{"title":"Robotic-Assisted rehabilitation in stroke patients using the hybrid assistive limb (Hal): A narrative review.","authors":"Liu Yuzhu, Gauri Krishnaswamy","doi":"10.1177/09287329261440743","DOIUrl":"https://doi.org/10.1177/09287329261440743","url":null,"abstract":"<p><p>BackgroundStroke remains a leading cause of long-term disability worldwide. Robotic-assisted rehabilitation, particularly with the Hybrid Assistive Limb (HAL), has emerged as an innovative approach to enhance motor recovery and functional outcomes. HAL is a wearable exoskeleton that detects bioelectrical signals and provides real-time support, offering unique opportunities for task-specific and intensive neurorehabilitation.ObjectiveThis narrative review summarizes recent clinical evidence on the application of HAL in stroke rehabilitation, focusing on its effects on gait, upper limb recovery, activities of daily living (ADL), and safety, while discussing its limitations and future directions.MethodsA literature search of PubMed and Scopus was conducted for studies investigating HAL-assisted rehabilitation in stroke patients. Eligible studies included randomized controlled trials, systematic reviews, pilot studies, and relevant narrative reviews.ResultsEvidence from randomized and non-randomized studies suggests that HAL-assisted rehabilitation can improve gait velocity, balance, and, to a lesser extent, upper limb function in both acute and chronic stroke populations. Several systematic reviews and RCTs (2022-2025) have confirmed its potential benefits compared to conventional physiotherapy, though findings remain heterogeneous. HAL is generally safe and well tolerated, but high costs, limited availability, and methodological variations across studies constrain generalizability.ConclusionHAL-assisted rehabilitation represents a promising adjunct to conventional stroke therapy, with growing evidence supporting its efficacy in motor recovery. However, current data are limited by small sample sizes, inconsistent protocols, and lack of long-term follow-up. Large-scale, multicenter randomized controlled trials are warranted to establish its clinical utility, cost-effectiveness, and integration into routine care.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329261440743"},"PeriodicalIF":1.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting one-year mortality risk in ICU patients with ischemic stroke using multi-algorithm machine learning and a nomogram.","authors":"Jian Huang, Yalin Dong, Xiaozhu Liu, Lijun Li","doi":"10.1177/09287329261423369","DOIUrl":"https://doi.org/10.1177/09287329261423369","url":null,"abstract":"<p><p><b>Introduction:</b> Ischemic stroke is a leading cause of mortality, and patients requiring intensive care unit (ICU) admission carry a guarded prognosis. We aimed to develop and validate a predictive model for estimating one-year mortality risk in ICU-admitted ischemic stroke patients.MethodsIn this retrospective cohort study, data from 1974 ischemic stroke patients were extracted from the MIMIC-IV database. Patients were randomly allocated into a training set (n = 1582) and a test set (n = 392) in an 8:2 ratio. Five machine learning algorithms (CART, RF, SVM, GBM, and NB) were employed for initial feature screening. Key predictors were subsequently integrated into a multivariate logistic regression model, which was visualized as a nomogram. The model's performance was evaluated using discrimination, calibration, and clinical utility metrics and was compared against established severity scores (SOFA, SAPS II, LODS, OASIS, GCS).ResultsThe final nomogram incorporated nine predictors: age, heart rate, weight, glucose, anion gap, calcium, alkaline phosphatase (ALP), red cell distribution width (RDW), and mean corpuscular hemoglobin concentration (MCHC). The model demonstrated an AUC of 0.739 (95% CI: 0.715-0.764) in the training set and 0.737 (95% CI: 0.688-0.786) in the test set. Calibration curves indicated good agreement between predictions and observations. Decision curve and clinical impact curve analyses confirmed the nomogram's favorable clinical net benefit, and it outperformed all comparator scoring systems in discriminatory ability.ConclusionsWe developed and validated a practical nomogram that effectively integrates key clinical variables to predict one-year mortality risk in ICU patients with ischemic stroke. This tool demonstrates robust performance and potential clinical utility for risk stratification.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329261423369"},"PeriodicalIF":1.8,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deciphering atrial repolarization morphology: A spline interpolation framework for atrial arrhythmia diagnosis.","authors":"Arya Bhardwaj, Bala Chakravarthy Neelapu, R Pradeep Kumar, Kunal Pal, J Sivaraman","doi":"10.1177/09287329261424119","DOIUrl":"https://doi.org/10.1177/09287329261424119","url":null,"abstract":"<p><p>BackgroundThe characterization of atrial repolarization (Ta wave) remains largely elusive due to its inherently low amplitude and concealment beneath the dominant QRS complex.ObjectiveThis study aims to witness Ta wave within QRS complex using spline interpolation framework.Methodology10-s ECGs of 50 Sinus Tachycardia (SiT) and 20 Atrial Tachycardia (AT) were recorded using standard 12-lead. Lead-II signals were pre-processed for noise removal and fiducial points detection. Later, three spline models were used to synthesize hidden Ta wave using the datapoints from PR and ST segment. Further, validation analysis was performed to select the optimal spline model with the Ta wave of Atrio-Ventricular Block (AVB) ECG.ResultsIt was noted that the clamped cubic & B-spline interpolation model gave the best SSIM score of 0.7 and lowest power spectrum % difference of 1.33 of interpolated Ta wave within QRS complex. Further, Ta wave voltage and temporal features including Ta dispersion, area, peak location, Ta area/duration, duration/amplitude, and Ta2/Ta1 were crafted. Statistically significant P, Ta & P-Ta features were fed to seven Machine Learning (ML) models. The best ML models, were used to design a stacked ensemble architecture with combined P-Ta features to enhance the classification accuracy 99% and F1 score 0.99.ConclusionThe proposed method demonstrated that along with the existing P wave features, Ta wave features have potential in better classification of atrial arrhythmia, while interpolation model offers ease of implementation and adaptability to diverse clinical applications.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329261424119"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lukas Gschoßmann, Valentin Schedel, Franz Süß, Markus Weber, Andrea Pfingsten, Sebastian Dendorfer
{"title":"Comparing kinematic and kinetic demands on the knee joint during selected physiotherapy exercises and activities of daily living.","authors":"Lukas Gschoßmann, Valentin Schedel, Franz Süß, Markus Weber, Andrea Pfingsten, Sebastian Dendorfer","doi":"10.1177/09287329251413413","DOIUrl":"10.1177/09287329251413413","url":null,"abstract":"<p><p>BackgroundThe knee is one of the most common areas to suffer injuries or be affected by surgery. Physiotherapy rehabilitation was shown to support recovery, but evidence guiding optimal rehabilitation practices is limited. To recommend appropriate exercises, it is essential to understand the musculoskeletal requirements involved in both physiotherapy and activities of daily living (ADLs).ObjectiveThis study aimed to evaluate and compare the knee joint kinematics, joint forces and muscle activity in knee flexors and extensors during selected rehabilitation exercises and ADLs.MethodsKinematic and kinetic data from 30 healthy participants were collected during 20 different tasks. Full-body musculoskeletal simulations were performed to estimate peak knee joint angles, angular velocities, joint reaction forces, and muscle activity of the knee flexors and extensors.ResultsComparatively high requirements were observed for lunges, squats, stair walking and gait. Medium requirements were observed for sitting down and rising from a chair. Low requirements were observed for balance shifts and variations of the single leg stand.ConclusionOverall, ADLs like gait and stair walking show surprisingly high requirements compared to many exercises employed in physiotherapy. These findings are a step towards biomechanically informed exercise selection and the development of personalized rehabilitation programs.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251413413"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural determinants of effective academic-industry technology transfer in biomedical engineering.","authors":"Jolanta Pauk, Konrad Pauk, Anna Stec","doi":"10.1177/09287329251381507","DOIUrl":"https://doi.org/10.1177/09287329251381507","url":null,"abstract":"<p><p>BackgroundWhile macro-level factors influencing collaboration are well-studied, the daily operational processes between academia and industry remain unclear, especially in biomedical engineering, where coordination is complex and critical. This study fills this gap by analyzing decision-making, governance, and coordination practices from both perspectives to improve technology transfer and innovation outcomes.MethodsThis study employed a mixed-methods approach, including a structured questionnaire distributed among academic and industrial stakeholders, complemented by detailed case studies illustrating practical examples of collaboration in biomedical technology transfer.ResultsFindings reveal both converging and diverging motivations: academia values access to new technologies and societal impact, while industry prioritizes rapid market implementation and competitiveness. Key barriers include time constraints, conflicting publication and confidentiality demands, and challenges in intellectual property negotiations. Support mechanisms such as long-term funding, administrative support, and hybrid work models facilitate collaboration. Case studies demonstrate that successful partnerships hinge on clear regulatory frameworks and mutual understanding of objectives.ConclusionsFuture university-industry partnerships should prioritize clear communication, joint IP frameworks, and inclusive governance from the start. Involving clinical practitioners and end-users early improves product relevance, while proactive regulatory planning, supported by institutional guidance, helps avoid delays and compliance issues.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251381507"},"PeriodicalIF":1.8,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of KAP-based nursing program in managing digestive symptoms in colorectal cancer patients undergoing chemotherapy: A retrospective controlled study.","authors":"Wenli Chen, Dandan Jiang, Renru Duan, Shuwen Li","doi":"10.1177/09287329261432852","DOIUrl":"https://doi.org/10.1177/09287329261432852","url":null,"abstract":"<p><p>ObjectiveTo improve gastrointestinal (GI) symptom clusters in colorectal cancer (CRC) patients undergoing chemotherapy by implementing a nursing program based on Knowledge, Attitudes, and Practice (KAP).MethodsThis retrospective study analyzed the medical records of 292 CRC patients who received chemotherapy from June 2023 to December 2024 in Bozhou Hospital Affiliated to Anhui Medical University. Patients were divided into a control group (CG, n = 150) and an intervention group (IG, n = 142) according to the GI symptom cluster nursing intervention program. GI symptoms, self-management efficacy, level of beliefs, psychological status, functional status, and quality of life were assessed in patients before the intervention (T1), after the fourth chemotherapy session (T2), and after the eighth chemotherapy session (T3).ResultsAt T1, there were no significant differences between the two groups in any of the assessed indices. At T2 and T3, the GI symptom clusters, the number of symptoms, the incidence of symptom clusters, and the nausea, loss of appetite, dry mouth, vomiting, diarrhea, change in appetite, and fullness in the patients of the IG were significantly lower than those of the CG. (P < 0.05). In addition, patients in the IG showed significant improvements in self-management efficacy, belief level, psychological condition, functional status and quality of life (P < 0.05).ConclusionThe KAP-based nursing program is both acceptable and feasible for managing GI symptom clusters in CRC patients undergoing chemotherapy. It effectively improves patients' GI symptoms and enhances their self-management efficacy, belief levels, psychological status, functional status, and quality of life.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329261432852"},"PeriodicalIF":1.8,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohd Amirul, Rodianah Alias, Mohd Faizal Ali Akhbar, Muhammad Rizwan, Afifah Juri
{"title":"A review on Ag-Ta<sub>2</sub>O<sub>5</sub> Bio-interfaces: Multifunctional coatings for antibacterial and biocompatible surgical tools.","authors":"Mohd Amirul, Rodianah Alias, Mohd Faizal Ali Akhbar, Muhammad Rizwan, Afifah Juri","doi":"10.1177/09287329261423370","DOIUrl":"https://doi.org/10.1177/09287329261423370","url":null,"abstract":"<p><p>BackgroundConventional surgical instruments made from Stainless steel (SS), Titanium (Ti), and Tantalum (Ta) are widely utilized because of their excellent corrosion resistance and strength-to-weight ratio. However, these materials lack antibacterial properties, which could increase the risk of surgical site infections. Recent advancements in antimicrobial and biocompatible coatings, particularly Ag-Ta<sub>2</sub>O<sub>5</sub> (Silver-Tantalum Pentoxide), present better solutions for new surgical instrument design. Despite numerous studies published on this topic, a comprehensive review specifically addressing Ag-Ta<sub>2</sub>O<sub>5</sub> coatings remains absent, resulting in fragmented information across the literature. Systematizing this information and consolidating the developments in this field are beneficial, and this is the motivation behind this review.ObjectiveFor these reasons, this review examines the development and applications of these advanced coatings, with a focus on their antimicrobial and biocompatible properties.MethodsWe critically examine the technological challenges, innovative coating methodologies, and the comparative advantages of Ag-Ta<sub>2</sub>O<sub>5</sub> over traditional and hybrid coatings.ResultsFurthermore, this review identifies future research directions and proposes strategic collaborations among clinicians, engineers, policymakers, and materials scientists to expedite the clinical adoption of these coatings.ConclusionIt is envisioned that this review paper will serve as a valuable source of information for engineers, researchers, and clinicians to stay current with the latest developments in this area and for new researchers to initiate their exploration of coating technology.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329261423370"},"PeriodicalIF":1.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Personalized EMG preprocessing and normalization for musculoskeletal simulation.","authors":"Dovydas Cicėnas, Jurgita Žižienė, Kristina Daunoravičienė","doi":"10.1177/09287329261432854","DOIUrl":"https://doi.org/10.1177/09287329261432854","url":null,"abstract":"<p><p>BackgroundAccurate interpretation of electromyography (EMG) signals is essential for reliable control of musculoskeletal (MS) models in biomechanics and rehabilitation applications. Conventional preprocessing methods may not account for subject-specific signal characteristics and task-related muscle function.ObjectiveThis study aimed to develop and validate an adaptive and personalized EMG preprocessing pipeline to enhance the physiological accuracy of EMG-driven musculoskeletal models during elbow flexion-extension tasks.MethodsEMG signals from six upper limb muscles were recorded using a Delsys system while participants performed elbow flexion-extension movements. The signals were preprocessed using individualized spectral filtering and a dual-stage normalization approach. First, dynamic maximum voluntary contraction (MVC) based min-max normalization was applied to standardize signal amplitudes. Second, functional weighting was used to scale each muscle's activation based on its biomechanical contribution to the movement. The processed signals were used as input to an OpenSim elbow model, and resulting joint kinematics were compared to reference motion data captured by an Xsens system.ResultsThe EMG-driven OpenSim model showed strong agreement with the Xsens data, with correlation coefficients exceeding 0.98 and root mean square error (RMSE) values below 8°. While a minor systematic offset was observed, joint angle trajectories remained consistent and physiologically plausible across trials.ConclusionThe proposed subject-specific EMG preprocessing pipeline enhances the accuracy and interpretability of biomechanical models. Future research should explore adaptive signal alignment techniques and AI-based processing methods to improve model robustness in dynamic and wearable scenarios.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329261432854"},"PeriodicalIF":1.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The acute effects of single aerobic exercise on arterial stiffness and endothelial function in throwing athletes and untrained individuals: Focusing on throwing athletes.","authors":"Koshiba Hiroya, Maeshima Etsuko","doi":"10.1177/09287329261423371","DOIUrl":"https://doi.org/10.1177/09287329261423371","url":null,"abstract":"<p><p>BackgroundArterial stiffness and endothelial dysfunction are early markers of cardiovascular disease (CVD) risk. While moderate-intensity aerobic exercise has demonstrated vascular benefits in untrained individuals, its acute effects on strength-trained athletes remain unclear.ObjectiveThis study investigates the impact of a single aerobic session on arterial stiffness and endothelial function in strength-trained throwers and untrained controls.MethodsEleven male university throwers and eleven healthy controls participated. Participants completed 30 min of moderate-intensity cycling at 50% of heart rate reserve. Brachial-ankle pulse wave velocity (baPWV) and reactive hyperemia-peripheral arterial tonometry index (RHI) were measured at baseline, immediately after exercise, and 40 min post-exercise.ResultsArterial stiffness decreased significantly in the controls (<i>p</i> = 0.003) but showed no change in the throwers. Endothelial function, as measured by RHI, improved significantly in both groups post-exercise (<i>p</i> < 0.001). There was no significant difference in RHI improvement between groups.ConclusionsIn the throwers group, a single session of moderate-intensity aerobic exercise did not lead to a significant reduction in arterial stiffness but resulted in an improvement in endothelial function. These findings suggest that while endothelial function in strength-trained throwers can benefit acutely from aerobic exercise, their arterial stiffness may require more intensive or longer-duration aerobic interventions to achieve significant improvements.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329261423371"},"PeriodicalIF":1.8,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of transit time flow meter spike waveform on graft patency and its hemodynamic characteristics in coronary artery bypass grafting.","authors":"Minghui Wei, Zhou Zhao, Mengyao Duan, Gaoyang Li, Yanan Xu, Junyan Ge, Xiaoxiao Li, Ruoqi Zhao, Yue Feng, Boyan Mao","doi":"10.1177/09287329261432409","DOIUrl":"https://doi.org/10.1177/09287329261432409","url":null,"abstract":"<p><p>ObjectiveDuring coronary artery bypass grafting(CABG), surgeons commonly use transit time flow meter (TTFM) to determine the graft patency. This study is to explore the effect of a special \"spike waveform\" in CABG on graft patency and its hemodynamic environment.MethodsWe collected the data of 1154 patients undergoing CABG, including intraoperative TTFM waveform and coronary CTA at 1 week after surgery. 239 patients had 1-year follow-up CTA. We divided the grafts into spike and non-spike waveform groups, and assessed the patency of grafts. Additionally, we constructed an ideal model of CABG, we also calculated and extracted the hemodynamic parameters of the grafts.ResultsFor immediate patency, the occlusion rates of spike and non-spike waveforms of left internal mammary artery(LIMA) were 0 and 5.13%, those of saphenous vein graft(SVG) were 8.59% and 5.79%. As for medium-long term patency, the occlusion rates of spike and non-spike waveforms were 0 and 12.56% for LIMA, and 42.47% and 16.84% for SVG. Regarding hemodynamics, the relative residence time(RRT) and Max Oscillating shear index(MaxOSI) of the LIMA spike waveform were significantly higher than those of the non-spike waveform, and the mean OSI and MaxOSI of the SVG spike waveform were substantially higher than those of the non-spike waveform.ConclusionsSpike waveform slightly reduces the immediate patency of SVG and significantly reduces the medium-long term patency, while no effect on the patency of LIMA is found. In terms of hemodynamics, both LIMA and SVG with spike waveforms exhibit unfavorable hemodynamic conditions within the grafts.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329261432409"},"PeriodicalIF":1.8,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}