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Annual Review of Virology最新文献

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The Life Cycle of the Vaccinia Virus Genome. 牛痘病毒基因组的生命周期。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-05-18 DOI: 10.1146/annurev-virology-091919-104752
Matthew D. Greseth, P. Traktman
{"title":"The Life Cycle of the Vaccinia Virus Genome.","authors":"Matthew D. Greseth, P. Traktman","doi":"10.1146/annurev-virology-091919-104752","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-104752","url":null,"abstract":"Poxviruses, of which vaccinia virus is the prototype, are a large family of double-stranded DNA viruses that replicate exclusively in the cytoplasm of infected cells. This physical and genetic autonomy from the host cell nucleus necessitates that these viruses encode most, if not all, of the proteins required for replication in the cytoplasm. In this review, we follow the life of the viral genome through space and time to address some of the unique challenges that arise from replicating a 195-kb DNA genome in the cytoplasm. We focus on how the genome is released from the incoming virion and deposited into the cytoplasm; how the endoplasmic reticulum is reorganized to form a replication factory, thereby compartmentalizing and helping to protect the replicating genome from immune sensors; how the cellular milieu is tailored to support high-fidelity replication of the genome; and finally, how newly synthesized genomes are faithfully and specifically encapsidated into new virions. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46175112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Understanding the Impacts of Bacteriophage Viruses: From Laboratory Evolution to Natural Ecosystems. 了解噬菌体病毒的影响：从实验室进化到自然生态系统。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-05-18 DOI: 10.1146/annurev-virology-091919-075914
B. Koskella, C. A. Hernandez, Rachel M. Wheatley
{"title":"Understanding the Impacts of Bacteriophage Viruses: From Laboratory Evolution to Natural Ecosystems.","authors":"B. Koskella, C. A. Hernandez, Rachel M. Wheatley","doi":"10.1146/annurev-virology-091919-075914","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-075914","url":null,"abstract":"Viruses of bacteriophages (phages) have broad effects on bacterial ecology and evolution in nature that mediate microbial interactions, shape bacterial diversity, and influence nutrient cycling and ecosystem function. The unrelenting impact of phages within the microbial realm is the result, in large part, of their ability to rapidly evolve in response to bacterial host dynamics. The knowledge gained from laboratory systems, typically using pairwise interactions between single-host and single-phage systems, has made clear that phages coevolve with their bacterial hosts rapidly, somewhat predictably, and primarily by counteradapting to host resistance. Recent advancement in metagenomics approaches, as well as a shifting focus toward natural microbial communities and host-associated microbiomes, is beginning to uncover the full picture of phage evolution and ecology within more complex settings. As these data reach their full potential, it will be critical to ask when and how insights gained from studies of phage evolution in vitro can be meaningfully applied to understanding bacteria-phage interactions in nature. In this review, we explore the myriad ways that phages shape and are themselves shaped by bacterial host populations and communities, with a particular focus on observed and predicted differences between the laboratory and complex microbial communities. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45644856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Natural Selection, Intracellular Bottlenecks of Virus Populations, and Viral Superinfection Exclusion. 自然选择、病毒群体的细胞内瓶颈和病毒重叠感染排除。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-05-13 DOI: 10.1146/annurev-virology-100520-114758
Camila Perdoncini Carvalho, Ruifan Ren, Junping Han, F. Qu
{"title":"Natural Selection, Intracellular Bottlenecks of Virus Populations, and Viral Superinfection Exclusion.","authors":"Camila Perdoncini Carvalho, Ruifan Ren, Junping Han, F. Qu","doi":"10.1146/annurev-virology-100520-114758","DOIUrl":"https://doi.org/10.1146/annurev-virology-100520-114758","url":null,"abstract":"Natural selection acts on cellular organisms by ensuring the genes responsible for an advantageous phenotype consistently reap the phenotypic advantage. This is possible because reproductive cells of these organisms are almost always haploid, separating the beneficial gene from its rival allele at every generation. How natural selection acts on plus-strand RNA viruses is unclear because these viruses frequently load host cells with numerous genome copies and replicate thousands of progeny genomes in each cell. Recent studies suggest that these viruses encode the Bottleneck, Isolate, Amplify, Select (BIAS) mechanism that blocks all but a few viral genome copies from replication, thus creating the environment in which the bottleneck-escaping viral genome copies are isolated from each other, allowing natural selection to reward beneficial mutations and purge lethal errors. This BIAS mechanism also blocks the genomes of highly homologous superinfecting viruses, thus explaining cellular-level superinfection exclusion. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48854584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The Ups and Downs of an Out-of-the-Box Scientist with a Curious Mind. 一个具有好奇心的特立独行的科学家的起起落落。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-05-05 DOI: 10.1146/annurev-virology-100520-013446
M. Roossinck
{"title":"The Ups and Downs of an Out-of-the-Box Scientist with a Curious Mind.","authors":"M. Roossinck","doi":"10.1146/annurev-virology-100520-013446","DOIUrl":"https://doi.org/10.1146/annurev-virology-100520-013446","url":null,"abstract":"My early life was challenging, and not conducive to the study of science, but my first introduction to viruses was an epiphany for me. I spent the whole of my career dedicated to understanding viruses, driven largely by curiosity. This led me down many different avenues of study, and to work with many wonderful colleagues, most of whom remain friends. Some highlights of my career include the discovery of a mutualistic three-way symbiosis involving a virus, a fungus, and a plant; genetic mapping of a pathogenicity gene in tomato; uncovering a virus in 1,000-year-old corncobs; exploring virus biodiversity in wild plants; and establishing a system to use a fungal virus to understand the epidemiology of its host. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43042329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunities, Technology, and the Joy of Discovery. 机遇、技术和发现的乐趣。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-04-01 DOI: 10.1146/annurev-virology-100520-012840
P. Spear
{"title":"Opportunities, Technology, and the Joy of Discovery.","authors":"P. Spear","doi":"10.1146/annurev-virology-100520-012840","DOIUrl":"https://doi.org/10.1146/annurev-virology-100520-012840","url":null,"abstract":"My grandparents were immigrants. My paternal grandfather was illiterate. Yet my parents were able to complete college and to become teachers. I had a conventional upbringing in a small town in Florida, graduating from high school in 1960. I was fortunate enough to graduate cum laude from Florida State University and to earn other credentials leading to faculty positions at outstanding institutions of higher education: the University of Chicago and Northwestern University. At a time when women were rarely the leaders of research groups, I was able to establish a well-funded research program and to make contributions to our understanding of viral entry into cells. My best research was done after I became confident enough to seek productive interactions with collaborators. I am grateful for the collaborators and collaborations that moved our field forward and for my trainees who have gone on to successes in many different careers. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44207769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccine Safety, Efficacy, and Trust Take Time. 疫苗的安全性、有效性和信任需要时间。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-vi-08-102220-100001
Terence S Dermody, Daniel DiMaio, Lynn W Enquist
{"title":"Vaccine Safety, Efficacy, and Trust Take Time.","authors":"Terence S Dermody, Daniel DiMaio, Lynn W Enquist","doi":"10.1146/annurev-vi-08-102220-100001","DOIUrl":"https://doi.org/10.1146/annurev-vi-08-102220-100001","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"iii-iv"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vi-08-102220-100001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38598909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
New Insights into Chikungunya Virus Infection and Pathogenesis. 基孔肯雅病毒感染与发病机制的新认识
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-13 DOI: 10.1146/annurev-virology-091919-102021
Vasiliya Kril, Olivier Aïqui-Reboul-Paviet, Laurence Briant, Ali Amara
{"title":"New Insights into Chikungunya Virus Infection and Pathogenesis.","authors":"Vasiliya Kril,&nbsp;Olivier Aïqui-Reboul-Paviet,&nbsp;Laurence Briant,&nbsp;Ali Amara","doi":"10.1146/annurev-virology-091919-102021","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-102021","url":null,"abstract":"<p><p>Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for major outbreaks of disease since 2004 in the Indian Ocean islands, South east Asia, and the Americas. CHIKV causes debilitating musculoskeletal disorders in humans that are characterized by fever, rash, polyarthralgia, and myalgia. The disease is often self-limiting and nonlethal; however, some patients experience atypical or severe clinical manifestations, as well as a chronic rheumatic syndrome. Unfortunately, no efficient antivirals against CHIKV infection are available so far, highlighting the importance of deepening our knowledge of CHIKV host cell interactions and viral replication strategies. In this review, we discuss recent breakthroughs in the molecular mechanisms that regulate CHIKV infection and lay down the foundations to understand viral pathogenesis. We describe the role of the recently identified host factors co-opted by the virus for infection and pathogenesis, and emphasize the importance of CHIKV nonstructural proteins in both replication complex assembly and host immune response evasion.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"327-347"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
FAST Proteins: Development and Use of Reverse Genetics Systems for Reoviridae Viruses. 快速蛋白:呼肠孤病毒科病毒反向遗传系统的开发和应用。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-virology-091919-070225
Yuta Kanai, Takeshi Kobayashi
{"title":"FAST Proteins: Development and Use of Reverse Genetics Systems for <i>Reoviridae</i> Viruses.","authors":"Yuta Kanai,&nbsp;Takeshi Kobayashi","doi":"10.1146/annurev-virology-091919-070225","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-070225","url":null,"abstract":"<p><p>Reverse genetics systems for viruses, the technology used to generate gene-engineered recombinant viruses from artificial genes, enable the study of the roles of the individual nucleotides and amino acids of viral genes and proteins in infectivity, replication, and pathogenicity. The successful development of a reverse genetics system for poliovirus in 1981 accelerated the establishment of protocols for other RNA viruses important for human health. Despite multiple efforts, rotavirus (RV), which causes severe gastroenteritis in infants, was refractory to reverse genetics analysis, and the first complete reverse genetics system for RV was established in 2017. This novel technique involves use of the fusogenic protein FAST (fusion-associated small transmembrane) derived from the bat-borne Nelson Bay orthoreovirus, which induces massive syncytium formation. Co-transfection of a FAST-expressing plasmid with complementary DNAs encoding RV genes enables rescue of recombinant RV. This review focuses on methodological insights into the reverse genetics system for RV and discusses applications and potential improvements to this system.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"515-536"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39469038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Bacteriophages and the Immune System. 噬菌体和免疫系统。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-05-20 DOI: 10.1146/annurev-virology-091919-074551
Medeea Popescu, Jonas D Van Belleghem, Arya Khosravi, Paul L Bollyky
{"title":"Bacteriophages and the Immune System.","authors":"Medeea Popescu,&nbsp;Jonas D Van Belleghem,&nbsp;Arya Khosravi,&nbsp;Paul L Bollyky","doi":"10.1146/annurev-virology-091919-074551","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-074551","url":null,"abstract":"<p><p>Bacteriophages-viruses that infect bacteria-are abundant within our bodies, but their significance to human health is only beginning to be explored. Here, we synthesize what is currently known about our phageome and its interactions with the immune system. We first review how phages indirectly affect immunity via bacterial expression of phage-encoded proteins. We next review how phages directly influence innate immunity and bacterial clearance. Finally, we discuss adaptive immunity against phages and its implications for phage/bacterial interactions. In light of these data, we propose that our microbiome can be understood as an interconnected network of bacteria, bacteriophages, and human cells and that the stability of these tri-kingdom interactions may be important for maintaining our immunologic and metabolic health. Conversely, the disruption of this balance, through exposure to exogenous phages, microbial dysbiosis, or immune dysregulation, may contribute to disease.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"415-435"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39002425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
The Social Life of Viruses. 病毒的社会生活
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-09 DOI: 10.1146/annurev-virology-091919-071712
Rafael Sanjuán
{"title":"The Social Life of Viruses.","authors":"Rafael Sanjuán","doi":"10.1146/annurev-virology-091919-071712","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-071712","url":null,"abstract":"<p><p>Despite their simplicity, viruses exhibit certain types of social interactions. Situations in which a given virus achieves higher fitness in combination with other members of the viral population have been described at the level of transmission, replication, suppression of host immune responses, and host killing, enabling the evolution of viral cooperation. Although cellular coinfection with multiple viral particles is the typical playground for these interactions, cooperation between viruses infecting different cells is also established through cellular and viral-encoded communication systems. In general, the stability of cooperation is compromised by cheater genotypes, as best exemplified by defective interfering particles. As predicted by social evolution theory, cheater invasion can be avoided when cooperators interact preferentially with other cooperators, a situation that is promoted in spatially structured populations. Processes such as transmission bottlenecks, organ compartmentalization, localized spread of infection foci, superinfection exclusion, and even discrete intracellular replication centers promote multilevel spatial structuring in viruses.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"183-199"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39168525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
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