{"title":"The Collaborative Cross as a Model for Studying Viral Infections.","authors":"P A Sylvester, M T Heise","doi":"10.1146/annurev-virology-100422-031014","DOIUrl":null,"url":null,"abstract":"<p><p>Inbred mouse strains are an invaluable resource for modeling virus-host interactions and studying how specific host genes affect virus-induced disease. However, many viruses cause a spectrum of disease outcomes in humans ranging from asymptomatic infection to severe disease or death. Conventional mouse strains do not recapitulate human genetic diversity and often fail to reproduce the full spectrum of virus-induced disease phenotypes seen in humans. The Collaborative Cross (CC) recombinant inbred mouse population is a genetically diverse set of mouse strains designed to model the genetic and phenotypic diversity seen in human populations. The CC has been used to study the effect of host genetic variation on the pathogenesis of several human viruses, and we review the utility of the CC as a resource both for developing new models of virus-induced disease and for the identification and study of host gene variants that affect susceptibility to virus-induced disease.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":8.1000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Virology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-virology-100422-031014","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Inbred mouse strains are an invaluable resource for modeling virus-host interactions and studying how specific host genes affect virus-induced disease. However, many viruses cause a spectrum of disease outcomes in humans ranging from asymptomatic infection to severe disease or death. Conventional mouse strains do not recapitulate human genetic diversity and often fail to reproduce the full spectrum of virus-induced disease phenotypes seen in humans. The Collaborative Cross (CC) recombinant inbred mouse population is a genetically diverse set of mouse strains designed to model the genetic and phenotypic diversity seen in human populations. The CC has been used to study the effect of host genetic variation on the pathogenesis of several human viruses, and we review the utility of the CC as a resource both for developing new models of virus-induced disease and for the identification and study of host gene variants that affect susceptibility to virus-induced disease.
期刊介绍：
The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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