噬菌体和免疫系统。

IF 8.1 1区 医学 Q1 VIROLOGY
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-05-20 DOI:10.1146/annurev-virology-091919-074551
Medeea Popescu, Jonas D Van Belleghem, Arya Khosravi, Paul L Bollyky
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引用次数: 44

摘要

噬菌体——感染细菌的病毒——在我们体内大量存在,但它们对人类健康的重要性才刚刚开始被探索。在这里,我们综合了目前已知的噬菌体及其与免疫系统的相互作用。我们首先回顾了噬菌体是如何通过细菌表达噬菌体编码蛋白间接影响免疫的。接下来我们将回顾噬菌体如何直接影响先天免疫和细菌清除。最后,我们讨论了针对噬菌体的适应性免疫及其对噬菌体/细菌相互作用的影响。根据这些数据,我们建议我们的微生物组可以被理解为细菌,噬菌体和人类细胞的相互连接的网络,这些三界相互作用的稳定性可能对维持我们的免疫和代谢健康很重要。相反,通过暴露于外源性噬菌体、微生物生态失调或免疫失调而破坏这种平衡可能导致疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bacteriophages and the Immune System.

Bacteriophages-viruses that infect bacteria-are abundant within our bodies, but their significance to human health is only beginning to be explored. Here, we synthesize what is currently known about our phageome and its interactions with the immune system. We first review how phages indirectly affect immunity via bacterial expression of phage-encoded proteins. We next review how phages directly influence innate immunity and bacterial clearance. Finally, we discuss adaptive immunity against phages and its implications for phage/bacterial interactions. In light of these data, we propose that our microbiome can be understood as an interconnected network of bacteria, bacteriophages, and human cells and that the stability of these tri-kingdom interactions may be important for maintaining our immunologic and metabolic health. Conversely, the disruption of this balance, through exposure to exogenous phages, microbial dysbiosis, or immune dysregulation, may contribute to disease.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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