Comparison of the biocompatibility and osteogenesis potential of whitlockite and an activin A/BMP2 chimera using a rat calvarial defect model: a pilot study.

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Periodontal and Implant Science Pub Date : 2024-06-21 DOI:10.5051/jpis.2304280214

Jung-Tae Lee, Sungtae Kim

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引用次数: 0

Abstract

Purpose: The aim of this study was to evaluate bone regeneration using whitlockite (WH) nanoparticles, collagenated bovine bone mineral, and an activin A/BMP2 chimera (AB204) on calvarial defects in rats.

Methods: This study was conducted using 8 rats. Five-millimeter circular defects were formed on each side of the calvaria. The defects were randomly assigned to 3 groups (BO group: BioOss collagen, BO/WH group: BO + WH, and BO/WH/AB204 group: BO + WH + AB204). After healing periods of 2 and 4 weeks, histological and histomorphometric analyses were performed after sacrifice.

Results: The BO/WH/AB204 group showed superior bone healing compared to the other 2 groups (BO and BO/WH). In the BO and BO/WH groups, new bone formation was found in the defect margin. However, in the BO/WH/AB204 group, new bone was observed on the upper and lower surfaces of the grafted area. The new bone area of the BO/WH/AB204 group at 4 weeks was significantly higher than that of the same group at 2 weeks. At 4 weeks, the total augmented area and material area in the BO/WH/AB204 group were significantly lower than the corresponding values at 2 weeks.

Conclusions: The BO/WH/AB204 group showed superior results of bone regeneration at 2 and 4 weeks compared to the BO and BO/WH groups. AB204 seems to play an important role in bone regeneration.

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利用大鼠腓骨缺损模型比较白锁石和活化素 A/BMP2 嵌合体的生物相容性和成骨潜力：一项试验研究。

目的：本研究旨在评估使用白锁石（WH）纳米颗粒、胶原牛骨矿物质和活化素 A/BMP2嵌合体（AB204）对大鼠腓骨缺损的骨再生效果：本研究使用了 8 只大鼠。方法：该研究使用 8 只大鼠进行，在两侧腓骨上各形成 5 毫米的圆形缺损。这些缺损被随机分配到 3 组（BO 组：BioOss 胶原、BO/W 组：BioOss 胶原、BO/W 组：BioOss 胶原）：BO组：BioOss胶原蛋白；BO/WH组：BO + WH；BO/WH组：BioOss胶原蛋白：BO+WH组和BO/WH/AB204组：BO+WH+AB204）。愈合期分别为 2 周和 4 周，切片后进行组织学和组织形态学分析：结果：与其他两组（BO 组和 BO/WH 组）相比，BO/WH/AB204 组的骨愈合效果更好。在 BO 组和 BO/WH 组中，缺损边缘有新骨形成。但在 BO/WH/AB204 组中，移植区域的上下表面都有新骨形成。4 周时，BO/WH/AB204 组的新骨面积明显高于 2 周时的同组。4 周时，BO/WH/AB204 组的总增量面积和材料面积明显低于 2 周时的相应值：结论：与 BO 组和 BO/WH 组相比，BO/WH/AB204 组在 2 周和 4 周时的骨再生效果更佳。AB204 似乎在骨再生中发挥了重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Periodontal and Implant Science DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Journal of Periodontal & Implant Science (JPIS) is a peer-reviewed and open-access journal providing up-to-date information relevant to professionalism of periodontology and dental implantology. JPIS is dedicated to global and extensive publication which includes evidence-based original articles, and fundamental reviews in order to cover a variety of interests in the field of periodontal as well as implant science.