Annual Review of Virology最新文献_第9页

Understanding the Complex Phage-Host Interactions in Biofilm Communities. 了解生物膜群落中复杂的噬菌体-宿主相互作用。

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-06-29 DOI: 10.1146/annurev-virology-091919-074222

Diana P Pires, Luís D R Melo, Joana Azeredo

引用次数: 29

I Am Here: It Took a Global Village. 我在这里:一个地球村。

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-virology-091919-104940

Mavis Agbandje-McKenna

{"title":"I Am Here: It Took a Global Village.","authors":"Mavis Agbandje-McKenna","doi":"10.1146/annurev-virology-091919-104940","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-104940","url":null,"abstract":"The saying \"It takes a village to raise a child\" has never been truer than in my case. This autobiographical article documents my growing up and working on three different continents and my influencers along the way. Born in a village in Nigeria, West Africa, I spent the first 12 years of life with my grandmother living in a mud house and attending a village primary school. I walked barefoot to school every day, learned to read, and wrote on a chalk slate. At the age of 13, I moved to my second \"village,\" London, England. In secondary school my love of science began to blossom. I attained a double major in chemistry and human biology from the University of Hertfordshire and a PhD in biophysics from the University of London, with a research project aimed at designing anticancer agents. I was mentored by Terence Jenkins and Stephen Neidle. For my postdoctoral training, I crossed the ocean again, to the United States, my third \"village.\" In Michael Rossmann's group at Purdue University, my love for viruses was ignited. My independent career in structural virology began at Warwick University, England, working on pathogenic single-stranded DNA packaging viruses. In 2020, I am a full professor at the University of Florida. Most of my research is focused on the adeno-associated viruses, gene delivery vectors. My list of mentors has grown and includes Nick Muzyczka. Here, the mentee has become the mentor, and along the way, we attained a number of firsts in the field of structural virology and contributed to the field at the national and international stages.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"1-21"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39469039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prospects for the Global Elimination of Hepatitis B. 全球消除乙型肝炎的前景。

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-virology-091919-062728

Timothy M Block, Kyong-Mi Chang, Ju-Tao Guo

引用次数: 17

Historical Perspective on the Discovery of the Quasispecies Concept. 准种概念发现的历史透视。

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-virology-091919-105900

Esteban Domingo, Carlos García-Crespo, Celia Perales

{"title":"Historical Perspective on the Discovery of the Quasispecies Concept.","authors":"Esteban Domingo, Carlos García-Crespo, Celia Perales","doi":"10.1146/annurev-virology-091919-105900","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-105900","url":null,"abstract":"Viral quasispecies are dynamic distributions of nonidentical but closely related mutant and recombinant viral genomes subjected to a continuous process of genetic variation, competition, and selection that may act as a unit of selection. The quasispecies concept owes its theoretical origins to a model for the origin of life as a collection of mutant RNA replicators. Independently, experimental evidence for the quasispecies concept was obtained from sampling of bacteriophage clones, which revealed that the viral populations consisted of many mutant genomes whose frequency varied with time of replication. Similar findings were made in animal and plant RNA viruses. Quasispecies became a theoretical framework to understand viral population dynamics and adaptability. The evidence came at a time when mutations were considered rare events in genetics, a perception that was to change dramatically in subsequent decades. Indeed, viral quasispecies was the conceptual forefront of a remarkable degree of biological diversity, now evident for cell populations and organisms, not only for viruses. Quasispecies dynamics unveiled complexities in the behavior of viral populations,with consequences for disease mechanisms and control strategies. This review addresses the origin of the quasispecies concept, its major implications on both viral evolution and antiviral strategies, and current and future prospects.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"51-72"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39471073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

The Current Status of Latency Reversing Agents for HIV-1 Remission. HIV-1缓解的潜伏期逆转药物的现状

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-virology-091919-103029

Anthony Rodari, Gilles Darcis, Carine M Van Lint

引用次数: 27

Viruses and Metabolism: The Effects of Viral Infections and Viral Insulins on Host Metabolism. 病毒与代谢:病毒感染和病毒胰岛素对宿主代谢的影响。

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-virology-091919-102416

Khyati Girdhar, Amaya Powis, Amol Raisingani, Martina Chrudinová, Ruixu Huang, Tu Tran, Kaan Sevgi, Yusuf Dogus Dogru, Emrah Altindis

{"title":"Viruses and Metabolism: The Effects of Viral Infections and Viral Insulins on Host Metabolism.","authors":"Khyati Girdhar, Amaya Powis, Amol Raisingani, Martina Chrudinová, Ruixu Huang, Tu Tran, Kaan Sevgi, Yusuf Dogus Dogru, Emrah Altindis","doi":"10.1146/annurev-virology-091919-102416","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-102416","url":null,"abstract":"Over the past decades, there have been tremendous efforts to understand the cross-talk between viruses and host metabolism. Several studies have elucidated the mechanisms through which viral infections manipulate metabolic pathways including glucose, fatty acid, protein, and nucleotide metabolism. These pathways are evolutionarily conserved across the tree of life and extremely important for the host's nutrient utilization and energy production. In this review, we focus on host glucose, glutamine, and fatty acid metabolism and highlight the pathways manipulated by the different classes of viruses to increase their replication. We also explore a new system of viral hormones in which viruses mimic host hormones to manipulate the host endocrine system. We discuss viral insulin/IGF-1-like peptides and their potential effects on host metabolism. Together, these pathogenesis mechanisms targeting cellular signaling pathways create a multidimensional network of interactions between host and viral proteins. Defining and better understanding these mechanisms will help us to develop new therapeutic tools to prevent and treat viral infections.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"373-391"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39471517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Virus Structures and Dynamics by Magic-Angle Spinning NMR. 魔角旋转核磁共振病毒结构和动力学。

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-virology-011921-064653

Gal Porat-Dahlerbruch, Amir Goldbourt, Tatyana Polenova

{"title":"Virus Structures and Dynamics by Magic-Angle Spinning NMR.","authors":"Gal Porat-Dahlerbruch, Amir Goldbourt, Tatyana Polenova","doi":"10.1146/annurev-virology-011921-064653","DOIUrl":"https://doi.org/10.1146/annurev-virology-011921-064653","url":null,"abstract":"Techniques for atomic-resolution structural biology have evolved during the past several decades. Breakthroughs in instrumentation, sample preparation, and data analysis that occurred in the past decade have enabled characterization of viruses with an unprecedented level of detail. Here we review the recent advances in magic-angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy for structural analysis of viruses and viral assemblies. MAS NMR is a powerful method that yields information on 3D structures and dynamics in a broad range of experimental conditions. After a brief introduction, we discuss recent structural and functional studies of several viruses investigated with atomic resolution at various levels of structural organization, from individual domains of a membrane protein reconstituted into lipid bilayers to virus-like particles and intact viruses. We present examples of the unique information revealed by MAS NMR about drug binding, conduction mechanisms, interactions with cellular host factors, and DNA packaging in biologically relevant environments that are inaccessible by other methods.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"219-237"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973440/pdf/nihms-1790240.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39471071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Small-Molecule Inhibition of Viral Fusion Glycoproteins. 小分子抑制病毒融合糖蛋白

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-01 DOI: 10.1146/annurev-virology-022221-063725

Han-Yuan Liu, Priscilla L Yang

引用次数: 0

Advances in Viroid-Host Interactions. 类病毒-宿主相互作用研究进展。

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-13 DOI: 10.1146/annurev-virology-091919-092331

Beatriz Navarro, Ricardo Flores, Francesco Di Serio

引用次数: 35

Reflections on a Career in Plant Virology: A Chip Floating on a Stream. 对植物病毒学事业的思考:漂浮在溪流上的芯片。

IF 11.3 1区医学

Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-13 DOI: 10.1146/annurev-virology-091919-105056

Andrew O Jackson

引用次数: 0