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Annual Review of Virology最新文献

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The Role of Viruses in Identifying and Analyzing RNA Silencing. 病毒在鉴定和分析RNA沉默中的作用。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 Epub Date: 2022-06-02 DOI: 10.1146/annurev-virology-091919-064218
David C Baulcombe
{"title":"The Role of Viruses in Identifying and Analyzing RNA Silencing.","authors":"David C Baulcombe","doi":"10.1146/annurev-virology-091919-064218","DOIUrl":"10.1146/annurev-virology-091919-064218","url":null,"abstract":"<p><p>Adaptive antiviral immunity in plants is an RNA-based mechanism in which small RNAs derived from both strands of the viral RNA are guides for an Argonaute (AGO) nuclease. The primed AGO specifically targets and silences the viral RNA. In plants this system has diversified to involve mobile small interfering RNAs (siRNAs), an amplification system involving secondary siRNAs and targeting mechanisms involving DNA methylation. Most, if not all, plant viruses encode multifunctional proteins that are suppressors of RNA silencing that may also influence the innate immune system and fine-tune the virus-host interaction. Animal viruses similarly trigger RNA silencing, although it may be masked in differentiated cells by the interferon system and by the action of the virus-encoded suppressor proteins. There is huge potential for RNA silencing to combat viral disease in crops, farm animals, and people, although there are complications associated with the various strategies for siRNA delivery including transgenesis. Alternative approaches could include using breeding or small molecule treatment to enhance the inherent antiviral capacity of infected cells.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"353-373"},"PeriodicalIF":8.1,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10580051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APOBEC3: Friend or Foe in Human Papillomavirus Infection and Oncogenesis? APOBEC3：人类乳头瘤病毒感染和肿瘤发生中的朋友还是敌人？
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 Epub Date: 2022-06-07 DOI: 10.1146/annurev-virology-092920-030354
Cody J Warren, Mario L Santiago, Dohun Pyeon
{"title":"APOBEC3: Friend or Foe in Human Papillomavirus Infection and Oncogenesis?","authors":"Cody J Warren, Mario L Santiago, Dohun Pyeon","doi":"10.1146/annurev-virology-092920-030354","DOIUrl":"10.1146/annurev-virology-092920-030354","url":null,"abstract":"<p><p>Human papillomavirus (HPV) infection is a causative agent of multiple human cancers, including cervical and head and neck cancers. In these HPV-positive tumors, somatic mutations are caused by aberrant activation of DNA mutators such as members of the apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of cytidine deaminases. APOBEC3 proteins are most notable for their restriction of various viruses, including anti-HPV activity. However, the potential role of APOBEC3 proteins in HPV-induced cancer progression has recently garnered significant attention. Ongoing research stems from the observations that elevated APOBEC3 expression is driven by HPV oncogene expression and that APOBEC3 activity is likely a significant contributor to somatic mutagenesis in HPV-positive cancers. This review focuses on recent advances in the study of APOBEC3 proteins and their roles in HPV infection and HPV-driven oncogenesis. Further, we discuss critical gaps and unanswered questions in our understanding of APOBEC3 in virus-associated cancers.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"375-395"},"PeriodicalIF":11.3,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637027/pdf/nihms-1845347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41180317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Systems Biology of Virus-Host Protein Interactions: From Hypothesis Generation to Mechanisms of Replication and Pathogenesis. 病毒-宿主蛋白相互作用的系统生物学:从假说的产生到复制和发病机制。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 DOI: 10.1146/annurev-virology-100520-011851
Priya S Shah, Nitin S Beesabathuni, Adam T Fishburn, Matthew W Kenaston, Shiaki A Minami, Oanh H Pham, Inglis Tucker
{"title":"Systems Biology of Virus-Host Protein Interactions: From Hypothesis Generation to Mechanisms of Replication and Pathogenesis.","authors":"Priya S Shah,&nbsp;Nitin S Beesabathuni,&nbsp;Adam T Fishburn,&nbsp;Matthew W Kenaston,&nbsp;Shiaki A Minami,&nbsp;Oanh H Pham,&nbsp;Inglis Tucker","doi":"10.1146/annurev-virology-100520-011851","DOIUrl":"https://doi.org/10.1146/annurev-virology-100520-011851","url":null,"abstract":"<p><p>As obligate intracellular parasites, all viruses must co-opt cellular machinery to facilitate their own replication. Viruses often co-opt these cellular pathways and processes through physical interactions between viral and host proteins. In addition to facilitating fundamental aspects of virus replication cycles, these virus-host protein interactions can also disrupt physiological functions of host proteins, causing disease that can be advantageous to the virus or simply a coincidence. Consequently, unraveling virus-host protein interactions can serve as a window into molecular mechanisms of virus replication and pathogenesis. Identifying virus-host protein interactions using unbiased systems biology approaches provides an avenue for hypothesis generation. This review highlights common systems biology approaches for identification of virus-host protein interactions and the mechanistic insights revealed by these methods. We also review conceptual innovations using comparative and integrative systems biology that can leverage global virus-host protein interaction data sets to more rapidly move from hypothesis generation to mechanism.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"397-415"},"PeriodicalIF":11.3,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150767/pdf/nihms-1891242.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9379720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Lessons from Acquired Natural Immunity and Clinical Trials to Inform Next-Generation Human Cytomegalovirus Vaccine Development. 获得性自然免疫和临床试验的经验教训，为下一代人类巨细胞病毒疫苗的开发提供信息。
IF 8.1 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 Epub Date: 2022-06-15 DOI: 10.1146/annurev-virology-100220-010653
Xintao Hu, Hsuan-Yuan Wang, Claire E Otero, Jennifer A Jenks, Sallie R Permar
{"title":"Lessons from Acquired Natural Immunity and Clinical Trials to Inform Next-Generation Human Cytomegalovirus Vaccine Development.","authors":"Xintao Hu, Hsuan-Yuan Wang, Claire E Otero, Jennifer A Jenks, Sallie R Permar","doi":"10.1146/annurev-virology-100220-010653","DOIUrl":"10.1146/annurev-virology-100220-010653","url":null,"abstract":"<p><p>Human cytomegalovirus (HCMV) infection, the most common cause of congenital disease globally, affecting an estimated 1 million newborns annually, can result in lifelong sequelae in infants, such as sensorineural hearing loss and brain damage. HCMV infection also leads to a significant disease burden in immunocompromised individuals. Hence, an effective HCMV vaccine is urgently needed to prevent infection and HCMV-associated diseases. Unfortunately, despite more than five decades of vaccine development, no successful HCMV vaccine is available. This review summarizes what we have learned from acquired natural immunity, including innate and adaptive immunity; the successes and failures of HCMV vaccine human clinical trials; the progress in related animal models; and the analysis of protective immune responses during natural infection and vaccination settings. Finally, we propose novel vaccine strategies that will harness the knowledge of protective immunity and employ new technology and vaccine concepts to inform next-generation HCMV vaccine development.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"491-520"},"PeriodicalIF":8.1,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154983/pdf/nihms-1892870.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9457783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Replication Compartments of Eukaryotic and Bacterial DNA Viruses: Common Themes Between Different Domains of Host Cells. 真核生物和细菌DNA病毒的复制区室:宿主细胞不同区域之间的共同主题。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 DOI: 10.1146/annurev-virology-012822-125828
David M Knipe, Amy Prichard, Surendra Sharma, Joe Pogliano
{"title":"Replication Compartments of Eukaryotic and Bacterial DNA Viruses: Common Themes Between Different Domains of Host Cells.","authors":"David M Knipe,&nbsp;Amy Prichard,&nbsp;Surendra Sharma,&nbsp;Joe Pogliano","doi":"10.1146/annurev-virology-012822-125828","DOIUrl":"https://doi.org/10.1146/annurev-virology-012822-125828","url":null,"abstract":"<p><p>Subcellular organization is essential for life. Cells organize their functions into organelles to concentrate their machinery and supplies for optimal efficiency. Likewise, viruses organize their replication machinery into compartments or factories within their host cells for optimal replicative efficiency. In this review, we discuss how DNA viruses that infect both eukaryotic cells and bacteria assemble replication compartments for synthesis of progeny viral DNA and transcription of the viral genome. Eukaryotic DNA viruses assemble replication compartments in the nucleus of the host cell while DNA bacteriophages assemble compartments called phage nuclei in the bacterial cytoplasm. Thus, DNA viruses infecting host cells from different domains of life share common replication strategies.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"307-327"},"PeriodicalIF":11.3,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
The Role of Viral RNA Degrading Factors in Shutoff of Host Gene Expression. 病毒RNA降解因子在阻断宿主基因表达中的作用。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 Epub Date: 2022-06-07 DOI: 10.1146/annurev-virology-100120-012345
Léa Gaucherand, Marta Maria Gaglia
{"title":"The Role of Viral RNA Degrading Factors in Shutoff of Host Gene Expression.","authors":"Léa Gaucherand,&nbsp;Marta Maria Gaglia","doi":"10.1146/annurev-virology-100120-012345","DOIUrl":"https://doi.org/10.1146/annurev-virology-100120-012345","url":null,"abstract":"<p><p>Many viruses induce shutoff of host gene expression (host shutoff) as a strategy to take over cellular machinery and evade host immunity. Without host shutoff activity, these viruses generally replicate poorly in vivo, attesting to the importance of this antiviral strategy. In this review, we discuss one particularly advantageous way for viruses to induce host shutoff: triggering widespread host messenger RNA (mRNA) decay. Viruses can trigger increased mRNA destruction either directly, by encoding RNA cleaving or decapping enzymes, or indirectly, by activating cellular RNA degradation pathways. We review what is known about the mechanism of action of several viral RNA degradation factors. We then discuss the consequences of widespread RNA degradation on host gene expression and on the mechanisms of immune evasion, highlighting open questions. Answering these questions is critical to understanding how viral RNA degradation factors regulate host gene expression and how this process helps viruses evade host responses and replicate.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"213-238"},"PeriodicalIF":11.3,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530000/pdf/nihms-1819195.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41178957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Advances in Understanding Neuropathogenesis of Rift Valley Fever Virus. 裂谷热病毒神经发病机制的研究进展
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 DOI: 10.1146/annurev-virology-091919-065806
Kaleigh A Connors, Amy L Hartman
{"title":"Advances in Understanding Neuropathogenesis of Rift Valley Fever Virus.","authors":"Kaleigh A Connors,&nbsp;Amy L Hartman","doi":"10.1146/annurev-virology-091919-065806","DOIUrl":"https://doi.org/10.1146/annurev-virology-091919-065806","url":null,"abstract":"Rift Valley fever virus (RVFV) is an emerging arboviral pathogen that causes disease in both livestock and humans. Severe disease manifestations of Rift Valley fever (RVF) in humans include hemorrhagic fever, ocular disease, and encephalitis. This review describes the current understanding of the pathogenesis of RVF encephalitis. While some data from human studies exist, the development of several animal models has accelerated studies of the neuropathogenesis of RVFV. We review current animal models and discuss what they have taught us about RVFV encephalitis. We briefly describe alternative models that have been used to study other neurotropic arboviruses and how these models may help contribute to our understanding RVFV encephalitis. We conclude with some unanswered questions and future directions.","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"437-450"},"PeriodicalIF":11.3,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10117614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Amoebae: Hiding in Plain Sight: Unappreciated Hosts for the Very Large Viruses. 变形虫:隐藏在显眼的地方:超大病毒未被发现的宿主。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 DOI: 10.1146/annurev-virology-100520-125832
Victória Fulgêncio Queiroz, Rodrigo Araújo Lima Rodrigues, Paulo Victor de Miranda Boratto, Bernard La Scola, Julien Andreani, Jônatas Santos Abrahão
{"title":"Amoebae: Hiding in Plain Sight: Unappreciated Hosts for the Very Large Viruses.","authors":"Victória Fulgêncio Queiroz,&nbsp;Rodrigo Araújo Lima Rodrigues,&nbsp;Paulo Victor de Miranda Boratto,&nbsp;Bernard La Scola,&nbsp;Julien Andreani,&nbsp;Jônatas Santos Abrahão","doi":"10.1146/annurev-virology-100520-125832","DOIUrl":"https://doi.org/10.1146/annurev-virology-100520-125832","url":null,"abstract":"<p><p>For decades, viruses have been isolated primarily from humans and other organisms. Interestingly, one of the most complex sides of the virosphere was discovered using free-living amoebae as hosts. The discovery of giant viruses in the early twenty-first century opened a new chapter in the field of virology. Giant viruses are included in the phylum <i>Nucleocytoviricota</i> and harbor large and complex DNA genomes (up to 2.7 Mb) encoding genes never before seen in the virosphere and presenting gigantic particles (up to 1.5 μm). Different amoebae have been used to isolate and characterize a plethora of new viruses with exciting details about novel viral biology. Through distinct isolation techniques and metagenomics, the diversity and complexity of giant viruses have astonished the scientific community. Here, we discuss the latest findings on amoeba viruses and how using these single-celled organisms as hosts has revealed entities that have remained hidden in plain sight for ages.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"79-98"},"PeriodicalIF":11.3,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10400534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Cyclic Nucleotide Signaling in Phage Defense and Counter-Defense. 环状核苷酸信号在噬菌体防御和反防御中的作用。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 DOI: 10.1146/annurev-virology-100120-010228
Januka S Athukoralage, Malcolm F White
{"title":"Cyclic Nucleotide Signaling in Phage Defense and Counter-Defense.","authors":"Januka S Athukoralage,&nbsp;Malcolm F White","doi":"10.1146/annurev-virology-100120-010228","DOIUrl":"https://doi.org/10.1146/annurev-virology-100120-010228","url":null,"abstract":"<p><p>Advances in our understanding of prokaryotic antiphage defense mechanisms in the past few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a crucial role in switching infected cells into an antiviral state. Defense pathways including type III CRISPR (clustered regularly interspaced palindromic repeats), CBASS (cyclic nucleotide-based antiphage signaling system), PYCSAR (pyrimidine cyclase system for antiphage resistance), and Thoeris all use cyclic nucleotides as second messengers to activate a diverse range of effector proteins. These effectors typically degrade or disrupt key cellular components such as nucleic acids, membranes, or metabolites, slowing down viral replication kinetics at great cost to the infected cell. Mechanisms to manipulate the levels of cyclic nucleotides are employed by cells to regulate defense pathways and by viruses to subvert them. Here we review the discovery and mechanism of the key pathways, signaling molecules and effectors, parallels and differences between the systems, open questions, and prospects for future research in this area.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"451-468"},"PeriodicalIF":11.3,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10589761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Citrus Tristeza Virus: From Pathogen to Panacea. 柑橘Tristeza病毒:从病原体到灵丹妙药。
IF 11.3 1区 医学
Annual Review of Virology Pub Date : 2022-09-29 DOI: 10.1146/annurev-virology-100520-114412
Svetlana Y Folimonova, Yong-Duo Sun
{"title":"<i>Citrus Tristeza Virus</i>: From Pathogen to Panacea.","authors":"Svetlana Y Folimonova,&nbsp;Yong-Duo Sun","doi":"10.1146/annurev-virology-100520-114412","DOIUrl":"https://doi.org/10.1146/annurev-virology-100520-114412","url":null,"abstract":"<p><p><i>Citrus tristeza virus</i> (CTV) is the most destructive viral pathogen of citrus. During the past century, CTV induced grave epidemics in citrus-growing areas worldwide that have resulted in a loss of more than 100 million trees. At present, the virus continues to threaten citrus production in many different countries. Research on CTV is accompanied by distinctive challenges stemming from the large size of its RNA genome, the narrow host range limited to slow-growing <i>Citrus</i> species and relatives, and the complexity of CTV populations. Despite these hurdles, remarkable progress has been made in understanding the CTV-host interactions and in converting the virus into a tool for crop protection and improvement. This review focuses on recent advances that have shed light on the mechanisms underlying CTV infection. Understanding these mechanisms is pivotal for the development of means to control CTV diseases and, ultimately, turn this virus into an ally.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"417-435"},"PeriodicalIF":11.3,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10409018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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