Technology and Health Care最新文献

{"title":"Characteristic features of infants with pneumonia testing positive for specific immunoglobulin E.","authors":"Li Hao, Songqing Wang, Wei Ji","doi":"10.1177/09287329241301643","DOIUrl":"10.1177/09287329241301643","url":null,"abstract":"<p><p>ObjectiveTo analyse the characteristic features of infants with pneumonia who test positive for serum milk-specific immunoglobulin E (sIgE) and to provide a reference for the diagnosis, management and prevention of the condition.MethodsWe retrospectively analysed data from 284 infants admitted to our hospital with pneumonia between January 2017 and December 2020 who underwent serum allergen testing. Based on the results, patients were categorised into three groups: pure milk sIgE-positive; mixed milk sIgE-positive; and allergen sIgE-negative. We then compared the general conditions, clinical characteristics, laboratory tests, imaging results and pathogenic data across these groups.ResultsAmong the patient population, 16.20% (46/284) tested positive for pure milk sIgE, 32.75% (93/284) tested positive for mixed milk sIgE and 51.06% (145/284) were negative for any allergen sIgE. Statistically significant differences were observed among the three groups in terms of general conditions, breastfeeding status, pre-existing respiratory infections and history of respiratory infections (>3 times) (<i>p </i>< 0.05 for each). The median length of hospital stay was longer in the pure milk sIgE-positive group and the mixed milk sIgE-positive group (8 [range 7-10] days) compared with the allergen sIgE-negative group (8 [range 6-9] days) (<i>p </i>< 0.05). The eosinophil counts of the mixed milk sIgE-positive group were significantly higher than in the other two groups (<i>p </i>< 0.05). <i>Haemophilus influenzae</i> of the pure milk sIgE-positive group was significantly higher than in the other two groups (<i>p </i>< 0.05).ConclusionThe presence of mixed milk sIgE allergens does not exacerbate clinical symptoms. However, infants who test positive solely for milk sIgE and have pneumonia require longer hospitalisation. This suggests that extra attention is necessary for infants with milk allergies when they develop pneumonia.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"1868-1877"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing machine learning algorithms to identify biomarkers associated with Alzheimer's disease and ferroptosis-related genes.","authors":"Di Wang, Chunsheng Lin, Gang Liu, Xin Wang, Shengwang Han, Zengxin Han","doi":"10.1177/09287329251322278","DOIUrl":"10.1177/09287329251322278","url":null,"abstract":"<p><p>BackgroundAlzheimer's disease (AD) is a complex neurodegenerative disorder that complicates our understanding of its origins. Identifying AD-specific biomarkers can reveal its mechanisms and foster the development of innovative diagnostics and therapies, aiming to unlock new ways to combat this pervasive condition.MethodsWe analyzed gene expression data using Weighted Gene Co-expression Network Analysis (WGCNA) and machine learning (random forest, lasso regression, and SVM-REF) to differentiate AD patients from controls and explore gene functions.ResultsWe identified 641 differentially expressed genes (DEGs) and 22 co-expressed genes, with functional enrichment analysis revealing their involvement in immune responses. Notably, EGR1 emerged as a potential diagnostic and therapeutic target.ConclusionIn our study, we applied WGCNA, DEGs and diverse machine learning approaches to uncover potential biomarkers linked to Alzheimer's Disease (AD) and ferroptosis. A particular hub gene emerged as a promising candidate for novel diagnostic and therapeutic markers specifically within the context of ferroptosis in AD. This discovery sheds new light on the pathogenesis of AD, potentially facilitating the development of groundbreaking diagnostic and therapeutic techniques.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"2041-2063"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-skin disease classification using hybrid deep learning model.","authors":"K Jeyageetha, K Vijayalakshmi, S Suresh, A Bhuvanesh","doi":"10.1177/09287329241312628","DOIUrl":"10.1177/09287329241312628","url":null,"abstract":"<p><p>Among the many cancers that people face today, skin cancer is among the deadliest and most dangerous. As a result, improving patients' chances of survival requires skin cancer to be identified and classified early. Therefore, it is critical to assist radiologists in detecting skin cancer through the development of Computer Aided Diagnosis (CAD) techniques. The diagnostic procedure currently makes heavy use of Deep Learning (DL) techniques for disease identification. In addition, skin lesion extraction and improved classification performance are achieved through Region Growing (RG) based segmentation. At the outset of this study, noise is reduced using an Adaptive Wiener Filter (AWF), and hair is removed using a Maximum Gradient Intensity (MGI). Then, the best RG, which is the result of integrating RG with the Modified Honey Badger Optimiser (MHBO), does the segmentation. Finally, several forms of skin cancer are classified using the DL model MobileSkinNetV2. The experiments were conducted on the ISIC dataset and the results show that the accuracy and precision were improved to 99.01% and 98.6%, respectively. In comparison to existing models, the experimental results show that the proposed model performs competitively, which is great news for dermatologists treating cancer.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"1736-1754"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stepwise ablation strategy in radiofrequency ablation improves acute and long-term outcomes of scar-related ventricular tachycardias.","authors":"Pin Wang, Yanan Zuo, Chenglong Miao, Lu Xu, Yanwei Wang, Suyun Liu, Ru Xing, Bingyan Guo","doi":"10.1177/09287329241307799","DOIUrl":"10.1177/09287329241307799","url":null,"abstract":"<p><p>BackgroundThe optimal intervention procedures for scar-related ventricular tachycardia (VT) is still unclear.ObjectiveThis study aimed to compare the acute and long-term outcomes of a stepwise ablation approach targeting critical sites identified through activation mapping during VT or pace mapping followed by substrate ablation with substrate modification alone in patients with scar-related VT.MethodsData of 41 patients with scar-related VTs treated with stepwise ablation (Group 1, n = 29) or substrate modification alone during sinus rhythm (Group 2, n = 12) were retrospectively reviewed. The procedure acute success and long-term success during follow-up were compared.ResultsThere was no statistical difference between the two groups on basic characteristics. Group 1 demonstrated shorter ablation time (P = 0.02), longer VT-free survival rates at a median follow-up of 24.0 months (P = 0.02) and a lower VT recurrence rate (hazard ratio: 0.17, 95% confidence interval: [0.03, 0.93], P = 0.04) compared to Group 2. The acute success and ratio of ablation area to scar area were comparable between the two groups (P ≥ 0.05).ConclusionThe stepwise ablation strategy shows promise for improving acute and long-term outcomes and reducing the recurrence risk in patients with scar-related VT.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"1827-1838"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of transitional care on the psychological state of patients with advanced lung cancer chemotherapy.","authors":"A-Mao Tang, Miao Wang, Li Ning, Lijun Lin, Yi-Min Li","doi":"10.1177/09287329251314258","DOIUrl":"10.1177/09287329251314258","url":null,"abstract":"<p><p>BackgroundLung cancer is one of the malignant tumors with the highest morbidity and mortality worldwide. Patients with an advanced stage need to face negative effects from chemotherapy, dread of dying, weakened role function and physical and mental suffering.ObjectivesTo examine the effect of transitional care on the psychological state of patients with advanced lung cancer chemotherapy.MethodsSeventy-two patients with advanced lung cancer who underwent chemotherapy in our hospital were arbitrarily split into the experimental group (30 cases) and the control group (31 cases). The control group received routine discharge care, whereas the experimental group received transitional care. The scores were compared before the first chemotherapy, the day after the end of the first-cycle chemotherapy, and the third week after the end of the 4-week chemotherapy according to SCL-90, PSS, PFE-R, SES, QLQ-C30, the rate of unplanned re-diagnosis and nursing satisfactory.ResultsThere was no significant difference in all aspects of scores between the two groups before and after chemotherapy (P > 0.05). Whereas there were significant differences in emotional function, fatigue, insomnia, depression and interpersonal sensitivity between the two groups after 4 cycles of chemotherapy (P < 0.05). The scores of PSS and PFE-R decreased significantly in the two groups, and the SES and QLQ-C30 in the experimental group were significantly higher than those in the control group (all P < 0.05).FindingsApplying transitional care intervention can lessen patients' negative emotions since being discharged with advanced lung cancer following chemotherapy and diminish the rate of unplanned re-diagnosis.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"2015-2025"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143505233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An immersive virtual reality serious game set for the clinical assessment of spatial attention impairments: Effects of avatars on perspective?","authors":"Khawla Ajana, Gauthier Everard, Thierry Lejeune, Martin Gareth Edwards","doi":"10.1177/09287329241296380","DOIUrl":"10.1177/09287329241296380","url":null,"abstract":"<p><p>BackgroundHemineglect (HN) is a post-stroke condition, frequently defined as an impairment in finding spatial targets within an egocentric frame of reference, where the stimulus is coded relative to the self. However, the egocentric reference frame can change with the presence of another person. Immersive virtual reality (IVR) offers several advantages over paper-and-pencil tests typically used to assess HN, such as a realistic and controlled environment, standardised stimulus presentation, and sensitive response acquisition. We developed a new serious game in IVR to assess HN. Here we investigated (1) the feasibility and user experience of this serious game, and (2) the effect of the presence of an avatar on HN.MethodsWe first tested a group of 61 control individuals (CI), followed by a group of post-stroke 11 individuals without HN (SI:HN-), 6 with HN (SI:HN+), and 17 resampled age matched group of control individuals (CI). All participants performed the \"Peach test\", which required them to find and respond to a target presented among distractors, either alone or in the presence of an avatar. We measured response time (RT) and omissions. The SI:HN- and SI:HN + groups also completed a paper-and-pencil test for HN and a user experience questionnaire.ResultsThe first analysis of results with CI showed no differences in responding to the target when in ipsi- compared to contra-lateral spaces, nor in peri- compared to extra-personal spaces. There were also no differences in responding to the target in the no-avatar condition relative to the two avatars conditions. In the second analysis, SI:HN + were slower than SI:HN- and CI. Although an interaction between group and Laterality was predicted, the results showed that there was no Laterality effect for any of the groups. An interaction between group and proximity, showed that both SI groups were slower in the extra- compared to peri-personal spaces. The user experience was globally positively rated by the SI.ConclusionWe developed a serious game in IVR for the assessment of HN. Although most our findings were inconclusive, the Peach test showed excellent user experience results.Trial registration http://www.clinicaltrials.gov ; Unique identifier: NCT04694833, Date of registration: 11/24/2020.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"1626-1644"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based AI model for sinusitis diagnosis.","authors":"Jingfei Zhang, Dianyi Wang, Wentao Li, Jingyi Wang","doi":"10.1177/09287329241309799","DOIUrl":"10.1177/09287329241309799","url":null,"abstract":"<p><p>Problem statementWhile CT (Computed Tomography) is commonly used, its diagnostic accuracy for chronic sinusitis remains uncertain. Moreover, the high cost of CT examinations limits its use as a routine diagnostic method. There is an urgent need to develop an AI-assisted diagnostic model for sinusitis.ObjectiveThe primary aim of this study is to develop an AI-assisted diagnostic model for sinusitis that can improve diagnostic accuracy and accessibility compared to traditional CT methods.MethodologyThis study utilized a retrospective approach, focusing on patients diagnosed with chronic sinusitis via CT and normal patients admitted to the People's Hospital between January 2018 and January 2019. A total of 5000 sinus CT images were collected. All cases underwent T (targeted) coronal plain scans in the hospital's CT room, ensuring complete CT images. In constructing the chronic sinusitis classification model based on deep learning, 5000 CT images of soft tissue windows and sinuses were gathered. This included 1000 CT images for each of the four groups diagnosed with sphenoid sinusitis, frontal sinusitis, ethmoid sinusitis, and maxillary sinusitis, along with 1000 images from normal cases (250 images per group). The sigmoid function replaced the softmax function, and the binary cross-entropy function was used to assess the model's predictive accuracy.ResultsThe model achieved an accuracy of 85.8%, outperforming doctors with low (71.7%), medium (78.4%), and senior (73.4%) qualifications. The model demonstrated high accuracy, superior feature extraction, and resolution capabilities.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"1800-1817"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of 3D transesophageal echocardiography in native mitral valve endocarditis - A case report and review of the literature.","authors":"Zorica Mladenovic, Gordana Milic, Predrag Djuric, Zoran Jovic, Vesna Begovic, Edin Begic","doi":"10.1177/09287329241296813","DOIUrl":"10.1177/09287329241296813","url":null,"abstract":"<p><p>The aim of this paper is to present a case of infective endocarditis (IE) caused by <i>Staphylococcus aureus (S. aureus),</i> focusing on diagnostic and therapeutic approaches. The paper highlights the importance of 2D transesophageal echocardiography (TOE) and discusses the capabilities and advances of appliance of the 3D TOE in patient evaluation, better understanding of the diagnosis, and timely treatment. The use of this advance echocardiographic modality allows clear visualization of complex and destructive tissue lesions, such as the perforation observed and presented in this case.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"1711-1716"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring mini SmartApp usability for ankylosing spondylitis from the perspective of patients and health providers.","authors":"Zepu Wang, Longji Chen, Anqi Wang, Lin Cheng, Jiaxin Fan, Ting Fu, Yan Sang, Hongwu Shen","doi":"10.1177/09287329241312489","DOIUrl":"10.1177/09287329241312489","url":null,"abstract":"<p><p>ObjectiveTo identify beneficial experiences, areas needing improvement, and potential additional value, with a view to providing a reference for the application of mobile health management in clinical practice.MethodsThis study applied a mixed research approach to measure the mini smartApp usability among participants who were diagnosed with ankylosing spondylitis at rheumatology and immunology department of the Affiliated Hospital of Nantong University between October 2022 to March 2023 and research staff. This study lasted two weeks. We using the Post-Study System Usability Questionnaire (PSSUQ) and face-to-face semi-structured interview to evaluate the mini smartApp's usability.ResultsAltogether 105 participants having follow-up data at 2 weeks were included, of which 94 were AS patients and 13 were research staff. All participants thought the mini SmartApp was useful, with regard to the scores of PSSUQ between baseline was 1.1 (SD:0.63) and 2-week intervention period was 0.98 (SD:0.53). Four themes emerged from test of usability, participants thought mini SmartApp easy to use and can bring several benefits. However, the theme of needing more useful function revealed that mini SmartApp need further improvement in future use.ConclusionOverall, the mini SmartApp has the potential to be a valuable tool in assisting AS patients with home-based exercise and improving their overall management of the disease.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"1949-1958"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mendelian randomization approach for advancing healthcare innovation: From pregnancy hypertension to schizophrenia.","authors":"Wenjie Peng, Qingqi Ran, Fang Wu, Zhangxue Hu","doi":"10.1177/09287329251316227","DOIUrl":"10.1177/09287329251316227","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia, a severe mental disorder, is strongly associated with perinatal factors, including pregnancy hypertension, which affects fetal neurodevelopment. The causal relationship between pregnancy hypertension and schizophrenia remains unclear.</p><p><strong>Objective: </strong>To investigate the causal relationship between pregnancy hypertension and schizophrenia using a two-sample Mendelian randomization (MR) study.</p><p><strong>Methods: </strong>Pregnancy hypertension (cases/controls: 7686/115,8993) was considered as exposure and schizophrenia (cases/controls: 76755/243,649) as outcome. A two-sample MR study genetically estimated associations, with the inverse variance-weighted method as primary analysis. A two-step MR study explored potential mediators. Sensitivity tests assessed pleiotropy, heterogeneity, and stability.</p><p><strong>Results: </strong>Four single nucleotide polymorphisms (SNPs) were identified as genetic instruments for pregnancy hypertension (P < 5 × 10^-8, r² < 0.001). Pregnancy hypertension increased the risk of schizophrenia (odds ratio = 1.098, 95% CI = 1.025-1.173, P = 0.007), while reverse MR analysis found no significant link (odds ratio = 1.03, 95% CI = 0.980-1.082, P = 0.235). The two-step study revealed pregnancy hypertension elevated levels of 1,4-Dihydroxy-2-naphthoic acid (odds ratio = 1.351, 95% CI = 1.097-1.664, P = 0.004), which decreased schizophrenia risk (odds ratio = 0.97, 95% CI = 0.942-0.998, P = 0.040).</p><p><strong>Conclusion: </strong>Pregnancy hypertension is a high-risk factor for schizophrenia, with 1,4-Dihydroxy-2-naphthoic acid potentially mitigating this effect. These findings offer insights for the prophylaxis of schizophrenia and highlight the need for further research into underlying mechanisms.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"1926-1937"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}