基于比较形态学特征学习的肺癌病理图像智能分类。

IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Fangfang Peng, Saihong Li
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引用次数: 0

摘要

背景:肺癌病理图像的准确分类对于诊断和治疗都具有至关重要的意义。然而,复杂的细胞形态和标记图像的稀缺性往往阻碍了鲁棒分类模型的发展,这是该领域的一个关键瓶颈。目的:本研究旨在将未标记数据纳入训练过程,从而通过使用比较学习技术增强肺癌病理图像的分类。方法:介绍了一种方法,其中自信分类的未标记图像与标记图像相结合,丰富了训练数据集。这种方法借鉴了最近邻对比学习的原则,以培养更具挑战性的学习环境,并增加对比样本的可变性。为了有效地提取关键的细胞形态特征,采用了基于ResNet50架构的编码器,并采用了可变形和动态卷积技术。结果:实验结果表明,即使在标记数据有限的情况下,所提出的分类策略也显著提高了肺癌图像分类的准确性,从而强调了该方法的鲁棒性。结论:将比较学习与标记和未标记图像相结合,辅以先进卷积技术的应用,是增强肺癌病理图像分类的一种有前途的途径。这项研究提出了一个实际的解决方案,以迫切需要准确和有效的诊断工具在肿瘤领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intelligent classification of lung cancer pathology images through comparative morphological feature learning.

Background: The accurate classification of lung cancer pathology images is of paramount importance for both diagnostic and therapeutic purposes. However, the development of robust classification models is often hindered by the intricate cellular morphologies and the scarcity of labeled images, which is a critical bottleneck in the field.

Objectives: The study is designed to incorporate unlabeled data into the training process, thereby enhancing the classification of lung cancer pathology images through the use of comparative learning techniques.

Methods: A methodology is introduced wherein confidently classified unlabeled images are integrated with labeled ones, enriching the training dataset. This approach draws on principles of farthest and nearest neighbor contrastive learning to cultivate a more challenging learning environment and to augment the variability of contrastive samples. To effectively extract key cellular morphological features, an encoder based on the ResNet50 architecture, fortified with deformable and dynamic convolutional techniques, is utilized.

Results: Demonstrated by experimental results, the proposed classification strategy achieves a significant improvement in the accuracy of lung cancer image classification, even under conditions characterized by a limited availability of labeled data, thus underscoring the robustness of the method.

Conclusion: The integration of comparative learning with both labeled and unlabeled images, complemented by the application of advanced convolutional techniques, is shown to be a promising avenue for enhancing the classification of lung cancer pathology images. This research is presented as a practical solution to the urgent need for accurate and efficient diagnostic tools in the field of oncology.

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来源期刊
Technology and Health Care
Technology and Health Care HEALTH CARE SCIENCES & SERVICES-ENGINEERING, BIOMEDICAL
CiteScore
2.10
自引率
6.20%
发文量
282
审稿时长
>12 weeks
期刊介绍: Technology and Health Care is intended to serve as a forum for the presentation of original articles and technical notes, observing rigorous scientific standards. Furthermore, upon invitation, reviews, tutorials, discussion papers and minisymposia are featured. The main focus of THC is related to the overlapping areas of engineering and medicine. The following types of contributions are considered: 1.Original articles: New concepts, procedures and devices associated with the use of technology in medical research and clinical practice are presented to a readership with a widespread background in engineering and/or medicine. In particular, the clinical benefit deriving from the application of engineering methods and devices in clinical medicine should be demonstrated. Typically, full length original contributions have a length of 4000 words, thereby taking duly into account figures and tables. 2.Technical Notes and Short Communications: Technical Notes relate to novel technical developments with relevance for clinical medicine. In Short Communications, clinical applications are shortly described. 3.Both Technical Notes and Short Communications typically have a length of 1500 words. Reviews and Tutorials (upon invitation only): Tutorial and educational articles for persons with a primarily medical background on principles of engineering with particular significance for biomedical applications and vice versa are presented. The Editorial Board is responsible for the selection of topics. 4.Minisymposia (upon invitation only): Under the leadership of a Special Editor, controversial or important issues relating to health care are highlighted and discussed by various authors. 5.Letters to the Editors: Discussions or short statements (not indexed).
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