Technology and Health Care最新文献

{"title":"Thymoquinone regulates osteosarcoma cell proliferation through the P53 signaling pathway: A network pharmacology and molecular docking based health technology study.","authors":"Chenliang Zhou, Ruiyao Wang, Fang Liu, Kun-Yu Liu, Jiaqi Bi, Zhange Yu","doi":"10.1177/09287329261424110","DOIUrl":"10.1177/09287329261424110","url":null,"abstract":"<p><p>BackgroundOsteosarcoma (OS) has long presented a formidable challenge to human health and well-being. While traditional treatments, such as clinical chemotherapy and surgical intervention, have shown efficacy, they are frequently accompanied by adverse effects and often lead to a poor prognosis.ObjectiveThymoquinone (TQ) is recognized for its antitumor properties; however, the specific molecular mechanisms underlying its effects against OS remain inadequately understood. Emerging evidence suggests a strong correlation between p53 gene deletion and the onset and progression of various human cancers. This study aimed to elucidate the pharmacological targets and anti-OS mechanisms of TQ using systems bioinformatics approaches, including network pharmacology and molecular docking simulations.MethodsA comprehensive screening process identified 23 potential targets associated with the anti-OS effects of TQ. Subsequent bioinformatics analysis identified 8 core targets involved in TQ's anti-OS activity. Enrichment analysis indicated that these core targets modulate a range of biological processes and may influence multiple molecular pathways.ResultsPreliminary <i>in vitro</i> data indicated that TQ effectively reduces OS cell proliferation, induces apoptosis, and downregulates the expression of P53 and HMOX1 proteins.ConclusionOur findings elucidate the molecular mechanisms underlying TQ's effectiveness against OS, highlighting potential apoptosis-related therapeutic targets, such as P53 and CYCLIN D1, for the treatment of OS with TQ.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"354-365"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast phantom enhancement: Taguchi-type optimization for CT scan imaging quality and additive manufacturing realization.","authors":"Ying-Liang Chou, Fu-Tsai Chiang, Ching-Hsiu Ke, Jia-Hua Hsu, Chun-Chieh Liang, Samrit Kittipayak, Lung-Kwang Pan, Lung-Fa Pan, Kai-Yuan Cheng","doi":"10.1177/09287329261417465","DOIUrl":"10.1177/09287329261417465","url":null,"abstract":"<p><p>An indigenous breast phantom was customized to optimize the imaging quality of the CT scan according to Taguchi's methodology. A 3D printer made the base gauge of the breast phantom, and the polysmooth^TM filament was sprayed. The gauge can be categorized into three major parts vertical and horizontal line pairs, two V-shape slices, and two arrays of nodules with various sizes, then a spherical shell mad by paraffin casting and the sunflower oil was infused as filling material. The Taguchi approach led to the development of a customized measuring device that enabled quantitative assessment aimed at improving the spatial resolution of CT image quality. Five essential factors for operating the CT chest scan (kVp, mAs, FOV, Pitch, and gantry rotation time) were organized according to Taguchi L₁₈(2¹ × 3⁴) suggestion. Three well-trained radiologists ranked the imaging quality in three discrete time periods according to the imaging quality's sharpness, contrast, and spatial resolution. The derived average, standard deviation, and signal-to-noise ratio of specific factors were reorganized and analyzed from the multiple measurements to propose the optimal CT chest scan protocol recommendation. Accordingly, the optimal suggestion was A1(120 kVp), B3(200 mAs), C2(FOV 350 mm²), D1(pitch 0.516) and E2(rotation time 0.75 s) to fulfill the ALARA principle. In this research, a numerical metric termed the minimum detectable difference (MDD) was introduced to evaluate imaging performance, and its calculated value demonstrated a resolution capability of approximately 1.57 mm.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"261-273"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects and mechanisms of baicalin on MK-801 induced schizophrenia model mice.","authors":"Qi Wang, Ling Lv, Zhaoxia Li, Shuang Wang, Chengyi Zhang, Xinyue Zhang, Lijie Han, Siwei Wang, Yiting Liu, Ziyan Guo, Guohao Xu, Zilong Lun, Yao Ma, Xi Chen, Yilin Wang","doi":"10.1177/09287329251412965","DOIUrl":"10.1177/09287329251412965","url":null,"abstract":"<p><p>BackgroundSchizophrenia (SCZ) pharmacotherapy relies on Western medications with limited efficacy/significant adverse effects. Baicalin (BA), a purified botanical monomer, shows promise as a safer multitarget antipsychotic candidate.ObjectiveTo study the effect and mechanism of Baicalin on MK-801 induced schizophrenia model mice.MethodsBehavioral assessments (water maze, open field, dark avoidance, forced swimming tests) evaluated emotional/cognitive functions in MK-801 induced schizophrenia mice. Histological staining analyzed hippocampal, prefrontal cortical, and striatal morphology. Serum inflammatory markers (NF-<i>κ</i>B, IL-6, IL-1<i>β</i>, TNF-<i>α</i>) and oxidative stress indicators (SOD, MDA) were quantified by ELISA, alongside hippocampal neurotransmitter levels (DA, 5-HT, GABA, AChE). This study employed a network pharmacology approach to screen the mechanisms of action of baicalin in the treatment of schizophrenia. Western blotting determined hippocampal PI3K/Akt/GSK3<i>β</i> pathway protein expression.ResultsNetwork pharmacology analysis revealed that baicalin may exert its therapeutic effects in the treatment of schizophrenia through modulation of the PI3K-Akt signaling pathway. Versus model group, BA doses significantly decreased: IL-1<i>β</i>, IL-6, GABA, AChE, MDA, TNF-<i>α</i>, NF-<i>κ</i>B; open field total distance; forced swimming immobility; dark avoidance errors (<i>p</i> < 0.05). Increased: DA, 5-HT; water maze platform crossings; dark avoidance latency (<i>p</i> < 0.05). Staining confirmed BA reduced cerebral oxidative stress/neuroinflammation. Western blot showed dose-dependent elevation of p-Akt/Akt and p-GSK3<i>β</i>/GSK3<i>β</i> ratios.ConclusionBaicalin may improve cognitive impairments in MK801-induced schizophrenia model mice through the PI3K/Akt/GSK3<i>β</i> signaling pathway, exhibiting anti-neuroinflammatory and neuroprotective effects.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"274-286"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic robotic arm remotely controlled by IMU sensor for hazardous chemical experiment.","authors":"Taegang Kim, Geunho Do, Il-Jung Kwon, Ji-Won Kim, Junghyuk Ko","doi":"10.1177/09287329261417466","DOIUrl":"10.1177/09287329261417466","url":null,"abstract":"<p><p>BackgroundIn recent years, the importance of chemical experiments has increased, and the frequency of chemical experiments has also increased. As the frequency of chemical experiments increases, the number of chemical experiment-related accidents increases proportionally.ObjectiveAccordingly, we design a remote control biomimetic robotic arm that can safely and actively handle hazardous chemicals on behalf of human to reduce human casualties caused by chemical experiment accidents without compromising the autonomy of experimentation.MethodsThis biomimetic robotic arm can identically mimic the operator arm's movement. The robotic arm moves with 6 degrees of freedom (DOF). The inertial measurement unit (IMU) sensor we designed ourselves is based on micro-electromechanical system (MEMS) technology, and in the IMU sensor the accelerometer-gyroscope sensor and the wireless communication module are integrated. This IMU sensor calculates its own instantaneous angle on a particular axis. The micro controller unit (MCU) controls motor using the angle data of the IMU sensor so that the robotic arm moves in the same movement as the operator arm to which the IMU sensor is attached.ResultsThree IMU sensors were attached to the operator's upper body, upper arm, and lower arm, enabling the robotic arm to accurately replicate the operator's movements. Performance evaluation through comparative experiments confirmed that the robotic arm closely tracked the operator's joint motion and overall trajectory. Although a time delay of approximately 1.4 s was observed due to communication and processing latency, the system maintained stable performance under various motion and load conditions, with joint angle errors remaining below 5.2%.ConclusionThe proposed system enables biomimetic motion of a robotic arm using IMU-based sensing and wireless control, allowing hazardous chemicals to be handled safely during chemical experiments.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"197-207"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning algorithms for diagnostic prediction of diabetic retinopathy.","authors":"Yifeng Dou, Jiantao Liu","doi":"10.1177/09287329251410736","DOIUrl":"10.1177/09287329251410736","url":null,"abstract":"<p><p>BackgroundDiabetic Retinopathy (DR) remains a leading cause of blindness among diabetic patients worldwide, necessitating early and accurate diagnostic interventions. While traditional screening methods rely heavily on manual ophthalmologic evaluations, recent advancements in machine learning (ML) and deep learning (DL) have opened new avenues for automated, scalable, and interpretable diagnostic tools. However, challenges persist in developing models that are not only high-performing but also transparent enough to gain clinical trust.ObjectiveThis study introduces a novel, standardized, and interpretable ML framework designed specifically to enhance diagnostic efficiency and accuracy for DR risk prediction. By prioritizing model interpretability alongside predictive performance, our approach aims to bridge the gap between cutting-edge AI technology and clinical applicability.MethodsWe evaluated eleven ML algorithms, optimizing hyperparameters via grid search and five-fold cross-validation to identify top-performing models. A key innovation lies in our dynamic weighted voting ensemble (Voting_soft), which integrates multiple classifiers based on model confidence, thereby leveraging the strengths of diverse algorithms. Model performance was rigorously assessed using accuracy, sensitivity, and area under the curve (AUC) metrics, with ROC and PR curves comparing performance across varying training dataset proportions. Crucially, we employed SHAP (SHapley Additive exPlanations) for interpretability analysis, providing clinicians with actionable insights into feature contributions.ResultsThrough LightGBM-based correlation analysis and AUC curve determination, fourteen clinical features were identified as optimal predictors. Notably, the CatBoost model achieved superior performance on a 20% test set, while the Extreme Random Tree model demonstrated robustness on a 30% test set. Our dynamic weighted voting ensemble (Voting_soft) outperformed individual models in terms of AUC across both datasets. SHAP analysis revealed that age, triglycerides, sex, and HDL-C were key predictors of DR prevalence, offering clinically meaningful explanations for model decisions.ConclusionsThis study presents a groundbreaking ML-based DR risk prediction system that excels in both accuracy and interpretability. The integration of SHAP analysis not only enhances model transparency but also empowers clinicians with a deeper understanding of diagnostic decision-making, ultimately improving the precision and efficiency of DR screening. Our dynamic voting ensemble approach sets a new benchmark for interpretable, multi-model integration in medical diagnostics.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"124-135"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145858769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the rules of acupoint selection along meridians in the treatment of insomnia by guasha therapy.","authors":"Yanhuan Qi, Haimin Li, Yun Chen, Yinqin Zhong, Meixia Ye, Jie Chen, Ying Liu","doi":"10.1177/09287329251358625","DOIUrl":"10.1177/09287329251358625","url":null,"abstract":"<p><p>BackgroundInsomnia is a prevalent global health issue that significantly impacts quality of life and poses a substantial economic burden. While conventional pharmacological and non-pharmacological treatments exist, they are often limited by side effects, dependency, or low clinical applicability. Guasha therapy, a traditional Chinese medicine nursing technique, shows promise for treating insomnia, but lacks standardized, evidence-based guidelines for its clinical application.ObjectiveTo analyze the regularity of meridian and acupoint selection in the treatment of insomnia with scraping therapy by using data mining technology.MethodsA computer-based search of PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, Weipu Database(VIP), and Chinese Biomedical Literature Database (CBM) was conducted to retrieve the literature on scraping therapy for insomnia from the establishment of the database to March 15,2024.Excel was used to establish a database of acupoints for scraping therapy for insomnia, and the frequency of acupoints and meridians and the meridian tropism of acupoints were analyzed. SPSS 26.0 was used to cluster the high-frequency acupoints. The Apriori algorithm model provided by SPSS Modeler 18.0 was used to analyze the association rules of acupoint compatibility. Cytoscape 3.10.1 software was used to construct a complex network of meridian compatibility, and to analyze the core meridian of scraping in the treatment of insomnia.ResultsA total of 119 literatures were finally included, including 144 acupoints, with a total of 1121 frequencies. The most commonly used acupoints were Xinshu (BL15), Baihui (GV20), and Shenmen (HT7), and the commonly used compatibility acupoints were Xinshu-Pishu (BL20) and Xinshu-Pishu-Shenmen. The main meridians are Bladder meridian of foot-taiyang, Governor vessel, Gallbladder meridian of foot-shaoyang and Heart meridian of hand-shaoyin, which are the core meridian routes.ConclusionsData mining can effectively analyze the commonly used acupoints, acupoint compatibility rules and meridian rules of Gua Sha in the treatment of insomnia. The analysis results align with the traditional Chinese medicine principle of primarily following meridians, combining syndrome and root, enhancing the treatment effectiveness of insomnia, and providing a reference for clinical practice and research.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"63-74"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localization of drug-resistant epilepsy using chemical exchange saturation transfer and magnetic resonance spectroscopy.","authors":"Gen Yan, Yinghua Xuan, Yanyan Tang, Jing Xu, Yongmin Chang, Renhua Wu","doi":"10.1177/09287329251389492","DOIUrl":"10.1177/09287329251389492","url":null,"abstract":"<p><p>This study investigates the efficacy of two advanced magnetic resonance technologies, proton magnetic resonance spectroscopy (1H MRS) and chemical exchange saturation transfer (CEST), for the precise detection of epileptic foci through the quantification of glutamate in a patient with drug-resistant epilepsy. A 21-year old female patient with drug-resistant epilepsy was examined using magnetic resonance imaging (MRI), MRS, and CEST with a 3.0-T MRI scanner with an 8-channel phased array head coil. Despite the absence of identifiable lesions on conventional MRI scans, CEST identified regions of high glutamate concentration in the left hippocampus, consistent with an epileptic focus. These results were confirmed with MRS. The findings of this investigation indicate that CEST is an effective method for the detection of high levels of glutamate, which correspond with epileptic foci. We therefore propose that CEST and MRS be incorporated into the standard diagnostic protocol used for patients with drug-resistant, MRI-negative epilepsy.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"75-82"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance verification of blood vessel detection system using near-infrared light.","authors":"Jieun Park, Junghun Kim","doi":"10.1177/09287329251414328","DOIUrl":"10.1177/09287329251414328","url":null,"abstract":"<p><p>BackgroundNear-infrared (NIR) imaging technology has been increasingly applied in clinical and biomedical engineering fields for subcutaneous vein detection and vascular guidance. However, most existing systems still face limitations such as inconsistent visualization under various skin tones and difficulties in achieving real-time projection alignment.ObjectiveThe objective of this study is to develop a near-infrared (NIR)-based vascular detection system and to evaluate its performance.MethodsThe developed system provides intuitive visualization by projecting vascular images in real time onto the same skin region. Performance validation was conducted using a vascular model and the abdominal vessels of rabbits.ResultsIn the vascular model experiment, the localization accuracy was 98.9%, and in the rabbit experiment, the detection success rate for vessels with a diameter of ≥1 mm was 100%.ConclusionsThe proposed method was confirmed to reduce the time required for acquiring anatomical knowledge and to minimize complications by preventing incorrect venipuncture.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"313-321"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valproic acid physiological pharmacokinetics simulation for epilepsy patients via a refined seven-compartmental model: A pilot study.","authors":"Tsung-Han Lin, Shih-Hsun Huang, Keng-Yi Wu, Tzu-Hsien Chao, Lung-Kwang Pan, Ya-Hui Lin, Bing-Ru Peng","doi":"10.1177/09287329261417461","DOIUrl":"10.1177/09287329261417461","url":null,"abstract":"<p><p>This study simulated valproic acid (VPA) physiological pharmacokinetics for epilepsy patients via a refined seven-compartmental model. The seven compartments were defined as oral, GI Tract, liver, whole body (WB), cerebrospinal fluid (CSF), kidney, and bladder. A first-order system of seven differential equations was defined according to this specific model and solved by a self-developed program run in MATLAB to evaluate the VPA time-dependent change among compartments. Each compartment's preset dissolving half-life (in hours) was as follows: oral 0.05, GI Tract 0.10, liver 0.5, WB 2.2, CSF 0.8, kidney 1.2, and bladder 0.5, respectively. The derived results were reorganized according to various presets of dissolving half-lives of the liver, WB, CSF, or kidney to analyze the VPA time-dependent changes under various scenarios. Either the liver or WB was the dominant compartment in this model, which mainly controlled the VPA changes. In contrast, others compartments followed the principle of secular equilibrium in the chain decay of radioactive nuclides. Accordingly, the VPA degradation changes in WB (\"mother\" compartment) mainly affected the VPA changes in other (\"daughter\") compartments. Thus, the predicted VPA degradation in CSF, kidney, or bladder was always longer than in WB despite its dissolving half-life changes. The predicted results of VPA changes in various compartments were also compared with other studies, and a reasonable agreement was reached on whether the dissolving half-life of the liver or WB ranged from the original 0.2/2.2 to 1.4/0.9 h. The programable capability of this self-developed program allows one to easily modify the primary preset to comply with findings from other studies and has great potential in similar applications.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"208-221"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Checkpoint blockade immunotherapy for multiple recurrences of radiation-induced maxillary sinus sarcoma: A case report.","authors":"Yuge Li, Yan Zhong, Lijuan Ge, Guiyuan Peng","doi":"10.1177/09287329251358636","DOIUrl":"10.1177/09287329251358636","url":null,"abstract":"<p><p>BackgroundRadiotherapy has become a fundamental treatment modality of head and neck (HN) malignancies, which provides a chance of long-term survival. However, radiation also amplifies the risk of developing radiation-induced sarcoma (RIS) in the irradiated tissue. Radiation-induced maxillary sinus sarcoma (RIMSS) is an extremely rare and highly lethal malignancy of the HN. RIS is mainly treated with surgery, but the anatomical district and the infiltrative nature of RIS make it challenging to achieve negative margins, resulting in high fatality rate with the mean survival time of approximately one year. Immunotherapy, as an effective treatment option is rapidly evolving for HN tumors. However, checkpoint Blockade Immunotherapy (CBI) combined with chemotherapy as maintenance therapy for RIS of HN is rarely reported.Case presentationThe study presents a 36-year-old female with numerous recurrences of RIMSS, who experienced a dramatic response to checkpoint blockade immunotherapy after rapidly progressing on involved-field radiotherapy and multiple surgeries. After using immunotherapy combined with chemotherapy, the patient had a nearly complete response (CR) and maintained with single-agent programmed cell death 1 (PD-1) inhibitors.ResultsThe patient achieved a durable response, with progression-free survival (PFS) lasting 18 months.ConclusionUsing CBI as maintenance therapy for RIMSS represents a novel treatment option, especially for unresectable patients. Further investigation is warranted to optimize a multimodal treatment and improve response.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"83-89"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}