Annual Review of Virology最新文献_第3页

Experimental Considerations for the Evaluation of Viral Biomolecular Condensates. 评估病毒生物分子凝聚物的实验考虑因素。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 DOI: 10.1146/annurev-virology-093022-010014

Christine A Roden, Amy S Gladfelter

{"title":"Experimental Considerations for the Evaluation of Viral Biomolecular Condensates.","authors":"Christine A Roden, Amy S Gladfelter","doi":"10.1146/annurev-virology-093022-010014","DOIUrl":"https://doi.org/10.1146/annurev-virology-093022-010014","url":null,"abstract":"Biomolecular condensates are nonmembrane-bound assemblies of biological polymers such as protein and nucleic acids. An increasingly accepted paradigm across the viral tree of life is (a) that viruses form biomolecular condensates and (b) that the formation is required for the virus. Condensates can promote viral replication by promoting packaging, genome compaction, membrane bending, and co-opting of host translation. This review is primarily concerned with exploring methodologies for assessing virally encoded biomolecular condensates. The goal of this review is to provide an experimental framework for virologists to consider when designing experiments to (a) identify viral condensates and their components, (b) reconstitute condensation cell free from minimal components, (c) ask questions about what conditions lead to condensation, (d) map these questions back to the viral life cycle, and (e) design and test inhibitors/modulators of condensation as potential therapeutics. This experimental framework attempts to integrate virology, cell biology, and biochemistry approaches.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"11 1","pages":"105-124"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studying Retroviral Life Cycles Using Visible Viruses and Live Cell Imaging. 利用可见病毒和活细胞成像揭示逆转录病毒生命周期

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-012608

Jorge F Guerrero, Sydney L Lesko, Edward L Evans, Nathan M Sherer

{"title":"Studying Retroviral Life Cycles Using Visible Viruses and Live Cell Imaging.","authors":"Jorge F Guerrero, Sydney L Lesko, Edward L Evans, Nathan M Sherer","doi":"10.1146/annurev-virology-100422-012608","DOIUrl":"10.1146/annurev-virology-100422-012608","url":null,"abstract":"Viruses exploit key host cell factors to accomplish each individual stage of the viral replication cycle. To understand viral pathogenesis and speed the development of new antiviral strategies, high-resolution visualization of virus-host interactions is needed to define where and when these events occur within cells. Here, we review state-of-the-art live cell imaging techniques for tracking individual stages of viral life cycles, focusing predominantly on retroviruses and especially human immunodeficiency virus type 1, which is most extensively studied. We describe how visible viruses can be engineered for live cell imaging and how nonmodified viruses can, in some instances, be tracked and studied indirectly using cell biosensor systems. We summarize the ways in which live cell imaging has been used to dissect the retroviral life cycle. Finally, we discuss select challenges for the future including the need for better labeling strategies, increased resolution, and multivariate systems that will allow for the study of full viral replication cycles.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"125-146"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Risk of Virus Emergence in South America: A Subtle Balance Between Increasingly Favorable Conditions and a Protective Environment. 南美洲出现病毒的风险：日益有利的条件与保护性环境之间的微妙平衡。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-024648

Benoit de Thoisy, Tiago Gräf, Daniel Santos Mansur, Adriana Delfraro, Claudia Nunes Duarte Dos Santos

{"title":"The Risk of Virus Emergence in South America: A Subtle Balance Between Increasingly Favorable Conditions and a Protective Environment.","authors":"Benoit de Thoisy, Tiago Gräf, Daniel Santos Mansur, Adriana Delfraro, Claudia Nunes Duarte Dos Santos","doi":"10.1146/annurev-virology-100422-024648","DOIUrl":"10.1146/annurev-virology-100422-024648","url":null,"abstract":"South American ecosystems host astonishing biodiversity, with potentially great richness in viruses. However, these ecosystems have not yet been the source of any widespread, epidemic viruses. Here we explore a set of putative causes that may explain this apparent paradox. We discuss that human presence in South America is recent, beginning around 14,000 years ago; that few domestications of native species have occurred; and that successive immigration events associated with Old World virus introductions reduced the likelihood of spillovers and adaptation of local viruses into humans. Also, the diversity and ecological characteristics of vertebrate hosts might serve as protective factors. Moreover, although forest areas remained well preserved until recently, current brutal, sudden, and large-scale clear cuts through the forest have resulted in nearly no ecotones, which are essential for creating an adaptive gradient of microbes, hosts, and vectors. This may be temporarily preventing virus emergence. Nevertheless, the mid-term effect of such drastic changes in habitats and landscapes, coupled with explosive urbanization and climate changes, must not be overlooked by health authorities.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"43-65"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiviral and Immunomodulatory Effects of Interferon Lambda at the Maternal-Fetal Interface. λ干扰素在母胎界面的抗病毒和免疫调节作用

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-111821-101531

Margaret R Dedloff, Helen M Lazear

引用次数: 0

Expanding the Plant Virome: Umbra-Like Viruses Use Host Proteins for Movement. 扩展植物病毒体：类伞状病毒利用宿主蛋白质移动

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-111821-122718

Anne E Simon, Diego F Quito-Avila, Sayanta Bera

{"title":"Expanding the Plant Virome: Umbra-Like Viruses Use Host Proteins for Movement.","authors":"Anne E Simon, Diego F Quito-Avila, Sayanta Bera","doi":"10.1146/annurev-virology-111821-122718","DOIUrl":"10.1146/annurev-virology-111821-122718","url":null,"abstract":"Before the very recent discovery of umbra-like viruses (ULVs), the signature defining feature of all plant RNA viruses was the encoding of specialized RNA-binding movement proteins (MPs) for transiting their RNA genomes through gated plasmodesmata to establish systemic infections. The vast majority of ULVs share umbravirus-like RNA-dependent RNA polymerases and 3'-terminal structures, but they differ by not encoding cell-to-cell and long-distance MPs and by not relying on a helper virus for trans-encapsidation and plant-to-plant transmission. The recent finding that two groups of ULVs do not necessarily encode MPs is expanding our understanding of the minimum requirements for modern plant RNA viruses. ULV CY1 from citrus uses host protein PHLOEM PROTEIN 2 (PP2) for systemic movement, and related ULVs encode a capsid protein, thereby providing an explanation for the lack of helper viruses present in many ULV-infected plants. ULVs thus resemble the first viruses that infected plants, which were likely deposited from feeding organisms and would have similarly required the use of host proteins such as PP2 to exit initially infected cells.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"283-308"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embracing Complexity: What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity. 拥抱复杂性：新型测序方法对疱疹病毒基因组多样性的启示》（What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity.

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-010336

Alejandro Ortigas-Vasquez, Moriah Szpara

引用次数: 0

Are There More Human Cancer Viruses Left to Be Found? 是否还有更多人类癌症病毒有待发现？

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 DOI: 10.1146/annurev-virology-111821-103721

Patrick S Moore, Yuan Chang

引用次数: 0

Bacteriophage T4 as a Protein-Based, Adjuvant- and Needle-Free, Mucosal Pandemic Vaccine Design Platform. 将噬菌体 T4 作为基于蛋白质、无佐剂和无针头的黏膜大流行病疫苗设计平台。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-111821-111145

Jingen Zhu, Pan Tao, Ashok K Chopra, Venigalla B Rao

{"title":"Bacteriophage T4 as a Protein-Based, Adjuvant- and Needle-Free, Mucosal Pandemic Vaccine Design Platform.","authors":"Jingen Zhu, Pan Tao, Ashok K Chopra, Venigalla B Rao","doi":"10.1146/annurev-virology-111821-111145","DOIUrl":"10.1146/annurev-virology-111821-111145","url":null,"abstract":"The COVID-19 pandemic has transformed vaccinology. Rapid deployment of mRNA vaccines has saved countless lives. However, these platforms have inherent limitations including lack of durability of immune responses and mucosal immunity, high cost, and thermal instability. These and uncertainties about the nature of future pandemics underscore the need for exploring next-generation vaccine platforms. Here, we present a novel protein-based, bacteriophage T4 platform for rapid design of efficacious vaccines against bacterial and viral pathogens. Full-length antigens can be displayed at high density on a 120 × 86 nm phage capsid through nonessential capsid binding proteins Soc and Hoc. Such nanoparticles, without any adjuvant, induce robust humoral, cellular, and mucosal responses when administered intranasally and confer sterilizing immunity. Combined with structural stability and ease of manufacture, T4 phage provides an excellent needle-free, mucosal pandemic vaccine platform and allows equitable vaccine access to low- and middle-income communities across the globe.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"395-420"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11690488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

False Alarm: XMRV, Cancer, and Chronic Fatigue Syndrome. 虚假警报XMRV、癌症和慢性疲劳综合征。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-111821-125122

John M Coffin, Mary F Kearney

引用次数: 0

Artificial Intelligence and Scientific Reviews. 人工智能与科学评论》。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-vi-11-060624-100111

Julie K Pfeiffer, Terence S Dermody

引用次数: 0