Technology and Health Care最新文献

{"title":"LncRNA-TIL1H mediates targeted regulation of the drug-resistant gene MDR1 and RAD21 to promote immune resistance and accelerate osteosarcoma progression.","authors":"Qiu-Yang Lu, Mei-Ling Lan, Nan Dai, Kai Xiong, Yu Fu, Wei Liang","doi":"10.1177/09287329251360524","DOIUrl":"https://doi.org/10.1177/09287329251360524","url":null,"abstract":"<p><p>BackgroundTargeted regulation of drug-resistant gene expression through lncRNA has emerged as a novel research direction for overcoming immune resistance in osteosarcoma. However, the specific effects and regulatory mechanisms of lncRNA-TIL1H on immune resistance in osteosarcoma remain unclear.ObjectiveTo explore the mechanism by which lncRNA-TIL1H targets the regulation of the drug-resistant genes MDR1 and RAD21.MethodsClinical samples including osteosarcoma tissues and adjacent tissues were collected for qPCR and WB analysis of lncRNA-TIL1H expression as well as MDR1 and RAD21. Acquisition of drug-resistant osteosarcoma cells by cisplatin treatment MG-63/R. The cells were divided into four groups: MG-63, MG-63/R, si-NC-MG-63/R, and si-TIL1H-MG-63/R group. Cell proliferation and colony formation, and migration and invasion were detected by CCK-8, Transwell and scratch assays. In addition, the effects on osteosarcoma after interfering with lncRNA-TIL1H were further explored by the animal experiments, including HE staining and immunohistochemistry.ResultsThe expression of lncRNA-TIL1H and the drug-resistant genes MDR1 and RAD21 significantly increased in osteosarcoma. si-TIL1H effectively inhibited cell proliferation, invasion, migration and decreased the expression of drug-resistant genes in MG-63/R. Finally, the animal experiments revealed that si-lncRNA-TIL1H inhibited tumor proliferation.ConclusionThe expression of lncRNA-TIL1H in MG-63/R promotes the upregulation of drug-resistant genes MDR1 and RAD21, leading to the occurrence of immune resistance and accelerating osteosarcoma progression.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251360524"},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the efficacy and user experience of virtual reality exposure therapy for social anxiety disorder: A pilot study.","authors":"Warut Aunjitsakul, Kanthee Anantapong, Pakawat Wiwattanaworaset, Aimorn Jiraphan, Teerapat Teetharatkul, Katti Sathaporn, Kreuwan Jongbowonwiwat, Sitthichok Chaichulee","doi":"10.1177/09287329251360523","DOIUrl":"https://doi.org/10.1177/09287329251360523","url":null,"abstract":"<p><p>BackgroundSocial anxiety disorder (SAD) significantly impairs social functioning. Virtual reality exposure therapy (VRET) offers a promising treatment by providing a controlled, customizable environment. This study aimed to develop and evaluate the efficacy and user experience of a VRET program.MethodsThe study was conducted in two phases: Phase I with the general population and Phase II with individuals diagnosed with SAD at a university hospital. Social anxiety, depression, anxiety, and stress were measured using the Social Interaction Anxiety Scale and the Depression Anxiety and Stress Scale at three time points: before, immediately after, and two weeks post-VRET. The Virtual Reality Neuroscience Questionnaire assessed user experience, game mechanics, in-game assistance, and any VR-induced symptoms. Our VRET program utilized graded exposure techniques within culturally relevant social scenarios.ResultsBoth groups exhibited significant reductions in social anxiety levels following VRET sessions (ps < 0.01) compared to pre-VRET levels. However, individuals with SAD reported increased social anxiety at the two-week follow-up, while the general population maintained their improvement. The VR software received satisfactory ratings for usability, safety, and acceptability.ConclusionThis program demonstrates potential for reducing social anxiety and provides a satisfactory VR experience, supporting its feasibility for individuals with SAD in a developing country. Given the pilot nature and limited sample size, these findings should be interpreted cautiously. Future research with larger samples and repeated sessions is needed to enhance efficacy and ensure long-term benefits. Comprehensive treatment protocols, including tutorials, relaxation techniques, and stress monitoring, are recommended for optimal outcomes.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251360523"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial quantitative analysis of gemstone spectral imaging CT: Analysis and discussion of the application value for the differentiation of small liver metastases (<3 cm).","authors":"Qin Feng, Yao Hu, Qiuxia Wang, Daoyu Hu, Zhen Li, Hao Tang","doi":"10.1177/09287329251360091","DOIUrl":"https://doi.org/10.1177/09287329251360091","url":null,"abstract":"<p><p>BackgroundHepatic metastases are the most common malignant tumors in the liver. Conventional contrast-enhanced CT examinations face challenges in distinguishing between benign and malignant atypical metastatic liver lesions with a diameter <3 cm, and evaluating their therapeutic efficacy remains particularly difficult.ObjectiveTo assess the clinical value of quantitative iodine analysis and spectral curves for diagnosing and differentiating liver metastases using gemstone spectral CT.MethodsAmong 915 patients with suspected hepatic metastases, 140 cases (87 males, 53 females) were pathologically confirmed. Primary malignancies included colorectal cancer (41 cases), gastric cancer (21 cases), lung cancer (35 cases), pancreatic cancer (31 cases), and breast cancer (12 cases). A total of 425 small lesions (<3 cm) were detected. CT values at lesion centers and peripheries were measured and compared against normal liver parenchyma. Quantitative iodine concentrations and spectral curve slopes were analyzed to evaluate differences in small hepatic metastases originating from distinct primary malignanciesResultsIn the differentiation of hepatic metastatic subtypes, mean CT values demonstrated diagnostic utility in distinguishing colorectal cancer from gastric in AP (Arterial Phase, P = 0.001) in the Center of lesions.On the contrary, the quantitative analysis of focus edge iodine reliably distinguished the AP (P < 0.000), lung cancer (P = 0.023) and pancreatic cancer (P < 0.000) of colorectal cancer and gastric cancer. The results have statistical significance.ConclusionsGSI(Gemstone spectral Imaging)-derived spectral curve slope and quantitative iodine analysis may facilitate differential diagnosis of small hepatic metastatic lesions with diverse primary origins, especially the source of colorectal cancer.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251360091"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An explainable RSPWVD based EEG microstate sequence approach for scalp connectivity estimation and channel selection in patients with epilepsy.","authors":"Jia Wen Li, Guan Yuan Feng, Xi Ming Ren, Chen Ling, Shuang Zhang, Yu Ping Qin, Jiu Jiang Wang, Yuan Yu Yu, Xin Liu, Rong Jun Chen","doi":"10.1177/09287329251356661","DOIUrl":"https://doi.org/10.1177/09287329251356661","url":null,"abstract":"<p><p>BackgroundElectroencephalography (EEG), a noninvasive technique for recording the brain's electrical activity, has been widely utilized to investigate neurological disorders.ObjectiveEEG recordings can estimate scalp connectivity and select representative channels, which reveal network connectivity and associated brain regions. These details are considered essential for understanding the characteristics of neurological disorders.MethodsThis work proposes an explainable Reassigned Smoothed Pseudo Wigner-Ville Distribution (RSPWVD) based EEG microstate sequence approach to achieve scalp connectivity estimation and channel selection. Epilepsy, one of the most frequently studied neurological disorders using EEG, has been selected for method validation. Receiver Operating Characteristic (ROC) curve analysis and consistency analysis with conventional techniques are performed to specify key parameters such as connection thresholds and time durations, ensuring the reliability of the outcomes.ResultsThe experimental results of the clinical Karunya dataset indicate that the proposed microstate sequence compressed from the EEG contains sufficient information to estimate scalp connectivity and select representative channels. The scalp connectivity results reveal differences between focal and generalized seizures, where focal seizures exhibit more localized connectivity and generalized seizures display a widespread distribution. Moreover, statistical results demonstrate that the F4, C4, T4, and P4 channels present a higher rate of being representative channels in this dataset.ConclusionsThe proposed approach offers valuable characteristics, indicating brain networks that assist in epilepsy analysis by focusing on the most informative scalp locations and reducing computational complexity. It lays the groundwork for investigating various neurological disorders through scalp behaviors from EEG, guiding personalized diagnostics and therapeutic strategies.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251356661"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Checkpoint blockade immunotherapy for multiple recurrences of radiation-induced maxillary sinus sarcoma: A case report.","authors":"Yuge Li, Yan Zhong, Lijuan Ge, Guiyuan Peng","doi":"10.1177/09287329251358636","DOIUrl":"https://doi.org/10.1177/09287329251358636","url":null,"abstract":"<p><p>BackgroundRadiotherapy has become a fundamental treatment modality of head and neck (HN) malignancies, which provides a chance of long-term survival. However, radiation also amplifies the risk of developing radiation-induced sarcoma (RIS) in the irradiated tissue. Radiation-induced maxillary sinus sarcoma (RIMSS) is an extremely rare and highly lethal malignancy of the HN. RIS is mainly treated with surgery, but the anatomical district and the infiltrative nature of RIS make it challenging to achieve negative margins, resulting in high fatality rate with the mean survival time of approximately one year. Immunotherapy, as an effective treatment option is rapidly evolving for HN tumors. However, checkpoint Blockade Immunotherapy (CBI) combined with chemotherapy as maintenance therapy for RIS of HN is rarely reported.Case presentationThe study presents a 36-year-old female with numerous recurrences of RIMSS, who experienced a dramatic response to checkpoint blockade immunotherapy after rapidly progressing on involved-field radiotherapy and multiple surgeries. After using immunotherapy combined with chemotherapy, the patient had a nearly complete response (CR) and maintained with single-agent programmed cell death 1 (PD-1) inhibitors.ResultsThe patient achieved a durable response, with progression-free survival (PFS) lasting 18 months.ConclusionUsing CBI as maintenance therapy for RIMSS represents a novel treatment option, especially for unresectable patients. Further investigation is warranted to optimize a multimodal treatment and improve response.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251358636"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation study of JAK2-STAT3 signaling pathway and CD4 + T lymphocyte subset changes in CMPA children.","authors":"Wei Pan, Weihong Tang, Zhongmin Wang, Yunyun Deng, Shan Ye","doi":"10.1177/09287329251360089","DOIUrl":"https://doi.org/10.1177/09287329251360089","url":null,"abstract":"<p><p>BackgroundCow's milk protein allergy (CMPA) is a common food allergy in children, affecting growth, development, and quality of life. The pathogenesis involves immune dysregulation, particularly CD4+ T lymphocyte subsets, which play a key role in immune responses. The JAK2-STAT3 signaling pathway is critical for immune cell regulation, but its role in CMPA-associated immune changes remains unclear.MethodsA total of 103 CMPA patients and 100 healthy controls were enrolled. Peripheral blood samples were collected from patients before and after a 3-month CMPA avoidance diet. Flow cytometry, ELISA, western blotting, and qRT-PCR were used to analyze CD4+ T cell subsets (Th1, Th2, Th17), cytokine levels, and JAK2-STAT3 pathway activity.ResultsCMPA patients exhibited increased Th2 and Th17 proportions and reduced Th1 cells compared to controls. JAK2 and STAT3 phosphorylation levels were elevated, while SOCS1/SOCS3 expression was downregulated. After dietary avoidance, Th2 and Th17 proportions decreased, Th1 increased, and JAK2-STAT3 activation normalized. Pearson correlation analysis revealed positive associations between JAK2-STAT3 activation and Th2/Th17 proportions and a negative correlation with Th1.ConclusionsThe JAK2-STAT3 signaling pathway is abnormally activated in CMPA and correlates with CD4+ T lymphocyte subset imbalances. Targeting this pathway may offer therapeutic potential for CMPA management.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251360089"},"PeriodicalIF":1.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamics and restenosis risk assessment in Budd-Chiari syndrome: A CFD study.","authors":"Shikun Zhang, Zhen Wang, Wenyue Sun, Qingrong Zhou, Hui Tang, Junbin Xu, Peijun Qi, Yinghong Zhao, Fei Wang, Chao Chen","doi":"10.1177/09287329251360084","DOIUrl":"https://doi.org/10.1177/09287329251360084","url":null,"abstract":"<p><p>Background and ObjectiveBudd-Chiari syndrome (BCS) presents challenges in postoperative restenosis risk prediction due to unclear hemodynamic pathophysiology. Despite advances in interventional therapies, tools linking hemodynamic abnormalities to vascular remodeling are lacking. This study aimed to evaluate hemodynamic changes in BCS patients with inferior vena cava (IVC) stenosis using patient-specific MRI and computational fluid dynamics (CFD) to establish predictive biomarkers and optimize management.Methods3D IVC models were reconstructed from preoperative, postoperative, and healthy control MRI data. Dynamic hemodynamic parameters, including flow velocity, pressure gradients, wall shear stress (WSS), and vortex patterns, were analyzed via CFD simulations under physiologically accurate boundary conditions.ResultsPreoperative IVC stenosis caused severe disturbances. Post-intervention, parameters decreased (e.g., peak stenotic velocity from 1.91 m/s to 0.97 m/s; trans-stenotic pressure gradient from 3562 Pa to 1404 Pa) but remained higher than normal (peak velocity: 0.27 m/s; pressure fluctuation: Δ1225 Pa). Persistent vortices near stent edges and incomplete pressure normalization were observed, correlating with restenosis incidence. These findings highlight unresolved WSS (post-op peak WSS: 18.2 Pa vs normal: 6.18 Pa) and abnormal flow dynamics (e.g., prolonged vortex duration) as key recurrence risks.ConclusionThis study provides a hemodynamic framework for BCS, showing that intervention alleviates stenosis but doesn't restore normal flow. Residual stress emphasizes the need for adjunct therapies. The CFD approach offers predictive insights, advocating personalized monitoring for improved BCS outcomes.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251360084"},"PeriodicalIF":1.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on lung cancer diagnosis based on machine learning.","authors":"Haihui Huang, Aitong Zhong, Decheng Miao","doi":"10.1177/09287329251358616","DOIUrl":"https://doi.org/10.1177/09287329251358616","url":null,"abstract":"<p><p>BackgroundIn clinical diagnosis, determining the level of malignancy in tumors and differentiating between benign and malignant tumors are common classification challenges. Accurate and early diagnosis is essential for targeted treatment, and machine learning methods can assist in making these judgments.MethodsThis paper focuses on the classification of the lung tissue as benign or malignant and assessing the degree of aggressiveness in lung cancer. The study employed artificial neural network (ANN), logistic regression, and ridge penalized logistic regression, which are methods without built-in feature selection. Additionally, lasso penalized logistic regression, elastic-net penalized logistic regression, and sparse logistic regression with the hybrid L1/2 + 2 regularization (HLR), which are methods with built-in feature selection, were also utilized.ResultsIn the study on classifying benign and malignant lung tissue, ANN demonstrated the best predictive performance among the methods without built-in feature selection, achieving an average test accuracy of 91.82%. Among the methods with built-in feature selection, HLR outperformed the others with an average test accuracy of 96.67%. When determining the level of malignancy in lung tumors, ANN surpassed other methods without built-in feature selection, attaining an average test accuracy of 84.74%. In comparison, HLR exceeded the performance of other methods with built-in feature selection, reaching an average test accuracy of 93.33%.ConclusionsThe experimental results indicated that HLR with built-in feature selection and ANN without built-in feature selection exhibited strong competitiveness among the methods investigated in both classifying benign and malignant lung tissue and assessing the degree of aggressiveness in lung cancer.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251358616"},"PeriodicalIF":1.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the mechanism and substance basis of Dingxiang Shidi Decoction for the treatment of chemotherapy-induced nausea and vomiting by integrating mass spectrometry, network pharmacology and molecular docking.","authors":"Min Zhan, Qian Wang, Jun Yan, Qiaoxuan Zhang, Liqiao Han, Zemin Wan, Shasha Li, Xianzhang Huang","doi":"10.1177/09287329251358624","DOIUrl":"https://doi.org/10.1177/09287329251358624","url":null,"abstract":"<p><p>BackgroundChemotherapy-induced nausea and vomiting (CINV) remains a prevalent and debilitating side effect of cancer treatment with limited therapeutic options. Dingxiang Shidi Decoction (DXSD), a classical Chinese herbal formula, has demonstrated clinical efficacy in CINV management. However, its active components and mechanism of action require systematic investigation.ObjectiveThis study aims to elucidate the pharmacologically active constituents of DXSD and their anti-CINV mechanisms.MethodsWe employed advanced analytical techniques including UPLC-MS/MS and GC-MS to analyze the chemical components of DXSD. Network pharmacology techniques were applied to explore its pharmacological mechanisms. And molecular docking simulation was conducted to further refine the drug-target interaction.ResultsA total of 292 chemical compounds were identified in DXSD, comprising 165 water-soluble components, 56 volatile components, and 84 network database entries. By integrating 564 drug targets with 888 CINV disease targets, we identified 143 potential therapeutic targets. Further protein-protein interaction (PPI) network analysis revealed 12 key active ingredients and 13 key therapeutic targets. Enrichment analysis suggested that DXSD may reduce inflammation, modulate neurotransmitter stimulation in the gastrointestinal tract, and regulate cellular proliferation and differentiation. Notably, key active ingredients, predominantly aromatic compounds such as sabinene, (-)-α-cubebene, α-copaene, β-caryophyllene, aromandendrene, γ-muurolene, (-)-α-muurolene, α-phellandrene, α-terpinene, γ-terpinene, (+)-δ-cadinene, and Gomisin B, demonstrated significant binding affinity with multiple targets, particularly AKT1, BCL2, EGFR, MTOR, and STAT3.ConclusionsThis study reveals the active components and therapeutic mechanisms of DXSD against CINV, supporting its clinical application and demonstrating the potential of aromatherapy as an effective treatment strategy.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251358624"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the rules of acupoint selection along meridians in the treatment of insomnia by guasha therapy.","authors":"Yanhuan Qi, Haimin Li, Yun Chen, Yinqin Zhong, Meixia Ye, Jie Chen, Ying Liu","doi":"10.1177/09287329251358625","DOIUrl":"https://doi.org/10.1177/09287329251358625","url":null,"abstract":"<p><p>BackgroundInsomnia is a prevalent global health issue that significantly impacts quality of life and poses a substantial economic burden. While conventional pharmacological and non-pharmacological treatments exist, they are often limited by side effects, dependency, or low clinical applicability. Guasha therapy, a traditional Chinese medicine nursing technique, shows promise for treating insomnia, but lacks standardized, evidence-based guidelines for its clinical application.ObjectiveTo analyze the regularity of meridian and acupoint selection in the treatment of insomnia with scraping therapy by using data mining technology.MethodsA computer-based search of PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, Weipu Database(VIP), and Chinese Biomedical Literature Database (CBM) was conducted to retrieve the literature on scraping therapy for insomnia from the establishment of the database to March 15,2024.Excel was used to establish a database of acupoints for scraping therapy for insomnia, and the frequency of acupoints and meridians and the meridian tropism of acupoints were analyzed. SPSS 26.0 was used to cluster the high-frequency acupoints. The Apriori algorithm model provided by SPSS Modeler 18.0 was used to analyze the association rules of acupoint compatibility. Cytoscape 3.10.1 software was used to construct a complex network of meridian compatibility, and to analyze the core meridian of scraping in the treatment of insomnia.ResultsA total of 119 literatures were finally included, including 144 acupoints, with a total of 1121 frequencies. The most commonly used acupoints were Xinshu (BL15), Baihui (GV20), and Shenmen (HT7), and the commonly used compatibility acupoints were Xinshu-Pishu (BL20) and Xinshu-Pishu-Shenmen. The main meridians are Bladder meridian of foot-taiyang, Governor vessel, Gallbladder meridian of foot-shaoyang and Heart meridian of hand-shaoyin, which are the core meridian routes.ConclusionsData mining can effectively analyze the commonly used acupoints, acupoint compatibility rules and meridian rules of Gua Sha in the treatment of insomnia. The analysis results align with the traditional Chinese medicine principle of primarily following meridians, combining syndrome and root, enhancing the treatment effectiveness of insomnia, and providing a reference for clinical practice and research.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251358625"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}