Jun-Beom Park, Shin-Young Park, Jung-Chul Park, Yong-Gun Kim, Hwan Tae Ahn, Seung-Yun Shin
{"title":"Attendance at conferences for researchers and editorial boards: the post-COVID landscape.","authors":"Jun-Beom Park, Shin-Young Park, Jung-Chul Park, Yong-Gun Kim, Hwan Tae Ahn, Seung-Yun Shin","doi":"10.5051/jpis.245403edi01","DOIUrl":"10.5051/jpis.245403edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"54 3","pages":"137-138"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early wound healing at 1 week postoperatively in periodontal tissue regeneration therapy: enamel matrix derivative versus recombinant human fibroblast growth factor.","authors":"Yohei Nakayama, Moe Ogihara-Takeda, Yumi Saito, Arisa Yamaguchi, Yorimasa Ogata","doi":"10.5051/jpis.2400740037","DOIUrl":"https://doi.org/10.5051/jpis.2400740037","url":null,"abstract":"<p><strong>Purpose: </strong>Recombinant human fibroblast growth factor-2 (rhFGF-2) has demonstrated positive effects on wound healing at 2 weeks after periodontal surgery relative to enamel matrix derivative (EMD). However, the effects at earlier postoperative stages have not been reported. This retrospective study compared the early wound healing outcomes 1 week after surgery using the modified papilla preservation technique (mPPT) with either EMD or rhFGF-2 therapy.</p><p><strong>Methods: </strong>We compiled a list of all mPPT sites treated with EMD or rhFGF-2 during the survey period (September 2011 to March 2022). Early wound healing was assessed using the early wound healing score (EHS) and the modified early wound healing index (mEHI). Inter-rater reliability for the EHS and mEHI was established using intraclass correlation coefficients. Factors influencing mPPT were identified by analyzing the correlation coefficients between the EHS items, mEHI items, and potential influencing factors. After adjusting for factors impacting EHS, mEHI, and mPPT, we compared the EHS and mEHI between EMD and rhFGF-2 groups.</p><p><strong>Results: </strong>In total, 72 sites were evaluated. The scores for incision line, step, and dehiscence were significantly higher in those receiving rhFGF-2 (n=42) compared to those treated with EMD (n=30). The EHS item scores did not differ significantly between groups. Among patients aged ≥50 years, but not those <50 years, significantly higher step and dehiscence scores were found in the rhFGF-2 group than the EMD group (<i>P</i><0.01). Additionally, for patients exhibiting a clinical attachment level (CAL) ≥8 mm, the step score was significantly higher in the rhFGF-2 group than in the EMD group (<i>P</i><0.05), but this trend was not reflected in those with a CAL <8 mm.</p><p><strong>Conclusions: </strong>In this study, early wound closure at mPPT sites was more effectively achieved with rhFGF-2 than with EMD. Nevertheless, biochemical assessments are required to compare the re-epithelialization effects of these therapies.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young Kim, Si-Won Kang, Ju Ri Ye, Seong Eun Kim, Yong Kwon Chae, Ok Hyung Nam
{"title":"Osteogenic potential of Frondoside A in human periodontal ligament cells: an RNA-Seq analysis.","authors":"Young Kim, Si-Won Kang, Ju Ri Ye, Seong Eun Kim, Yong Kwon Chae, Ok Hyung Nam","doi":"10.5051/jpis.2303840192","DOIUrl":"https://doi.org/10.5051/jpis.2303840192","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the effects of Frondoside A (FA) on the osteogenic differentiation of human periodontal ligament (PDL) cells.</p><p><strong>Methods: </strong>Human PDL cells were cultured in osteogenic medium and treated with FA at concentrations of 0, 0.05, and 0.2 µM for 14 days. The expression levels of genes associated with osteogenic differentiation were assessed using quantitative real-time polymerase chain reaction analysis. Subsequently, RNA sequencing was performed to identify enriched gene sets following FA treatment. Alkaline phosphatase (ALP) activity was measured to confirm the osteogenic potential of FA.</p><p><strong>Results: </strong>Treatment with 0.2 µM FA significantly increased the expression levels of runt-related transcription factor 2 (<i>RUNX2</i>), <i>ALP</i>, and osteocalcin (<i>OCN</i>) at day 3, while also significantly elevating the expression of dentin sialophosphoprotein (<i>DSPP</i>), <i>RUNX2</i>, <i>ALP</i>, <i>OCN</i>, and osterix (<i>OSX</i>) at day 14 (<i>P</i><0.017). Hallmark gene sets enriched during FA treatment were associated with the KRAS (normalized enrichment score [NES]=2.02, <i>Q</i>=0.000), interferon alpha (IFN-α) (NES=1.88, <i>Q</i>=0.001), IFN-γ (NES=1.85, <i>Q</i><0.001), hypoxia (NES=1.79, <i>Q</i>=0.001), and p53 (NES=1.77, <i>Q</i>=0.001) signaling pathways. Additionally, treatment with 0.2 µM FA significantly intensified ALP staining at day 14 (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Within the limitations of this study, FA treatment influenced periodontal regeneration by promoting the osteogenic differentiation of human PDL cells.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Waad Kheder, Ab Rani Samsudin, Soumya Sheela, Sausan Al Kawas
{"title":"Correlation between the size of released titanium particles and changes in the surface of dental implants during insertion into bone blocks: an <i>in vitro</i> study.","authors":"Waad Kheder, Ab Rani Samsudin, Soumya Sheela, Sausan Al Kawas","doi":"10.5051/jpis.2204380219","DOIUrl":"https://doi.org/10.5051/jpis.2204380219","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the size and amount of titanium particles immediately released following dental implant insertion into bovine bone blocks and aimed to correlate them with the surface roughness of the implants.</p><p><strong>Methods: </strong>Twelve bone blocks were prepared from bovine mandibles. Six tapered (group A) and 6 cylindrical (group B) dental implants were inserted into the bone blocks under water irrigation, following the standard drilling protocol. After insertion, the implants were immediately removed from the bone. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and atomic force microscopy were performed to investigate the released titanium particles and implant surface roughness, respectively. The amount of titanium ions in the irrigation water was measured using inductively coupled plasma mass spectrometry. Dynamic light scattering (DLS) was used to determine the size range of the released titanium particles.</p><p><strong>Results: </strong>The percentages of titanium content on the surface of implants decreased in both groups after implantation into bone blocks. SEM-EDX analysis confirmed the presence of titanium particles embedded in the implanted bone bed. Group B implants showed significantly higher concentrations of titanium ions in the collected water than group A implants (0.868 and 0.565 µg/L, respectively). Group A implants demonstrated high pre-implantation surface roughness, which led to a much greater decrease in post-implantation surface roughness than was observed for group B implants. DLS analysis showed that the titanium particles released from group A implants were within the nano-size range, whereas those released from group B implants were within the micro-size range.</p><p><strong>Conclusions: </strong>Dental implant placement leads to a decrease in implant surface roughness and the immediate release of titanium particles into the peri-implant bone. Variations in the size range and amount of released particles were correlated with implant surface roughness. This finding has clinical implications and warrants additional <i>in vivo</i> studies.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyeong-Jin Baek, Hyejin Lee, Jae-Ryun Lee, Jung-Hyun Park, Keun-Suh Kim, Min-Jeong Kwoen, Tae-Yeon Lee, Jin-Woo Kim, Hyo-Jung Lee
{"title":"Pulp and periapical disease as a risk factor for osteonecrosis of the jaw: a national cohort-based study in Korea.","authors":"Hyeong-Jin Baek, Hyejin Lee, Jae-Ryun Lee, Jung-Hyun Park, Keun-Suh Kim, Min-Jeong Kwoen, Tae-Yeon Lee, Jin-Woo Kim, Hyo-Jung Lee","doi":"10.5051/jpis.2300120006","DOIUrl":"10.5051/jpis.2300120006","url":null,"abstract":"<p><strong>Purpose: </strong>This longitudinal cohort study aimed to evaluate the relationship between osteonecrosis of the jaw and pulp and periapical disease in patients who were administered bisphosphonates.</p><p><strong>Methods: </strong>Using data from a nationwide cohort, we examined the association among dental caries, pulp and periapical disease, and osteonecrosis of the jaw in women aged >50 years who received bisphosphonates for more than 1 year between 2002 and 2015. Because of ambiguities in the diagnosis of osteonecrosis of the jaw in population-based data, we operationally defined and categorized the condition into established and potential osteonecrosis of the jaw.</p><p><strong>Results: </strong>Pulp and periapical disease significantly increased the development of both established and potential osteonecrosis of the jaw (hazard ratio, 2.21; 95% confidence interval, 1.40-3.48; and hazard ratio, 2.22; 95% confidence interval, 1.65-2.98, respectively). Root canal treatment did not have any influence on the development of osteonecrosis of the jaw.</p><p><strong>Conclusions: </strong>Pulp and periapical disease may be a major risk factor for osteonecrosis of the jaw. The study findings suggest that patients should undergo regular dental examinations to detect pulp and periapical disease before or during the administration of bisphosphonates and that root canal treatment should be considered to decrease the risk of osteonecrosis of the jaw.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"65-74"},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9911261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haeji Yum, Hee-Seung Han, Kitae Kim, Sungtae Kim, Young-Dan Cho
{"title":"The cumulative survival rate of sandblasted, large-grit, acid-etched dental implants: a retrospective analysis.","authors":"Haeji Yum, Hee-Seung Han, Kitae Kim, Sungtae Kim, Young-Dan Cho","doi":"10.5051/jpis.2301440072","DOIUrl":"10.5051/jpis.2301440072","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective study aimed to assess the long-term cumulative survival rate of titanium, sandblasted, large-grit, acid-etched implants over a 10-year follow-up period and investigate the factors affecting the survival rate and change in marginal bone loss (MBL).</p><p><strong>Methods: </strong>The study included 400 patients who underwent dental implant placement at the Department of Periodontology of Seoul National University Dental Hospital (SNUDH) between 2005 and 2015. Panoramic radiographic images and dental records of patients were collected and examined using Kaplan-Meier analysis, Cox proportional hazards regression analysis, and multiple regression analysis to determine the survival rates and identify any factors related to implant failure and MBL.</p><p><strong>Results: </strong>A total of 782 implants were placed with a follow-up period ranging from 0 to 16 years (mean: 8.21±3.75 years). Overall, 25 implants were lost, resulting in a cumulative survival rate of 96.8%. Comparisons of the research variables regarding cumulative survival rate mostly yielded insignificant results. The mean mesial and distal MBLs were 1.85±2.31 mm and 1.59±2.03 mm, respectively. Factors influencing these values included age, diabetes mellitus (DM), jaw location, implant diameter, bone augmentation surgery, and prosthetic unit.</p><p><strong>Conclusions: </strong>This study found that the implant survival rates at SNUDH fell within the acceptable published criteria. The patients' sex, age, DM status, implant location, implant design, implant size, surgical type, bone augmentation, and prosthetic unit had no discernible influence on long-term implant survival. Sandblasted, large-grit, acid-etched implants might offer advantages in terms of implant longevity and consistent clinical outcomes.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"122-135"},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9902033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun-Beom Park, Shin-Young Park, Jung-Chul Park, Yong-Gun Kim, Hwan Tae Ahn, Seung-Yun Shin
{"title":"Revolutionizing scholarly publishing by integrating artificial intelligence into editorial and peer review processes.","authors":"Jun-Beom Park, Shin-Young Park, Jung-Chul Park, Yong-Gun Kim, Hwan Tae Ahn, Seung-Yun Shin","doi":"10.5051/jpis.245402edi01","DOIUrl":"https://doi.org/10.5051/jpis.245402edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"54 2","pages":"63-64"},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefan P Bienz, Edwin Ruales-Carrera, Wan-Zhen Lee, Christoph H F Hämmerle, Ronald E Jung, Daniel S Thoma
{"title":"Early implant placement in sites with ridge preservation or spontaneous healing: histologic, profilometric, and CBCT analyses of an exploratory RCT.","authors":"Stefan P Bienz, Edwin Ruales-Carrera, Wan-Zhen Lee, Christoph H F Hämmerle, Ronald E Jung, Daniel S Thoma","doi":"10.5051/jpis.2300460023","DOIUrl":"10.5051/jpis.2300460023","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to compare changes in soft and hard tissue and the histologic composition following early implant placement in sites with alveolar ridge preservation or spontaneous healing (SH), as well as implant performance up to 1 year after crown insertion.</p><p><strong>Methods: </strong>Thirty-five patients with either intact buccal bone plates or dehiscence of up to 50% following single-tooth extraction of incisors, canines, or premolars were included in the study. They were randomly assigned to undergo one of three procedures: deproteinized bovine bone mineral with 10% collagen (DBBM-C) covered by a collagen matrix (DBBM-C/CM), DBBM-C alone, or SH. At 8 weeks, implant placement was carried out, and cone-beam computed tomography scans and impressions were obtained for profilometric analysis. Patients were followed up after the final crown insertion and again at 1 year post-procedure.</p><p><strong>Results: </strong>Within the first 8 weeks following tooth extraction, the median height of the buccal soft tissue contour changed by -2.11 mm for the DBBM-C/CM group, -1.62 mm for the DBBM-C group, and -1.93 mm for the SH group. The corresponding height of the buccal mineralized tissue changed by -0.27 mm for the DBBM-C/CM group, -2.73 mm for the DBBM-C group, and -1.48 mm for the SH group. The median contour changes between crown insertion and 1 year were -0.19 mm in the DBBM-C/CM group, -0.09 mm in the DBBM-C group, and -0.29 mm in the SH group.</p><p><strong>Conclusions: </strong>Major vertical and horizontal ridge contour changes occurred, irrespective of the treatment modality, up to 8 weeks following tooth extraction. The DBBM-C/CM preserved more mineralized tissue throughout this period, despite a substantial reduction in the overall contour. All 3 protocols led to stable tissues for up to 1 year.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"108-121"},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9902031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of COVID-19 spread on visit intervals and clinical parameters for patients with periodontitis in supportive periodontal therapy: a retrospective study.","authors":"Mizuho Yamazaki-Takai, Yumi Saito, Shoichi Ito, Moe Ogihara-Takeda, Tsuyoshi Katsumata, Ryo Kobayashi, Shuta Nakagawa, Tomoko Nishino, Namiko Fukuoka, Kota Hosono, Mai Yamasaki, Yosuke Yamazaki, Yuto Tsuruya, Arisa Yamaguchi, Yorimasa Ogata","doi":"10.5051/jpis.2300620031","DOIUrl":"10.5051/jpis.2300620031","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the relationship between the number of days that hospital visits were postponed and changes in clinical parameters due to the spread of coronavirus disease 2019 (COVID-19), after the Japanese government declared a state of emergency in April 2020.</p><p><strong>Methods: </strong>Regarding the status of postponement of appointments, we analyzed the patients who had visited the Nihon University Hospital at Matsudo for more than 1 year for supportive periodontal therapy (SPT) and classified them into low-, moderate- and high-risk subgroups according to the periodontal risk assessment (PRA). Clinical parameters for periodontal disease such as probing depth (PD), full-mouth bleeding score (FMBS), full-mouth plaque score, periodontal inflamed surface area (PISA), and periodontal epithelial surface area (PESA) were analyzed in 2 periods, from October 2019 to March 2020 and after April 2020. Correlation coefficients between days of deferral and the degree of changes in clinical parameters were calculated.</p><p><strong>Results: </strong>The mean age of the 749 patients was 67.56±10.85 years, and 63.82% were female. Out of 749 patients, 33.24% deferred their SPT appointments after April 2020. The average total of postponement days was 109.49±88.84. The number of postponement days was positively correlated with changes in average PD (rs=0.474) and PESA (rs=0.443) in the high-risk subgroup of FMBS, and average PD (rs=0.293) and PESA (rs=0.253) in the high-risk subgroup of tooth number (TN). Patients belonging to the high-risk subgroups for both FMBS and TN had a positive correlation between postponement days and PISA (rs=0.56).</p><p><strong>Conclusions: </strong>The findings, the spread of COVID-19 appears to have extended the visit interval for some SPT patients. Moreover, longer visit intervals were correlated with the worsening of some clinical parameters for SPT patients with high PRA.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"75-84"},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9911259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative analysis of the <i>in vivo</i> kinetic properties of various bone substitutes filled into a peri-implant canine defect model.","authors":"Jingyang Kang, Masaki Shibasaki, Masahiko Terauchi, Narumi Oshibe, Katsuya Hyodo, Eriko Marukawa","doi":"10.5051/jpis.2204660233","DOIUrl":"10.5051/jpis.2204660233","url":null,"abstract":"<p><strong>Purpose: </strong>Deproteinized bovine bone or synthetic hydroxyapatite are 2 prevalent bone grafting materials used in the clinical treatment of peri-implant bone defects. However, the differences in bone formation among these materials remain unclear. This study evaluated osteogenesis kinetics in peri-implant defects using 2 types of deproteinized bovine bone (Bio-Oss<sup>®</sup> and Bio-Oss/Collagen<sup>®</sup>) and 2 types of synthetic hydroxyapatite (Apaceram-AX<sup>®</sup> and Refit<sup>®</sup>). We considered factors including newly generated bone volume; bone, osteoid, and material occupancy; and bone-to-implant contact.</p><p><strong>Methods: </strong>A beagle model with a mandibular defect was created by extracting the bilateral mandibular third and fourth premolars. Simultaneously, an implant was inserted into the defect, and the space between the implant and the surrounding bone walls was filled with Bio-Oss, Bio-Oss/Collagen, Apaceram-AX, Refit, or autologous bone. Micro-computed tomography and histological analyses were conducted at 3 and 6 months postoperatively (Refit and autologous bone were not included at the 6-month time point due to their rapid absorption).</p><p><strong>Results: </strong>All materials demonstrated excellent biocompatibility and osteoconductivity. At 3 months, Bio-Oss and Apaceram-AX exhibited significantly greater volumes of formation than the other materials, with Bio-Oss having a marginally higher amount. However, this outcome was reversed at 6 months, with no significant difference between the 2 materials at either time point. Apaceram-AX displayed notably slower bioresorption and the largest quantity of residual material at both time points. In contrast, Refit had significantly greater bioresorption, with complete resorption and rapid maturation involving cortical bone formation at the crest at 3 months, Refit demonstrated the highest mineralized tissue and osteoid occupancy after 3 months, albeit without statistical significance.</p><p><strong>Conclusions: </strong>Overall, the materials demonstrated varying post-implantation behaviors <i>in vivo</i>. Thus, in a clinical setting, both the properties of these materials and the specific conditions of the defects needing reinforcement should be considered to identify the most suitable material.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"96-107"},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}