Journal of Periodontal and Implant Science最新文献

{"title":"Early healing of soft tissue following alveolar ridge preservation according to the sealing material: a retrospective clinical study.","authors":"Ga-Ram Jung, Jin-Young Park, Chang-Sung Kim","doi":"10.5051/jpis.2505320266","DOIUrl":"https://doi.org/10.5051/jpis.2505320266","url":null,"abstract":"<p><strong>Purpose: </strong>This study compared early soft-tissue healing after open-healing alveolar ridge preservation (ARP) in periodontally compromised extraction sockets according to the type of resorbable sealing material used.</p><p><strong>Methods: </strong>A total of 127 extraction sockets were categorized into 3 groups according to the sealing material used: (i) absorbable atelocollagen sponge, (ii) resorbable non-cross-linked collagen membrane (CM group), and (iii) acellular dermal matrix. Serial intraoral photographs were obtained at 4 time points: immediately after surgery (T0), at 1.0±0.3 weeks (T1), at 4±1 weeks (T2), and at 15±3 weeks (T3). The primary outcome was open wound percentage, which was used to characterize early soft-tissue healing. Secondary outcomes included the Modified Early Wound Healing Score (m-EHS), time to complete epithelialization, the need for additional bone grafting at implant placement, and marginal bone loss (MBL) after implantation.</p><p><strong>Results: </strong>The CM group showed a distinct early healing pattern characterized by a transient increase in wound exposure at T1. This group also had a significantly higher frequency of additional bone grafting at implant placement (<i>P</i>=0.001). However, MBL after implantation did not differ significantly among the groups. A higher open wound percentage at 1 week postoperatively was positively correlated with greater distal MBL (<i>P</i>=0.006). The m-EHS and final epithelialization time did not differ significantly among the groups.</p><p><strong>Conclusions: </strong>Early soft-tissue healing after open-healing ARP varied according to the sealing material used. The CM group showed greater early wound exposure and more frequent additional grafting. Greater early wound exposure was also associated with greater distal bone loss. These findings suggest that sealing material characteristics may influence early healing and later clinical outcomes.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of vestibule depth with peri-implant inflammation and soft tissue stability independent of keratinized mucosa width: a cross-sectional study.","authors":"Berkin Inan, Hanife Merva Parlak, Gokcen Akcicek, M Baris Guncu, Abdullah C Akman, Ayhan Parmaksiz, H Gencay Keceli, Guliz N Guncu","doi":"10.5051/jpis.2503220161","DOIUrl":"https://doi.org/10.5051/jpis.2503220161","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated whether vestibule depth (VD) affects peri-implant inflammation and mucosal margin stability in the posterior mandible independently of keratinized mucosa width (KMW).</p><p><strong>Methods: </strong>A total of 129 patients, each with a single implant in the mandibular premolar or molar region, were included. Clinical variables, including gingival index, plaque index (PI), peri-implant probing depth, clinical attachment level (CAL), gingival bleeding time index (GBTI), VD, KMW, mucosal thickness (MT), mucosal recession (MR), peri-implant soft tissue phenotype, and peri-implant soft tissue dehiscence (PISTD), were assessed. Multiple linear regression analysis was performed to determine the associations of GBTI, MR, and PISTD type with the independent variables PI, KMW, age, implant diameter, sex, function time, implant location, CAL, MT, VD, and phenotype classification.</p><p><strong>Results: </strong>Implants with adequate KMW (≥2 mm) displayed greater VD and MT, less MR, and a thicker phenotype than implants with inadequate KMW (<2 mm) (<i>P</i><0.001 for all). PISTD class II defects were observed more frequently in the group with adequate KMW, whereas class III defects were more common among the patients with inadequate KMW (<i>P</i>=0.001). Implants with sufficient VD (≥6 mm) showed greater KMW and MT and less MR than implants with insufficient VD (<6 mm) (<i>P</i>=0.026 for MR; <i>P</i><0.001 for all other comparisons). Based on the multiple regression analysis, KMW was significantly associated with GBTI, MR, and PISTD types and subtypes (<i>P</i><0.05 for all), whereas VD was not significantly associated with any of these variables.</p><p><strong>Conclusions: </strong>VD was not significantly associated with peri-implant inflammation or soft tissue stability, whereas KMW showed a stronger association with these parameters. These findings suggest that KMW, independent of VD, plays an important role in peri-implant soft tissue health in the posterior mandible.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based assessment of periodontitis progression using serial panoramic radiographs: a multicenter study incorporating indirect and direct grading approaches.","authors":"Keun-Suh Kim, Chun-Ui Lee, Jun-Seok Kang, Woo-Joo Kim, Hyo-Jung Lee, Jae-Hong Lee","doi":"10.5051/jpis.2504860243","DOIUrl":"https://doi.org/10.5051/jpis.2504860243","url":null,"abstract":"<p><strong>Purpose: </strong>This multicenter study aimed to evaluate the diagnostic performance and clinical feasibility of a deep learning (DL) model for assessing periodontitis progression using serial panoramic radiographs.</p><p><strong>Methods: </strong>A total of 7,106 panoramic images from 1,378 patients were retrospectively collected from 3 university hospitals. A YOLOv8-based DL model was trained separately for indirect (single-timepoint) and direct (serial) assessments to segment and classify alveolar bone levels. Diagnostic performance metrics, including accuracy, sensitivity, specificity, and the area under the receiver operating characteristic (ROC) curve (AUC), were evaluated for both the DL model and human evaluators. Comparative ROC analyses and assessment-time comparisons were conducted to evaluate discriminative ability and efficiency.</p><p><strong>Results: </strong>The DL model demonstrated high diagnostic accuracy, particularly for indirect grading (accuracy, 89.6%; AUC, 0.913), and outperformed both interns and periodontal residents. Direct grading also performed well (accuracy, 79.5%; AUC, 0.854), although this performance was slightly lower due to the greater complexity of evaluating serial images. The DL model outperformed human evaluators (accuracy range, 38.0%-80.0%) while requiring significantly less assessment time (91.0±6.8 seconds vs. 143.7±33.6 seconds for interns).</p><p><strong>Conclusions: </strong>This multicenter study demonstrates that DL-based assessment of periodontitis progression using serial panoramic radiographs achieves high diagnostic accuracy (89.6% and 79.5% for indirect and direct assessment, respectively) while markedly improving time efficiency. This approach has strong potential as a standardized adjunctive diagnostic tool for periodontal clinical decision-making.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of abutment- or implant-level fixed partial dentures on marginal bone level around implants in vertically thickened soft tissues: a 1-year follow-up randomized clinical trial.","authors":"Imantas Vatenas, Ki-Tae Koo, Jungwon Lee, Rimgaile Rinkeviciutė, Jonas Alkimavicius, Laura Linkeviciene, Tomas Linkevicius","doi":"10.5051/jpis.2504740237","DOIUrl":"https://doi.org/10.5051/jpis.2504740237","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated phase-specific peri-implant marginal bone level (MBL) changes associated with abutment disconnection and reconnection during prosthetic procedures by comparing implant-level (IL) and abutment-level (AL) restorative protocols over a 1-year period.</p><p><strong>Methods: </strong>This two-arm randomized controlled clinical trial included patients receiving posterior mandibular fixed partial dentures following soft tissue augmentation. Implants were randomly assigned (1:1) to IL or AL protocols. In the IL group, repeated abutment disconnection and reconnection were performed during prosthetic procedures, whereas in the AL group, a definitive abutment was connected and maintained without disconnection. Standardized periapical radiographs were obtained at implant placement (T0), 2 weeks after second-stage surgery (T1), at definitive prosthesis delivery (T2), and 1 year after loading (T3). MBL changes were analyzed by phase: suprastructure connection (T1-T0), prosthetic (T2-T1), maintenance (T3-T2), and cumulative (T3-T0). Statistical significance was set at <i>P</i><0.05.</p><p><strong>Results: </strong>Implant success was 100% at 1 year in both groups. In the IL group, MBL changes were Δ(T1-T0)=-0.41±0.43 mm, Δ(T2-T1)=-0.34±0.38 mm, and Δ(T3-T2)=-0.31±0.43 mm, with a cumulative change of Δ(T3-T0)=-1.06±0.49 mm. In the AL group, the corresponding values were -0.81±0.44 mm, -0.14±0.24 mm, -0.12±0.30 mm, and -1.08±0.39 mm, respectively. Phase-specific remodeling differed between protocols, whereas the cumulative 1-year change was comparable.</p><p><strong>Conclusions: </strong>Under conditions of vertical soft tissue augmentation, abutment disconnection and reconnection were associated with phase-specific MBL remodeling; however, cumulative 1-year MBL changes were similar between IL and AL protocols.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the depth of surface decontamination during peri-implantitis treatment: a scanning electron microscopy analysis.","authors":"Jinho Chung, Jung-Seok Lee, Young-Taek Kim, Bo-Ah Lee","doi":"10.5051/jpis.2501940097","DOIUrl":"https://doi.org/10.5051/jpis.2501940097","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective in treating peri-implantitis is the elimination of biofilm from the implant surface. This study aimed to measure the width of the contaminant-free zone in implants removed from patients and to determine the extent of surface decontamination achieved during peri-implantitis treatment.</p><p><strong>Methods: </strong>Patients presenting with the chief complaint of implant discomfort were recruited. The inclusion criterion was implant removal due to biological or mechanical complications, including marginal bone loss extending to the apical third of the implant fixture, fixture tearing, or fixture fractures. Removed implants were analyzed using scanning electron microscopy (SEM). The width of the contaminant-free zone was defined as the distance from the apical end of the biofilm to the apical and coronal first bone-to-implant contact, measured with a caliper in conjunction with SEM. The mean width of the contaminant-free zone was compared across implant characteristics using the independent <i>t</i>-test.</p><p><strong>Results: </strong>A total of 49 implants were removed from 39 patients. The mean width of the contaminant-free zone was 0.66±0.67 mm (range, 0-3.0 mm). No significant differences in the width of the contaminant-free zone were observed according to sex, age, presence of diabetes, smoking habits, implant location, reason for removal, fixture type, fixture length, or prosthetic type (<i>P</i>>0.05). No variable significantly affected the width of the contaminant-free zone.</p><p><strong>Conclusions: </strong>The width of the contaminant-free zone was found to be less than 1 mm. Therefore, precise and delicate debridement of all fixture surfaces above the remaining marginal bone is required during peri-implantitis treatment.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The implementation of implant placement protocols and their short-term impact on marginal bone levels in the esthetic zone: a retrospective cohort study.","authors":"Mahpareh Marefat, Duong Tran, Irina Dragan, Hayel Abdul-Ghani, Robert Maxwell Watson, Bishoy Anis Saad, Elsy D Orellana","doi":"10.5051/jpis.2403740187","DOIUrl":"https://doi.org/10.5051/jpis.2403740187","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to estimate the prevalence of International Team for Implantology (ITI)-defined implant placement and loading protocols in the maxillary anterior region. Secondary aims were to assess the impact of different ITI protocols on short-term peri-implant marginal bone levels and implant failure following prosthetic loading.</p><p><strong>Methods: </strong>A retrospective chart review was conducted on 468 implants placed in partially edentulous patients at Tufts University School of Dental Medicine between 2014 and 2018. Implant placement was categorized into 4 groups: immediate placement following extraction; placement after 4-8 weeks; placement after 12-16 weeks; and placement after 6 months. Prosthetic loading was categorized into 3 groups: immediate loading within 1 week, loading between 1 week and 2 months, and loading after 2 months. Mesial and distal bone levels were measured on periapical radiographs at baseline after implant placement and at the final visit of a 12-month follow-up period using the AxiUm ruler tool, with adjustments for radiographic distortion.</p><p><strong>Results: </strong>Most implants (53.2%) were placed at least 6 months post-extraction and loaded after more than 2 months. Additionally, 17.5% of implants were placed in fresh extraction sockets but loaded after more than 2 months. No significant differences in short-term marginal bone levels or implant failure were observed among ITI protocol groups. However, mesial and distal bone loss increased by 0.061 mm and 0.066 mm, respectively, for every 1-mm increase in implant length. Furthermore, Nobel implants exhibited significantly greater mesial bone loss (0.336 mm) and distal bone loss (0.262 mm) compared with Straumann implants.</p><p><strong>Conclusions: </strong>Although no significant differences were observed in short-term marginal bone levels and implant failure among protocols, the study suggested that implant length and brand might affect marginal bone loss, but further long-term studies are needed to draw more definitive conclusions and explore additional factors impacting implant success.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of preclinical animal models for bone regeneration: comparative and translational insights from rodents to large animals.","authors":"Dongseob Lee, Yong-Moo Lee, Ki-Tae Koo, Seung-Ju Lee, Young-Chang Ko, Jungwon Lee","doi":"10.5051/jpis.2505280264","DOIUrl":"https://doi.org/10.5051/jpis.2505280264","url":null,"abstract":"<p><p>Preclinical animal models are essential for evaluating the biological performance, safety, and translational potential of bone regeneration strategies before human application. Because no single species can fully replicate human skeletal biology, careful selection of an appropriate model is necessary to generate reliable and clinically meaningful evidence. This narrative review summarizes the characteristics, advantages, and limitations of commonly used experimental species, with particular emphasis on their anatomical and biomechanical similarity to humans and their suitability for modeling localized and systemic bone-healing conditions. Rodent models are widely used for early-stage screening because they are cost-effective, genetically manipulable, and well-suited for mechanistic studies. However, their limited cortical thickness, strong intrinsic healing capacity, and lack of true Haversian remodeling reduce their translational applicability for evaluating large defects or load-bearing sites. Rabbit models provide an intermediate platform for testing medium-sized defects, with more clearly defined critical-size thresholds and partial Haversian remodeling. Dogs offer clinically realistic surgical handling, human-like bone remodeling, and the ability to standardize complex intraoral defects, although their use is declining because of ethical and regulatory considerations. Minipigs and pigs show the closest correspondence to human craniofacial bone structure, density, and biomechanics, making them highly valuable for late-stage translational validation. However, their strong healing potential and large body size require carefully standardized defect designs and rigorous experimental controls. Across all species, acute versus chronic defects, infected versus noninfected environments, and systemically healthy versus compromised conditions substantially influence healing outcomes. Standardized defect dimensions, appropriate observation periods, and robust quantitative assessment methods are critical for ensuring reproducibility. An understanding of species-specific healing patterns and methodological considerations enables investigators to design preclinical experiments that more closely reflect clinical scenarios and support the development of predictable regenerative therapies.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of gingival junctional epithelium-associated genes reflected in periodontal clinical parameters.","authors":"Misaki Matsuzaki, Yoshito Ochiai, Takumi Morita, Kazuma Igarashi, Masatomo Wada, Yumi Saito, Arisa Yamaguchi, Mizuho Yamazaki-Takai, Hideki Takai, Yorimasa Ogata, Yohei Nakayama","doi":"10.5051/jpis.2504980249","DOIUrl":"https://doi.org/10.5051/jpis.2504980249","url":null,"abstract":"<p><strong>Purpose: </strong>The expression of gingival junctional epithelium (JE)-associated genes, including amelotin (<i>AMTN</i>), odontogenic ameloblast-associated protein (<i>ODAM</i>), and follicular dendritic cell-secreted protein (<i>FDCSP</i>), has been reported to increase during gingival inflammation. However, the associations between the expression levels of JE-associated genes and periodontal clinical parameters remain unclear. This study aimed to investigate this association.</p><p><strong>Methods: </strong>The study included patients with chronic periodontitis who were undergoing supportive periodontal therapy (SPT). Saliva samples were collected and analyzed using quantitative real-time polymerase chain reaction. Statistical analyses were performed to determine the associations between the RNA levels of JE-associated genes and periodontal clinical parameters.</p><p><strong>Results: </strong>In total, 101 patients were included in this study. After excluding undetectable values for JE-associated gene messenger RNA levels, Spearman rank correlation analysis revealed weak positive correlations between <i>AMTN</i> expression and the bleeding on probing (BOP) rate (n=46, <i>r_s</i>=0.4152), periodontal inflamed surface area (<i>r_s</i>=0.3912), and the proportion of sites with probing depth of 4-5 mm (<i>r_s</i>=0.3270). No significant correlations were observed between <i>ODAM</i> (n=79) or <i>FDCSP</i> (n=84) expression and periodontal clinical parameters. Multiple regression analysis using these clinical parameters as response variables and JE-associated genes as explanatory variables revealed a positive association between <i>AMTN</i> expression and BOP rate. In a second regression model with the reverse structure, <i>AMTN</i> expression was also associated with significant differences in BOP rate. Receiver operating characteristic curve analysis further indicated a significant relationship between <i>AMTN</i> expression and a 9% BOP rate threshold.</p><p><strong>Conclusions: </strong>Despite the limited sample size resulting from undetectable JE-associated gene expression levels, salivary <i>AMTN</i> expression may have potential as a biomarker for the ancillary evaluation of periodontal inflammatory activity during SPT. Further studies with larger sample sizes are needed to confirm these findings across diverse populations.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of miR-155 and IL-6 in the shared pathogenesis of periodontitis and rheumatoid arthritis: a cross-sectional case-control study.","authors":"Kratee Sharma, Archisha Bansal, Veerubhotla Shanmuka Kedarnath, Kothinti Sreevathsa Reddy, Shweta Aggarwal, Chirag Gupta, Seema Gupta, Manish Sharma","doi":"10.5051/jpis.2504300215","DOIUrl":"https://doi.org/10.5051/jpis.2504300215","url":null,"abstract":"<p><strong>Purpose: </strong>Periodontitis (PD) and rheumatoid arthritis (RA) share inflammatory pathways, with interleukin-6 (IL-6) and microRNA-155 (miR-155) implicated as key mediators. This study quantified salivary IL-6 and serum miR-155 levels across 4 groups (PD only, RA only with a healthy periodontium, comorbid PD+RA, and healthy controls) and examined their associations with clinical severity indices of both diseases.</p><p><strong>Methods: </strong>This cross-sectional case-control study enrolled 120 participants (30 per group). Periodontitis was diagnosed according to the 2017 American Academy of Periodontology/European Federation of Periodontology classification, and RA was diagnosed according to the 2010 American College of Rheumatology/European League Against Rheumatism criteria. Salivary IL-6 and serum miR-155 were measured using quantitative real-time polymerase chain reaction.</p><p><strong>Results: </strong>Combined salivary IL-6 and serum miR-155 expression differed significantly across groups (multivariate analysis of covariance, Pillai's trace=0.892, <i>P</i><0.001), with the highest levels observed in the comorbid group. Both biomarkers showed strong positive correlations with periodontal clinical parameters (Spearman ρ=0.704-0.958) and moderate-to-strong correlations with RA disease activity measures (ρ=0.391-0.782; all <i>P</i><0.001). The periodontal severity composite score explained 94.3% of the variance and correlated most strongly with IL-6 (ρ=0.958). Receiver operating characteristic analyses yielded area under the curve (AUC) values of 0.75-1.00, including perfect discrimination (AUC=1.00) in multiple comparisons.</p><p><strong>Conclusions: </strong>Salivary IL-6 and serum miR-155 were strongly associated with the presence and severity of both PD and RA and were markedly elevated in comorbid cases, supporting their potential as biomarkers. Longitudinal studies are needed to establish temporality and causality.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMP9 promotes peri-implant osseointegration in beagle defects.","authors":"Hee-Seung Han, Dong Woo Lee, Sungtae Kim, Jue Yeon Lee, Yoon Jeong Park, Chong Pyung Chung, Young-Dan Cho","doi":"10.5051/jpis.2505500275","DOIUrl":"https://doi.org/10.5051/jpis.2505500275","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the <i>in vivo</i> efficacy of bone morphogenetic protein 9 (BMP9) relative to bone morphogenetic protein 2 (BMP2) in a beagle peri-implant critical-size defect model.</p><p><strong>Methods: </strong>Peri-implant defects were created in beagle dogs and treated with either a collagen sponge (CS) or deproteinized bovine bone mineral with collagen (OCS-B Xenomatrix collagen [OCS-BC]), with or without BMP2 or BMP9. After 8 weeks, bone regeneration and osseointegration were evaluated using radiographic, histological, and biomechanical analyses.</p><p><strong>Results: </strong>Radiographic analysis demonstrated that BMP treatment significantly increased peri-implant mineralization, with bone mineral density increasing from 0.597±0.151 (control) to 0.896±0.173 in the CS+BMP9 group (<i>P</i><0.0001). Histological and histomorphometric analyses corroborated these findings, showing greater new bone formation and higher bone-to-implant contact (BIC) (7.943±7.048 vs. 68.90±20.27 in the CS+BMP9 group; <i>P</i><0.05) without overt inflammatory reactions. Region-of-interest (ROI)-based micro-computed tomography analysis (200 μm) and resonance frequency analysis further supported improved osseointegration and stability, with osseointegration increasing from 20.32±6.976 to 70.37±0.785 in the CS+BMP9 group (<i>P</i><0.0001) and the implant stability quotient (ISQ) peaking at 70.92±3.523 in the OCS-BC+BMP9 group (<i>P</i><0.0001). Two-way analysis of variance indicated scaffold-dependent magnitudes for bulk endpoints, whereas interaction terms were not significant for BIC, ROI-based osseointegration, or ISQ, supporting preservation of BMP9-associated benefits across scaffold types for these outcomes.</p><p><strong>Conclusions: </strong>BMP9 produced overall improvements comparable to BMP2 and may provide more reproducible osseointegration-related outcomes across scaffold types.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}