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Annual Review of Virology最新文献

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Interactions Between Commensal Microbes and Mosquito-Borne Viruses. 共生微生物与蚊媒病毒之间的相互作用。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 Epub Date: 2025-03-11 DOI: 10.1146/annurev-virology-092623-101222
Yibin Zhu, Yingyi Cao, Liping Jiang, Penghua Wang, Gong Cheng
{"title":"Interactions Between Commensal Microbes and Mosquito-Borne Viruses.","authors":"Yibin Zhu, Yingyi Cao, Liping Jiang, Penghua Wang, Gong Cheng","doi":"10.1146/annurev-virology-092623-101222","DOIUrl":"10.1146/annurev-virology-092623-101222","url":null,"abstract":"<p><p>Emerging and re-emerging mosquito-borne viruses pose a significant threat to global public health. Unfortunately, effective preventive and therapeutic measures are scarce. An in-depth understanding of the mechanisms regulating viral pathogenesis, vector competence, and viral transmission between mammalian hosts and vectors may lay the foundations for new preventive and therapeutic approaches. Here, we summarize the intricate interactions between commensal microbes and mosquito-borne viruses in mammalian hosts and mosquitoes, including how the host gut microbiota influences the pathogenesis of viral infection; how the host skin microbiota affects the attractiveness of hosts to mosquitoes and viral transmission; and how symbiotic microbes, including endosymbiotic bacteria, fungi, and insect-specific viruses in mosquitoes, regulate viral transmission through gut immune regulation and microbe-derived effectors. In addition, we discuss the potential of symbiotic microbe-based interventions to suppress the transmission of mosquito-borne viral diseases.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"79-92"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lab Legends and Field Phantoms: The Tale of Virus-Resistant Plants. 实验室传说和野外幻影：抗病毒植物的故事。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 Epub Date: 2025-06-11 DOI: 10.1146/annurev-virology-092623-101850
Patricia M B Fernandes, Antonio Alberto R Fernandes, Marlonni Maurastoni, Silas P Rodrigues
{"title":"Lab Legends and Field Phantoms: The Tale of Virus-Resistant Plants.","authors":"Patricia M B Fernandes, Antonio Alberto R Fernandes, Marlonni Maurastoni, Silas P Rodrigues","doi":"10.1146/annurev-virology-092623-101850","DOIUrl":"10.1146/annurev-virology-092623-101850","url":null,"abstract":"<p><p>Plant viruses present significant challenges to global agriculture, causing crop losses, threatening food security, and imposing economic burdens. Advances in biotechnology have revolutionized strategies to attack these threats, with genetically modified and genome-edited virus-resistant plants, developed using precision tools such as RNA interference and CRISPR/Cas technology, playing pivotal roles. Despite these breakthroughs, fragmented regulatory frameworks and divergent policies across regions including the European Union and the Global South hinder the global adoption of such innovations. Multifaceted approaches, including gene pyramiding, microbiome-based strategies, and pathogen-targeted defenses, show promise for enhancing plant resilience. This review explores the biological, regulatory, and ethical dimensions of deploying virus-resistant crops, emphasizing the need for harmonization of international regulation to maximize biotechnological benefits. By addressing these challenges, biotechnology can advance sustainable agriculture, secure food systems, and mitigate the effect of plant viral diseases.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"23-42"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Fascination with Gastrointestinal Viruses. 对胃肠道病毒的迷恋
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 DOI: 10.1146/annurev-virology-092623-111211
Mary Kolb Estes
{"title":"A Fascination with Gastrointestinal Viruses.","authors":"Mary Kolb Estes","doi":"10.1146/annurev-virology-092623-111211","DOIUrl":"10.1146/annurev-virology-092623-111211","url":null,"abstract":"<p><p>My arrival into this world came quickly, according to my mother, and it feels like my life has mirrored that rapid beginning. I have enjoyed a rich, varied, and stimulating life and career that have gone through several phases. I credit genetics, my family, technological advances, and many environmental factors for shaping my career. Being a virologist allowed me to be curious and creative and to make several unexpected discoveries. This has been a fun and rewarding journey, but it wasn't always easy. I am not accustomed to talking about myself, but I am happy to share some scientific achievements and professional challenges with the hope that they illustrate the joy of research and the need for resilience and persistence to assure progress and acceptance of unexpected results.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"12 1","pages":"1-21"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virologists Can Help Make America Healthy Again. 病毒学家可以帮助美国恢复健康。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 Epub Date: 2025-08-30 DOI: 10.1146/annurev-vi-12-041725-010437
Terence S Dermody, Julie K Pfeiffer
{"title":"Virologists Can Help Make America Healthy Again.","authors":"Terence S Dermody, Julie K Pfeiffer","doi":"10.1146/annurev-vi-12-041725-010437","DOIUrl":"10.1146/annurev-vi-12-041725-010437","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"iii-vii"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grapevine Red Blotch Disease: A Threat to the Grape and Wine Industries. 葡萄红斑病：对葡萄和葡萄酒工业的威胁。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 Epub Date: 2025-04-15 DOI: 10.1146/annurev-virology-092623-101702
Elizabeth Cieniewicz, Marc Fuchs
{"title":"Grapevine Red Blotch Disease: A Threat to the Grape and Wine Industries.","authors":"Elizabeth Cieniewicz, Marc Fuchs","doi":"10.1146/annurev-virology-092623-101702","DOIUrl":"10.1146/annurev-virology-092623-101702","url":null,"abstract":"<p><p>Grapevine red blotch disease emerged as a major threat to the North American viticulture more than 25 years ago. Prior to the discovery of its causal agent, grapevine red blotch virus (GRBV), the disease was likely mistaken for other vineyard problems. Over the last decade and a half, research on red blotch disease focused on GRBV biology; diagnostics; transmission biology; disease epidemiology; ecology of its vector, the treehopper <i>Spissistilus festinus</i>; and strategies for disease management. Research has also uncovered some of the physiological effects of GRBV on grapevines (inhibition of hexose translocation from leaves to fruits, transcriptional suppression of phenylpropanoid pathways), fruit (low soluble solids, poor ripening, reduced phenolic extractability, high titratable acidity), and wine (altered sensory attributes such as less fruit aromas and poor color and mouthfeel). The economic effects of the disease in different grape-producing regions of the United States are estimated to be as high as $68,548 per hectare over a 25-year vineyard lifespan. Here we reflect on major red blotch research progress and discuss future priorities. We also highlight the contribution of GRBV to the grapevine community as a major driver of enhanced cooperation among researchers, growers, nurseries, extension agents, policymakers, regulators, and service providers. We anticipate that strengthened interactions among all the members of the grapevine community and science-based disease management responses in vineyards will curtail GRBV spread and improve vineyard health.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"335-353"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral Codon Usage and the Host Transfer RNA. 病毒密码子使用与宿主转移RNA。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 Epub Date: 2025-04-23 DOI: 10.1146/annurev-virology-092623-105418
Elena Muscolino, Juana Díez
{"title":"Viral Codon Usage and the Host Transfer RNA.","authors":"Elena Muscolino, Juana Díez","doi":"10.1146/annurev-virology-092623-105418","DOIUrl":"10.1146/annurev-virology-092623-105418","url":null,"abstract":"<p><p>The expansion of viruses within cells requires efficient viral protein production. Counterintuitively, many viral genomes are enriched in suboptimal codons, which are typically associated with reduced protein outputs. Recent research using chikungunya virus (CHIKV) as a prototype model highlights the role of host transfer RNA (tRNA) modifications, collectively known as the tRNA epitranscriptome, in resolving this paradox. Upon infection, CHIKV triggers a DNA damage stress response that ultimately leads to changes in the tRNA epitranscriptome. These changes reprogram codon optimality, selectively enhancing the translation of specific suboptimal codons that are highly enriched in both host stress response genes and the viral genome. Hence, CHIKV codon usage optimally aligns with the tRNA modification landscape in infected cells. We propose that this interplay between viral codon usage, stress responses, and tRNA modifications is a shared strategy among viruses beyond CHIKV. Targeting this interplay may pave the way for the development of broad-spectrum antiviral therapies.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"223-237"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Structural Perspective on the Alphavirus Life Cycle. 甲病毒生命周期的结构视角。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1146/annurev-virology-093022-010359
Dahai Luo, Yaw Bia Tan, Michelle Cheok Yien Law, Jing Jin
{"title":"A Structural Perspective on the Alphavirus Life Cycle.","authors":"Dahai Luo, Yaw Bia Tan, Michelle Cheok Yien Law, Jing Jin","doi":"10.1146/annurev-virology-093022-010359","DOIUrl":"10.1146/annurev-virology-093022-010359","url":null,"abstract":"<p><p>Alphaviruses are mosquito-borne, enveloped viruses with a positive-sense, single-stranded RNA genome. Alphaviruses enter host cells via receptor-mediated endocytosis, using various cellular surface receptors such as matrix remodeling-associated protein 8 (MXRA8), low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3), and very low-density lipoprotein receptor (VLDLR), which facilitate binding to the viral glycoproteins. Following entry, viral proteins are expressed and nonstructural proteins assemble into replication complexes in host cells, driving RNA synthesis and genome replication. Viral assembly occurs at the plasma membrane, where nascent virions bud from the host cell in a process driven by capsid and spike proteins. Recent combinatorial structural studies have provided detailed molecular insights into various steps of the alphavirus life cycle. These structural insights into the alphavirus life cycle enhance our understanding of viral replication and assembly, with significant implications for antiviral strategies and the development of alphavirus-based vaccine vectors.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"299-314"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral Modulation of Host Splicing. 宿主剪接的病毒调节。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 Epub Date: 2025-04-25 DOI: 10.1146/annurev-virology-092623-102539
Bridget E Begg, Max B Ferretti, Matthew A Tracey, Kristen W Lynch
{"title":"Viral Modulation of Host Splicing.","authors":"Bridget E Begg, Max B Ferretti, Matthew A Tracey, Kristen W Lynch","doi":"10.1146/annurev-virology-092623-102539","DOIUrl":"10.1146/annurev-virology-092623-102539","url":null,"abstract":"<p><p>The discovery of precursor messenger RNA splicing was made through the study of adenovirus in the 1970s, and since then, the role of splicing in viral infection has been an important area of study. However, most of the work in this area prior to the past decade has focused on the splicing of viral genes. Only recently has there been an explosion of studies investigating how viral infection influences the splicing of host genes and the effect of this regulation on host-viral interplay. This review focuses on this growing interest and understanding of how viruses affect host splicing, the functional consequences of this regulation, and the questions that are motivating ongoing research surrounding host splicing changes during viral infection.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"203-222"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction. 介绍。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 DOI: 10.1146/annurev-virology-071425-095749
Terence S Dermody, Julie K Pfeiffer
{"title":"Introduction.","authors":"Terence S Dermody, Julie K Pfeiffer","doi":"10.1146/annurev-virology-071425-095749","DOIUrl":"https://doi.org/10.1146/annurev-virology-071425-095749","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"12 1","pages":"i-ii"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community-Scale Molecular Surveillance for Human Viruses. 社区尺度的人类病毒分子监测。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.1146/annurev-virology-092623-102821
Ari N Machtinger, Heather M Machkovech, Shelby L O'Connor, Marc C Johnson, Martin M Shafer, Thomas C Friedrich, David H O'Connor
{"title":"Community-Scale Molecular Surveillance for Human Viruses.","authors":"Ari N Machtinger, Heather M Machkovech, Shelby L O'Connor, Marc C Johnson, Martin M Shafer, Thomas C Friedrich, David H O'Connor","doi":"10.1146/annurev-virology-092623-102821","DOIUrl":"10.1146/annurev-virology-092623-102821","url":null,"abstract":"<p><p>Environmental surveillance, including wastewater and air sampling, has emerged as a powerful complement to traditional clinical surveillance for monitoring viral circulation. Advances in sampling and detection technologies, many spurred by the COVID-19 pandemic, have enabled more sensitive and comprehensive characterization of viruses in diverse types of commingled samples from multiple individuals. Expanding environmental monitoring globally presents challenges and opportunities, particularly in low- and middle-income countries where centralized sewage infrastructure may be limited. Ethical implementation will require balancing privacy and transparency through community engagement. Future directions include using environmental surveillance to detect emerging zoonoses, fill gaps when clinical testing wanes, and inform public health actions. While logistical, regulatory, and ethical challenges remain, coordination across scientific and public health stakeholders can enable environmental monitoring to transform epidemic intelligence. This review summarizes recent developments in environmental surveillance systems and discusses how they can mitigate the introduction and spread of viruses in communities.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"115-134"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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