Uncovering potential molecular markers and pathological mechanisms of Parkinson's disease and myocardial infarction based on bioinformatics analysis.

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL

Technology and Health Care Pub Date : 2025-02-05 DOI:10.1177/09287329241307805

Jian Liu, Lu Xing, Tianye Lan, Qiang Wang, Yitong Wang, Xuenan Chen, Weimin Zhao, Liwei Sun

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引用次数: 0

Abstract

Background: The direct association between Parkinson's disease (PD) and Myocardial infarction (MI) has been the subject of relatively limited research.

Objective: The purpose of this study was to identify the genes most associated with PD and MI to explore their common pathogenesis.

Methods: The gene expression profiles of PD and MI were downloaded from GEO database. Differential expression analysis was performed to identify the common differential expression genes (DEGs) of PD and MI, followed by functional annotation. Subsequently, protein-protein interaction network were constructed, and hub DEGs were identified based on CytoHubba plugin and LASSO regression analysis. To explore the potential molecular mechanism of hub DEGs, GSEA analysis, immune correlation analysis, drug prediction and molecular docking were performed, and transcription factors (TF) and lncRNA-miRNA-mRNA (ceRNA) regulatory networks were constructed.

Results: A total of 48 DEGs with the same expression trend were identified in the MI vs. normal control (NC) and PD vs. NC groups. Functional annotation results showed that the common DEGs were significantly enriched in immune and inflammation-related pathways. RPS4Y1 and UTY were the most relevant hub DEGs for PD and MI, and may be involved in the HALLMARK_MYC_TARGETS_V1 and HALLMARK_PROTEIN_SECRETION pathways. TP63 was a common TF of RPS4Y1 and UTY. The PVT1/KCNQ1OT1-hsa-miR-31-5p-RPS4Y1 and KCNQ1OT1-hsa-let-7a-5p/hsa-miR-19b-3p-UTY axes may play an important role in regulating PD and MI. CYCLOHEXIMIDE and ATALAREN may be potential drugs for the treatment of PD and MI comorbidity. In addition, PD and MI exhibit different patterns of immune cell infiltration and immune function status, which may be related to the specific pathological processes of the disease.

Conclusions: This study revealed for the first time that RPS4Y1 and UTY may be common biomarkers of PD and MI and may be potential therapeutic targets. This study provides new perspective on the common molecular mechanisms between PD and MI.

查看原文本刊更多论文

基于生物信息学分析揭示帕金森病和心肌梗死的潜在分子标记和病理机制。

背景：帕金森病（PD）与心肌梗死（MI）之间的直接关系一直是相对有限的研究主题。目的：本研究的目的是鉴定与PD和MI最相关的基因，探讨它们的共同发病机制。方法：从GEO数据库下载PD和MI的基因表达谱。通过差异表达分析，鉴定PD和MI的共同差异表达基因（DEGs），并进行功能注释。随后，构建蛋白-蛋白相互作用网络，并基于CytoHubba插件和LASSO回归分析鉴定轮毂deg。为探索中枢DEGs的潜在分子机制，通过GSEA分析、免疫相关分析、药物预测和分子对接，构建转录因子（TF）和lncRNA-miRNA-mRNA （ceRNA）调控网络。结果：心肌梗死组与正常对照组（NC）、PD组与NC组共鉴定出48个表达趋势相同的deg。功能注释结果显示，常见的deg在免疫和炎症相关途径中显著富集。RPS4Y1和UTY是PD和MI最相关的枢纽基因，可能参与HALLMARK_MYC_TARGETS_V1和hallmark_protein_分泌途径。TP63是RPS4Y1和UTY的共同TF。PVT1/ kcnq10t1 -hsa- mir -31-5p- rps4y1和kcnq10t1 -hsa-let-7a-5p/hsa-miR-19b-3p-UTY轴可能在PD和MI的调节中发挥重要作用，环己亚胺和ATALAREN可能是治疗PD和MI合病的潜在药物。此外，PD和MI表现出不同的免疫细胞浸润模式和免疫功能状态，这可能与疾病的特定病理过程有关。结论：本研究首次揭示了RPS4Y1和UTY可能是PD和MI的共同生物标志物，可能是潜在的治疗靶点。本研究为PD与心肌梗死共同的分子机制研究提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Technology and Health Care HEALTH CARE SCIENCES & SERVICES-ENGINEERING, BIOMEDICAL

CiteScore

2.10

自引率

6.20%

发文量

282

审稿时长

>12 weeks

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