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Annual Review of Virology最新文献

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Viral Codon Usage and the Host Transfer RNA. 病毒密码子使用与宿主转移RNA。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-23 DOI: 10.1146/annurev-virology-092623-105418
Elena Muscolino, Juana Díez
{"title":"Viral Codon Usage and the Host Transfer RNA.","authors":"Elena Muscolino, Juana Díez","doi":"10.1146/annurev-virology-092623-105418","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-105418","url":null,"abstract":"<p><p>The expansion of viruses within cells requires efficient viral protein production. Counterintuitively, many viral genomes are enriched in suboptimal codons, which are typically associated with reduced protein outputs. Recent research using chikungunya virus (CHIKV) as a prototype model highlights the role of host transfer RNA (tRNA) modifications, collectively known as the tRNA epitranscriptome, in resolving this paradox. Upon infection, CHIKV triggers a DNA damage stress response that ultimately leads to changes in the tRNA epitranscriptome. These changes reprogram codon optimality, selectively enhancing the translation of specific suboptimal codons that are highly enriched in both host stress response genes and the viral genome. Hence, CHIKV codon usage optimally aligns with the tRNA modification landscape in infected cells. We propose that this interplay between viral codon usage, stress responses, and tRNA modifications is a shared strategy among viruses beyond CHIKV. Targeting this interplay may pave the way for the development of broad-spectrum antiviral therapies.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues. 胎儿组织中抗神经毒性病原体的母体抗体。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-18 DOI: 10.1146/annurev-virology-092623-094004
Matthew D Slein, Margaret E Ackerman, David A Leib
{"title":"Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues.","authors":"Matthew D Slein, Margaret E Ackerman, David A Leib","doi":"10.1146/annurev-virology-092623-094004","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-094004","url":null,"abstract":"<p><p>Infection by neurovirulent pathogens in utero and during the neonatal period can lead to fetal and neonatal mortality as well as neurological morbidity with lifelong consequences. Fortunately, maternal antibodies (Abs) serve as a means to protect humans as their immune system forms and matures. For some of the particularly consequential viral infections of early life, preclinical and clinical evidence demonstrate an unambiguously protective role of maternal Abs; for others, maternal Abs also have the potential to contribute to disease pathology. Here, we discuss how maternal Abs are temporarily inherited and distributed in fetal tissue. We focus on how this transgenerational form of immunity influences mortality and neurological morbidity as a result of herpes simplex virus, human cytomegalovirus, and flavivirus infections in early life.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grapevine Red Blotch Disease: A Threat to the Grape and Wine Industries. 葡萄红斑病：对葡萄和葡萄酒工业的威胁。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-15 DOI: 10.1146/annurev-virology-092623-101702
Elizabeth Cieniewicz, Marc Fuchs
{"title":"Grapevine Red Blotch Disease: A Threat to the Grape and Wine Industries.","authors":"Elizabeth Cieniewicz, Marc Fuchs","doi":"10.1146/annurev-virology-092623-101702","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-101702","url":null,"abstract":"<p><p>Grapevine red blotch disease emerged as a major threat to the North American viticulture more than 25 years ago. Prior to the discovery of its causal agent, grapevine red blotch virus (GRBV), the disease was likely mistaken for other vineyard problems. Over the last decade and a half, research on red blotch disease focused on GRBV biology; diagnostics; transmission biology; disease epidemiology; ecology of its vector, the treehopper <i>Spissistilus festinus</i>; and strategies for disease management. Research has also uncovered some of the physiological effects of GRBV on grapevines (inhibition of hexose translocation from leaves to fruits, transcriptional suppression of phenylpropanoid pathways), fruit (low soluble solids, poor ripening, reduced phenolic extractability, high titratable acidity), and wine (altered sensory attributes such as less fruit aromas and poor color and mouthfeel). The economic effects of the disease in different grape-producing regions of the United States are estimated to be as high as $68,548 per hectare over a 25-year vineyard lifespan. Here we reflect on major red blotch research progress and discuss future priorities. We also highlight the contribution of GRBV to the grapevine community as a major driver of enhanced cooperation among researchers, growers, nurseries, extension agents, policymakers, regulators, and service providers. We anticipate that strengthened interactions among all the members of the grapevine community and science-based disease management responses in vineyards will curtail GRBV spread and improve vineyard health.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies. APOBEC3G拮抗Vif，或当结构满足生物学和进化研究。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-04-07 DOI: 10.1146/annurev-virology-092623-091351
Yen-Li Li, Caroline Langley, Michael Emerman, John D Gross
{"title":"APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies.","authors":"Yen-Li Li, Caroline Langley, Michael Emerman, John D Gross","doi":"10.1146/annurev-virology-092623-091351","DOIUrl":"10.1146/annurev-virology-092623-091351","url":null,"abstract":"<p><p>Restriction factors serve as innate host defenses against viruses and act as critical barriers to cross-species transmission. In response, viruses have evolved accessory proteins to counteract restriction factors, enabling evasion of innate immune responses. The interplay between primate APOBEC3G (A3G) and lentiviral virion infectivity factor (Vif) exemplifies a molecular arms race between a restriction factor and its viral antagonist. This review integrates evolutionary and functional analyses of this system, showing how genetic signatures of molecular arms races map onto high-resolution cryo-electron microscopy structures. However, A3G's interaction with Vif is not limited to the evolutionary dynamic interface, characterized by rapidly evolving residues under selective pressure, but also involves a conserved interface mediated by RNA binding that positions A3G for antagonism by Vif. These findings propose a model wherein Vif and potentially other viral antagonists target functional complexes using a dual strategy: leveraging both adaptive interfaces subject to evolutionary pressures and conserved interfaces that constrain host escape mechanisms.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions Between Commensal Microbes and Mosquito-Borne Viruses. 共生微生物与蚊媒病毒之间的相互作用。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2025-03-11 DOI: 10.1146/annurev-virology-092623-101222
Yibin Zhu, Yingyi Cao, Liping Jiang, Penghua Wang, Gong Cheng
{"title":"Interactions Between Commensal Microbes and Mosquito-Borne Viruses.","authors":"Yibin Zhu, Yingyi Cao, Liping Jiang, Penghua Wang, Gong Cheng","doi":"10.1146/annurev-virology-092623-101222","DOIUrl":"https://doi.org/10.1146/annurev-virology-092623-101222","url":null,"abstract":"<p><p>Emerging and re-emerging mosquito-borne viruses pose a significant threat to global public health. Unfortunately, effective preventive and therapeutic measures are scarce. An in-depth understanding of the mechanisms regulating viral pathogenesis, vector competence, and viral transmission between mammalian hosts and vectors may lay the foundations for new preventive and therapeutic approaches. Here, we summarize the intricate interactions between commensal microbes and mosquito-borne viruses in mammalian hosts and mosquitoes, including how the host gut microbiota influences the pathogenesis of viral infection; how the host skin microbiota affects the attractiveness of hosts to mosquitoes and viral transmission; and how symbiotic microbes, including endosymbiotic bacteria, fungi, and insect-specific viruses in mosquitoes, regulate viral transmission through gut immune regulation and microbe-derived effectors. In addition, we discuss the potential of symbiotic microbe-based interventions to suppress the transmission of mosquito-borne viral diseases.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction. 介绍。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2024-09-01 DOI: 10.1146/annurev-vi-11-071524-100001
Terence S Dermody, Julie K Pfeiffer
{"title":"Introduction.","authors":"Terence S Dermody, Julie K Pfeiffer","doi":"10.1146/annurev-vi-11-071524-100001","DOIUrl":"https://doi.org/10.1146/annurev-vi-11-071524-100001","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"11 1","pages":"i-ii"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Molecular Maze of Potyviral and Host Protein Interactions. 病毒与宿主蛋白质相互作用的分子迷宫
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-034124
Maija E Pollari, William W E Aspelin, Linping Wang, Kristiina M Mäkinen
{"title":"The Molecular Maze of Potyviral and Host Protein Interactions.","authors":"Maija E Pollari, William W E Aspelin, Linping Wang, Kristiina M Mäkinen","doi":"10.1146/annurev-virology-100422-034124","DOIUrl":"10.1146/annurev-virology-100422-034124","url":null,"abstract":"<p><p>The negative effects of potyvirus diseases on the agricultural industry are extensive and global. Understanding how protein-protein interactions contribute to potyviral infections is imperative to developing resistant varieties that help counter the threat potyviruses pose. While many protein-protein interactions have been reported, only a fraction are essential for potyviral infection. Accumulating evidence demonstrates that potyviral infection processes are interconnected. For instance, the interaction between the eukaryotic initiation factor 4E (eIF4E) and viral protein genome-linked (VPg) is crucial for both viral translation and protecting viral RNA (vRNA). Additionally, recent evidence for open reading frames on the reverse-sense vRNA and for nonequimolar expression of viral proteins has challenged the previous polyprotein expression model. These discoveries will surely reveal more about the potyviral protein interactome. In this review, we present a synthesis of the potyviral infection cycle and discuss influential past discoveries and recent work on protein-protein interactions in various infection processes.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"147-170"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Entry to the Nucleus: How Retroviruses Commute. 从进入细胞核到细胞核：逆转录病毒是如何传播的？
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-023502
Camila E Osega, Fernando J Bustos, Gloria Arriagada
{"title":"From Entry to the Nucleus: How Retroviruses Commute.","authors":"Camila E Osega, Fernando J Bustos, Gloria Arriagada","doi":"10.1146/annurev-virology-100422-023502","DOIUrl":"10.1146/annurev-virology-100422-023502","url":null,"abstract":"<p><p>Once inside host cells, retroviruses generate a double-stranded DNA copy of their RNA genomes via reverse transcription inside a viral core, and this viral DNA is subsequently integrated into the genome of the host cell. Before integration can occur, the core must cross the cell cortex, be transported through the cytoplasm, and enter the nucleus. Retroviruses have evolved different mechanisms to accomplish this journey. This review examines the various mechanisms retroviruses, especially HIV-1, have evolved to commute throughout the cell. Retroviruses cross the cell cortex while modulating actin dynamics and use microtubules as roads while connecting with microtubule-associated proteins and motors to reach the nucleus. Although a clearer picture exists for HIV-1 compared with other retroviruses, there is still much to learn about how retroviruses accomplish their commute.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"89-104"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Cold War and Phage Therapy: How Geopolitics Stalled Development of Viruses as Antibacterials. 冷战与噬菌体疗法：地缘政治如何阻碍了作为抗菌剂的病毒的发展》（The Cold War and Phage Therapy: How Geopolics Stilly Development of Viruses as Antibacterials）。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-040919
William C Summers
{"title":"The Cold War and Phage Therapy: How Geopolitics Stalled Development of Viruses as Antibacterials.","authors":"William C Summers","doi":"10.1146/annurev-virology-100422-040919","DOIUrl":"10.1146/annurev-virology-100422-040919","url":null,"abstract":"<p><p>The bacteriolytic character of bacteriophages was employed as antibacterial therapy almost from the time of their discovery in 1917. In the United States, phage therapy was sporadic during the 1920s and 1930s but had dwindled into obscurity by the post-WWII period. This demise of phage therapy has traditionally been attributed to the superiority of antibiotics, discovered and first used during the war years, but this explanation is complicated by the fact that phage therapy outside the United States has had a longer and more successful life, especially in the countries of Eastern Europe. This review considers another, probably synergetic factor that was specific to the medical uses of phage in the United States: the geopolitical climate fostered by the Cold War reaction against Soviet science and its associated specter, socialized medicine. This analysis suggests that even such a purely scientific matter involving bacterial viruses cannot escape social forces and political ideologies.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"381-393"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses. 细胞搭便车指南：阿尔法疱疹病毒外壳中的世界》（A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses）。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1146/annurev-virology-100422-022751
Katinka Döhner, Manutea Christophe Serrero, Abel Viejo-Borbolla, Beate Sodeik
{"title":"A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses.","authors":"Katinka Döhner, Manutea Christophe Serrero, Abel Viejo-Borbolla, Beate Sodeik","doi":"10.1146/annurev-virology-100422-022751","DOIUrl":"10.1146/annurev-virology-100422-022751","url":null,"abstract":"<p><p>The nucleoplasm, the cytosol, the inside of virions, and again the cytosol comprise the world in which the capsids of alphaherpesviruses encounter viral and host proteins that support or limit them in performing their tasks. Here, we review the fascinating conundrum of how specific protein-protein interactions late in alphaherpesvirus infection orchestrate capsid nuclear assembly, nuclear egress, and cytoplasmic envelopment, but target incoming capsids to the nuclear pores in naive cells to inject the viral genomes into the nucleoplasm for viral transcription and replication. Multiple capsid interactions with viral and host proteins have been characterized using viral mutants and assays that reconstitute key stages of the infection cycle. Keratinocytes, fibroblasts, mucosal epithelial cells, neurons, and immune cells employ cell type-specific intrinsic and cytokine-induced resistance mechanisms to restrict several stages of the viral infection cycle. However, concomitantly, alphaherpesviruses have evolved countermeasures to ensure efficient capsid function during infection.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"215-238"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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