Technology and Health Care最新文献

{"title":"Deciphering the mechanism and substance basis of Dingxiang Shidi Decoction for the treatment of chemotherapy-induced nausea and vomiting by integrating mass spectrometry, network pharmacology and molecular docking.","authors":"Min Zhan, Qian Wang, Jun Yan, Qiaoxuan Zhang, Liqiao Han, Zemin Wan, Shasha Li, Xianzhang Huang","doi":"10.1177/09287329251358624","DOIUrl":"10.1177/09287329251358624","url":null,"abstract":"<p><p>BackgroundChemotherapy-induced nausea and vomiting (CINV) remains a prevalent and debilitating side effect of cancer treatment with limited therapeutic options. Dingxiang Shidi Decoction (DXSD), a classical Chinese herbal formula, has demonstrated clinical efficacy in CINV management. However, its active components and mechanism of action require systematic investigation.ObjectiveThis study aims to elucidate the pharmacologically active constituents of DXSD and their anti-CINV mechanisms.MethodsWe employed advanced analytical techniques including UPLC-MS/MS and GC-MS to analyze the chemical components of DXSD. Network pharmacology techniques were applied to explore its pharmacological mechanisms. And molecular docking simulation was conducted to further refine the drug-target interaction.ResultsA total of 292 chemical compounds were identified in DXSD, comprising 165 water-soluble components, 56 volatile components, and 84 network database entries. By integrating 564 drug targets with 888 CINV disease targets, we identified 143 potential therapeutic targets. Further protein-protein interaction (PPI) network analysis revealed 12 key active ingredients and 13 key therapeutic targets. Enrichment analysis suggested that DXSD may reduce inflammation, modulate neurotransmitter stimulation in the gastrointestinal tract, and regulate cellular proliferation and differentiation. Notably, key active ingredients, predominantly aromatic compounds such as sabinene, (-)-α-cubebene, α-copaene, β-caryophyllene, aromandendrene, γ-muurolene, (-)-α-muurolene, α-phellandrene, α-terpinene, γ-terpinene, (+)-δ-cadinene, and Gomisin B, demonstrated significant binding affinity with multiple targets, particularly AKT1, BCL2, EGFR, MTOR, and STAT3.ConclusionsThis study reveals the active components and therapeutic mechanisms of DXSD against CINV, supporting its clinical application and demonstrating the potential of aromatherapy as an effective treatment strategy.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"51-62"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of virtual reality walking-in-place exercise and seated cycling on grip strength, lower limb strength, and five times sit-to-stand test in elderly individuals with dementia: A parallel randomized controlled trial.","authors":"SunWook Park, Seong-Gil Kim","doi":"10.1177/09287329251392398","DOIUrl":"10.1177/09287329251392398","url":null,"abstract":"<p><p>BackgroundThe prevalence of dementia is increasing among the aging global population. Innovative exercise interventions, such as virtual reality-based walking-in-place exercise (VR-WIPE) and seated cycling, are emerging for this population.ObjectiveThis study aimed to evaluate and compare the effects of these two exercise methods on physical function.MethodsThe study included 20 adult women (mean age: 78.9 ± 4.61 years) diagnosed with dementia and registered at a daycare center. Participants were randomly assigned to one of two groups according to intervention: experimental (n = 10); or control (n = 10). The experimental group received VR-WIPE, whereas the control group performed seated cycling. The primary outcome was the 5xSTS test, assessing functional mobility. Secondary outcomes included grip strength and lower limb strength.ResultsGrip strength increased significantly only in the seated cycling group (<i>p</i> < 0.05), with a small effect size (Cohen's d = 0.23). Both the cycling and VR-WIPE groups showed significant improvement in 5xSTS and lower limb strength (<i>p</i> < 0.05). Between-group comparisons revealed that the seated cycling group demonstrated significantly greater improvements in hip flexion and knee extension strength (Cohen's d = 1.36, 1.09, respectively), while ankle plantar flexion strength was significantly higher in the VR-WIPE group (<i>p</i> < 0.05, Cohen's d = 1.66).ConclusionsBoth seated cycling and VR-WIPE effectively improved lower limb strength and 5xSTS performance in older adult women with dementia. Seated cycling yielded greater improvements in hip and knee strength, whereas VR-WIPE was more effective in enhancing ankle plantar flexion strength.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"136-144"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous health care evaluating for acute ischemic stroke patients with significant factor neural network relapse prediction model.","authors":"Lili Yu, Zhaoli Kong, Youwei Zhao","doi":"10.1177/09287329251392397","DOIUrl":"10.1177/09287329251392397","url":null,"abstract":"<p><p>The effect of continuous medical service intervention on health management for people who have suffered from Acute Ischemic Stroke (AIS) is an important issue in health care tracking. To pick out core aspects related to health, a relapse prediction model, evaluate the efficiency of continuous care and boost post-discharge results, a structured study is designed. After investigation and scientific verification, important signs and symptoms were chosen to set up a Significant Factors Neural Network Relapse Prediction Model (SFNNR) which aims to predict possible relapses based on previous patterns in medical data. The continuous care group was compared with the control group, and it turned out that participants in continuous care had significantly better results with fewer chances of having relapses and controlling chronic risks while displaying less psychological stress compared to the control group; furthermore, the continuous medical service showed great value on long-term management of AIS patients. The study points out that the integrated care approach should be taken more seriously as it can help healthcare staff predict the risk of relapse accurately so as to come up with personalized plans to control the relapse probability of the patients.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"229-245"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of thigh and shank affected side acceleration parameter during stroke hemiplegic gait.","authors":"Jeong-Woo Seo, Sangkwan Lee","doi":"10.1177/09287329251363425","DOIUrl":"10.1177/09287329251363425","url":null,"abstract":"<p><p>BackgroundDespite its clinical relevance, there is a relative lack of research examining flexibility and stability based on the acceleration or speed of localized limb segments, such as the shank and thigh.ObjectiveThis study aimed to evaluate gait characteristics based on acceleration in the thigh and shank to identify differences between the affected and unaffected sides in stroke hemiplegic patients.MethodForty individuals with stroke-induced hemiplegia were assessed during a 5-meter walk using a 3D motion analysis system and Inertial Measurement Units (IMUs). Spatial-temporal and acceleration parameters were calculated.ResultsSignificant differences were observed between the affected and unaffected sides in stance time, swing time, swing phase, and stance phase. In terms of acceleration, the mean acceleration in the anterior-posterior (AP) direction of the thigh and the mean value of the center of mass (CoM) in the AP direction differed significantly. These spatial-temporal findings were consistent with known characteristics of hemiplegic gait. A notable posterior shift of the thigh CoM on the affected side was identified, likely reflecting impaired propulsion and reduced stability.ConclusionThe posterior displacement of the thigh CoM on the affected side may represent a compensatory mechanism to maintain balance during gait. Clinically, this posterior CoM shift could serve as a meaningful indicator of hemiplegic gait and a potential target for rehabilitation interventions aimed at restoring gait symmetry and improving functional mobility.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"179-186"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of O-GlcNAcylation related genes and immune infiltration profile in ischemic stroke utilizing bioinformatics and machine learning.","authors":"Hongchao Liu, Zhihao Wei, Yajun Yang, Yu Zhang, Jiaqiong Li","doi":"10.1177/09287329251389496","DOIUrl":"10.1177/09287329251389496","url":null,"abstract":"<p><p>BackgroundIschemic stroke (IS) is a prevalent and serious neurological disorder, and inflammation and immune responses are crucial in the development of IS. O-GlcNAcylation is a form of post-translational modification that plays roles in numerous significant biological processes.ObjectiveThe major objective of the current study was to examine the involvement of O-GlcNAcylation associated genes in the pathogenesis of IS.MethodsWe downloaded two IS datasets from the GEO database, and subsequently the infiltration level of immune cells was quantified and compared. Differentially expressed O-GlcNAcylation genes were identified and machine learning algorithms were utilized to screen the hub genes. Subsequently, the IS samples were further classified based on hub genes through consensus clustering.ResultsOverall, nineteen O-GlcNAcylation related DEGs were identified. Through the machine learning algorithms, eight hub genes related to immune cell infiltration was identified. GSEA results showed that hub genes significantly correlated with immune system, RNA metabolism, and translation. Then two distinct subclusters mediated by O-GlcNAcylation were further defined, and functional analysis of cluster-specific DEGs demonstrated their participation in processes related to inflammation and immune response.ConclusionThe O-GlcNAcylation has a significant impact on the pathogenesis of IS, which is correlated with immunological response and metabolic activity. The findings of this research could serve as a valuable guide for exploring the molecular mechanisms of IS and offer insights into drug screening and immunotherapy for IS.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"90-110"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupotomy combined with oral pharmacotherapy for osteoarthritis: A systematic review and Bayesian network meta-analysis.","authors":"Zhengyao Zhang, Huiyi Li, Muyuan Zhai, Yiting Duan, Xiuzhi Zhang, Bo Liu, Dewei Zhao","doi":"10.1177/09287329251392395","DOIUrl":"10.1177/09287329251392395","url":null,"abstract":"<p><p>BackgroundOsteoarthritis (OA), a prevalent degenerative joint disease causing pain and disability, burdens global health. Acupotomy offers a minimally invasive alternative to surgery but faces limitations like variable efficacy. Combining acupotomy with oral pharmacotherapy (conventional or herbal medicine) may optimize outcomes through synergistic effects.ObjectiveTo systematically evaluate the efficacy and safety of acupotomy combined with oral medication for the treatment of osteoarthritis through a Bayesian network meta-analysis (NMA).MethodsThis study followed PRISMA-P guidelines. Randomised controlled trials (RCTs)were selected through 6 databases. Primary outcomes included overall effective rate, WOMAC score, VAS pain score, and adverse events.Results31 RCTs (3323 patients and 8 interventions) included. NMA revealed that Combinations outperformed other interventions in most comparisons. SUCRA represents the probability that an intervention ranks among the best. Notably, \"acupotomy + herbal medicine\" consistently ranked among the best across all three outcomes.ConclusionAcupotomy combined with oral medications demonstrated superior clinical efficacy and significant application potential. In clinical, acupotomy combined with conventional medications (e.g., NSAIDs) may be prioritised to alleviate acute symptoms, whereas acupotomy combined with herbal medicine shows more promising potential in long-term functional recovery. Treatment protocols should be tailored to individual patient conditions to maximise therapeutic outcomes.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"154-166"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoquinone regulates osteosarcoma cell proliferation through the P53 signaling pathway: A network pharmacology and molecular docking based health technology study.","authors":"Chenliang Zhou, Ruiyao Wang, Fang Liu, Kun-Yu Liu, Jiaqi Bi, Zhange Yu","doi":"10.1177/09287329261424110","DOIUrl":"10.1177/09287329261424110","url":null,"abstract":"<p><p>BackgroundOsteosarcoma (OS) has long presented a formidable challenge to human health and well-being. While traditional treatments, such as clinical chemotherapy and surgical intervention, have shown efficacy, they are frequently accompanied by adverse effects and often lead to a poor prognosis.ObjectiveThymoquinone (TQ) is recognized for its antitumor properties; however, the specific molecular mechanisms underlying its effects against OS remain inadequately understood. Emerging evidence suggests a strong correlation between p53 gene deletion and the onset and progression of various human cancers. This study aimed to elucidate the pharmacological targets and anti-OS mechanisms of TQ using systems bioinformatics approaches, including network pharmacology and molecular docking simulations.MethodsA comprehensive screening process identified 23 potential targets associated with the anti-OS effects of TQ. Subsequent bioinformatics analysis identified 8 core targets involved in TQ's anti-OS activity. Enrichment analysis indicated that these core targets modulate a range of biological processes and may influence multiple molecular pathways.ResultsPreliminary <i>in vitro</i> data indicated that TQ effectively reduces OS cell proliferation, induces apoptosis, and downregulates the expression of P53 and HMOX1 proteins.ConclusionOur findings elucidate the molecular mechanisms underlying TQ's effectiveness against OS, highlighting potential apoptosis-related therapeutic targets, such as P53 and CYCLIN D1, for the treatment of OS with TQ.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"354-365"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast phantom enhancement: Taguchi-type optimization for CT scan imaging quality and additive manufacturing realization.","authors":"Ying-Liang Chou, Fu-Tsai Chiang, Ching-Hsiu Ke, Jia-Hua Hsu, Chun-Chieh Liang, Samrit Kittipayak, Lung-Kwang Pan, Lung-Fa Pan, Kai-Yuan Cheng","doi":"10.1177/09287329261417465","DOIUrl":"10.1177/09287329261417465","url":null,"abstract":"<p><p>An indigenous breast phantom was customized to optimize the imaging quality of the CT scan according to Taguchi's methodology. A 3D printer made the base gauge of the breast phantom, and the polysmooth^TM filament was sprayed. The gauge can be categorized into three major parts vertical and horizontal line pairs, two V-shape slices, and two arrays of nodules with various sizes, then a spherical shell mad by paraffin casting and the sunflower oil was infused as filling material. The Taguchi approach led to the development of a customized measuring device that enabled quantitative assessment aimed at improving the spatial resolution of CT image quality. Five essential factors for operating the CT chest scan (kVp, mAs, FOV, Pitch, and gantry rotation time) were organized according to Taguchi L₁₈(2¹ × 3⁴) suggestion. Three well-trained radiologists ranked the imaging quality in three discrete time periods according to the imaging quality's sharpness, contrast, and spatial resolution. The derived average, standard deviation, and signal-to-noise ratio of specific factors were reorganized and analyzed from the multiple measurements to propose the optimal CT chest scan protocol recommendation. Accordingly, the optimal suggestion was A1(120 kVp), B3(200 mAs), C2(FOV 350 mm²), D1(pitch 0.516) and E2(rotation time 0.75 s) to fulfill the ALARA principle. In this research, a numerical metric termed the minimum detectable difference (MDD) was introduced to evaluate imaging performance, and its calculated value demonstrated a resolution capability of approximately 1.57 mm.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"261-273"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects and mechanisms of baicalin on MK-801 induced schizophrenia model mice.","authors":"Qi Wang, Ling Lv, Zhaoxia Li, Shuang Wang, Chengyi Zhang, Xinyue Zhang, Lijie Han, Siwei Wang, Yiting Liu, Ziyan Guo, Guohao Xu, Zilong Lun, Yao Ma, Xi Chen, Yilin Wang","doi":"10.1177/09287329251412965","DOIUrl":"10.1177/09287329251412965","url":null,"abstract":"<p><p>BackgroundSchizophrenia (SCZ) pharmacotherapy relies on Western medications with limited efficacy/significant adverse effects. Baicalin (BA), a purified botanical monomer, shows promise as a safer multitarget antipsychotic candidate.ObjectiveTo study the effect and mechanism of Baicalin on MK-801 induced schizophrenia model mice.MethodsBehavioral assessments (water maze, open field, dark avoidance, forced swimming tests) evaluated emotional/cognitive functions in MK-801 induced schizophrenia mice. Histological staining analyzed hippocampal, prefrontal cortical, and striatal morphology. Serum inflammatory markers (NF-<i>κ</i>B, IL-6, IL-1<i>β</i>, TNF-<i>α</i>) and oxidative stress indicators (SOD, MDA) were quantified by ELISA, alongside hippocampal neurotransmitter levels (DA, 5-HT, GABA, AChE). This study employed a network pharmacology approach to screen the mechanisms of action of baicalin in the treatment of schizophrenia. Western blotting determined hippocampal PI3K/Akt/GSK3<i>β</i> pathway protein expression.ResultsNetwork pharmacology analysis revealed that baicalin may exert its therapeutic effects in the treatment of schizophrenia through modulation of the PI3K-Akt signaling pathway. Versus model group, BA doses significantly decreased: IL-1<i>β</i>, IL-6, GABA, AChE, MDA, TNF-<i>α</i>, NF-<i>κ</i>B; open field total distance; forced swimming immobility; dark avoidance errors (<i>p</i> < 0.05). Increased: DA, 5-HT; water maze platform crossings; dark avoidance latency (<i>p</i> < 0.05). Staining confirmed BA reduced cerebral oxidative stress/neuroinflammation. Western blot showed dose-dependent elevation of p-Akt/Akt and p-GSK3<i>β</i>/GSK3<i>β</i> ratios.ConclusionBaicalin may improve cognitive impairments in MK801-induced schizophrenia model mice through the PI3K/Akt/GSK3<i>β</i> signaling pathway, exhibiting anti-neuroinflammatory and neuroprotective effects.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"274-286"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic robotic arm remotely controlled by IMU sensor for hazardous chemical experiment.","authors":"Taegang Kim, Geunho Do, Il-Jung Kwon, Ji-Won Kim, Junghyuk Ko","doi":"10.1177/09287329261417466","DOIUrl":"10.1177/09287329261417466","url":null,"abstract":"<p><p>BackgroundIn recent years, the importance of chemical experiments has increased, and the frequency of chemical experiments has also increased. As the frequency of chemical experiments increases, the number of chemical experiment-related accidents increases proportionally.ObjectiveAccordingly, we design a remote control biomimetic robotic arm that can safely and actively handle hazardous chemicals on behalf of human to reduce human casualties caused by chemical experiment accidents without compromising the autonomy of experimentation.MethodsThis biomimetic robotic arm can identically mimic the operator arm's movement. The robotic arm moves with 6 degrees of freedom (DOF). The inertial measurement unit (IMU) sensor we designed ourselves is based on micro-electromechanical system (MEMS) technology, and in the IMU sensor the accelerometer-gyroscope sensor and the wireless communication module are integrated. This IMU sensor calculates its own instantaneous angle on a particular axis. The micro controller unit (MCU) controls motor using the angle data of the IMU sensor so that the robotic arm moves in the same movement as the operator arm to which the IMU sensor is attached.ResultsThree IMU sensors were attached to the operator's upper body, upper arm, and lower arm, enabling the robotic arm to accurately replicate the operator's movements. Performance evaluation through comparative experiments confirmed that the robotic arm closely tracked the operator's joint motion and overall trajectory. Although a time delay of approximately 1.4 s was observed due to communication and processing latency, the system maintained stable performance under various motion and load conditions, with joint angle errors remaining below 5.2%.ConclusionThe proposed system enables biomimetic motion of a robotic arm using IMU-based sensing and wireless control, allowing hazardous chemicals to be handled safely during chemical experiments.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"197-207"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}