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The Ups and Downs of an Out-of-the-Box Scientist with a Curious Mind. 一个具有好奇心的特立独行的科学家的起起落落。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-05-05 DOI: 10.1146/annurev-virology-100520-013446
M. Roossinck
{"title":"The Ups and Downs of an Out-of-the-Box Scientist with a Curious Mind.","authors":"M. Roossinck","doi":"10.1146/annurev-virology-100520-013446","DOIUrl":"https://doi.org/10.1146/annurev-virology-100520-013446","url":null,"abstract":"My early life was challenging, and not conducive to the study of science, but my first introduction to viruses was an epiphany for me. I spent the whole of my career dedicated to understanding viruses, driven largely by curiosity. This led me down many different avenues of study, and to work with many wonderful colleagues, most of whom remain friends. Some highlights of my career include the discovery of a mutualistic three-way symbiosis involving a virus, a fungus, and a plant; genetic mapping of a pathogenicity gene in tomato; uncovering a virus in 1,000-year-old corncobs; exploring virus biodiversity in wild plants; and establishing a system to use a fungal virus to understand the epidemiology of its host. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43042329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunities, Technology, and the Joy of Discovery. 机遇、技术和发现的乐趣。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-04-01 DOI: 10.1146/annurev-virology-100520-012840
P. Spear
{"title":"Opportunities, Technology, and the Joy of Discovery.","authors":"P. Spear","doi":"10.1146/annurev-virology-100520-012840","DOIUrl":"https://doi.org/10.1146/annurev-virology-100520-012840","url":null,"abstract":"My grandparents were immigrants. My paternal grandfather was illiterate. Yet my parents were able to complete college and to become teachers. I had a conventional upbringing in a small town in Florida, graduating from high school in 1960. I was fortunate enough to graduate cum laude from Florida State University and to earn other credentials leading to faculty positions at outstanding institutions of higher education: the University of Chicago and Northwestern University. At a time when women were rarely the leaders of research groups, I was able to establish a well-funded research program and to make contributions to our understanding of viral entry into cells. My best research was done after I became confident enough to seek productive interactions with collaborators. I am grateful for the collaborators and collaborations that moved our field forward and for my trainees who have gone on to successes in many different careers. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44207769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccine Safety, Efficacy, and Trust Take Time. 疫苗的安全性、有效性和信任需要时间。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-vi-08-102220-100001
Terence S Dermody, Daniel DiMaio, Lynn W Enquist
{"title":"Vaccine Safety, Efficacy, and Trust Take Time.","authors":"Terence S Dermody, Daniel DiMaio, Lynn W Enquist","doi":"10.1146/annurev-vi-08-102220-100001","DOIUrl":"https://doi.org/10.1146/annurev-vi-08-102220-100001","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"iii-iv"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-vi-08-102220-100001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38598909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
New Insights into Chikungunya Virus Infection and Pathogenesis. 基孔肯雅病毒感染与发病机制的新认识
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-13 DOI: 10.1146/annurev-virology-091919-102021
Vasiliya Kril, Olivier Aïqui-Reboul-Paviet, Laurence Briant, Ali Amara
{"title":"New Insights into Chikungunya Virus Infection and Pathogenesis.","authors":"Vasiliya Kril,&nbsp;Olivier Aïqui-Reboul-Paviet,&nbsp;Laurence Briant,&nbsp;Ali Amara","doi":"10.1146/annurev-virology-091919-102021","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-102021","url":null,"abstract":"<p><p>Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for major outbreaks of disease since 2004 in the Indian Ocean islands, South east Asia, and the Americas. CHIKV causes debilitating musculoskeletal disorders in humans that are characterized by fever, rash, polyarthralgia, and myalgia. The disease is often self-limiting and nonlethal; however, some patients experience atypical or severe clinical manifestations, as well as a chronic rheumatic syndrome. Unfortunately, no efficient antivirals against CHIKV infection are available so far, highlighting the importance of deepening our knowledge of CHIKV host cell interactions and viral replication strategies. In this review, we discuss recent breakthroughs in the molecular mechanisms that regulate CHIKV infection and lay down the foundations to understand viral pathogenesis. We describe the role of the recently identified host factors co-opted by the virus for infection and pathogenesis, and emphasize the importance of CHIKV nonstructural proteins in both replication complex assembly and host immune response evasion.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"327-347"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
FAST Proteins: Development and Use of Reverse Genetics Systems for Reoviridae Viruses. 快速蛋白:呼肠孤病毒科病毒反向遗传系统的开发和应用。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 DOI: 10.1146/annurev-virology-091919-070225
Yuta Kanai, Takeshi Kobayashi
{"title":"FAST Proteins: Development and Use of Reverse Genetics Systems for <i>Reoviridae</i> Viruses.","authors":"Yuta Kanai,&nbsp;Takeshi Kobayashi","doi":"10.1146/annurev-virology-091919-070225","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-070225","url":null,"abstract":"<p><p>Reverse genetics systems for viruses, the technology used to generate gene-engineered recombinant viruses from artificial genes, enable the study of the roles of the individual nucleotides and amino acids of viral genes and proteins in infectivity, replication, and pathogenicity. The successful development of a reverse genetics system for poliovirus in 1981 accelerated the establishment of protocols for other RNA viruses important for human health. Despite multiple efforts, rotavirus (RV), which causes severe gastroenteritis in infants, was refractory to reverse genetics analysis, and the first complete reverse genetics system for RV was established in 2017. This novel technique involves use of the fusogenic protein FAST (fusion-associated small transmembrane) derived from the bat-borne Nelson Bay orthoreovirus, which induces massive syncytium formation. Co-transfection of a FAST-expressing plasmid with complementary DNAs encoding RV genes enables rescue of recombinant RV. This review focuses on methodological insights into the reverse genetics system for RV and discusses applications and potential improvements to this system.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"515-536"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39469038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Bacteriophages and the Immune System. 噬菌体和免疫系统。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-05-20 DOI: 10.1146/annurev-virology-091919-074551
Medeea Popescu, Jonas D Van Belleghem, Arya Khosravi, Paul L Bollyky
{"title":"Bacteriophages and the Immune System.","authors":"Medeea Popescu,&nbsp;Jonas D Van Belleghem,&nbsp;Arya Khosravi,&nbsp;Paul L Bollyky","doi":"10.1146/annurev-virology-091919-074551","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-074551","url":null,"abstract":"<p><p>Bacteriophages-viruses that infect bacteria-are abundant within our bodies, but their significance to human health is only beginning to be explored. Here, we synthesize what is currently known about our phageome and its interactions with the immune system. We first review how phages indirectly affect immunity via bacterial expression of phage-encoded proteins. We next review how phages directly influence innate immunity and bacterial clearance. Finally, we discuss adaptive immunity against phages and its implications for phage/bacterial interactions. In light of these data, we propose that our microbiome can be understood as an interconnected network of bacteria, bacteriophages, and human cells and that the stability of these tri-kingdom interactions may be important for maintaining our immunologic and metabolic health. Conversely, the disruption of this balance, through exposure to exogenous phages, microbial dysbiosis, or immune dysregulation, may contribute to disease.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"415-435"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39002425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
The Social Life of Viruses. 病毒的社会生活
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-09 DOI: 10.1146/annurev-virology-091919-071712
Rafael Sanjuán
{"title":"The Social Life of Viruses.","authors":"Rafael Sanjuán","doi":"10.1146/annurev-virology-091919-071712","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-071712","url":null,"abstract":"<p><p>Despite their simplicity, viruses exhibit certain types of social interactions. Situations in which a given virus achieves higher fitness in combination with other members of the viral population have been described at the level of transmission, replication, suppression of host immune responses, and host killing, enabling the evolution of viral cooperation. Although cellular coinfection with multiple viral particles is the typical playground for these interactions, cooperation between viruses infecting different cells is also established through cellular and viral-encoded communication systems. In general, the stability of cooperation is compromised by cheater genotypes, as best exemplified by defective interfering particles. As predicted by social evolution theory, cheater invasion can be avoided when cooperators interact preferentially with other cooperators, a situation that is promoted in spatially structured populations. Processes such as transmission bottlenecks, organ compartmentalization, localized spread of infection foci, superinfection exclusion, and even discrete intracellular replication centers promote multilevel spatial structuring in viruses.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"183-199"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39168525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Bacteriophage ICP1: A Persistent Predator of Vibrio cholerae. 噬菌体ICP1:霍乱弧菌的持久捕食者。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-27 DOI: 10.1146/annurev-virology-091919-072020
Caroline M Boyd, Angus Angermeyer, Stephanie G Hays, Zachary K Barth, Kishen M Patel, Kimberley D Seed
{"title":"Bacteriophage ICP1: A Persistent Predator of <i>Vibrio cholerae</i>.","authors":"Caroline M Boyd,&nbsp;Angus Angermeyer,&nbsp;Stephanie G Hays,&nbsp;Zachary K Barth,&nbsp;Kishen M Patel,&nbsp;Kimberley D Seed","doi":"10.1146/annurev-virology-091919-072020","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-072020","url":null,"abstract":"<p><p>Bacteriophages or phages-viruses of bacteria-are abundant and considered to be highly diverse. Interestingly, a particular group of lytic <i>Vibrio cholerae</i>-specific phages (vibriophages) of the International Centre for Diarrheal Disease Research, Bangladesh cholera phage 1 (ICP1) lineage show high levels of genome conservation over large spans of time and geography, despite a constant coevolutionary arms race with their host. From a collection of 67 sequenced ICP1 isolates, mostly from clinical samples, we find these phages have mosaic genomes consisting of large, conserved modules disrupted by variable sequences that likely evolve mostly through mobile endonuclease-mediated recombination during coinfection. Several variable regions have been associated with adaptations against antiphage elements in <i>V. cholerae</i>; notably, this includes ICP1's CRISPR-Cas system. The ongoing association of ICP1 and <i>V. cholerae</i> in cholera-endemic regions makes this system a rich source for discovery of novel defense and counterdefense strategies in bacteria-phage conflicts in nature.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"285-304"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39226046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Quantitative Temporal Viromics. 定量时间病毒组学。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-06-15 DOI: 10.1146/annurev-virology-091919-104458
Alice Fletcher-Etherington, Michael P Weekes
{"title":"Quantitative Temporal Viromics.","authors":"Alice Fletcher-Etherington,&nbsp;Michael P Weekes","doi":"10.1146/annurev-virology-091919-104458","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-104458","url":null,"abstract":"<p><p>The abundance, localization, modifications, and protein-protein interactions of many host cell and virus proteins can change dynamically throughout the course of any viral infection. Studying these changes is critical for a comprehensive understanding of how viruses replicate and cause disease, as well as for the development of antiviral therapeutics and vaccines. Previously, we developed a mass spectrometry-based technique called quantitative temporal viromics (QTV), which employs isobaric tandem mass tags (TMTs) to allow precise comparative quantification of host and virus proteomes through a whole time course of infection. In this review, we discuss the utility and applications of QTV, exemplified by numerous studies that have since used proteomics with a variety of quantitative techniques to study virus infection through time.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"159-181"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39233232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System. ZAP抗病毒系统对病毒基因表达和复制的靶向限制。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-06-15 DOI: 10.1146/annurev-virology-091919-104213
Mattia Ficarelli, Stuart J D Neil, Chad M Swanson
{"title":"Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System.","authors":"Mattia Ficarelli,&nbsp;Stuart J D Neil,&nbsp;Chad M Swanson","doi":"10.1146/annurev-virology-091919-104213","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-104213","url":null,"abstract":"<p><p>The zinc finger antiviral protein (ZAP) restricts the replication of a broad range of RNA and DNA viruses. ZAP directly binds viral RNA, targeting it for degradation and inhibiting its translation. While the full scope of RNA determinants involved in mediating selective ZAP activity is unclear, ZAP binds CpG dinucleotides, dictating at least part of its target specificity. ZAP interacts with many cellular proteins, although only a few have been demonstrated to be essential for its antiviral activity, including the 3'-5' exoribonuclease exosome complex, TRIM25, and KHNYN. In addition to inhibiting viral gene expression, ZAP also directly and indirectly targets a subset of cellular messenger RNAs to regulate the innate immune response. Overall, ZAP protects a cell from viral infection by restricting viral replication and regulating cellular gene expression. Further understanding of the ZAP antiviral system may allow for novel viral vaccine and anticancer therapy development.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"8 1","pages":"265-283"},"PeriodicalIF":11.3,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39233234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
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