发布求助
文献互助 智能选刊 最新文献

Annual Review of Virology最新文献

筛选
英文 中文
Virologists Can Help Make America Healthy Again. 病毒学家可以帮助美国恢复健康。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-15 DOI: 10.1146/annurev-vi-12-041725-010437
Terence S Dermody, Julie K Pfeiffer
{"title":"Virologists Can Help Make America Healthy Again.","authors":"Terence S Dermody, Julie K Pfeiffer","doi":"10.1146/annurev-vi-12-041725-010437","DOIUrl":"https://doi.org/10.1146/annurev-vi-12-041725-010437","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"i-v"},"PeriodicalIF":8.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Collaborative Cross as a Model for Studying Viral Infections. 协同交叉作为研究病毒感染的模型。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-06 DOI: 10.1146/annurev-virology-100422-031014
P A Sylvester, M T Heise
{"title":"The Collaborative Cross as a Model for Studying Viral Infections.","authors":"P A Sylvester, M T Heise","doi":"10.1146/annurev-virology-100422-031014","DOIUrl":"https://doi.org/10.1146/annurev-virology-100422-031014","url":null,"abstract":"<p><p>Inbred mouse strains are an invaluable resource for modeling virus-host interactions and studying how specific host genes affect virus-induced disease. However, many viruses cause a spectrum of disease outcomes in humans ranging from asymptomatic infection to severe disease or death. Conventional mouse strains do not recapitulate human genetic diversity and often fail to reproduce the full spectrum of virus-induced disease phenotypes seen in humans. The Collaborative Cross (CC) recombinant inbred mouse population is a genetically diverse set of mouse strains designed to model the genetic and phenotypic diversity seen in human populations. The CC has been used to study the effect of host genetic variation on the pathogenesis of several human viruses, and we review the utility of the CC as a resource both for developing new models of virus-induced disease and for the identification and study of host gene variants that affect susceptibility to virus-induced disease.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Future of Virology Education. 病毒学教育的未来。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-05-01 DOI: 10.1146/annurev-virology-092623-110921
Melissa S Maginnis
{"title":"The Future of Virology Education.","authors":"Melissa S Maginnis","doi":"10.1146/annurev-virology-092623-110921","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-110921","url":null,"abstract":"<p><p>The rapidly evolving pace of scientific information, technology, and innovation in pedagogical approaches provides an opportunity to consider the future of virology education. Virology curriculum guidelines for undergraduate and graduate education call for student-centered approaches with a focus on integrating concepts by virology topics rather than by virus family. Through backward design, courses should be structured based on desired student learning outcomes in virology, and then the process and content should be developed to align with the learning goals. Learning goals and content in graduate virology education place additional emphasis on skill building and higher-order analysis. Evidence-based teaching practices favor active-learning strategies that promote student engagement and critical thinking such as group work, journal club discussions, and experiential learning over a lecture-based education model. Teaching approaches should also foster the establishment of supportive learning environments that meet the needs of a varied population of learners and promote belonging in the virology community.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral Modulation of Host Splicing. 宿主剪接的病毒调节。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-25 DOI: 10.1146/annurev-virology-092623-102539
Bridget E Begg, Max B Ferretti, Matthew A Tracey, Kristen W Lynch
{"title":"Viral Modulation of Host Splicing.","authors":"Bridget E Begg, Max B Ferretti, Matthew A Tracey, Kristen W Lynch","doi":"10.1146/annurev-virology-092623-102539","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-102539","url":null,"abstract":"<p><p>The discovery of precursor messenger RNA splicing was made through the study of adenovirus in the 1970s, and since then, the role of splicing in viral infection has been an important area of study. However, most of the work in this area prior to the past decade has focused on the splicing of viral genes. Only recently has there been an explosion of studies investigating how viral infection influences the splicing of host genes and the effect of this regulation on host-viral interplay. This review focuses on this growing interest and understanding of how viruses affect host splicing, the functional consequences of this regulation, and the questions that are motivating ongoing research surrounding host splicing changes during viral infection.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral Codon Usage and the Host Transfer RNA. 病毒密码子使用与宿主转移RNA。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-23 DOI: 10.1146/annurev-virology-092623-105418
Elena Muscolino, Juana Díez
{"title":"Viral Codon Usage and the Host Transfer RNA.","authors":"Elena Muscolino, Juana Díez","doi":"10.1146/annurev-virology-092623-105418","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-105418","url":null,"abstract":"<p><p>The expansion of viruses within cells requires efficient viral protein production. Counterintuitively, many viral genomes are enriched in suboptimal codons, which are typically associated with reduced protein outputs. Recent research using chikungunya virus (CHIKV) as a prototype model highlights the role of host transfer RNA (tRNA) modifications, collectively known as the tRNA epitranscriptome, in resolving this paradox. Upon infection, CHIKV triggers a DNA damage stress response that ultimately leads to changes in the tRNA epitranscriptome. These changes reprogram codon optimality, selectively enhancing the translation of specific suboptimal codons that are highly enriched in both host stress response genes and the viral genome. Hence, CHIKV codon usage optimally aligns with the tRNA modification landscape in infected cells. We propose that this interplay between viral codon usage, stress responses, and tRNA modifications is a shared strategy among viruses beyond CHIKV. Targeting this interplay may pave the way for the development of broad-spectrum antiviral therapies.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues. 胎儿组织中抗神经毒性病原体的母体抗体。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-18 DOI: 10.1146/annurev-virology-092623-094004
Matthew D Slein, Margaret E Ackerman, David A Leib
{"title":"Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues.","authors":"Matthew D Slein, Margaret E Ackerman, David A Leib","doi":"10.1146/annurev-virology-092623-094004","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-094004","url":null,"abstract":"<p><p>Infection by neurovirulent pathogens in utero and during the neonatal period can lead to fetal and neonatal mortality as well as neurological morbidity with lifelong consequences. Fortunately, maternal antibodies (Abs) serve as a means to protect humans as their immune system forms and matures. For some of the particularly consequential viral infections of early life, preclinical and clinical evidence demonstrate an unambiguously protective role of maternal Abs; for others, maternal Abs also have the potential to contribute to disease pathology. Here, we discuss how maternal Abs are temporarily inherited and distributed in fetal tissue. We focus on how this transgenerational form of immunity influences mortality and neurological morbidity as a result of herpes simplex virus, human cytomegalovirus, and flavivirus infections in early life.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grapevine Red Blotch Disease: A Threat to the Grape and Wine Industries. 葡萄红斑病：对葡萄和葡萄酒工业的威胁。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-15 DOI: 10.1146/annurev-virology-092623-101702
Elizabeth Cieniewicz, Marc Fuchs
{"title":"Grapevine Red Blotch Disease: A Threat to the Grape and Wine Industries.","authors":"Elizabeth Cieniewicz, Marc Fuchs","doi":"10.1146/annurev-virology-092623-101702","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-101702","url":null,"abstract":"<p><p>Grapevine red blotch disease emerged as a major threat to the North American viticulture more than 25 years ago. Prior to the discovery of its causal agent, grapevine red blotch virus (GRBV), the disease was likely mistaken for other vineyard problems. Over the last decade and a half, research on red blotch disease focused on GRBV biology; diagnostics; transmission biology; disease epidemiology; ecology of its vector, the treehopper <i>Spissistilus festinus</i>; and strategies for disease management. Research has also uncovered some of the physiological effects of GRBV on grapevines (inhibition of hexose translocation from leaves to fruits, transcriptional suppression of phenylpropanoid pathways), fruit (low soluble solids, poor ripening, reduced phenolic extractability, high titratable acidity), and wine (altered sensory attributes such as less fruit aromas and poor color and mouthfeel). The economic effects of the disease in different grape-producing regions of the United States are estimated to be as high as $68,548 per hectare over a 25-year vineyard lifespan. Here we reflect on major red blotch research progress and discuss future priorities. We also highlight the contribution of GRBV to the grapevine community as a major driver of enhanced cooperation among researchers, growers, nurseries, extension agents, policymakers, regulators, and service providers. We anticipate that strengthened interactions among all the members of the grapevine community and science-based disease management responses in vineyards will curtail GRBV spread and improve vineyard health.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies. APOBEC3G拮抗Vif，或当结构满足生物学和进化研究。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-07 DOI: 10.1146/annurev-virology-092623-091351
Yen-Li Li, Caroline Langley, Michael Emerman, John D Gross
{"title":"APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies.","authors":"Yen-Li Li, Caroline Langley, Michael Emerman, John D Gross","doi":"10.1146/annurev-virology-092623-091351","DOIUrl":"10.1146/annurev-virology-092623-091351","url":null,"abstract":"<p><p>Restriction factors serve as innate host defenses against viruses and act as critical barriers to cross-species transmission. In response, viruses have evolved accessory proteins to counteract restriction factors, enabling evasion of innate immune responses. The interplay between primate APOBEC3G (A3G) and lentiviral virion infectivity factor (Vif) exemplifies a molecular arms race between a restriction factor and its viral antagonist. This review integrates evolutionary and functional analyses of this system, showing how genetic signatures of molecular arms races map onto high-resolution cryo-electron microscopy structures. However, A3G's interaction with Vif is not limited to the evolutionary dynamic interface, characterized by rapidly evolving residues under selective pressure, but also involves a conserved interface mediated by RNA binding that positions A3G for antagonism by Vif. These findings propose a model wherein Vif and potentially other viral antagonists target functional complexes using a dual strategy: leveraging both adaptive interfaces subject to evolutionary pressures and conserved interfaces that constrain host escape mechanisms.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions Between Commensal Microbes and Mosquito-Borne Viruses. 共生微生物与蚊媒病毒之间的相互作用。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-03-11 DOI: 10.1146/annurev-virology-092623-101222
Yibin Zhu, Yingyi Cao, Liping Jiang, Penghua Wang, Gong Cheng
{"title":"Interactions Between Commensal Microbes and Mosquito-Borne Viruses.","authors":"Yibin Zhu, Yingyi Cao, Liping Jiang, Penghua Wang, Gong Cheng","doi":"10.1146/annurev-virology-092623-101222","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-101222","url":null,"abstract":"<p><p>Emerging and re-emerging mosquito-borne viruses pose a significant threat to global public health. Unfortunately, effective preventive and therapeutic measures are scarce. An in-depth understanding of the mechanisms regulating viral pathogenesis, vector competence, and viral transmission between mammalian hosts and vectors may lay the foundations for new preventive and therapeutic approaches. Here, we summarize the intricate interactions between commensal microbes and mosquito-borne viruses in mammalian hosts and mosquitoes, including how the host gut microbiota influences the pathogenesis of viral infection; how the host skin microbiota affects the attractiveness of hosts to mosquitoes and viral transmission; and how symbiotic microbes, including endosymbiotic bacteria, fungi, and insect-specific viruses in mosquitoes, regulate viral transmission through gut immune regulation and microbe-derived effectors. In addition, we discuss the potential of symbiotic microbe-based interventions to suppress the transmission of mosquito-borne viral diseases.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction. 介绍。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2024-09-01 DOI: 10.1146/annurev-vi-11-071524-100001
Terence S Dermody, Julie K Pfeiffer
{"title":"Introduction.","authors":"Terence S Dermody, Julie K Pfeiffer","doi":"10.1146/annurev-vi-11-071524-100001","DOIUrl":"https://doi.org/10.1146/annurev-vi-11-071524-100001","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"11 1","pages":"i-ii"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信