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Annual Review of Virology最新文献

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The Knowns and Unknowns of Herpesvirus Nuclear Egress. 疱疹病毒核出口的已知与未知。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-04-11 DOI: 10.1146/annurev-virology-111821-105518
Barbara G Klupp, Thomas C Mettenleiter
{"title":"The Knowns and Unknowns of Herpesvirus Nuclear Egress.","authors":"Barbara G Klupp,&nbsp;Thomas C Mettenleiter","doi":"10.1146/annurev-virology-111821-105518","DOIUrl":"10.1146/annurev-virology-111821-105518","url":null,"abstract":"<p><p>Nuclear egress of herpesvirus capsids across the intact nuclear envelope is an exceptional vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of herpesvirus capsids into the cytosol. Budding of the (nucleo)capsid at and scission from the inner nuclear membrane (INM) is mediated by the viral nuclear egress complex (NEC) resulting in a transiently enveloped virus particle in the perinuclear space followed by fusion of the primary envelope with the outer nuclear membrane (ONM). The dimeric NEC oligomerizes into a honeycomb-shaped coat underlining the INM to induce membrane curvature and scission. Mutational analyses complemented structural data defining functionally important regions. Questions remain, including where and when the NEC is formed and how membrane curvature is mediated, vesicle formation is regulated, and directionality is secured. The composition of the primary enveloped virion and the machinery mediating fusion of the primary envelope with the ONM is still debated. While NEC-mediated budding apparently follows a highly conserved mechanism, species and/or cell type-specific differences complicate understanding of later steps.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"305-323"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9283338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Structures and Mechanisms of Nonsegmented, Negative-Strand RNA Virus Polymerases. 非分段负链RNA病毒聚合酶的结构和机制。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-05-03 DOI: 10.1146/annurev-virology-111821-102603
Mohamed Ouizougun-Oubari, Rachel Fearns
{"title":"Structures and Mechanisms of Nonsegmented, Negative-Strand RNA Virus Polymerases.","authors":"Mohamed Ouizougun-Oubari,&nbsp;Rachel Fearns","doi":"10.1146/annurev-virology-111821-102603","DOIUrl":"10.1146/annurev-virology-111821-102603","url":null,"abstract":"<p><p>The nonsegmented, negative-strand RNA viruses (nsNSVs), also known as the order <i>Mononegavirales</i>, have a genome consisting of a single strand of negative-sense RNA. Integral to the nsNSV replication cycle is the viral polymerase, which is responsible for transcribing the viral genome, to produce an array of capped and polyadenylated messenger RNAs, and replicating it to produce new genomes. To perform the different steps that are necessary for these processes, the nsNSV polymerases undergo a series of coordinated conformational transitions. While much is still to be learned regarding the intersection of nsNSV polymerase dynamics, structure, and function, recently published polymerase structures, combined with a history of biochemical and molecular biology studies, have provided new insights into how nsNSV polymerases function as dynamic machines. In this review, we consider each of the steps involved in nsNSV transcription and replication and suggest how these relate to solved polymerase structures.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"199-215"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9404562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Structure and Role of O-Linked Glycans in Viral Envelope Proteins. O-连接的甘氨酸在病毒包膜蛋白中的结构和作用。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-07-06 DOI: 10.1146/annurev-virology-111821-121007
Sigvard Olofsson, Marta Bally, Edward Trybala, Tomas Bergström
{"title":"Structure and Role of O-Linked Glycans in Viral Envelope Proteins.","authors":"Sigvard Olofsson,&nbsp;Marta Bally,&nbsp;Edward Trybala,&nbsp;Tomas Bergström","doi":"10.1146/annurev-virology-111821-121007","DOIUrl":"10.1146/annurev-virology-111821-121007","url":null,"abstract":"<p><p>N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-glycan heterogeneity. O-glycans are organized as solitary glycans or in clusters of multiple glycans forming mucin-like domains. They are functional both in the viral life cycle and in viral colonization of their host. Negatively charged O-glycans are crucial for the interactions between glycosaminoglycan-binding viruses and their host. A novel mechanism, based on controlled electrostatic repulsion, explains how such viruses solve the conflict between optimized viral attachment to target cells and efficient egress of progeny virus. Conserved solitary O-glycans appear important for viral uptake in target cells by contributing to viral envelope fusion. Dual roles of viral O-glycans in the host B cell immune response, either epitope blocking or epitope promoting, may be exploitable for vaccine development. Finally, specific virus-induced O-glycans may be involved in viremic spread.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"283-304"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling. CBASS至cGAS STING：核苷酸第二信使免疫信号的起源和机制。
IF 8.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-06-28 DOI: 10.1146/annurev-virology-111821-115636
Kailey M Slavik, Philip J Kranzusch
{"title":"CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling.","authors":"Kailey M Slavik, Philip J Kranzusch","doi":"10.1146/annurev-virology-111821-115636","DOIUrl":"10.1146/annurev-virology-111821-115636","url":null,"abstract":"<p><p>Host defense against viral pathogens is an essential function for all living organisms. In cell-intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of infection and communicate to downstream adaptor or effector proteins to activate immune defense. Remarkably, recent evidence demonstrates that much of the core machinery of innate immunity is shared across eukaryotic and prokaryotic domains of life. Here, we review a pioneering example of evolutionary conservation in innate immunity: the animal cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) signaling pathway and its ancestor in bacteria, CBASS (cyclic nucleotide-based antiphage signaling system) antiphage defense. We discuss the unique mechanism by which animal cGLRs (cGAS-like receptors) and bacterial CD-NTases (cGAS/dinucleotide-cyclase in <i>Vibrio</i> (DncV)-like nucleotidyltransferases) in these pathways link pathogen detection with immune activation using nucleotide second messenger signals. Comparing the biochemical, structural, and mechanistic details of cGAS-STING, cGLR signaling, and CBASS, we highlight emerging questions in the field and examine evolutionary pressures that may have shaped the origins of nucleotide second messenger signaling in antiviral defense.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"423-453"},"PeriodicalIF":8.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Have We Learned by Resurrecting the 1918 Influenza Virus? 我们从1918年流感病毒的复活中学到了什么？
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 DOI: 10.1146/annurev-virology-111821-104408
Brad Gilbertson, Kanta Subbarao
{"title":"What Have We Learned by Resurrecting the 1918 Influenza Virus?","authors":"Brad Gilbertson,&nbsp;Kanta Subbarao","doi":"10.1146/annurev-virology-111821-104408","DOIUrl":"https://doi.org/10.1146/annurev-virology-111821-104408","url":null,"abstract":"<p><p>The 1918 Spanish influenza pandemic was one of the deadliest infectious disease events in recorded history, resulting in approximately 50-100 million deaths worldwide. The origins of the 1918 virus and the molecular basis for its exceptional virulence remained a mystery for much of the 20th century because the pandemic predated virologic techniques to isolate, passage, and store influenza viruses. In the late 1990s, overlapping fragments of influenza viral RNA preserved in the tissues of several 1918 victims were amplified and sequenced. The use of influenza reverse genetics then permitted scientists to reconstruct the 1918 virus entirely from cloned complementary DNA, leading to new insights into the origin of the virus and its pathogenicity. Here, we discuss some of the advances made by resurrection of the 1918 virus, including the rise of innovative molecular research, which is a topic in the dual use debate.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"10 1","pages":"25-47"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41121716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunomodulation by Enteric Viruses. 肠道病毒的免疫调节。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-06-28 DOI: 10.1146/annurev-virology-111821-112317
Lucie Bernard-Raichon, Ken Cadwell
{"title":"Immunomodulation by Enteric Viruses.","authors":"Lucie Bernard-Raichon,&nbsp;Ken Cadwell","doi":"10.1146/annurev-virology-111821-112317","DOIUrl":"10.1146/annurev-virology-111821-112317","url":null,"abstract":"<p><p>Enteric viruses display intricate adaptations to the host mucosal immune system to successfully reproduce in the gastrointestinal tract and cause maladies ranging from gastroenteritis to life-threatening disease upon extraintestinal dissemination. However, many viral infections are asymptomatic, and their presence in the gut is associated with an altered immune landscape that can be beneficial or adverse in certain contexts. Genetic variation in the host and environmental factors including the bacterial microbiota influence how the immune system responds to infections in a remarkably viral strain-specific manner. This immune response, in turn, determines whether a given virus establishes acute versus chronic infection, which may have long-lasting consequences such as susceptibility to inflammatory disease. In this review, we summarize our current understanding of the mechanisms involved in the interaction between enteric viruses and the immune system that underlie the impact of these ubiquitous infectious agents on our health.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"477-502"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
For Better or Worse: Modulation of the Host DNA Damage Response by Human Papillomavirus. 好与坏：人类乳头瘤病毒对宿主DNA损伤反应的调节。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-04-11 DOI: 10.1146/annurev-virology-111821-103452
Caleb J Studstill, Cary A Moody
{"title":"For Better or Worse: Modulation of the Host DNA Damage Response by Human Papillomavirus.","authors":"Caleb J Studstill, Cary A Moody","doi":"10.1146/annurev-virology-111821-103452","DOIUrl":"10.1146/annurev-virology-111821-103452","url":null,"abstract":"<p><p>High-risk human papillomaviruses (HPVs) are associated with several human cancers. HPVs are small, DNA viruses that rely on host cell machinery for viral replication. The HPV life cycle takes place in the stratified epithelium, which is composed of different cell states, including terminally differentiating cells that are no longer active in the cell cycle. HPVs have evolved mechanisms to persist and replicate in the stratified epithelium by hijacking and modulating cellular pathways, including the DNA damage response (DDR). HPVs activate and exploit DDR pathways to promote viral replication, which in turn increases the susceptibility of the host cell to genomic instability and carcinogenesis. Here, we review recent advances in our understanding of the regulation of the host cell DDR by high-risk HPVs during the viral life cycle and discuss the potential cellular consequences of modulating DDR pathways.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"325-345"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9283339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seeing Biomolecular Condensates Through the Lens of Viruses. 从病毒的视角看生物分子凝聚态。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-04-11 DOI: 10.1146/annurev-virology-111821-103226
Alexander Borodavka, Julia Acker
{"title":"Seeing Biomolecular Condensates Through the Lens of Viruses.","authors":"Alexander Borodavka,&nbsp;Julia Acker","doi":"10.1146/annurev-virology-111821-103226","DOIUrl":"10.1146/annurev-virology-111821-103226","url":null,"abstract":"<p><p>Phase separation of viral biopolymers is a key factor in the formation of cytoplasmic viral inclusions, known as sites of virus replication and assembly. This review describes the mechanisms and factors that affect phase separation in viral replication and identifies potential areas for future research. Drawing inspiration from studies on cellular RNA-rich condensates, we compare the hierarchical coassembly of ribosomal RNAs and proteins in the nucleolus to the coordinated coassembly of viral RNAs and proteins taking place within viral factories in viruses containing segmented RNA genomes. We highlight the common characteristics of biomolecular condensates in viral replication and how this new understanding is reshaping our views of virus assembly mechanisms. Such studies have the potential to uncover unexplored antiviral strategies targeting these phase-separated states.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"163-182"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9283340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Times They Are a-Changing. 时代在改变。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 DOI: 10.1146/annurev-vi-10-102822-100111
Lynn W Enquist
{"title":"The Times They Are a-Changing.","authors":"Lynn W Enquist","doi":"10.1146/annurev-vi-10-102822-100111","DOIUrl":"10.1146/annurev-vi-10-102822-100111","url":null,"abstract":"","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"ii-iii"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40487522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Glimpse into the Past: What Ancient Viral Genomes Reveal About Human History. 回顾过去：古代病毒基因组揭示了人类历史。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-06-02 DOI: 10.1146/annurev-virology-111821-123859
Axel A Guzmán-Solís, Miguel Alejandro Navarro, María C Ávila-Arcos, Daniel Blanco-Melo
{"title":"A Glimpse into the Past: What Ancient Viral Genomes Reveal About Human History.","authors":"Axel A Guzmán-Solís,&nbsp;Miguel Alejandro Navarro,&nbsp;María C Ávila-Arcos,&nbsp;Daniel Blanco-Melo","doi":"10.1146/annurev-virology-111821-123859","DOIUrl":"10.1146/annurev-virology-111821-123859","url":null,"abstract":"Humans have battled viruses for millennia. However, directly linking the symptomatology of disease outbreaks to specific viral pathogens was not possible until the twentieth century. With the advent of the genomic era and the development of advanced protocols for isolation, sequencing, and analysis of ancient nucleic acids from diverse human remains, the identification and characterization of ancient viruses became feasible. Recent studies have provided invaluable information about past epidemics and made it possible to examine assumptions and inferences on the origin and evolution of certain viral families. In parallel, the study of ancient viruses also uncovered their importance in the evolution of the human lineage and their key roles in shaping major events in human history. In this review, we describe the strategies used for the study of ancient viruses, along with their limitations, and provide a detailed account of what past viral infections have revealed about human history. Expected final online publication date for the Annual Review of Virology, Volume 10 is September 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":" ","pages":"49-75"},"PeriodicalIF":11.3,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9937232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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