Polycystic ovary syndrome in women is associated with longer anogenital distance, a new potential biomaker for PCOS.

IF 1.8 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care Pub Date : 2025-07-01 Epub Date: 2025-02-19 DOI:10.1177/09287329251317142

Shumin Chen, Qiulin Cui, Yue Wu, Weiwen Fan

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引用次数: 0

Abstract

BackgroundFetal androgen exposure plays a pivotal role in Polycystic ovary syndrome (PCOS) development and may result in elevated Anogenital distance (AGD). This meta-analysis aimed to investigate the clinical link between PCOS and AGD.MethodsA literature search was performed across various databases to identify studies evaluating AGD in adults with PCOS and without, regardless of language, up to December 2024. The quality of the studies was evaluated using the Newcastle-Ottawa Scale (NOS) scoring system. Random-effects models were utilized to determine mean differences (MDs) and 95% confidence intervals (CIs) in cases of high heterogeneity. This meta-analysis encompassed 4 studies involving a total of 837 participants.ResultsThe pooled analysis found a noteworthy increase of the AGD-ac and AGD-af in PCOS patient compared with the control groups, with an overall MD of AGD-ac = 5.23, 95% CI (2.60, 7.85), P-value < 0.0001, I²= 57%, and with an overall MD of AGD-af = 2.19, 95% CI (0.04, 4.35), P-value = 0.05, I²= 89%.ConclusionThe meta-analysis results indicated that women diagnosed with PCOS exhibit elongated AGD. This potential association between AGD and PCOS could serve as a novel clinical marker for the diagnosis of PCOS. Fetal androgen exposure may play a role in the pathogenesis of PCOS.

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女性多囊卵巢综合征与肛门生殖器距离较长有关，这是多囊卵巢综合征新的潜在生物标志物。

胎儿雄激素暴露在多囊卵巢综合征（PCOS）的发展中起着关键作用，并可能导致肛门生殖器距离（AGD）升高。本荟萃分析旨在探讨多囊卵巢综合征和AGD之间的临床联系。方法对截至2024年12月的各种数据库进行文献检索，以确定评估PCOS和非PCOS成人AGD的研究，无论语言如何。研究的质量采用纽卡斯尔-渥太华量表（NOS）评分系统进行评估。在异质性较高的情况下，采用随机效应模型确定平均差异（md）和95%置信区间（ci）。这项荟萃分析包括4项研究，共涉及837名参与者。结果合并分析发现，PCOS患者AGD-ac和AGD-af较对照组显著升高，AGD-ac的总MD = 5.23, 95% CI (2.60, 7.85)， p值2= 57%；AGD-af的总MD = 2.19, 95% CI (0.04, 4.35)， p值= 0.05,I2= 89%。结论荟萃分析结果显示，诊断为多囊卵巢综合征的女性表现为AGD延长。这种AGD与PCOS之间的潜在联系可以作为PCOS诊断的一种新的临床标志。胎儿雄激素暴露可能在多囊卵巢综合征的发病机制中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Technology and Health Care HEALTH CARE SCIENCES & SERVICES-ENGINEERING, BIOMEDICAL

CiteScore

2.10

自引率

6.20%

发文量

282

审稿时长

>12 weeks

期刊介绍： Technology and Health Care is intended to serve as a forum for the presentation of original articles and technical notes, observing rigorous scientific standards. Furthermore, upon invitation, reviews, tutorials, discussion papers and minisymposia are featured. The main focus of THC is related to the overlapping areas of engineering and medicine. The following types of contributions are considered: 1.Original articles: New concepts, procedures and devices associated with the use of technology in medical research and clinical practice are presented to a readership with a widespread background in engineering and/or medicine. In particular, the clinical benefit deriving from the application of engineering methods and devices in clinical medicine should be demonstrated. Typically, full length original contributions have a length of 4000 words, thereby taking duly into account figures and tables. 2.Technical Notes and Short Communications: Technical Notes relate to novel technical developments with relevance for clinical medicine. In Short Communications, clinical applications are shortly described. 3.Both Technical Notes and Short Communications typically have a length of 1500 words. Reviews and Tutorials (upon invitation only): Tutorial and educational articles for persons with a primarily medical background on principles of engineering with particular significance for biomedical applications and vice versa are presented. The Editorial Board is responsible for the selection of topics. 4.Minisymposia (upon invitation only): Under the leadership of a Special Editor, controversial or important issues relating to health care are highlighted and discussed by various authors. 5.Letters to the Editors: Discussions or short statements (not indexed).