Annual Review of Virology最新文献

APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies. APOBEC3G拮抗Vif，或当结构满足生物学和进化研究。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2025-04-08 DOI: 10.1146/annurev-virology-092623-091351

Yen-Li Li, Caroline Langley, Michael Emerman, John D Gross

{"title":"APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies.","authors":"Yen-Li Li, Caroline Langley, Michael Emerman, John D Gross","doi":"10.1146/annurev-virology-092623-091351","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-091351","url":null,"abstract":"Restriction factors serve as innate host defenses against viruses and act as critical barriers to cross-species transmission. In response, viruses have evolved accessory proteins to counteract restriction factors, enabling evasion of innate immune responses. The interplay between primate APOBEC3G (A3G) and lentiviral virion infectivity factor (Vif) exemplifies a molecular arms race between a restriction factor and its viral antagonist. This review integrates evolutionary and functional analyses of this system, showing how genetic signatures of molecular arms races map onto high-resolution cryo-electron microscopy structures. However, A3G's interaction with Vif is not limited to the evolutionary dynamic interface, characterized by rapidly evolving residues under selective pressure, but also involves a conserved interface mediated by RNA binding that positions A3G for antagonism by Vif. These findings propose a model wherein Vif and potentially other viral antagonists target functional complexes using a dual strategy: leveraging both adaptive interfaces subject to evolutionary pressures and conserved interfaces that constrain host escape mechanisms.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions Between Commensal Microbes and Mosquito-Borne Viruses. 共生微生物与蚊媒病毒之间的相互作用。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2025-03-11 DOI: 10.1146/annurev-virology-092623-101222

Yibin Zhu, Yingyi Cao, Liping Jiang, Penghua Wang, Gong Cheng

引用次数: 0

Introduction. 介绍。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 DOI: 10.1146/annurev-vi-11-071524-100001

Terence S Dermody, Julie K Pfeiffer

引用次数: 0

The Molecular Maze of Potyviral and Host Protein Interactions. 病毒与宿主蛋白质相互作用的分子迷宫

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-034124

Maija E Pollari, William W E Aspelin, Linping Wang, Kristiina M Mäkinen

{"title":"The Molecular Maze of Potyviral and Host Protein Interactions.","authors":"Maija E Pollari, William W E Aspelin, Linping Wang, Kristiina M Mäkinen","doi":"10.1146/annurev-virology-100422-034124","DOIUrl":"10.1146/annurev-virology-100422-034124","url":null,"abstract":"The negative effects of potyvirus diseases on the agricultural industry are extensive and global. Understanding how protein-protein interactions contribute to potyviral infections is imperative to developing resistant varieties that help counter the threat potyviruses pose. While many protein-protein interactions have been reported, only a fraction are essential for potyviral infection. Accumulating evidence demonstrates that potyviral infection processes are interconnected. For instance, the interaction between the eukaryotic initiation factor 4E (eIF4E) and viral protein genome-linked (VPg) is crucial for both viral translation and protecting viral RNA (vRNA). Additionally, recent evidence for open reading frames on the reverse-sense vRNA and for nonequimolar expression of viral proteins has challenged the previous polyprotein expression model. These discoveries will surely reveal more about the potyviral protein interactome. In this review, we present a synthesis of the potyviral infection cycle and discuss influential past discoveries and recent work on protein-protein interactions in various infection processes.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"147-170"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Entry to the Nucleus: How Retroviruses Commute. 从进入细胞核到细胞核：逆转录病毒是如何传播的？

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-023502

Camila E Osega, Fernando J Bustos, Gloria Arriagada

引用次数: 0

Experimental Considerations for the Evaluation of Viral Biomolecular Condensates. 评估病毒生物分子凝聚物的实验考虑因素。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 DOI: 10.1146/annurev-virology-093022-010014

Christine A Roden, Amy S Gladfelter

{"title":"Experimental Considerations for the Evaluation of Viral Biomolecular Condensates.","authors":"Christine A Roden, Amy S Gladfelter","doi":"10.1146/annurev-virology-093022-010014","DOIUrl":"https://doi.org/10.1146/annurev-virology-093022-010014","url":null,"abstract":"Biomolecular condensates are nonmembrane-bound assemblies of biological polymers such as protein and nucleic acids. An increasingly accepted paradigm across the viral tree of life is (a) that viruses form biomolecular condensates and (b) that the formation is required for the virus. Condensates can promote viral replication by promoting packaging, genome compaction, membrane bending, and co-opting of host translation. This review is primarily concerned with exploring methodologies for assessing virally encoded biomolecular condensates. The goal of this review is to provide an experimental framework for virologists to consider when designing experiments to (a) identify viral condensates and their components, (b) reconstitute condensation cell free from minimal components, (c) ask questions about what conditions lead to condensation, (d) map these questions back to the viral life cycle, and (e) design and test inhibitors/modulators of condensation as potential therapeutics. This experimental framework attempts to integrate virology, cell biology, and biochemistry approaches.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"11 1","pages":"105-124"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cold War and Phage Therapy: How Geopolitics Stalled Development of Viruses as Antibacterials. 冷战与噬菌体疗法：地缘政治如何阻碍了作为抗菌剂的病毒的发展》（The Cold War and Phage Therapy: How Geopolics Stilly Development of Viruses as Antibacterials）。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-040919

William C Summers

引用次数: 0

A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses. 细胞搭便车指南：阿尔法疱疹病毒外壳中的世界》（A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses）。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-022751

Katinka Döhner, Manutea Christophe Serrero, Abel Viejo-Borbolla, Beate Sodeik

{"title":"A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses.","authors":"Katinka Döhner, Manutea Christophe Serrero, Abel Viejo-Borbolla, Beate Sodeik","doi":"10.1146/annurev-virology-100422-022751","DOIUrl":"10.1146/annurev-virology-100422-022751","url":null,"abstract":"The nucleoplasm, the cytosol, the inside of virions, and again the cytosol comprise the world in which the capsids of alphaherpesviruses encounter viral and host proteins that support or limit them in performing their tasks. Here, we review the fascinating conundrum of how specific protein-protein interactions late in alphaherpesvirus infection orchestrate capsid nuclear assembly, nuclear egress, and cytoplasmic envelopment, but target incoming capsids to the nuclear pores in naive cells to inject the viral genomes into the nucleoplasm for viral transcription and replication. Multiple capsid interactions with viral and host proteins have been characterized using viral mutants and assays that reconstitute key stages of the infection cycle. Keratinocytes, fibroblasts, mucosal epithelial cells, neurons, and immune cells employ cell type-specific intrinsic and cytokine-induced resistance mechanisms to restrict several stages of the viral infection cycle. However, concomitantly, alphaherpesviruses have evolved countermeasures to ensure efficient capsid function during infection.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"215-238"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Risk of Virus Emergence in South America: A Subtle Balance Between Increasingly Favorable Conditions and a Protective Environment. 南美洲出现病毒的风险：日益有利的条件与保护性环境之间的微妙平衡。

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-024648

Benoit de Thoisy, Tiago Gräf, Daniel Santos Mansur, Adriana Delfraro, Claudia Nunes Duarte Dos Santos

{"title":"The Risk of Virus Emergence in South America: A Subtle Balance Between Increasingly Favorable Conditions and a Protective Environment.","authors":"Benoit de Thoisy, Tiago Gräf, Daniel Santos Mansur, Adriana Delfraro, Claudia Nunes Duarte Dos Santos","doi":"10.1146/annurev-virology-100422-024648","DOIUrl":"10.1146/annurev-virology-100422-024648","url":null,"abstract":"South American ecosystems host astonishing biodiversity, with potentially great richness in viruses. However, these ecosystems have not yet been the source of any widespread, epidemic viruses. Here we explore a set of putative causes that may explain this apparent paradox. We discuss that human presence in South America is recent, beginning around 14,000 years ago; that few domestications of native species have occurred; and that successive immigration events associated with Old World virus introductions reduced the likelihood of spillovers and adaptation of local viruses into humans. Also, the diversity and ecological characteristics of vertebrate hosts might serve as protective factors. Moreover, although forest areas remained well preserved until recently, current brutal, sudden, and large-scale clear cuts through the forest have resulted in nearly no ecotones, which are essential for creating an adaptive gradient of microbes, hosts, and vectors. This may be temporarily preventing virus emergence. Nevertheless, the mid-term effect of such drastic changes in habitats and landscapes, coupled with explosive urbanization and climate changes, must not be overlooked by health authorities.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"43-65"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studying Retroviral Life Cycles Using Visible Viruses and Live Cell Imaging. 利用可见病毒和活细胞成像揭示逆转录病毒生命周期

IF 8.1 1区医学

Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-012608

Jorge F Guerrero, Sydney L Lesko, Edward L Evans, Nathan M Sherer

{"title":"Studying Retroviral Life Cycles Using Visible Viruses and Live Cell Imaging.","authors":"Jorge F Guerrero, Sydney L Lesko, Edward L Evans, Nathan M Sherer","doi":"10.1146/annurev-virology-100422-012608","DOIUrl":"10.1146/annurev-virology-100422-012608","url":null,"abstract":"Viruses exploit key host cell factors to accomplish each individual stage of the viral replication cycle. To understand viral pathogenesis and speed the development of new antiviral strategies, high-resolution visualization of virus-host interactions is needed to define where and when these events occur within cells. Here, we review state-of-the-art live cell imaging techniques for tracking individual stages of viral life cycles, focusing predominantly on retroviruses and especially human immunodeficiency virus type 1, which is most extensively studied. We describe how visible viruses can be engineered for live cell imaging and how nonmodified viruses can, in some instances, be tracked and studied indirectly using cell biosensor systems. We summarize the ways in which live cell imaging has been used to dissect the retroviral life cycle. Finally, we discuss select challenges for the future including the need for better labeling strategies, increased resolution, and multivariate systems that will allow for the study of full viral replication cycles.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"125-146"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0