Technology and Health Care最新文献

Bayesian sequential decision-making for rare disease clinical trials. 罕见病临床试验的贝叶斯顺序决策。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-29 DOI: 10.1177/09287329251344056

Yuan Gao, Jianling Bai, Feng Chen

{"title":"Bayesian sequential decision-making for rare disease clinical trials.","authors":"Yuan Gao, Jianling Bai, Feng Chen","doi":"10.1177/09287329251344056","DOIUrl":"https://doi.org/10.1177/09287329251344056","url":null,"abstract":"BackgroundRare disease clinical trials face challenges due to limited sample sizes and ethical imperatives to minimize futile treatments. Bayesian sequential design dynamically optimizes decisions under uncertainty, offering efficiency gains over traditional fixed-sample approaches.MethodsPropose a framework integrating sequential Bayes factor and adaptive stopping rules for trials with binary endpoint. Bayesian posterior probabilities define early termination thresholds (superiority/futility), while Bayes Factor Design Analysis validates trial feasibility. Sequential Bayes factor updates iteratively guide interim decisions based on evidence strength.ResultsThe approach enables earlier trial termination (for superiority or futility), reducing sample size, time, and costs. Patients avoid unnecessary exposure to futility treatments, while results remain interpretable even if thresholds are unmet.ConclusionThe primary goal is to confirm treatment efficacy earlier, enabling trials to be stopped promptly for either superiority or futility treatments. This strategy reduces sample size, time, and financial costs, and prevents patient exposure to futile treatments. Moreover, the study aims to promote the adoption of Bayesian sequential decision-making, thereby accelerating rare disease clinical trial approvals and drug marketing.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251344056"},"PeriodicalIF":1.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telehealth in oral medicine: Evaluation of app usability and satisfaction among public health system professionals. 口腔医学中的远程医疗：公共卫生系统专业人员对应用程序可用性和满意度的评估。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-28 DOI: 10.1177/09287329251341085

Maria do Desterro Andrêzza Souza Costa, Quemuel Pereira da Silva, Hélder Domiciano Dantas Martins, Paulo Rogério Ferreti Bonan, Edson Hilan Gomes de Lucena

{"title":"Telehealth in oral medicine: Evaluation of app usability and satisfaction among public health system professionals.","authors":"Maria do Desterro Andrêzza Souza Costa, Quemuel Pereira da Silva, Hélder Domiciano Dantas Martins, Paulo Rogério Ferreti Bonan, Edson Hilan Gomes de Lucena","doi":"10.1177/09287329251341085","DOIUrl":"https://doi.org/10.1177/09287329251341085","url":null,"abstract":"ObjectiveEvaluate the usability and user satisfaction of an oral medicine application among public health professionals.MethodsA cross-sectional observational study was conducted with 101 dentists registered in the application, determined through sample size calculation. Data were collected using an online questionnaire. The System Usability Scale (SyUS) was used to assess usability, and an adapted questionnaire evaluated user satisfaction. Variables influencing satisfaction and usability were also analyzed.ResultsMost participants were female (73.3%), aged between 20 and 59 years (98%), with up to 10 years of professional experience (73%). The majority had a specialization (81%), including 24.8% in Collective and Family Health, and 80.2% worked in Primary Health Care. The mean SyUS usability score was 91.25 (scale: 0-100), exceeding the threshold of 70 for a viable product. Participants expressed high satisfaction with the app's theoretical and clinical support. Suggested improvements included a lesion database, chat functionality, interactive notifications, expanded attachment capacity, training initiatives, and broader specialty coverage.ConclusionThe application achieved high usability and satisfaction scores, proving essential, intuitive, and effective. It complements public health systems by supporting diagnosis and treatment, enhancing professional collaboration, and improving care quality while addressing continuity and problem-solving needs.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251341085"},"PeriodicalIF":1.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NAmiRNA-31 regulates cell cycle by activating ZWINT and promotes lung adenocarcinoma tumor development. NAmiRNA-31通过激活ZWINT调控细胞周期，促进肺腺癌肿瘤的发展。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-27 DOI: 10.1177/09287329251343503

Yan Liu, Feng Yu, Jiuyang Jiang

{"title":"NAmiRNA-31 regulates cell cycle by activating ZWINT and promotes lung adenocarcinoma tumor development.","authors":"Yan Liu, Feng Yu, Jiuyang Jiang","doi":"10.1177/09287329251343503","DOIUrl":"https://doi.org/10.1177/09287329251343503","url":null,"abstract":"ObjectiveThis study aimed to identify Nuclear-activated miRNA (NAmiRNA) and their target genes linked to the prognosis of Lung adenocarcinoma tumor (LUAD), and provide novel diagnostic and therapeutic targets for this devastating disease.MethodsPutative target (Messenger RNA)mRNA of the prognostic (MicroRNA)miRNA was obtained by interesting the differentially expressed mRNAs with predicted targets from targetscan database. Functional validation experiments were conducted utilizing LUAD cell lines to corroborate the interactions between the identified miRNA and their target mRNAs. Collect cancer and adjacent tissues from patients to detect the expression of target genes. The effects of miRNA-target gene interactions on LUAD cell growth were investigated by (Cell Counting Kit-8)CCK8, colony formation assay and flow cytometry.ResultsOur findings revealed that both miR-31 and its target gene, ZWINT, were considerably overexpressed in LUAD individuals. The results of qPCR and WB indicated that miR-31 effectively upregulated the expression of (Zeste White 10 interactor)ZWINT. The transfection with miR-31mimic enhanced the activity of LUAD cells and promoted colony growth. Knockdown of ZWINT expression resulted in (G2 to mitosis)G2/M phase cell arrest, concurrent with a decrease in Cyclin B1 and (Cyclin-Dependent Kinase 1)CDK1 proteins.Conclusion(nuclear activating mirna-31)NAmiRNA-31 and ZWINT are upregulated in LUAD, suggest their potential as biomarkers for the unfavorable prognosis.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251343503"},"PeriodicalIF":1.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robot-assisted feeding: A systematic review and future prospects. 机器人辅助喂养：系统回顾与未来展望。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-27 DOI: 10.1177/09287329251342392

Fei Liu, Zhi Li, Mingyue Hu

{"title":"Robot-assisted feeding: A systematic review and future prospects.","authors":"Fei Liu, Zhi Li, Mingyue Hu","doi":"10.1177/09287329251342392","DOIUrl":"https://doi.org/10.1177/09287329251342392","url":null,"abstract":"BackgroundRobot-assisted feeding systems aim to promote independence for individuals with motor impairments. Despite significant technological progress, widespread adoption remains limited due to challenges related to adaptability, safety, and cost.ObjectiveThis review investigates recent advancements in robot-assisted feeding, highlights key technical and usability challenges, and outlines future directions to improve system adaptability, autonomy, and cost-effectiveness.MethodsA systematic literature search was conducted for peer-reviewed articles published in the past decade. The analysis focuses on critical domains including hardware architecture, human-robot interaction (HRI) modalities, and control strategies.ResultsAdvances in artificial intelligence (AI) and HRI have enhanced system autonomy and user adaptability. Nevertheless, unresolved issues persist in handling diverse food types, achieving real-time responsiveness, and minimizing system costs. Emerging solutions-such as adaptive learning, Artificial Intelligence of Things (AIoT) integration, and modular design-offer promising pathways to overcome these barriers and support scalable deployment in real-world care settings.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251342392"},"PeriodicalIF":1.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect and safety assessment of low-concentration atropine eye drops on the growth and development of juvenile cynomolgus monkeys over a period of one year. 低浓度阿托品滴眼液对食蟹猴幼猴一年生长发育的影响及安全性评价。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-22 DOI: 10.1177/09287329251340497

Jianmin Guo, Yuankeng Huang, Junli Lin, Lu Liu, Xialing Lei, Jinlong Dai, Lang Huang, Yujiao Li, Qingqing Lin, Wei Yang

{"title":"Effect and safety assessment of low-concentration atropine eye drops on the growth and development of juvenile cynomolgus monkeys over a period of one year.","authors":"Jianmin Guo, Yuankeng Huang, Junli Lin, Lu Liu, Xialing Lei, Jinlong Dai, Lang Huang, Yujiao Li, Qingqing Lin, Wei Yang","doi":"10.1177/09287329251340497","DOIUrl":"https://doi.org/10.1177/09287329251340497","url":null,"abstract":"BackgroundLow-concentration atropine sulfate eye drops (LAED) are widely used in children to control myopia progression; however, their long-term safety and effects on children's development remain unclear.ObjectiveTo assess the safety and growth development effects of LAED in juvenile cynomolgus monkeys over one year.MethodsEighty-eight juvenile cynomolgus monkeys were randomly assigned to a negative control group or one of three treatment groups receiving daily LAED: 0.01 mg (0.01%), 0.02 mg (0.01%), or 0.08 mg (0.04%) per day, with 22 animals (11 males and 11 females) per group. The treatment period lasted 12 months, followed by a 2-month recovery observation. Toxicological, growth, and ophthalmological parameters were evaluated.ResultsNo test substance-related changes were observed in food intake, body weight, body temperature, hematology, biochemical parameters, immunoglobulins, ECGs, blood pressure, urinalysis, bone marrow, or histopathology across all groups. Growth parameters exhibited age-consistent upward trends. The 0.04% LAED dose caused transient pupil dilation throughout the treatment period, which resolved upon withdrawal, attributed to the pharmacological effects of atropine sulfate. Toxicokinetic analysis revealed minimal systemic exposure, with no evidence of drug accumulation after prolonged use.ConclusionThe no-observed-adverse-effect level (NOAEL) for 0.04% LAED (0.8 mg/monkey/day) in juvenile cynomolgus monkeys was established over a one-year period. No developmental or ocular toxicity was observed, providing a foundation for the clinical evaluation of LAED in delaying myopia progression in children.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251340497"},"PeriodicalIF":1.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A predictive model for real-time LSTM methods: Monitoring dynamic transmembrane pressure improves loop life and anticoagulant therapy accuracy in continuous renal replacement therapy. 实时LSTM方法的预测模型：监测动态跨膜压力可提高连续肾替代治疗的循环寿命和抗凝治疗准确性。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-21 DOI: 10.1177/09287329251337277

Fangzheng Wang, Rui Zhang, Liang Tan, Tieniu Mei, Hongya Chen, Yonghui Zhang, Yu Zeng, Zuzhi Chen, Ying Cao

{"title":"A predictive model for real-time LSTM methods: Monitoring dynamic transmembrane pressure improves loop life and anticoagulant therapy accuracy in continuous renal replacement therapy.","authors":"Fangzheng Wang, Rui Zhang, Liang Tan, Tieniu Mei, Hongya Chen, Yonghui Zhang, Yu Zeng, Zuzhi Chen, Ying Cao","doi":"10.1177/09287329251337277","DOIUrl":"https://doi.org/10.1177/09287329251337277","url":null,"abstract":"BackgroundContinuous Renal Replacement Therapy (CRRT), is essential for managing acute kidney injury (AKI) Dynamic monitoring of transmembrane pressure (TMP) during CRRT is crucial for predicting filter clotting and optimizing filter lifespan, which indirectly supports anticoagulation management.ObjectiveTo prolong the lifespan of CRRT circuits and enhance the precision of anticoagulation therapy by developing a predictive early warning model for CRRT circuit life, based on dynamic TMP monitoring.MethodsWe conducted a retrospective analysis in the ICU of the First Affiliated Hospital of Army Medical University. Leveraging the TMP data recorded by CRRT machines, we established an adaptive real-time predictive modeling framework, termed DTP (Dynamic Transmembrane Pressure Prediction), utilizing Long Short-Term Memory (LSTM) networks. This framework predicts TMP trends as an early indicator of filter clotting. Our models were validated using over 20,000 min of clinical data from 405 CRRT cases, predicting TMP trajectories within 50 min.ResuitsIn simulated treatment evaluations, our LSTM models accurately identified impending TMP increases, achieving recall rates exceeding 0.97 and F2 scores above 0.93. Notably, an average warning time of 23 min was provided prior to the TMP reaching the critical 260 mmHg threshold, indicating substantial filter clotting. An analysis of false alarms revealed patterns consistent with emerging instability and transient artifacts.ConclusionThe personalized early warning model developed within the DTP framework effectively predicts TMP changes, enhancing the accuracy and timeliness of medical interventions. This improvement reduces the incidence of adverse events, maximizes the lifespan of CRRT circuits, and ultimately decreases treatment and personnel costs.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251337277"},"PeriodicalIF":1.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the impact of chatbots on health decision-making: A multifactorial experimental approach. 评估聊天机器人对健康决策的影响：一种多因素实验方法。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-15 DOI: 10.1177/09287329251341071

Zehang Xie

{"title":"Assessing the impact of chatbots on health decision-making: A multifactorial experimental approach.","authors":"Zehang Xie","doi":"10.1177/09287329251341071","DOIUrl":"https://doi.org/10.1177/09287329251341071","url":null,"abstract":"BackgroundChatbots are increasingly integrated into healthcare, offering personalized and accessible health advice. However, the impact of factors such as chatbot authority, health information type, and interaction style on users' decision-making remains unclear.ObjectiveThis study aims to investigate how these elements influence users' willingness to adopt health advice provided by chatbots.MethodsA 2 × 2 × 2 factorial experiment was conducted with 480 university students to examine the effects of chatbot authority (authoritative vs. non-authoritative), health information type (preventive vs. treatment-related), and interaction style (formal vs. informal). Participants' willingness to adopt the health advice was measured before and after interacting with the chatbot.ResultsThe study found that a authoritative chatbot delivering treatment-related advice in a formal style significantly increased willingness to adopt the advice. Conversely, preventive information was more effective when presented informally by a non-authoritative chatbot. These results support the media evocation paradigm, which suggests that chatbots framed as authoritative figures evoke greater user engagement and trust in health contexts.ConclusionThe findings extend the media evocation paradigm by demonstrating that chatbot authority, information type, and interaction style should be aligned with the nature of health advice to maximize effectiveness. This study provides insights for designing chatbots that improve health decision-making by tailoring their communication strategies.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251341071"},"PeriodicalIF":1.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The virtual-real interaction system design and interaction characteristics research of an ankle rehabilitation robot based on digital twin. 基于数字孪生的踝关节康复机器人虚实交互系统设计及交互特性研究。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-15 DOI: 10.1177/09287329251337237

Shenglong Xie, Mengxiang Zhan, Yuntang Li, Fengguo Xi

{"title":"The virtual-real interaction system design and interaction characteristics research of an ankle rehabilitation robot based on digital twin.","authors":"Shenglong Xie, Mengxiang Zhan, Yuntang Li, Fengguo Xi","doi":"10.1177/09287329251337237","DOIUrl":"https://doi.org/10.1177/09287329251337237","url":null,"abstract":"BackgroundIn recent years, the large-scale epidemics and the increasing demand for rehabilitation generated a demand for remote rehabilitation, while digital twin provided technical support for home-based rehabilitation.ObjectiveIn order to monitor the operation status of rehabilitation robot and make dynamic adjustments, a virtual-real interaction system for an ankle rehabilitation robot (VRIS-ARR) is designed based on the digital twin theory, and its virtual-real interaction characteristics is researched.MethodsThe VRIS-ARR is consisted of physical layer, communication layer, virtual layer and application layer, and is designed by the application of software tools such as 3ds Max, Unity 3D, C#, Python. The database technology and multi-threaded development method are applied to realize the virtual-real interaction function of the system.ResultsThe performance and function experiments of the VRIS-ARR are carried out, and the system has the characteristics of strong virtual-real interaction, which can work smoothly with high control accuracy and without obvious delay.ConclusionThe experimental results indicate that the developed VRIS-ARR is very reliable between the ankle rehabilitation robot and the host computer.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251337237"},"PeriodicalIF":1.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causality of genetically determined serum metabolites on thoracic and abdominal aortic aneurysm: Mendelian randomization study. 基因决定的血清代谢物与胸腹主动脉瘤的因果关系：孟德尔随机化研究。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-15 DOI: 10.1177/09287329251339074

Ning Qi, Xinfeng Zhou, Yun Zhao, Lu Huang, Jiasen Cui

{"title":"Causality of genetically determined serum metabolites on thoracic and abdominal aortic aneurysm: Mendelian randomization study.","authors":"Ning Qi, Xinfeng Zhou, Yun Zhao, Lu Huang, Jiasen Cui","doi":"10.1177/09287329251339074","DOIUrl":"https://doi.org/10.1177/09287329251339074","url":null,"abstract":"BackgroundAortic aneurysms (AA), including thoracic (TAA) and abdominal (AAA) types, are life-threatening conditions with complex and poorly understood mechanisms. Metabolic alterations, particularly in amino acid and energy metabolism, have been linked to AA, but their roles remain unclear due to limited and confounded observational evidence.ObjectiveThis research aimed to comprehensively investigate the potential causal links between serum metabolites and the development of thoracic (TAA) and abdominal (AAA) aortic aneurysms.MethodsWe analyzed serum metabolites from the Metabolomics data, using datasets of 353,049 individuals for TAA (3510 cases) and 353,087 individuals for AAA (3548 cases). Mendelian randomization (MR) techniques, including MR-Egger regression and inverse-variance weighting (IVW), assessed causality, with heterogeneity tested using Cochran's Q and I2 statistics, and pleiotropy via the MR-Egger intercept. Sensitivity was further checked through leave-one-out analysis. SNP annotations identified genes linked to TAA and AAA, and metabolic pathways were also analyzed.ResultsNine metabolites were causally linked to TAA, with three as risk factors, while 18 metabolites were associated with AAA, including eight risk factors. 3-dehydrocarnitine showed contrasting effects, acting as a risk factor for TAA (OR = 2.704; P = 0.031) and a protective factor for AAA (OR = 0.303; P = 0.025). Pathway analysis revealed TAA-related pathways such as \"Pyruvaldehyde degradation\" and \"Arginine biosynthesis,\" while AAA was linked to \"Phenylalanine metabolism\" and \"Valine, leucine, and isoleucine biosynthesis.\" No horizontal pleiotropy was detected, and results were robust.ConclusionsIdentified metabolites and pathways may serve as potential biomarkers and therapeutic targets for the clinical assessment and prevention of TAA and AAA.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251339074"},"PeriodicalIF":1.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infliximab may contribute to remit rapidly progressive of IgA nephropathy secondary to Crohn's disease: A case report. 英夫利昔单抗可能有助于缓解克罗恩病继发性IgA肾病的快速进展：1例报告。

IF 1.4 4区医学

Technology and Health Care Pub Date : 2025-05-15 DOI: 10.1177/09287329251340770

Songyan Wan, Han Chen, Siqi Liu, Zhenliang Fan, Junfen Fan

{"title":"Infliximab may contribute to remit rapidly progressive of IgA nephropathy secondary to Crohn's disease: A case report.","authors":"Songyan Wan, Han Chen, Siqi Liu, Zhenliang Fan, Junfen Fan","doi":"10.1177/09287329251340770","DOIUrl":"https://doi.org/10.1177/09287329251340770","url":null,"abstract":"BackgroundIgA nephropathy (IgAN) is a glomerulonephritis characterized by IgA deposition in the mesangial of the glomerulus, and it is the most common glomerulonephritis. However, many patients with inflammatory bowel disease (IBD) also have secondary IgAN. Compared with primary IgAN, the secondary IgAN may be more complex. Many novel therapies, such as anti-TNFα therapy, have been shown to influence IgAN while controlling IBD.Case presentationA 52-year-old woman had been treated with infliximab and azathioprine for Crohn's disease, and taking entecavir for hepatitis B. Recently, the patient developed gross hematuria, acute renal insufficiency, and positive blood anti-GBM antibody after the exacerbation of Crohn's disease. Renal biopsies were performed after infliximab dosage was increased. Although the patient presented clinically as rapidly progressive glomerulonephritis, renal biopsy revealed IgAN with acute tubulointerstitial injury and crescent formation. Subsequently, the patient experienced spontaneous remission with decrease in both hematuria and creatinine. We then gave the patient a routine dose of methylprednisolone, and her condition remained stable during follow-up.ConclusionIn our case, IgAN may expose antigen by causing local inflammatory response to GBM, induce anti-GBM antibody production, and cause acute renal insufficiency in the patient. However, anti-TNF-α therapy may promote the remission of hematuria and renal insufficiency by inhibiting the inflammatory response in renal tissues. Therefore, more studies are needed to understand the specific role of anti-TNFα therapy in IgAN.","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251340770"},"PeriodicalIF":1.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0