The developing visual system: A building block on the path to autism

IF 4.6 2区 医学 Q1 NEUROSCIENCES
Jessica B. Girault
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引用次数: 0

Abstract

Longitudinal neuroimaging studies conducted over the past decade provide evidence of atypical visual system development in the first years of life in autism spectrum disorder (ASD). Findings from genomic analyses, family studies, and postmortem investigations suggest that changes in the visual system in ASD are linked to genetic factors, making the visual system an important neural phenotype along the path from genes to behavior that deserves further study. This article reviews what is known about the developing visual system in ASD in the first years of life; it also explores the potential canalizing role that atypical visual system maturation may have in the emergence of ASD by placing findings in the context of developmental cascades involving brain development, attention, and social and cognitive development. Critical gaps in our understanding of human visual system development are discussed, and future research directions are proposed to improve our understanding of ASD as a complex neurodevelopmental disorder with origins in early brain development.
发展中的视觉系统:通往自闭症之路的基石
过去十年进行的纵向神经成像研究提供了自闭症谱系障碍(ASD)患者在生命最初几年的非典型视觉系统发育的证据。基因组分析、家庭研究和尸检调查的结果表明,ASD视觉系统的变化与遗传因素有关,使视觉系统成为从基因到行为的重要神经表型,值得进一步研究。本文综述了自闭症儿童在生命最初几年的视觉系统发育情况;它还通过将研究结果置于涉及大脑发育、注意力、社会和认知发展的发育级联的背景下,探讨了非典型视觉系统成熟在ASD出现中的潜在分析作用。本文讨论了我们对人类视觉系统发育理解的关键空白,并提出了未来的研究方向,以提高我们对ASD作为一种起源于早期大脑发育的复杂神经发育障碍的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.60
自引率
10.60%
发文量
124
审稿时长
6-12 weeks
期刊介绍: The journal publishes theoretical and research papers on cognitive brain development, from infancy through childhood and adolescence and into adulthood. It covers neurocognitive development and neurocognitive processing in both typical and atypical development, including social and affective aspects. Appropriate methodologies for the journal include, but are not limited to, functional neuroimaging (fMRI and MEG), electrophysiology (EEG and ERP), NIRS and transcranial magnetic stimulation, as well as other basic neuroscience approaches using cellular and animal models that directly address cognitive brain development, patient studies, case studies, post-mortem studies and pharmacological studies.
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