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Annual Review of Virology最新文献

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Lab Legends and Field Phantoms: The Tale of Virus-Resistant Plants. 实验室传说和野外幻影：抗病毒植物的故事。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-06-11 DOI: 10.1146/annurev-virology-092623-101850
Patricia M B Fernandes, Antonio Alberto R Fernandes, Marlonni Maurastoni, Silas P Rodrigues
{"title":"Lab Legends and Field Phantoms: The Tale of Virus-Resistant Plants.","authors":"Patricia M B Fernandes, Antonio Alberto R Fernandes, Marlonni Maurastoni, Silas P Rodrigues","doi":"10.1146/annurev-virology-092623-101850","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-101850","url":null,"abstract":"<p><p>Plant viruses present significant challenges to global agriculture, causing crop losses, threatening food security, and imposing economic burdens. Advances in biotechnology have revolutionized strategies to attack these threats, with genetically modified and genome-edited virus-resistant plants, developed using precision tools such as RNA interference and CRISPR/Cas technology, playing pivotal roles. Despite these breakthroughs, fragmented regulatory frameworks and divergent policies across regions including the European Union and the Global South hinder the global adoption of such innovations. Multifaceted approaches, including gene pyramiding, microbiome-based strategies, and pathogen-targeted defenses, show promise for enhancing plant resilience. This review explores the biological, regulatory, and ethical dimensions of deploying virus-resistant crops, emphasizing the need for harmonization of international regulation to maximize biotechnological benefits. By addressing these challenges, biotechnology can advance sustainable agriculture, secure food systems, and mitigate the effect of plant viral diseases.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flavivirus Morphogenesis and Its Implications for Pathogenesis. 黄病毒的形态发生及其发病机制。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-06-10 DOI: 10.1146/annurev-virology-092623-110537
James McAuliffe, Karolina Bentkowska, Sumana Sanyal
{"title":"Flavivirus Morphogenesis and Its Implications for Pathogenesis.","authors":"James McAuliffe, Karolina Bentkowska, Sumana Sanyal","doi":"10.1146/annurev-virology-092623-110537","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-110537","url":null,"abstract":"<p><p>Flaviviruses represent major human pathogens transmitted by arthropod vectors, causing significant morbidity and mortality worldwide. Morphogenesis-the assembly and maturation of infectious flavivirus particles-is a complex process that occurs in association with host cell membranes and requires extensive cellular remodeling. This review examines recent advances in our understanding of flavivirus morphogenesis, from the molecular mechanisms driving virion assembly to their implications for viral pathogenesis. We discuss how viral proteins orchestrate the assembly process through interactions with the host cell machinery, particularly focusing on membrane reorganization, lipid metabolism, and post-translational modifications. The production of structurally heterogeneous viral particles is a key feature of flavivirus morphogenesis with important consequences for immune recognition and viral fitness. Understanding these fundamental aspects of the flavivirus life cycle has led to new insights into virus-host interactions and highlights promising targets for therapeutic intervention.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Insights into Noncanonical Influenza Virus Replication and Transcription. 非典型流感病毒复制和转录的分子洞察。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-06-09 DOI: 10.1146/annurev-virology-092623-101331
Michael S Oade, Aartjan J W Te Velthuis
{"title":"Molecular Insights into Noncanonical Influenza Virus Replication and Transcription.","authors":"Michael S Oade, Aartjan J W Te Velthuis","doi":"10.1146/annurev-virology-092623-101331","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-101331","url":null,"abstract":"<p><p>Influenza A viruses (IAVs) typically cause a mild to moderate respiratory disease, whereas infections with pandemic and highly pathogenic avian IAV strains are frequently associated with high morbidity and death. Various noncanonical or aberrant transcription and replication products have been implicated in the effect of IAV infection on disease outcomes. While early research indicated that all these molecules may be defective, recent findings coupled with analyses of the structure of the IAV RNA polymerase suggest that the production of noncanonical RNAs is not solely driven by errors. Instead, their place in infection may be more nuanced. In this review, we discuss our current understanding of the molecular steps that underlie noncanonical transcription and replication and which molecular mysteries remain.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conduits, Doppelgängers, and Chimeras: RNA Structures at the Virus-Host Interface. 导管，Doppelgängers和嵌合体：病毒-宿主界面的RNA结构。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-30 DOI: 10.1146/annurev-virology-100422-031237
Athanasios-Nasir Shaukat, Jinwei Zhang
{"title":"Conduits, Doppelgängers, and Chimeras: RNA Structures at the Virus-Host Interface.","authors":"Athanasios-Nasir Shaukat, Jinwei Zhang","doi":"10.1146/annurev-virology-100422-031237","DOIUrl":"https://doi.org/10.1146/annurev-virology-100422-031237","url":null,"abstract":"<p><p>Viruses and the hosts they parasitize are engaged in a perpetual tug-of-war that is fought at multiple virus-host interfaces from the cell surface to the nucleus. It is increasingly clear that structured RNA elements represent major players and conduits at the forefront of this push and pull. Viral RNA structures hijack or subvert host RNA polymerases; ribosomes; translation-associated enzymes; RNA processing, modification, and transport systems; antiviral immunity proteins; and more. Recent advances in visualizing complex RNA and ribonucleoprotein structures at the virus-host interfaces have provided timely new insights into molecular mechanisms of viral exploitation, host defense, and viral counter-defense. Through the lens of RNA structure and recognition, we compare and analyze a representative set of such interfaces to discern general patterns and recurring strategies. We find that virus-host interfaces frequently have their roots or doppelgängers in the existing cellular interfaces. This suggests widespread viral mimicry of cellular interfaces and interactions. Viral RNAs further borrow and amalgamate distinct features from several host RNAs to form chimeras, which simultaneously target multiple host systems for viral gains.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community-Scale Molecular Surveillance for Human Viruses. 社区尺度的人类病毒分子监测。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-28 DOI: 10.1146/annurev-virology-092623-102821
Ari N Machtinger, Heather M Machkovech, Shelby L O'Connor, Marc C Johnson, Martin M Shafer, Thomas C Friedrich, David H O'Connor
{"title":"Community-Scale Molecular Surveillance for Human Viruses.","authors":"Ari N Machtinger, Heather M Machkovech, Shelby L O'Connor, Marc C Johnson, Martin M Shafer, Thomas C Friedrich, David H O'Connor","doi":"10.1146/annurev-virology-092623-102821","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-102821","url":null,"abstract":"<p><p>Environmental surveillance, including wastewater and air sampling, has emerged as a powerful complement to traditional clinical surveillance for monitoring viral circulation. Advances in sampling and detection technologies, many spurred by the COVID-19 pandemic, have enabled more sensitive and comprehensive characterization of viruses in diverse types of commingled samples from multiple individuals. Expanding environmental monitoring globally presents challenges and opportunities, particularly in low- and middle-income countries where centralized sewage infrastructure may be limited. Ethical implementation will require balancing privacy and transparency through community engagement. Future directions include using environmental surveillance to detect emerging zoonoses, fill gaps when clinical testing wanes, and inform public health actions. While logistical, regulatory, and ethical challenges remain, coordination across scientific and public health stakeholders can enable environmental monitoring to transform epidemic intelligence. This review summarizes recent developments in environmental surveillance systems and discusses how they can mitigate the introduction and spread of viruses in communities.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poxvirus Host-Range Determinants: SAMD9/9L and Beyond. 痘病毒宿主范围决定因子：SAMD9/9L及其他。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-22 DOI: 10.1146/annurev-virology-092623-104658
Yan Xiang
{"title":"Poxvirus Host-Range Determinants: SAMD9/9L and Beyond.","authors":"Yan Xiang","doi":"10.1146/annurev-virology-092623-104658","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-104658","url":null,"abstract":"<p><p>The recent global spread of mpox virus, facilitated by a newly established human-to-human transmission mode, has rekindled interest in poxviruses and the molecular factors defining their host range. Poxviruses employ host-range factors, a subset of their immune evasion proteins, to overcome cell-intrinsic defenses in specific cell types or host species. Over the past decade, investigations of these factors have revealed previously unrecognized antiviral mechanisms and expanded our understanding of innate immunity. Among the key developments are the discovery of novel restriction factors, including SAMD9 and SAMD9L (SAMD9/9L), and expanded roles for established antiviral proteins such as IFITs, FAM111A, and ZAP. These advances not only clarify how poxvirus host range is determined but also offer valuable insights into the complexity and evolution of mammalian innate immunity. Here, I highlight new findings on poxvirus host-range determinants, with a particular focus on SAMD9/9L and the three distinct classes of poxvirus host-range factors that antagonize them.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virologists Can Help Make America Healthy Again. 病毒学家可以帮助美国恢复健康。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-15 DOI: 10.1146/annurev-vi-12-041725-010437
Terence S Dermody, Julie K Pfeiffer
{"title":"Virologists Can Help Make America Healthy Again.","authors":"Terence S Dermody, Julie K Pfeiffer","doi":"10.1146/annurev-vi-12-041725-010437","DOIUrl":"https://doi.org/10.1146/annurev-vi-12-041725-010437","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"i-v"},"PeriodicalIF":8.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Collaborative Cross as a Model for Studying Viral Infections. 协同交叉作为研究病毒感染的模型。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-06 DOI: 10.1146/annurev-virology-100422-031014
P A Sylvester, M T Heise
{"title":"The Collaborative Cross as a Model for Studying Viral Infections.","authors":"P A Sylvester, M T Heise","doi":"10.1146/annurev-virology-100422-031014","DOIUrl":"https://doi.org/10.1146/annurev-virology-100422-031014","url":null,"abstract":"<p><p>Inbred mouse strains are an invaluable resource for modeling virus-host interactions and studying how specific host genes affect virus-induced disease. However, many viruses cause a spectrum of disease outcomes in humans ranging from asymptomatic infection to severe disease or death. Conventional mouse strains do not recapitulate human genetic diversity and often fail to reproduce the full spectrum of virus-induced disease phenotypes seen in humans. The Collaborative Cross (CC) recombinant inbred mouse population is a genetically diverse set of mouse strains designed to model the genetic and phenotypic diversity seen in human populations. The CC has been used to study the effect of host genetic variation on the pathogenesis of several human viruses, and we review the utility of the CC as a resource both for developing new models of virus-induced disease and for the identification and study of host gene variants that affect susceptibility to virus-induced disease.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Future of Virology Education. 病毒学教育的未来。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-01 DOI: 10.1146/annurev-virology-092623-110921
Melissa S Maginnis
{"title":"The Future of Virology Education.","authors":"Melissa S Maginnis","doi":"10.1146/annurev-virology-092623-110921","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-110921","url":null,"abstract":"<p><p>The rapidly evolving pace of scientific information, technology, and innovation in pedagogical approaches provides an opportunity to consider the future of virology education. Virology curriculum guidelines for undergraduate and graduate education call for student-centered approaches with a focus on integrating concepts by virology topics rather than by virus family. Through backward design, courses should be structured based on desired student learning outcomes in virology, and then the process and content should be developed to align with the learning goals. Learning goals and content in graduate virology education place additional emphasis on skill building and higher-order analysis. Evidence-based teaching practices favor active-learning strategies that promote student engagement and critical thinking such as group work, journal club discussions, and experiential learning over a lecture-based education model. Teaching approaches should also foster the establishment of supportive learning environments that meet the needs of a varied population of learners and promote belonging in the virology community.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral Modulation of Host Splicing. 宿主剪接的病毒调节。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-25 DOI: 10.1146/annurev-virology-092623-102539
Bridget E Begg, Max B Ferretti, Matthew A Tracey, Kristen W Lynch
{"title":"Viral Modulation of Host Splicing.","authors":"Bridget E Begg, Max B Ferretti, Matthew A Tracey, Kristen W Lynch","doi":"10.1146/annurev-virology-092623-102539","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-102539","url":null,"abstract":"<p><p>The discovery of precursor messenger RNA splicing was made through the study of adenovirus in the 1970s, and since then, the role of splicing in viral infection has been an important area of study. However, most of the work in this area prior to the past decade has focused on the splicing of viral genes. Only recently has there been an explosion of studies investigating how viral infection influences the splicing of host genes and the effect of this regulation on host-viral interplay. This review focuses on this growing interest and understanding of how viruses affect host splicing, the functional consequences of this regulation, and the questions that are motivating ongoing research surrounding host splicing changes during viral infection.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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