Technology and Health Care最新文献

{"title":"Feasibility of using a multivariate serum biomarker model in early pregnancy to predict gestational hypertension.","authors":"Meixia Fang, Xiaoli Gao","doi":"10.1177/09287329241296399","DOIUrl":"https://doi.org/10.1177/09287329241296399","url":null,"abstract":"<p><p>BackgroundWith the increasing need for early prediction and intervention of Pregnancy-Induced Hypertension (PIH), researchers have begun to explore the use of multiserum biomarker models to improve the accuracy and reliability of predictions. It is estimated that between 5% and 8% of pregnant women worldwide experience pregnancy-induced hypertension, which is one of the leading causes of maternal death and adverse neonatal outcomes. Given the potential negative impact of pregnancy-induced hypertension on maternal and infant health, early identification of high-risk individuals and appropriate preventive measures are particularly important.ObjectiveTo assess the feasibility of using a multivariate serum biomarker model in early pregnancy to predict gestational hypertension.MethodsRetrospective analysis was conducted on the clinical data of 125 pregnant women admitted to our hospital from January 2021 to December 2022. The occurrence of gestational hypertension was recorded and multiple serum biomarkers were collected and compared between the exposure and non-exposure groups. Logistic regression analysis was performed to identify influencing factors for gestational hypertension. Correlations between each factor and gestational hypertension were analyzed, and a line chart model was constructed. The discriminative ability of the model was evaluated using the C-index, and internal validation was conducted using ten-fold cross-validation and bootstrap validation.ResultsOut of 125 pregnant women, 35 (28.00%) developed gestational hypertension. β-HCG and Hcy were identified as independent risk factors, while PAPP-A, AFP, and uE3 were identified as independent protective factors. There was a positive correlation between Hcy, β-HCG, and gestational hypertension, and a negative correlation between PAPP-A, AFP, uE3, and gestational hypertension. The predictive line chart model had a C-index of 0.885 and an average AUC value of 0.853 after internal validation.Conclusionβ-HCG and Hcy are risk factors, while PAPP-A, AFP, and uE3 are protective factors for gestational hypertension. A line chart model based on these factors can help identify pregnant women at risk of developing gestational hypertension in early pregnancy.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":"33 2","pages":"1046-1055"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of colour Doppler ultrasound, serum <b>β</b>-hCG concentration, and progesterone concentration in ectopic pregnancy.","authors":"Wanyan Li, Zhike Liu, Yiqin Ma, Tingting Zhao, Yanyan Liu, Leilei Qin, Yuzhen Yue, Xiaofei Chu, Yayang Duan","doi":"10.1177/09287329241296379","DOIUrl":"10.1177/09287329241296379","url":null,"abstract":"<p><p>BackgroundThe rising incidence of ectopic pregnancy (EP) in China underscores the critical need for early and accurate diagnosis to achieve optimal patient outcomes. Colour Doppler ultrasound, β-hCG, and progesterone testing are essential tools in the detection of EP, with transvaginal ultrasound offering precise visualization of EP lesions. Lower levels of β-hCG and progesterone in EP cases compared to normal pregnancies serve as key diagnostic markers. Awareness of atypical symptoms is crucial to prevent missed or misdiagnosed cases, underscoring the importance of timely intervention to mitigate severe complications.ObjectiveTo investigate the differences in colour Doppler ultrasound findings, serum β-hCG levels, and progesterone levels between normal and ectopic pregnancies, in order to provide insights into the clinical diagnosis and treatment of EP.MethodsSixty patients who showed no gestational sac in the uterus during early pregnancy and were either highly suspected or pathologically confirmed to have EP were selected for this study. As controls, fifty women with normal pregnancies during the same period were also included. Colour Doppler ultrasound findings (endometrial thickness, pelvic effusion, uterine effusion, and adnexal mass), serum β-hCG levels, and progesterone levels were recorded and compared between the two groups.ResultsColour Doppler ultrasound showed that the EP group had significantly greater incidences of pelvic effusion, uterine effusion, and an adnexal mass than did the control group. Moreover, the EP patients had significantly thinner endometria (8.3 ± 3.37 mm vs. 16.12 ± 3.09 mm; <i>P </i>< 0.05), lower serum β-hCG levels (846.18-1444.09 vs. 2429.24-3020.56; <i>P </i>< 0.05), and lower progesterone levels (9.1 ± 7.19 vs. 17.66 ± 5.63; <i>P </i>< 0.05) than did the controls. Receiver operating characteristic (ROC) analysis revealed that endometrial thickness, serum β-hCG concentration, and progesterone concentration had considerably high area under the curve (AUC), sensitivity, and specificity for the diagnosis of EP.ConclusionColour Doppler ultrasound, serum β-hCG concentration, and progesterone concentration have high diagnostic value for EP.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"789-796"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering diabetic foot ulcer prevention: A novel cloud-based plantar pressure monitoring system for enhanced self-care.","authors":"ShuiCai Wu, GuangYu Bin, WenFei Shi, Lan Lin, YongSong Xu, Dong Zhao, Stephen P Morgan, Shen Sun","doi":"10.1177/09287329241290943","DOIUrl":"10.1177/09287329241290943","url":null,"abstract":"<p><p>BackgroundThis study was prompted by the crucial impact of abnormal plantar pressure on diabetic foot ulcer development and the notable lack of its monitoring in daily life. Our research introduces a cloud-based, user-friendly plantar pressure monitoring system designed for seamless integration into daily routines.ObjectiveThis innovative system aims to enable early ulcer prediction and proactive prevention, thereby substantially improving diabetic foot care through enhanced self-care and timely intervention.MethodsA novel, user-centric plantar pressure monitoring system was developed, integrating a wearable device, mobile application, and cloud computing for instantaneous diabetic foot care. This configuration facilitates comprehensive monitoring at 64 underfoot points. It encourages user engagement in health management. The system wirelessly transmits data to the cloud, where insights are processed and made available on the app, fostering proactive self-care through immediate feedback. Tailored for daily use, our system streamlines home monitoring, enhancing early ulcer detection and preventative measures.ResultsA feasibility study validated our system's accuracy, demonstrating a relative error of approximately 4% compared to a commercial pressure sensing walkway. This precision affirms the system's efficacy for home-based monitoring and its potential in diabetic foot ulcer prevention, positioning it as a viable instrument for self-managed care.ConclusionsThe system dynamically captures and analyzes plantar pressure distribution and gait cycle details, highlighting its utility in early diabetic foot ulcer detection and management. Offering real-time, actionable data, it stands as a critical tool for individuals to actively participate in their foot health care, epitomizing the essence of self-managed healthcare practices.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"701-718"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of neurotensin in experimental terminal ileitis.","authors":"Hongyu Zhou, Quan He, Rong Xiao, Yeqing Chen, Feifei Zhu, Haojuan Zhu, Mingwei Han, Guohua Zhou","doi":"10.1177/09287329241295867","DOIUrl":"https://doi.org/10.1177/09287329241295867","url":null,"abstract":"<p><p>BackgroundTerminal ileitis (TI) is an inflammatory condition of the distal portion of the ileum.ObjectiveTo investigate the changes and significance of neurotensin (NT) in the course of experimental terminal ileitis (ETI).MethodsA total of 90 Sprague Dawley (SD) rats were randomly divided into the control, model, and suture groups (30 rats in each group). After 2, 4, and 8 weeks of surgery, 10 TI tissues were taken for endoscopic observation in each group. Hematoxylin-eosin (HE) staining was used to detect the pathological changes. The NT levels in serum and terminal ileum mucosa were detected by Enzyme-linked immunosorbent assay (ELISA).ResultsAcute inflammatory changes were observed in the suture and the model groups after 2-week of operation. At 4 weeks, compared to the control group, the inflammatory damage in the model group became heavier, but it was reduced in the suture group. At 8 weeks, the model group showed chronic inflammation. However, there was no obvious inflammatory cell infiltration in both the suture group and control group. NT levels were increased in the suture and model groups at 2 weeks, particularly in the model group, and they were significantly higher in the suture and model groups than those in the control group (<i>P </i>< 0.05). At 4 weeks, the NT levels in the model group continued to rise, while they decreased in the suture group (<i>P </i>< 0.05). After 8 weeks, NT levels in the model group were significantly higher than those in the suture and control groups (<i>P </i>< 0.05). Furthermore, from 2 weeks to 8 weeks, the NT concentration in the model group gradually increased, and the suture group increased for 2 weeks, followed by a downward trend.<b>Conclusions:</b> In the ETI, the changes in NT concentration in serum and TI mucosa were positively correlated with the degree of inflammation.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":"33 2","pages":"1081-1087"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intrathecal infusion port system on patients with advanced cancer pain and their caregivers.","authors":"Xiao-Qian Yang, Dan-Dan Hao, Peng Chen, Hai-Yan Jin, Li-Hua Deng, Jing Meng, Mei-Gui Chen","doi":"10.1177/09287329241291413","DOIUrl":"10.1177/09287329241291413","url":null,"abstract":"<p><p>BackgroundPain is one of the most common symptoms of cancer. It affects about two-thirds of patients with advanced cancer, and gets progressively worse as the disease advances.ObjectiveThe impact of the intrathecal infusion port system on patients with advanced cancer pain and the nursing workload on their primary caregivers was investigated in this study.MethodsBetween January 2018 and December 2021, a total of 26 patients with advanced cancer pain who received intrathecal infusion in our hospital, were enrolled in this study along with their primary caregivers. Assessments of patients' pain levels, adverse reactions, and quality of life, as well as the nursing workload of primary caregivers were evaluated.ResultsThe findings revealed a significant reduction in pain scores, decreasing from (7.42 ± 0.58) one week before treatment to (2.00 ± 0.56) one week after treatment, and maintaining a similar level at (2.07 ± 0.56) one month post-treatment, with a concomitant decrease in associated complications. Moreover, an improvement in overall quality of life was observed, as evident in the total physical health scores, which increased from (33.97 ± 7.14) one week prior to treatment to (47.44 ± 10.14) one week post-treatment and (48.56 ± 9.35) one month post-treatment. The total psychological health scores exhibited a positive trajectory, rising from (52.50 ± 23.55) one week before treatment to (65.00 ± 16.55) one week after treatment, ultimately reaching (69.42 ± 15.64) one month post-treatment. Furthermore, the primary caregivers' nursing workload experienced a consistent decline, decreasing from (51.54 ± 7.30) one week before treatment to (46.54 ± 5.57) one week after treatment and further diminishing to (45.32 ± 6.41) one month after treatment. Repeated measures of variance showed that there were significant differences in pain, quality of life, and primary caregivers' nursing workload at different time points (<i>P </i>< 0.05).ConclusionThe intrathecal infusion port system can effectively reduce the pain level of patients with advanced cancer pain, improve their quality of life, and reduce the nursing workload of their primary caregivers.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"781-788"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC01004/hsa-mir-125b-2-3p axis restrains ferroptosis in hepatocellular carcinoma by targeting HSPA4 via ceRNA mechanism.","authors":"Han Gao, Li Fan, Xue Gai, Rong Fu, Guohua Li, Kexin Jing, Jingwei Xu, Shengjian Sun","doi":"10.1177/09287329241291430","DOIUrl":"https://doi.org/10.1177/09287329241291430","url":null,"abstract":"<p><p>BackgroundHepatocellular carcinoma (HCC) is a primary cancer, accounting for 90% of primary liver cancer, mainly occurring in patients with cirrhosis and chronic liver disease.ObjectiveTo investigate the latent mechanisms of hepatocellular carcinoma (HCC) and find therapeutic targets.MethodsDifferentially expressed and overall survival related genes of HCC, and cell death related genes were intersected to obtain latent target genes. These genes were analyzed using ROC curve for diagnosing HCC. RT-qPCR and Western blot were performed to detect the expression level of genes. Wound healing tests were performed with or without si-HSPA4. Potential ceRNA axis was forecasted using TargetScan and miRanda and the dual luciferase reporter gene assay was used to verify the results. Finally, the images of H&E dye liquor-stained HCC tissue section, the CT images for patients in different tumor stage.ResultsLINC01004/hsa-miR-125b-2-3p/HSPA4 axis was forecasted and then was verified using dual-luciferase reporter assay. HSPA4 knockdown caused significant reduction of cell proliferation and ferroptosis. Si-HSPA4 related ferroptosis was generated through impairing iron transport via targeting restrain GPX4. For human subjects, the RT-qPCR analysis revealed the that the larger the tumor diameter, the higher the LINC01004, HSPA4, and GPX4 expression, and the lower the hsa-miR-125b-2-3p expression.ConclusionLINC01004/hsa-miR-125b-2-3p/HSPA4 regulatory axis involved in the ferroptosis of the progression of HCC via GPX4 dependent method, providing new therapeutic targets for HCC patients.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":"33 2","pages":"959-973"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of mNUTRIC score for chronic critical illness in patients of sepsis complicated with ARDS.","authors":"Mingxia Ji, Linlin Zhu, Mengyan Chen, Yi Wang, Weiyong Qiu, Ning Zhang","doi":"10.1177/09287329241296430","DOIUrl":"10.1177/09287329241296430","url":null,"abstract":"<p><p>ObjectiveTo explore the predictive value of the modified NUTrition Risk in the Critically ill (mNUTRIC) for patients with sepsis and acute respiratory distress syndrome (ARDS) developing into chronic critical illness (CCI).BackgroundSepsis is an important risk factor for Acute respiratory distress syndrome (ARDS), and sepsis induced ARDS accounts for 32% of patients. Patients with this subtype of ARDS have a worse prognosis than those with sepsis alone or ARDS, usually facing higher mortality rates and lower success rates of extubation, and have received more attention in clinical practice.MethodsA retrospective observational study was conducted on 118 patients admitted to the Intensive Care Unit (ICU) of Yiwu Central Hospital from January 2020 to May 2022. Patients were categorized into two groups: CCI and rapid recovery (RAP), based on the occurrence of CCI. Age, gender, white blood cell count, C-reactive protein, albumin, serum creatinine, sequential organ failure assessment (SOFA), acute physiology and chronic health evaluation II (APACHE II), mNUTRIC score, ICU length of stay, mechanical ventilation duration, and continuous renal replacement therapy (CRRT) were compared between the two groups. The association between mNUTRIC and CCI in patients with sepsis complicated by ARDS was further examined using three models and multivariate logistic regression.The receiver operating characteristic (ROC) curve was utilized to analyze the predictive values of mNUTRIC score, SOFA score, and APACHE II score for predicting the occurrence of CCI in patients with sepsis complicated by ARDS.ResultsThe age, mNUTRIC score, SOFA score, APACHE II score, ICU length of stay, mechanical ventilation duration, and CRRT ratio were significantly higher in the CCI group compared to the RAP group (all P < 0.05). Conversely, there were no statistically significant differences in white blood cell count, C-reactive protein, and albumin levels between the two groups (all P > 0.05). Multivariate logistic regression analysis identified the mNUTRIC score as an independent risk factor for CCI in patients with sepsis complicated by ARDS. The constructed models showed that the mNUTRIC score remained significant, while the SOFA score and APACHE II score did not.The area under the ROC curve analysis demonstrated that the mNUTRIC score had the highest AUC of 0.880, 95% Confidence Interval (CI): 0.808-0.933. The AUC for the SOFA score was 0.864, and for the APACHE II score was 0.825, all of which were statistically significant.ConclusionsThe mNUTRIC score is valuable in predicting the progression of sepsis combined with ARDS to CCI, and may even be superior to the SOFA score and APACHE II score.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"831-837"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of flipped classroom teaching model combining scientific research expansion in the teaching of thoracic surgery.","authors":"Zhu Liang, Chunyuan Chen, Zhanqiang Xie, Zhigang Wang, Xiaobi Cai, Lin Chen, Dinghua Xu","doi":"10.1177/09287329241290319","DOIUrl":"10.1177/09287329241290319","url":null,"abstract":"<p><p>BackgroundThe Department of Thoracic Surgery of the First Clinical Medical College of Guangdong Medical University took the lead in introducing the flipped classroom teaching mode combining scientific research expansion into the undergraduate teaching of clinical medicine in 2018. This teaching mode has achieved good teaching effects.ObjectiveThrough the flipped classroom based on role exchange, it is observed whether students can achieve a comprehensive understanding of lung cancer, whether they have basic scientific research quality, innovative application ability and stimulate students' enthusiasm for learning.MethodsDuring the research process, teachers prepare their lessons meticulously. Students interpret the study materials line by line as required, identify difficulties, and engage in discussions to resolve them. If unable to resolve, they can ask questions through various channels such as QQ, WeChat, or email. This allows students to choose their study time independently, achieving personalized learning. Teachers adjust in real-time and effectively formulate teaching plans, objectives, and progress.ResultsFor this teaching method reform, most students believed that this teaching improved their teamwork skills, PPT creation skills, and active problem-solving abilities, improved their understanding of scientific research, stimulated their interest in scientific research, deepened their understanding and understanding of lung cancer diagnosis and treatment, and enhanced their enthusiasm for learning.ConclusionThis not only stimulated students' enthusiasm for learning thoracic surgery but also improved their scientific research and clinical thinking abilities, resulting in good teaching outcomes.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"755-761"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of duloxetine for the treatment of vestibular migraine.","authors":"Tengteng Zhang, Shuping Zhang, Jinghui Sun, He Zhang, Luting Lv, Jie Li, Jiandong Wang, Zhidan Yu, Fei Che, Shuqin Wu","doi":"10.1177/09287329241291686","DOIUrl":"https://doi.org/10.1177/09287329241291686","url":null,"abstract":"<p><p>BackgroundMigraine is characterized by unilateral head pain with episodic attacks interspersed with symptom-free periods. This recurring and disabling neurovascular condition affects 18% of women and 6% of men, with a global prevalence of 2% for chronic migraine.ObjectiveThis study aims to estimate the effectiveness of duloxetine in treating vestibular migraine.MethodsThe study included a total of 72 patients who were admitted to the Neurology department between January 2020 and January 2022. Based on the presence or absence of duloxetine in their medical records, the patients were categorized into two groups: a duloxetine group and a control group. Parameters used to assess treatment effects on vestibular symptoms included DHI, VSS, SAS, SRSS, SF-36, and BPI. Follow-up and statistical analysis of all data were performed.ResultsDuloxetine treatment significantly reduced VSS, the DHI total score, and the number of vertiginous episodes in VM patients, while the other medicine treatment also decreased the incidence of vertiginous attacks. However, the reduction in duloxetine group presented a better treatment effect and a lower occurrence of adverse reactions contrasted to the control group.<b>Conclusions:</b> This study indicates that duloxetine treatment offers significant improvements in comparison to other medicine treatment. These results align with previous research on migraine prevention and contribute to the mounting evidence that supports duloxetine was used to treat vestibular migraine.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":"33 2","pages":"838-847"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional counseling's impact on muscle mass and quality of life in stage 4 chronic kidney disease malnourished patients.","authors":"Weiyan Sun, Lingxi Liu","doi":"10.1177/09287329241291370","DOIUrl":"https://doi.org/10.1177/09287329241291370","url":null,"abstract":"<p><p>BackgroundChronic Kidney Disease (CKD) is a significant public health issue, affecting 37 million people in the United States. CKD often leads to malnutrition, particularly in advanced stages, contributing to muscle wasting, reduced quality of life, and increased healthcare costs.ObjectiveThis retrospective study aimed to investigate the impact of early nutritional intervention and counseling on muscle mass and quality of life in malnourished stage 4 chronic kidney disease (CKD) patients.MethodsClinical data from stage 4 CKD patients with concomitant malnutrition admitted to a single center from January 2023 to December 2023 were retrospectively analyzed. Patients were divided into a standard intervention group and an early nutritional intervention and counseling group. Baseline characteristics, muscle mass parameters, quality of life assessments, nutritional parameters, and adverse events were compared between the two groups.ResultsThe baseline characteristics of the study participants were well-balanced between the two groups. The early nutrition intervention group demonstrated significant improvements in muscle mass parameters, including grip strength, skeletal muscle mass, muscle strength, calf circumference, and handgrip measurement, compared to the standard intervention group. Additionally, the early nutrition intervention group showed significant enhancements in several aspects of quality of life, including physical functioning, mental health, energy/fatigue, and general health scores. Improvements in nutritional parameters, such as protein intake, caloric intake, vitamin D levels, iron levels, and zinc levels, were also observed in the early nutrition intervention group. Notably, no significant differences in adverse events were found between the two groups.ConclusionThe study highlights the significant benefits of early nutritional intervention and counseling for malnourished stage 4 CKD patients. Early nutritional support positively impacts muscle mass, quality of life, and nutritional parameters. These findings emphasize the importance of nutrition in CKD management and the need for comprehensive nutritional support as a key component of care. This research paves the way for further studies and clinical initiatives to enhance nutritional care and improve the standard of care for CKD patients.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":"33 2","pages":"951-958"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}