention were driving prediction during early and middle childhood, but connections with the somatomotor, cingulo-opercular, and frontoparietal networks were more important in middle childhood. This work demonstrated that machine learning approaches can identify distinct functional connectivity profiles associated with cognitive abilities at different developmental stages in children and adolescents with ADHD.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101439"},"PeriodicalIF":4.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324001002/pdfft?md5=3a53747e73ae6f023ae78df1c319d83c&pid=1-s2.0-S1878929324001002-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leigh-Anne Cioffredi , Lea G. Yerby , Heather H. Burris , Katherine M. Cole , Stephanie M. Engel , Traci M. Murray , Natalie Slopen , Heather E. Volk , Ashley Acheson , the HBCD Social and Environmental Determinants Working Group
{"title":"Assessing prenatal and early childhood social and environmental determinants of health in the HEALthy Brain and Child Development Study (HBCD)","authors":"Leigh-Anne Cioffredi , Lea G. Yerby , Heather H. Burris , Katherine M. Cole , Stephanie M. Engel , Traci M. Murray , Natalie Slopen , Heather E. Volk , Ashley Acheson , the HBCD Social and Environmental Determinants Working Group","doi":"10.1016/j.dcn.2024.101429","DOIUrl":"10.1016/j.dcn.2024.101429","url":null,"abstract":"<div><p>The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The charge of the HBCD Social and Environmental Determinants (SED) working group is to develop and implement a battery of assessments to broadly characterize the social and physical environment during the prenatal period and early life to characterize risk and resilience exposures that can impact child growth and development. The SED battery consists largely of measures that will be repeated across the course of the HBCD Study with appropriate modifications for the age of the child and include participant demographics, indicators of socioeconomic status, stress and economic hardship, bias and discrimination (e.g., racism), acculturation, neighborhood safety, child and maternal exposures to adversity, environmental toxicants, social support, and other protective factors. Special considerations were paid to reducing participant burden, promoting diversity, equity, and inclusion, and adopting trauma-informed practices for the collection of sensitive information such as domestic violence exposure and adverse childhood experiences. Overall, the SED battery will provide essential data to advance understanding of child development and approaches to advance health equity across infant and child development.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101429"},"PeriodicalIF":4.6,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000902/pdfft?md5=63d0328b2df3d661867b412d47f15386&pid=1-s2.0-S1878929324000902-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raquel Cosío-Guirado , Mérida Galilea Tapia-Medina , Ceren Kaya , Maribel Peró-Cebollero , Erwin Rogelio Villuendas-González , Joan Guàrdia-Olmos
{"title":"A comprehensive systematic review of fMRI studies on brain connectivity in healthy children and adolescents: Current insights and future directions","authors":"Raquel Cosío-Guirado , Mérida Galilea Tapia-Medina , Ceren Kaya , Maribel Peró-Cebollero , Erwin Rogelio Villuendas-González , Joan Guàrdia-Olmos","doi":"10.1016/j.dcn.2024.101438","DOIUrl":"10.1016/j.dcn.2024.101438","url":null,"abstract":"<div><p>This systematic review considered evidence of children’s and adolescents' typical brain connectivity development studied through resting-state functional magnetic resonance imaging (rs-fMRI). With aim of understanding the state of the art, what has been researched thus far and what remains unknown, this paper reviews 58 studies from 2013 to 2023. Considering the results, rs-fMRI stands out as an appropriate technique for studying language and attention within cognitive domains, and personality traits such as impulsivity and empathy. The most used analyses encompass seed-based, independent component analysis (ICA), the amplitude of the low frequency fluctuations (ALFF), and fractional ALFF (fALFF). The findings highlight key themes, including age-related changes in intrinsic connectivity, sex-specific patterns, and the relevance of the Default Mode Network (DMN). Overall, there is a need for longitudinal approaches to trace the typical developmental trajectory of neural networks from childhood through adolescence with fMRI at rest.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101438"},"PeriodicalIF":4.6,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000999/pdfft?md5=676133c315c3aebca79eb2a2ebe3a954&pid=1-s2.0-S1878929324000999-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ronald E. Dahl , Emma Armstrong-Carter , Wouter van den Bos
{"title":"Wanting to matter and learning to care: A neurodevelopmental window of opportunity for (Pro) social learning?","authors":"Ronald E. Dahl , Emma Armstrong-Carter , Wouter van den Bos","doi":"10.1016/j.dcn.2024.101430","DOIUrl":"10.1016/j.dcn.2024.101430","url":null,"abstract":"<div><p>Wanting to matter—to feel socially recognized, appreciated, and capable of actions that benefit others—represents a fundamental motivation in human development. The motivational salience of mattering appears to increase in adolescence. Evidence suggests this is related to pubertal increases in the incentive salience for gaining social value and personal agency. This can provide a useful heuristic for understanding motivational proclivities (i.e. wanting to matter) that influence action-outcome learning as young adolescents are exploring and learning how to navigate increasingly complex social and relational environments. Adolescence also brings new capacities, motives, and opportunities for learning to care about and contribute to the benefit of others. Together, these create a window of opportunity: a sensitive period for learning to gain salient feelings of mattering through caring prosocial actions and valued societal contributions. Successfully discovering ways of mattering by doing things that matter to others may contribute to formative socio-emotional learning about self/other. Advances in understanding these social and relational learning processes and their neurodevelopmental underpinnings can inform strategies to improve developmental trajectories of social competence and wellbeing among adolescents growing up in a rapidly changing and increasingly techno-centric world.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101430"},"PeriodicalIF":4.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000914/pdfft?md5=0e0a2744de65871bfe6e37fb82c7b2e3&pid=1-s2.0-S1878929324000914-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna M. Parenteau , Sally Hang , Johnna R. Swartz , Anthony S. Wexler , Camelia E. Hostinar
{"title":"Clearing the air: A systematic review of studies on air pollution and childhood brain outcomes to mobilize policy change","authors":"Anna M. Parenteau , Sally Hang , Johnna R. Swartz , Anthony S. Wexler , Camelia E. Hostinar","doi":"10.1016/j.dcn.2024.101436","DOIUrl":"10.1016/j.dcn.2024.101436","url":null,"abstract":"<div><p>Climate change, wildfires, and environmental justice concerns have drawn increased attention to the impact of air pollution on children’s health and development. Children are especially vulnerable to air pollution exposure, as their brains and bodies are still developing. The objective of this systematic review was to synthesize available empirical evidence on the associations between air pollution exposure and brain outcomes in developmental samples (ages 0–18 years old). Studies were identified by searching the PubMed and Web of Science Core Collection databases and underwent a two-phase screening process before inclusion. 40 studies were included in the review, which included measures of air pollution and brain outcomes at various points in development. Results linked air pollution to varied brain outcomes, including structural volumetric and cortical thickness differences, alterations in white matter microstructure, functional network changes, metabolic and molecular effects, as well as tumor incidence. Few studies included longitudinal changes in brain outcomes. This review also suggests methodologies for incorporating air pollution measures in developmental cognitive neuroscience studies and provides specific policy recommendations to reduce air pollution exposure and promote healthy brain development by improving access to clean air.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101436"},"PeriodicalIF":4.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000975/pdfft?md5=d400e0f4a129ee2a17dcd7de73c4e604&pid=1-s2.0-S1878929324000975-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine M. Cole , Chloe J. Jordan , Micaela Parkinson , Karla R. Estrada , Elizabeth A. Hoffman , Julie M. Croff , Michelle P. Freund , Katia D. Howlett , the HBCD Communications, Engagement, and Dissemination Committee
{"title":"Communications, engagement, and dissemination strategies for the HEALthy Brain and Child Development (HBCD) Study","authors":"Katherine M. Cole , Chloe J. Jordan , Micaela Parkinson , Karla R. Estrada , Elizabeth A. Hoffman , Julie M. Croff , Michelle P. Freund , Katia D. Howlett , the HBCD Communications, Engagement, and Dissemination Committee","doi":"10.1016/j.dcn.2024.101431","DOIUrl":"10.1016/j.dcn.2024.101431","url":null,"abstract":"<div><p>The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Study success depends on the engagement and inclusion of diverse populations of pregnant participants and their children across the United States, including those at high and low risk for prenatal substance use. The Communications, Engagement, and Dissemination (CED) Committee is responsible for the development and implementation of a strategy to promote awareness about the study, encourage participation, and engage HBCD families, community partners, and collaborators. Initial work involved developing versatile recruitment and awareness materials with a consistent and inclusive message that reduces stigma and negative bias towards marginalized populations, including people with substance use and other mental health conditions. These efforts were shaped by an integrated product development workflow and early engagement with HBCD partners to address challenges. Ongoing work includes the expansion of HBCD outreach through newsletters and social media platforms with an emphasis on protecting participant privacy. Future activities will focus on disseminating scientific information through generation of infographics and webinars that will inform participants, families, and the public of discoveries generated from HBCD Study data.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101431"},"PeriodicalIF":4.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000926/pdfft?md5=0cfe110953ef6922249e62294f44e6ff&pid=1-s2.0-S1878929324000926-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neeltje E. Blankenstein , Samantha Bouwmeester , Sterre L. van Haeringen , Rowan T. van Klink , Lieke M. van der Meule , Lucres M.C. Jansen
{"title":"Who is at risk? Applying the biopsychosocial model to explain non-violent and violent delinquency in youth","authors":"Neeltje E. Blankenstein , Samantha Bouwmeester , Sterre L. van Haeringen , Rowan T. van Klink , Lieke M. van der Meule , Lucres M.C. Jansen","doi":"10.1016/j.dcn.2024.101428","DOIUrl":"10.1016/j.dcn.2024.101428","url":null,"abstract":"<div><p>Research has highlighted the relevance of biological measures in explaining antisocial behavior, but the inclusion of such measures in clinical practice is lagging behind. According to the integrative biopsychosocial model, biological measures should be studied together with psychological and social-environmental factors. In this data-driven study, we applied this comprehensive model to explain non-violent and violent delinquency of 876 at-risk youth (715 male, 9–27 years), by combining nine biological (autonomic-nervous-system; endocrinological), nine psychological, and seven social-environmental measures. Using latent-class-regression analysis we uncovered four distinct psychologically-driven biological clusters, which differed in non-violent and violent delinquency-risk, moderated by social-environmental variables: a biological–psychopathic traits; low problem; high problem; and biological–reactive group. Individual vulnerabilities to (non-)violent delinquency depended on social-environmental context that differed between clusters. These findings highlight the importance of biological and psychological factors, in the context of social-environmental factors, in explaining (non)-violent delinquency.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101428"},"PeriodicalIF":4.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000896/pdfft?md5=856af7a1d3799b57d54353e77203310b&pid=1-s2.0-S1878929324000896-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yajuan Si , Gretchen Bandoli , Katherine M. Cole , M. Daniele Fallin , Elizabeth A. Stuart , Kelly K. Gurka , Keri N. Althoff , Wesley K. Thompson , & the HBCD Design Workgroup and Biostatistics Workgroup
{"title":"Advancing high quality longitudinal data collection: Implications for the HEALthy Brain and Child Development (HBCD) Study design and recruitment","authors":"Yajuan Si , Gretchen Bandoli , Katherine M. Cole , M. Daniele Fallin , Elizabeth A. Stuart , Kelly K. Gurka , Keri N. Althoff , Wesley K. Thompson , & the HBCD Design Workgroup and Biostatistics Workgroup","doi":"10.1016/j.dcn.2024.101432","DOIUrl":"10.1016/j.dcn.2024.101432","url":null,"abstract":"<div><p>The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The HBCD Study aims to reflect the sociodemographic diversity of pregnant individuals in the U.S. The study will also oversample individuals who use substances during pregnancy and enroll similar individuals who do not use to allow for generalizable inferences of the impact of prenatal substance use on trajectories of child development. Without probability sampling or a randomization-based design, the study requires innovation during enrollment, close monitoring of group differences, and rigorous evaluation of external and internal validity across the enrollment period. In this article, we discuss the HBCD Study recruitment and enrollment data collection processes and potential analytic strategies to account for sources of heterogeneity and potential bias. First, we introduce the adaptive design and enrollment monitoring indices to assess and enhance external and internal validity. Second, we describe the visit schedule for in-person and remote data collection where dyads are randomly assigned to visit windows based on a jittered design to optimize longitudinal trajectory estimation. Lastly, we provide an overview of analytic procedures planned for estimating trajectories.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"69 ","pages":"Article 101432"},"PeriodicalIF":4.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000938/pdfft?md5=3ff9bd4565f3d550db7fece134e0d4ef&pid=1-s2.0-S1878929324000938-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}