Journal of Periodontal and Implant Science最新文献

{"title":"Bone regenerative therapy using molded collagenated equine bone mineral with rhBMP-2 in a canine peri-implantitis model: a proof of concept.","authors":"Hyun Ju Kim, Kyoung-Hwa Kim, Jin Uk Choi, Yong-Moo Lee, Yang-Jo Seol","doi":"10.5051/jpis.2501820091","DOIUrl":"10.5051/jpis.2501820091","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to establish a proof of concept for the guided bone regeneration (GBR) procedure using molded collagenated equine bone mineral (CEBM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) in a canine peri-implantitis model, and to identify the key factors essential for effective bone regeneration in peri-implant defects.</p><p><strong>Methods: </strong>Twelve dental implants were placed in the mandibles of 4 adult male beagle dogs. Each implant was randomly assigned to 1 of 3 groups: GBR with molded CEBM soaked in rhBMP-2 solution (CEBM/BMP2 group, n=4); GBR with molded CEBM alone (CEBM group, n=4); or open flap debridement (OFD group, n=4). Peri-implantitis was induced using cotton retraction cords following osseointegration. After ligature removal, all groups underwent OFD with implant surface decontamination, and GBR was subsequently performed according to group allocation. No further treatment was provided in the OFD group. Clinical and radiographic evaluations were conducted at 4-week intervals, and at 16 weeks, histological, fluorescent labeling, and micro-computed tomographic (micro-CT) analyses were performed.</p><p><strong>Results: </strong>The CEBM/BMP2 group demonstrated a significantly higher bone volume fraction in micro-CT analysis, alongside superior histomorphometric outcomes, including greater first bone-to-implant contact height, crestal height, and new bone area. The mean re-osseointegration ratio was notably higher in the CEBM/BMP2 group (buccal: 74%, lingual: 94%) compared to both the CEBM (buccal: 20%, lingual: 35%) and OFD groups (buccal: 12%, lingual: 45%).</p><p><strong>Conclusions: </strong>The GBR procedure using molded CEBM with rhBMP-2 substantially enhanced new bone formation and implant re-osseointegration in peri-implantitis-associated defects, compared to molded CEBM alone or OFD without GBR.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"145-160"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone regenerative capacity of the newly synthesized material QG3030: an <i>in vitro</i> and <i>in vivo</i> study.","authors":"Nguyen Pham-Hanh Luong, Kyoung-Hwa Kim, Ji-Eun Kook, Yang-Jo Seol","doi":"10.5051/jpis.2502920146","DOIUrl":"10.5051/jpis.2502920146","url":null,"abstract":"<p><strong>Purpose: </strong>Current bone grafting materials often lack inherent osteoinductive properties, underscoring the need for new therapeutic agents that promote regeneration. In this study, we evaluated the effects of QG3030, a novel osteoinductive derivative of lappaconitine, on the proliferation and osteogenic differentiation of rat bone marrow-derived stem cells (BMSCs) <i>in vitro</i>. Furthermore, we examined its influence on bone regeneration <i>in vivo</i> using a rat calvarial critical-sized defect model.</p><p><strong>Methods: </strong>The effects of QG3030 on BMSC proliferation and osteogenic differentiation were assessed <i>in vitro</i> using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the alkaline phosphatase (ALP) activity assay, and alizarin red S staining. For <i>in vivo</i> evaluation, 18 Sprague-Dawley rats with 8-mm critical-sized calvarial defects were randomly assigned to 3 groups (n=6 per group): deproteinized bovine bone mineral (DBBM; Bio-Oss) alone (B0, control), DBBM combined with 100 mg/mL QG3030 (B100), and DBBM combined with 300 mg/mL QG3030 (B300). Bone regeneration was analyzed after 8 weeks by micro-computed tomography (micro-CT), histology, and histomorphometry.</p><p><strong>Results: </strong><i>In vitro</i>, QG3030 improved BMSC viability, significantly increased ALP activity, and promoted matrix mineralization within the tested non-cytotoxic range. On <i>in vivo</i> micro-CT analysis, the B100 group exhibited significantly higher bone mineral density and new bone volume fraction (new bone volume/total volume) than the B0 group (<i>P</i>=0.043 for both). Furthermore, histomorphometry revealed significantly greater new bone area (<i>P</i>=0.046) and percentage of new bone (<i>P</i>=0.032) in the B300 group compared to the B0 group.</p><p><strong>Conclusions: </strong>Combining QG3030 with DBBM significantly enhanced bone regeneration in a rat calvarial critical-sized defect model, with QG3030 demonstrating distinct osteogenic effects both <i>in vitro</i> and <i>in vivo</i>. Accordingly, the combination of QG3030 and DBBM represents a promising therapeutic approach for bone regeneration strategies, especially in periodontology and implant dentistry, and warrants further investigation.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"129-144"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary second molar root fusion: incidence and relationship with alveolar bone loss in ICR mice.","authors":"Yerim Oh, Bo Hyun Jung, Ki-Yeon Yoo, In-Kyung Hwang, Jong-Bin Lee, Heung-Sik Um, Jae-Kwan Lee","doi":"10.5051/jpis.2501080054","DOIUrl":"10.5051/jpis.2501080054","url":null,"abstract":"<p><strong>Purpose: </strong>Fusion of molar roots is a common variation of root morphology known to adversely affect periodontal disease prognosis. Among methods for inducing experimental periodontal disease in animal models, the ligature-induced periodontitis (LIP) mouse model is most frequently employed. However, few studies have examined root abnormalities in experimental mice. This study aimed to investigate the incidence of root fusion in the maxillary second molars of mice and determine its relationship with alveolar bone loss, offering new insights into animal LIP models.</p><p><strong>Methods: </strong>From 2019 to February 2024, 222 Institute of Cancer Research mice (444 maxillary second molars), which served as control animals in periodontitis experiments conducted by the Department of Periodontology and the Department of Anatomy at the College of Dentistry, Gangneung-Wonju National University, were initially examined. After excluding fractured or missing teeth, 402 teeth were included in the final analysis. Root fusion was evaluated using micro-computed tomography and categorized by the degree of fusion. To examine the relationship between fused roots and alveolar bone loss, the distance from the cementoenamel junction to the alveolar bone crest was measured on the mesial and distal sides of the maxillary second molars.</p><p><strong>Results: </strong>Root fusion was found in 10.4% of animals and 6.5% of teeth. Two types of fusion were observed: mesio-palatal (MP) and disto-palatal. Partial root fusion was more frequent than complete fusion. Within the ligation group, teeth with MP fusion exhibited greater alveolar bone loss than those without root fusion (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Within the limitations of this study, maxillary second molars with MP root fusion accelerated alveolar bone loss in ligated teeth in a LIP mouse model. Future research should consider deviations resulting from MP root fusion.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"119-128"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the occasion of the 10th 'scaling with love' event to promote oral health for persons with disabilities.","authors":"Kyoung-Man Min","doi":"10.5051/jpis.265602edi01","DOIUrl":"10.5051/jpis.265602edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"56 2","pages":"83-86"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early healing outcomes of re-entry sinus floor elevation after prior complete sinus membrane perforation: a pilot preclinical study in a rabbit sinus model.","authors":"Hyun-Chang Lim, Seungil Shin, Jong-Hyuk Chung, Yeek Herr","doi":"10.5051/jpis.2501980099","DOIUrl":"10.5051/jpis.2501980099","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the early healing outcomes of re-entry sinus floor elevation (SFE) after previous complete sinus membrane perforation.</p><p><strong>Methods: </strong>In six rabbits, the sinus membrane of one maxillary sinus was intentionally perforated (≥10 mm), and a collagen matrix was applied. SFE was performed on both sinuses after 8 weeks, establishing 2 groups: SFE after previous complete sinus membrane perforation (group SFE_ComPerf) and SFE with an intact sinus membrane (group SFE). The animals were euthanized 4 weeks after SFE. Micro-computed tomographic (micro-CT), histological, and histomorphometric analyses were performed.</p><p><strong>Results: </strong>On micro-CT, no statistically significant differences were observed in total augmented volume or mineralized tissue volume. Histologically, impaired new bone formation was observed near the sinus membrane in the SFE_ComPerf group. Histomorphometric analysis revealed that the area of newly formed bone was significantly smaller in group SFE_ComPerf than in group SFE (5.8±2.7 mm² vs. 10.5±1.9 mm², <i>P</i><0.05). Such reduced bone formation in the SFE_ComPerf group was also evident in one region of interest (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Complete sinus membrane perforation (>10 mm) may compromise new bone formation in re-entry SFE.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"161-171"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of xenogeneic collagen matrices and autogenous graft-based techniques to increase mucosal thickness and keratinised mucosa width at implant sites: are autologous grafts still the gold standard? A systematic review and meta-analysis of randomised clinical trials.","authors":"Néstor Ríos-Osorio, Mangriveth Orozco-Agudelo, Iván Cespedes-Moreno, Marcela Contreras-Ibarra, Mario Guerrero-Torres, Adriana Castro-Calderón, Marggie Grajales, Oscar Jiménez-Peña","doi":"10.5051/jpis.2500260013","DOIUrl":"10.5051/jpis.2500260013","url":null,"abstract":"<p><p>This systematic review compares xenogeneic collagen matrices (XCMs) and autogenous graft-based techniques, focusing on 1) the effectiveness of XCMs (non-crosslinked XCM [XCM*] and crosslinked XCM [VCMX]) vs. connective tissue graft (CTG) for increasing buccal mucosal thickness (MT), and 2) the effectiveness of XCM* vs. free gingival graft (FGG) in augmenting buccal keratinised mucosa width (KMW) at implant sites. MEDLINE (PubMed), Web of Science, and Scopus were searched from inception to August 2024. Randomised controlled trials (RCTs) involving systemically healthy patients with peri-implant mucosal deficiencies (MT <2 mm and/or KMW <2 mm) were included. Studies were required to have 2 parallel control groups comparing XCMs with CTG and/or XCM* with FGG, and a minimum follow-up of 3 months. Data were extracted and analysed using a random-effects model, with risk of bias evaluated via the Cochrane risk of bias tool 2. Seventeen RCTs met inclusion criteria for qualitative synthesis (XCMs vs. CTG, n=12; XCMs vs. FGG, n=5), with 14 RCTs included in the meta-analysis (XCMs vs. CTG, n=9; XCMs vs. FGG, n=5). Subgroup analysis of XCM* or VCMX vs. CTG showed a significantly greater MT increase with CTG than with XCM* (pooled mean difference [MD], 0.27; 95% confidence interval [CI], 0.05 to 0.49; <i>P</i>=0.01). No significant difference in MT was observed between VCMX and CTG (pooled MD, 0.02; 95% CI, -0.17 to 0.22; <i>P</i>=0.83). For KMW, FGG provided a significantly greater increase than XCM* (pooled MD, 1.47; 95% CI, 0.63 to 2.30; <i>P</i>=0.0006). RCTs on XCMs vs. CTG showed moderate risk of bias, while those on XCM* vs. FGG showed low risk. XCM* is less effective than CTG for increasing MT at buccal implant sites, and less effective than FGG for increasing buccal KMW. No statistical difference was found between VCMX and CTG for MT augmentation. Trial Registration: PROSPERO Identifier: CRD42023495454.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"87-118"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of microbiome profiles across sample types in patients with peri-implantitis using 16S rRNA sequencing.","authors":"Da-Mi Kim, Inpyo Hong, Joo-Yeon Lee, Seulbin Im, Kyeong-Won Paeng, Ui-Won Jung, Jae-Kook Cha","doi":"10.5051/jpis.2501680084","DOIUrl":"10.5051/jpis.2501680084","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous studies have applied microbial analyses to peri-implantitis, including analyses of samples collected from various sites. While characteristics of the peri-implantitis microbiome have been identified, differences in sampling methods between studies have not been considered. The present study aimed to (1) characterize microbial similarities among saliva, gingival crevicular fluid (GCF), subgingival plaque (SGP) and inflammatory connective tissue (ICT) within the same participant with peri-implantitis; and (2) determine the microbial profiles of peri-implantitis sites.</p><p><strong>Methods: </strong>Saliva, GCF, and SGP samples were collected from 18 patients undergoing peri-implantitis surgery, and ICT samples were obtained after flap elevation. The collected samples were analyzed using 16S rRNA sequencing.</p><p><strong>Results: </strong>The sampling sites showed a mean bone loss of 6.9 mm and a maximum probing depth (PD) of 8.3 mm. Alpha diversity did not differ significantly among ICT, GCF, and SGP, whereas saliva exhibited a distinct diversity profile. Additionally, beta diversity analyses indicated that the microbial community structure differed significantly between saliva and the other samples. In taxonomic analyses, the microbial profiles of ICT, GCF, and SGP were clearly distinguishable from those of saliva. Saliva had lower proportions of Bacteroidetes and higher proportions of Proteobacteria and Actinobacteria species, especially at sites with deep PD. Pearson correlation analyses revealed strong correlations between ICT and both GCF and SGP, but not between ICT and saliva. Pathogenic species such as <i>Porphyromonas gingivalis</i>, <i>Tannerella forsythia</i>, <i>Treponema denticola</i>, <i>Campylobacter rectus</i>, <i>Filifactor alocis</i>, and <i>Porphyromonas endodontalis</i> were more abundant in ICT than in saliva.</p><p><strong>Conclusions: </strong>ICT, GCF, and SGP shared similar microbial profiles, whereas saliva exhibited a significantly different profile. ICT, GCF, and SGP had higher abundances of peri-implant pathogenic species, whereas saliva tended to have lower abundances; this difference was especially pronounced in deep pockets.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"172-186"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of crushing on the occupying volume ratio of mineralized xenograft in collagenated biomaterials: an <i>in vitro</i> study.","authors":"Betül Hwang, Nicolas Müller, Yoona Jung, Jisu Choi, Jung-Seok Lee","doi":"10.5051/jpis.2504880244","DOIUrl":"https://doi.org/10.5051/jpis.2504880244","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to (1) establish the occupying volume ratio (OVR), defined as the proportion of mineralized particulates within grafted sites, using particulate xenografts mixed with either saline or platelet-rich fibrin (PRF), and (2) evaluate how hydration and mechanical manipulation influence OVR in collagenated block-type xenografts.</p><p><strong>Methods: </strong>Three particulate xenografts and their corresponding collagenated blocks were evaluated. Particulate grafts were mixed with either saline or PRF. Collagenated blocks were assessed under 3 conditions: original, after saline hydration, and after mash-up, defined as mechanical crushing following hydration. All samples were compressed into standardized resin boxes (10×10×10 mm). Micro-computed tomography was used to quantify mineralized volume and calculate OVR.</p><p><strong>Results: </strong>Significant effects of material type (<i>P</i><0.01) and application condition (<i>P</i>=0.04) were observed for particulate grafts. The OVRs were 48.45±11.89% for saline and 44.24±10.37% for PRF. Among the tested materials, deproteinized porcine bone mineral (DPBM)-OX demonstrated the highest OVR under both conditions and showed significantly greater values than deproteinized bovine bone mineral (DBBM) and DPBM-TG (<i>P</i><0.05). In collagenated blocks, OVR decreased significantly in a stepwise manner, from 52.40±7.37% in the original state to 41.91±8.75% after hydration and 33.66±6.07% after mash-up. Following mash-up and standardized recompression within the mold, the mean OVRs were reduced to 35.12±5.97% for DBBM, 37.77±1.85% for DPBM-TG, and 28.10±5.12% for DPBM-OX.</p><p><strong>Conclusions: </strong>Collagenated xenografts undergo a significant reduction in mineral volume density following hydration and mechanical manipulation, which may compromise space maintenance and graft stability. These findings highlight the importance of careful graft handling to preserve volume and optimize regenerative outcomes.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profilometric and radiographic analyses after early implant placement in sites with ridge preservation or spontaneous healing: 3-year follow-up of an exploratory randomized controlled trial.","authors":"Nicolas P A Müller, Stefan P Bienz, Sofya Sadilina, Marc Balmer, Ronald E Jung, Daniel S Thoma","doi":"10.5051/jpis.2404280214","DOIUrl":"10.5051/jpis.2404280214","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this exploratory randomized controlled clinical trial was to compare profilometric and radiographic changes following early implant placement in sites treated with alveolar ridge preservation versus spontaneous healing (SH). Additionally, the study aimed to investigate clinical parameters of the implants up to 3 years following crown insertion.</p><p><strong>Methods: </strong>Thirty-five patients exhibiting either intact buccal bone plates or buccal dehiscence of up to 50% after single-tooth extraction of incisors, canines, or premolars were enrolled. Participants were randomly assigned to 1 of 3 groups: 1) deproteinized bovine bone mineral with 10% collagen covered by a collagen matrix (DBBM-C/CM), 2) deproteinized bovine bone mineral with 10% collagen alone (DBBM-C), or 3) SH. Implant placement occurred 8 weeks post-extraction. Profilometric analyses were performed utilizing impressions and digital scans. Patients underwent follow-up assessments for up to 3 years (FU-3Y) after the final crown insertion (fixed dental prosthesis insertion, FDPi).</p><p><strong>Results: </strong>The median contour changes between FDPi and FU-3Y were -0.23 mm for DBBM-C/CM, -0.21 mm for DBBM-C, and -0.33 mm for SH, demonstrating a statistically significant reduction over 3 years in all 3 groups (<i>P</i><0.05). Median radiographic changes observed up to FU-3Y were 0.02 mm for DBBM-C/CM, -0.5 mm for DBBM-C, and -0.18 mm for SH. These radiographic changes were neither statistically significant within groups nor between groups over time (<i>P</i>>0.05). Clinical parameters remained stable throughout the study period in all groups.</p><p><strong>Conclusions: </strong>The FU-3Y of this randomized clinical trial revealed stable clinical parameters and marginal bone levels in all evaluated groups. Although minor contour reductions were noted in all groups, these changes were deemed clinically acceptable.</p><p><strong>Trial registration: </strong>German Clinical Trials Register Identifier: DRKS00009496.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"57-71"},"PeriodicalIF":3.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International collaboration as a shared path forward.","authors":"Seung-Yun Shin","doi":"10.5051/jpis.265601edi01","DOIUrl":"10.5051/jpis.265601edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"56 1","pages":"1-2"},"PeriodicalIF":3.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}