Journal of Periodontal and Implant Science最新文献

{"title":"Association between oral health and handgrip strength: a systematic review.","authors":"Gargi Sarode, Aishwarya Joshi, Shruti Singh, Namrata Sengupta, Rahul Anand, Vini Mehta, Sachin Sarode","doi":"10.5051/jpis.2303560178","DOIUrl":"https://doi.org/10.5051/jpis.2303560178","url":null,"abstract":"<p><strong>Objective: </strong>It is well-established that muscle mass strength is a key factor in healthy physical functioning and is necessary for an active lifestyle. Handgrip strength (HGS) is the most convenient and cost-effective method for evaluating overall muscle strength in the body. Various studies have investigated the direct impact of inflammatory oral diseases on HGS, but with conflicting results. This systematic review investigated previous study data and analysed the causal factors in oral disease that affect HGS.</p><p><strong>Methods: </strong>The PubMed, Scopus, and Web of Science databases were searched for articles using relevant keywords. Based on the inclusion criteria, 8 cross-sectional studies were selected, and the extracted data was interpreted and analysed systematically. Quality assessment was done using the National Institutes of Health Quality Assessment Tool.</p><p><strong>Results: </strong>Although 4 studies were shown to have used good quality assessment tools, heterogeneity in the methodology and data analysis prevented us from conducting a meta-analysis. Most of the studies were conducted between 2020 to 2022 and 7 were from Asian countries. The findings of these studies indicated a positive correlation between good oral health and strong HGS. Poor oral habits and oral conditions such as periodontitis and tooth loss inversely affected HGS, as did intrinsic factors like age and sex.</p><p><strong>Conclusions: </strong>Limited global studies and heterogeneous study data emerged as the major shortcomings in our systematic study review and precluded meta-analysis. Therefore, further studies are needed with standard methodologies and outcome measures as well as good global representation.</p><p><strong>Trial registration: </strong>PROSPERO Identifier: CRD42023441854.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone regeneration and biosorption patterns of different bone substitutes: an <i>in vivo</i> study in rabbit skulls.","authors":"Seunghee Lee, Jungwoo Jung, Jungwon Lee, Young-Chang Ko, Dongseob Lee, Ki-Tae Koo, Yang-Jo Seol, Yong-Moo Lee","doi":"10.5051/jpis.2402840142","DOIUrl":"https://doi.org/10.5051/jpis.2402840142","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the bone regeneration and biosorption patterns of different bone substitutes in a rabbit skull defect model.</p><p><strong>Methods: </strong>Four circular 8 mm-defects were created in the cranium of 12 New Zealand white rabbits, each weighing approximately 3 kg. Each defect was randomly assigned to one of 4 treatment groups: cortical deproteinized porcine bone mineral (DPBM), cancellous DPBM, biphasic calcium phosphate (BCP) with a 6:4 ratio of hydroxyapatite (HA) to β-tricalcium phosphate (β-TCP) (TCP4), and BCP with a 2:8 ratio of HA to β-TCP (TCP8). The rabbits were euthanized at either 6 weeks (n=6) or 12 weeks (n=6) post-surgery. The harvested specimens were then analyzed both radiographically and histomorphometrically.</p><p><strong>Results: </strong>In the micro-computed tomography analysis, no statistically significant differences were observed among the 4 groups, except in the bone graft volume/tissue volume (GV/TV) at 12 weeks. Cortical DBPM exhibited a higher GV/TV ratio than cancellous DBPM at the same time point. The histomorphometric analysis revealed increased biosorption in cancellous DBPM compared to cortical DBPM at 12 weeks. However, the percentage of newly formed bone did not significantly differ among the 4 groups.</p><p><strong>Conclusions: </strong>All types of bone substitutes demonstrated similar patterns of bone regeneration at both 6 and 12 weeks of observation. However, cancellous DPBM exhibited a higher rate of bioabsorption compared to other bone substitutes, suggesting that it may have different indications or applications in guided bone regeneration protocols.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between bone quality and shrinkage in maxillary sinus augmentation using synthetic alloplast versus xenograft.","authors":"Rachad Kudsi, Dolphus R Dawson, Octavio A Gonzalez, Ahmad Kutkut, Michelle A Tucci, Rosario Porras-Aguilar, Ana Espinosa Momox, Mohanad Al-Sabbagh","doi":"10.5051/jpis.2401320066","DOIUrl":"https://doi.org/10.5051/jpis.2401320066","url":null,"abstract":"<p><strong>Purpose: </strong>This clinical study evaluated differences in bone quality within the maxillary sinus when either alloplast or xenograft material was applied.</p><p><strong>Methods: </strong>Twenty participants requiring lateral sinus approach augmentation for delayed implant placement were divided into 2 groups. The first group received a silica-calcium phosphate composite (SCPC) alloplast, while the second received a bovine bone xenograft (Bio-Oss). Cone-beam computed tomography (CBCT) was used to measure changes in bone height and area immediately after surgery and 5 months after augmentation. Picrosirius red staining of bone biopsies, obtained during implant placement, was analyzed under polarized microscopy. A MATLAB algorithm was used for analysis following image acquisition.</p><p><strong>Results: </strong>CBCT measurements revealed a statistically significant reduction in linear bone height among xenograft recipients (<i>P</i>≤0.001). This finding indicated greater resorption compared to the alloplast group, which exhibited no significant difference in bone height at 5 months following sinus augmentation. Furthermore, 40% of xenograft recipients displayed an absence of mineralized tissue formation, indicating a limited osteoconductive effect compared to the alloplast group, in which mineralized bone tissue was present in all samples. Polarized light microscopy and color intensity measurements of picrosirius red-stained bone biopsies revealed a significantly higher ratio of mineralized collagen I to collagen III in the newly formed bone for alloplast compared to xenograft recipients. Trichrome staining demonstrated collagen I mineralization with the presence of osteoblasts and osteocytes, indicating new bone formation. The newly formed bone in the alloplast group exhibited markers of maturation, including the formation of reversal lines, Haversian systems, and blood vessels. Resorption of the SCPC alloplast-grafted granules was also observed.</p><p><strong>Conclusions: </strong>The increased formation and maturation of new bone appear responsible for the preservation of bone height in alloplast group recipients.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly accurate measurement of the relative abundance of oral pathogenic bacteria using colony-forming unit-based qPCR.","authors":"Jiyoung Hwang, Jeong-Hoo Lee, Yeon-Jin Kim, Inseong Hwang, Young-Youn Kim, Hye-Sung Kim, Do-Young Park","doi":"10.5051/jpis.2304520226","DOIUrl":"10.5051/jpis.2304520226","url":null,"abstract":"<p><strong>Purpose: </strong>Quantitative polymerase chain reaction (qPCR) has recently been employed to measure the number of bacterial cells by quantifying their DNA fragments. However, this method can yield inaccurate bacterial cell counts because the number of DNA fragments varies among different bacterial species. To resolve this issue, we developed a novel optimized qPCR method to quantify bacterial colony-forming units (CFUs), thereby ensuring a highly accurate count of bacterial cells.</p><p><strong>Methods: </strong>To establish a new qPCR method for quantifying 6 oral bacteria namely, <i>Porphyromonas gingivalis</i>, <i>Treponema denticola</i>, <i>Tannerella forsythia</i>, <i>Prevotella intermedia</i>, <i>Fusobacterium nucleatum</i>, and <i>Streptococcus mutans</i>, the most appropriate primer-probe sets were selected based on sensitivity and specificity. To optimize the qPCR for predicting bacterial CFUs, standard curves were produced by plotting bacterial CFU against Ct values. To validate the accuracy of the predicted CFU values, a spiking study was conducted to calculate the recovery rates of the predicted CFUs to the true CFUs. To evaluate the reliability of the predicted CFU values, the consistency between the optimized qPCR method and shotgun metagenome sequencing (SMS) was assessed by comparing the relative abundance of the bacterial composition.</p><p><strong>Results: </strong>For each bacterium, the selected primer-probe set amplified serial-diluted standard templates indicative of bacterial CFUs. The resultant Ct values and the corresponding bacterial CFU values were used to construct a standard curve, the linearity of which was determined by a coefficient of determination (<i>r</i>²) >0.99. The accuracy of the predicted CFU values was validated by recovery rates ranging from 95.1% to 106.8%. The reliability of the predicted CFUs was reflected by the consistency between the optimized qPCR and SMS, as demonstrated by a Spearman rank correlation coefficient (<i>ρ</i>) value of 1 for all 6 bacteria.</p><p><strong>Conclusions: </strong>The CFU-based qPCR quantification method provides highly accurate and reliable quantitation of oral pathogenic bacteria.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"444-457"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the biocompatibility and osteogenesis potential of whitlockite and an activin A/BMP2 chimera using a rat calvarial defect model: a pilot study.","authors":"Jung-Tae Lee, Sungtae Kim","doi":"10.5051/jpis.2304280214","DOIUrl":"10.5051/jpis.2304280214","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate bone regeneration using whitlockite (WH) nanoparticles, collagenated bovine bone mineral, and an activin A/BMP2 chimera (AB204) on calvarial defects in rats.</p><p><strong>Methods: </strong>This study was conducted using 8 rats. Five-millimeter circular defects were formed on each side of the calvaria. The defects were randomly assigned to 3 groups (BO group: BioOss collagen, BO/WH group: BO + WH, and BO/WH/AB204 group: BO + WH + AB204). After healing periods of 2 and 4 weeks, histological and histomorphometric analyses were performed after sacrifice.</p><p><strong>Results: </strong>The BO/WH/AB204 group showed superior bone healing compared to the other 2 groups (BO and BO/WH). In the BO and BO/WH groups, new bone formation was found in the defect margin. However, in the BO/WH/AB204 group, new bone was observed on the upper and lower surfaces of the grafted area. The new bone area of the BO/WH/AB204 group at 4 weeks was significantly higher than that of the same group at 2 weeks. At 4 weeks, the total augmented area and material area in the BO/WH/AB204 group were significantly lower than the corresponding values at 2 weeks.</p><p><strong>Conclusions: </strong>The BO/WH/AB204 group showed superior results of bone regeneration at 2 and 4 weeks compared to the BO and BO/WH groups. AB204 seems to play an important role in bone regeneration.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"432-443"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic potential of Frondoside A in human periodontal ligament cells: an RNA-Seq analysis.","authors":"Young Kim, Si-Won Kang, Ju Ri Ye, Seong Eun Kim, Yong Kwon Chae, Ok Hyung Nam","doi":"10.5051/jpis.2303840192","DOIUrl":"10.5051/jpis.2303840192","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the effects of Frondoside A (FA) on the osteogenic differentiation of human periodontal ligament (PDL) cells.</p><p><strong>Methods: </strong>Human PDL cells were cultured in osteogenic medium and treated with FA at concentrations of 0, 0.05, and 0.2 µM for 14 days. The expression levels of genes associated with osteogenic differentiation were assessed using quantitative real-time polymerase chain reaction analysis. Subsequently, RNA sequencing was performed to identify enriched gene sets following FA treatment. Alkaline phosphatase (ALP) activity was measured to confirm the osteogenic potential of FA.</p><p><strong>Results: </strong>Treatment with 0.2 µM FA significantly increased the expression levels of runt-related transcription factor 2 (<i>RUNX2</i>), <i>ALP</i>, and osteocalcin (<i>OCN</i>) at day 3, while also significantly elevating the expression of dentin sialophosphoprotein (<i>DSPP</i>), <i>RUNX2</i>, <i>ALP</i>, <i>OCN</i>, and osterix (<i>OSX</i>) at day 14 (<i>P</i><0.017). Hallmark gene sets enriched during FA treatment were associated with the KRAS (normalized enrichment score [NES]=2.02, <i>Q</i>=0.000), interferon alpha (IFN-α) (NES=1.88, <i>Q</i>=0.001), IFN-γ (NES=1.85, <i>Q</i><0.001), hypoxia (NES=1.79, <i>Q</i>=0.001), and p53 (NES=1.77, <i>Q</i>=0.001) signaling pathways. Additionally, treatment with 0.2 µM FA significantly intensified ALP staining at day 14 (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Within the limitations of this study, FA treatment influenced periodontal regeneration by promoting the osteogenic differentiation of human PDL cells.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"393-404"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial, dental, periodontal, and tomographic characteristics of the etiology of excessive gingival display: a cross-sectional clinical study.","authors":"Luciana Tanaka de Castro, Maria Carolina Candosin Sementille, Mariana Schutzer Ragghianti Zangrando, Sebastião Luiz Aguiar Greghi, Carla Andreotti Damante, Eduardo Sant'Ana, Adriana Campos Passanezi Sant'Ana","doi":"10.5051/jpis.2302300115","DOIUrl":"10.5051/jpis.2302300115","url":null,"abstract":"<p><strong>Purpose: </strong>In this study, we examined the facial, dental, periodontal, and tomographic features associated with excessive gingival display (EGD) when smiling in young adults self-reporting a \"gummy smile,\" categorized by potential etiology.</p><p><strong>Methods: </strong>The study included 25 healthy adults (18-42 years old; 23 women and 2 men) who self-reported EGD. Participants completed a health questionnaire and underwent a periodontal examination assessing probing depth, clinical attachment level, keratinized gingival width, and gingival thickness (GT). Extraoral and intraoral photographs were taken for smile analysis and to determine facial and dental characteristics. Cone-beam computed tomography (CBCT), performed with a lip retractor in place, was used to measure the distance from the gingival margin (GM) to the cementoenamel junction (CEJ), the distance from the CEJ to the alveolar crest, buccal bone thickness, and GT. The extent of EGD when smiling was quantified as the distance from the GM at the upper central incisor to the upper lip edge when smiling fully. The smile was categorized into 4 types based on gingival exposure characteristics observed during full smile.</p><p><strong>Results: </strong>Most participants were female (92%), with a mean age of 28.77±6.56 years. The average EGD was 4.2±2.44 mm, extending bilaterally from the anterior to the posterior maxilla. Two primary etiological factors were identified, alone or in combination: vertical maxillary excess (VME), predominantly indicated by an anterior maxillary height greater than 29 mm and a large interlabial gap; and altered passive/active eruption (APE), primarily characterized by square teeth (64%), upper central incisor width-to-height ratio (CIW:CIH) exceeding 87.5%, and GM-CEJ distance on CBCT exceeding 2 mm.</p><p><strong>Conclusions: </strong>These findings suggest a multifactorial etiology of EGD, primarily associated with VME and APE. Clinical periodontal examination, CBCT conducted with a lip retractor, CIW:CIH, and soft tissue facial cephalometric analysis may aid in identifying the etiological factors of EGD.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"419-431"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current understanding of the etiology, diagnosis, treatment, and management of peri-implant diseases: a narrative review for the consensus report of the Korean Academy of Periodontology.","authors":"Yun-Jeong Kim, Young Woo Song, Shin-Young Park, Jae-Kook Cha, Hyo-Jung Lee, Seung-Min Yang, Jun-Beom Park, Ki-Tae Koo","doi":"10.5051/jpis.2403920196","DOIUrl":"10.5051/jpis.2403920196","url":null,"abstract":"<p><p>Over the past few decades, dental implants have been successfully utilized to replace teeth lost due to periodontal disease and other conditions. However, similar to natural teeth, dental implants are vulnerable to inflammatory peri-implant diseases, which can compromise their long-term viability. This review aims to summarize the current understanding of peri-implant diseases and discuss effective strategies for their diagnosis, treatment, and long-term management. Evidence related to peri-implant diseases was categorized and reviewed in 4 sections: 1) definition, prevalence, and classification; 2) risk indicators and etiological factors; 3) diagnostic criteria; and 4) treatment protocols for peri-implant diseases. The prevalence of peri-implant mucositis and peri-implantitis is significant, affecting 43% and 22% of implant cases, respectively. Key risk factors include poor oral hygiene, a history of periodontitis, and systemic conditions such as diabetes and smoking. The outcomes of treatment are influenced by the design of the implant prosthesis and the condition of the surrounding soft tissue. Management strategies include: 1) non-surgical treatment for implants diagnosed with peri-implant mucositis; 2) comprehensive treatment, which involves both mechanical and chemical debridement and surgical access, for implants affected by peri-implantitis; and 3) removal of failed implants, followed by the restoration of pre-existing peri-implant bone defects. Managing peri-implant diseases necessitates a comprehensive approach, encompassing risk assessment, tailored treatment planning, and stringent maintenance protocols. Regular follow-ups and patient education are critical for preventing disease recurrence and ensure the long-term success of implant therapy.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"54 6","pages":"377-392"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early wound healing at 1 week postoperatively in periodontal tissue regeneration therapy: enamel matrix derivative versus recombinant human fibroblast growth factor.","authors":"Yohei Nakayama, Moe Ogihara-Takeda, Yumi Saito, Arisa Yamaguchi, Yorimasa Ogata","doi":"10.5051/jpis.2400740037","DOIUrl":"10.5051/jpis.2400740037","url":null,"abstract":"<p><strong>Purpose: </strong>Recombinant human fibroblast growth factor-2 (rhFGF-2) has demonstrated positive effects on wound healing at 2 weeks after periodontal surgery relative to enamel matrix derivative (EMD). However, the effects at earlier postoperative stages have not been reported. This retrospective study compared the early wound healing outcomes 1 week after surgery using the modified papilla preservation technique (mPPT) with either EMD or rhFGF-2 therapy.</p><p><strong>Methods: </strong>We compiled a list of all mPPT sites treated with EMD or rhFGF-2 during the survey period (September 2011 to March 2022). Early wound healing was assessed using the early wound healing score (EHS) and the modified early wound healing index (mEHI). Inter-rater reliability for the EHS and mEHI was established using intraclass correlation coefficients. Factors influencing mPPT were identified by analyzing the correlation coefficients between the EHS items, mEHI items, and potential influencing factors. After adjusting for factors impacting EHS, mEHI, and mPPT, we compared the EHS and mEHI between EMD and rhFGF-2 groups.</p><p><strong>Results: </strong>In total, 72 sites were evaluated. The scores for incision line, step, and dehiscence were significantly higher in those receiving rhFGF-2 (n=42) compared to those treated with EMD (n=30). The EHS item scores did not differ significantly between groups. Among patients aged ≥50 years, but not those <50 years, significantly higher step and dehiscence scores were found in the rhFGF-2 group than the EMD group (<i>P</i><0.01). Additionally, for patients exhibiting a clinical attachment level (CAL) ≥8 mm, the step score was significantly higher in the rhFGF-2 group than in the EMD group (<i>P</i><0.05), but this trend was not reflected in those with a CAL <8 mm.</p><p><strong>Conclusions: </strong>In this study, early wound closure at mPPT sites was more effectively achieved with rhFGF-2 than with EMD. Nevertheless, biochemical assessments are required to compare the re-epithelialization effects of these therapies.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"405-418"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2023 Journal Citation Report impact factor update and achievements for the <i>Journal of Periodontal & Implant Science</i>.","authors":"Jun-Beom Park, Shin-Young Park, Jung-Chul Park, Yong-Gun Kim, Hwan Tae Ahn, Seung-Yun Shin","doi":"10.5051/jpis.245406edi01","DOIUrl":"10.5051/jpis.245406edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"54 6","pages":"375-376"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}