Annual Review of Virology最新文献

Introduction. 介绍。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 DOI: 10.1146/annurev-vi-11-071524-100001

Terence S Dermody, Julie K Pfeiffer

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The Molecular Maze of Potyviral and Host Protein Interactions. 病毒与宿主蛋白质相互作用的分子迷宫

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-034124

Maija E Pollari, William W E Aspelin, Linping Wang, Kristiina M Mäkinen

{"title":"The Molecular Maze of Potyviral and Host Protein Interactions.","authors":"Maija E Pollari, William W E Aspelin, Linping Wang, Kristiina M Mäkinen","doi":"10.1146/annurev-virology-100422-034124","DOIUrl":"10.1146/annurev-virology-100422-034124","url":null,"abstract":"The negative effects of potyvirus diseases on the agricultural industry are extensive and global. Understanding how protein-protein interactions contribute to potyviral infections is imperative to developing resistant varieties that help counter the threat potyviruses pose. While many protein-protein interactions have been reported, only a fraction are essential for potyviral infection. Accumulating evidence demonstrates that potyviral infection processes are interconnected. For instance, the interaction between the eukaryotic initiation factor 4E (eIF4E) and viral protein genome-linked (VPg) is crucial for both viral translation and protecting viral RNA (vRNA). Additionally, recent evidence for open reading frames on the reverse-sense vRNA and for nonequimolar expression of viral proteins has challenged the previous polyprotein expression model. These discoveries will surely reveal more about the potyviral protein interactome. In this review, we present a synthesis of the potyviral infection cycle and discuss influential past discoveries and recent work on protein-protein interactions in various infection processes.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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From Entry to the Nucleus: How Retroviruses Commute. 从进入细胞核到细胞核：逆转录病毒是如何传播的？

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-023502

Camila E Osega, Fernando J Bustos, Gloria Arriagada

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A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses. 细胞搭便车指南：阿尔法疱疹病毒外壳中的世界》（A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses）。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-022751

Katinka Döhner, Manutea Christophe Serrero, Abel Viejo-Borbolla, Beate Sodeik

{"title":"A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses.","authors":"Katinka Döhner, Manutea Christophe Serrero, Abel Viejo-Borbolla, Beate Sodeik","doi":"10.1146/annurev-virology-100422-022751","DOIUrl":"10.1146/annurev-virology-100422-022751","url":null,"abstract":"The nucleoplasm, the cytosol, the inside of virions, and again the cytosol comprise the world in which the capsids of alphaherpesviruses encounter viral and host proteins that support or limit them in performing their tasks. Here, we review the fascinating conundrum of how specific protein-protein interactions late in alphaherpesvirus infection orchestrate capsid nuclear assembly, nuclear egress, and cytoplasmic envelopment, but target incoming capsids to the nuclear pores in naive cells to inject the viral genomes into the nucleoplasm for viral transcription and replication. Multiple capsid interactions with viral and host proteins have been characterized using viral mutants and assays that reconstitute key stages of the infection cycle. Keratinocytes, fibroblasts, mucosal epithelial cells, neurons, and immune cells employ cell type-specific intrinsic and cytokine-induced resistance mechanisms to restrict several stages of the viral infection cycle. However, concomitantly, alphaherpesviruses have evolved countermeasures to ensure efficient capsid function during infection.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Cold War and Phage Therapy: How Geopolitics Stalled Development of Viruses as Antibacterials. 冷战与噬菌体疗法：地缘政治如何阻碍了作为抗菌剂的病毒的发展》（The Cold War and Phage Therapy: How Geopolics Stilly Development of Viruses as Antibacterials）。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-040919

William C Summers

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Experimental Considerations for the Evaluation of Viral Biomolecular Condensates. 评估病毒生物分子凝聚物的实验考虑因素。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 DOI: 10.1146/annurev-virology-093022-010014

Christine A Roden, Amy S Gladfelter

{"title":"Experimental Considerations for the Evaluation of Viral Biomolecular Condensates.","authors":"Christine A Roden, Amy S Gladfelter","doi":"10.1146/annurev-virology-093022-010014","DOIUrl":"https://doi.org/10.1146/annurev-virology-093022-010014","url":null,"abstract":"Biomolecular condensates are nonmembrane-bound assemblies of biological polymers such as protein and nucleic acids. An increasingly accepted paradigm across the viral tree of life is (a) that viruses form biomolecular condensates and (b) that the formation is required for the virus. Condensates can promote viral replication by promoting packaging, genome compaction, membrane bending, and co-opting of host translation. This review is primarily concerned with exploring methodologies for assessing virally encoded biomolecular condensates. The goal of this review is to provide an experimental framework for virologists to consider when designing experiments to (a) identify viral condensates and their components, (b) reconstitute condensation cell free from minimal components, (c) ask questions about what conditions lead to condensation, (d) map these questions back to the viral life cycle, and (e) design and test inhibitors/modulators of condensation as potential therapeutics. This experimental framework attempts to integrate virology, cell biology, and biochemistry approaches.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Studying Retroviral Life Cycles Using Visible Viruses and Live Cell Imaging. 利用可见病毒和活细胞成像揭示逆转录病毒生命周期

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-012608

Jorge F Guerrero, Sydney L Lesko, Edward L Evans, Nathan M Sherer

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The Risk of Virus Emergence in South America: A Subtle Balance Between Increasingly Favorable Conditions and a Protective Environment. 南美洲出现病毒的风险：日益有利的条件与保护性环境之间的微妙平衡。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-024648

Benoit de Thoisy, Tiago Gräf, Daniel Santos Mansur, Adriana Delfraro, Claudia Nunes Duarte Dos Santos

{"title":"The Risk of Virus Emergence in South America: A Subtle Balance Between Increasingly Favorable Conditions and a Protective Environment.","authors":"Benoit de Thoisy, Tiago Gräf, Daniel Santos Mansur, Adriana Delfraro, Claudia Nunes Duarte Dos Santos","doi":"10.1146/annurev-virology-100422-024648","DOIUrl":"10.1146/annurev-virology-100422-024648","url":null,"abstract":"South American ecosystems host astonishing biodiversity, with potentially great richness in viruses. However, these ecosystems have not yet been the source of any widespread, epidemic viruses. Here we explore a set of putative causes that may explain this apparent paradox. We discuss that human presence in South America is recent, beginning around 14,000 years ago; that few domestications of native species have occurred; and that successive immigration events associated with Old World virus introductions reduced the likelihood of spillovers and adaptation of local viruses into humans. Also, the diversity and ecological characteristics of vertebrate hosts might serve as protective factors. Moreover, although forest areas remained well preserved until recently, current brutal, sudden, and large-scale clear cuts through the forest have resulted in nearly no ecotones, which are essential for creating an adaptive gradient of microbes, hosts, and vectors. This may be temporarily preventing virus emergence. Nevertheless, the mid-term effect of such drastic changes in habitats and landscapes, coupled with explosive urbanization and climate changes, must not be overlooked by health authorities.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Embracing Complexity: What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity. 拥抱复杂性：新型测序方法对疱疹病毒基因组多样性的启示》（What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity.

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-010336

Alejandro Ortigas-Vasquez, Moriah Szpara

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Expanding the Plant Virome: Umbra-Like Viruses Use Host Proteins for Movement. 扩展植物病毒体：类伞状病毒利用宿主蛋白质移动

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-111821-122718

Anne E Simon, Diego F Quito-Avila, Sayanta Bera

{"title":"Expanding the Plant Virome: Umbra-Like Viruses Use Host Proteins for Movement.","authors":"Anne E Simon, Diego F Quito-Avila, Sayanta Bera","doi":"10.1146/annurev-virology-111821-122718","DOIUrl":"10.1146/annurev-virology-111821-122718","url":null,"abstract":"Before the very recent discovery of umbra-like viruses (ULVs), the signature defining feature of all plant RNA viruses was the encoding of specialized RNA-binding movement proteins (MPs) for transiting their RNA genomes through gated plasmodesmata to establish systemic infections. The vast majority of ULVs share umbravirus-like RNA-dependent RNA polymerases and 3'-terminal structures, but they differ by not encoding cell-to-cell and long-distance MPs and by not relying on a helper virus for trans-encapsidation and plant-to-plant transmission. The recent finding that two groups of ULVs do not necessarily encode MPs is expanding our understanding of the minimum requirements for modern plant RNA viruses. ULV CY1 from citrus uses host protein PHLOEM PROTEIN 2 (PP2) for systemic movement, and related ULVs encode a capsid protein, thereby providing an explanation for the lack of helper viruses present in many ULV-infected plants. ULVs thus resemble the first viruses that infected plants, which were likely deposited from feeding organisms and would have similarly required the use of host proteins such as PP2 to exit initially infected cells.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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