Shaping Viral Infection Outcomes via Organelle Remodeling.

IF 8.1 1区 医学 Q1 VIROLOGY
William A Hofstadter, Ileana M Cristea
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引用次数: 0

Abstract

Subcellular organelles are dynamic structures that tune their functions in conjunction with changes to their shapes and compositions. Each organelle has distinct structure-function relationships that change in response to diverse stimuli. Such remodeling events further affect organelle-organelle interaction networks facilitated by membrane contact sites, thereby activating rapid intra- and intercellular communication cascades. As viruses rely on repurposing the host cell machinery during infections, organelle remodeling is a fundamental facet and outcome of all viral infections. Some organelle remodeling events are unique to particular viruses, while others are shared by an array of viruses. Here, we review knowledge derived from this expanding yet still underexplored research area of infection-induced organelle remodeling. We focus on the molecular mechanisms used by viruses to temporally control organelle structure-function relationships. We highlight how organelle remodeling can inhibit host defenses or facilitate specific stages of a virus replication cycle, i.e., entry, replication, assembly, and spread.

通过细胞器重塑塑造病毒感染结果。
亚细胞细胞器是一种动态结构,可以根据其形状和组成的变化来调整其功能。每个细胞器都有不同的结构-功能关系,在不同的刺激下发生变化。这种重塑事件进一步影响由膜接触位点促进的细胞器-细胞器相互作用网络,从而激活快速的细胞内和细胞间通讯级联。由于病毒在感染过程中依赖于重新利用宿主细胞机制,因此细胞器重塑是所有病毒感染的一个基本方面和结果。一些细胞器重塑事件是特定病毒所特有的,而另一些则是一系列病毒共有的。在这里,我们回顾了从感染诱导的细胞器重塑这一不断扩大但仍未充分探索的研究领域中获得的知识。我们的重点是利用病毒的分子机制来暂时控制细胞器结构-功能关系。我们强调细胞器重塑如何抑制宿主防御或促进病毒复制周期的特定阶段,即进入,复制,组装和传播。
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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