病毒膜融合:蛋白质和脂质之间的舞蹈。

IF 8.1 1区 医学 Q1 VIROLOGY
Judith M White, Amanda E Ward, Laura Odongo, Lukas K Tamm
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引用次数: 0

摘要

至少有21个家族的包膜病毒感染哺乳动物,其中许多家族的成员对全球人类健康高度关注。所有包膜病毒都有一种专门的融合蛋白或融合复合物,它能引发关键的基因组释放膜融合事件,这在病毒在宿主细胞内部复制开始之前是至关重要的。因为所有的包膜病毒都是通过融合进入细胞的,我们有必要了解病毒融合蛋白的功能。病毒融合蛋白也是中和抗体的主要靶点,因此它们是关键的疫苗免疫原。在这里,我们回顾了目前关于病毒膜融合蛋白的概念,重点是它们是如何被触发的,融合前和融合后形式之间的结构中间体,以及它们与它们所参与的脂质双层的相互作用。我们还讨论了阻碍病毒细胞膜融合的细胞和治疗干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Viral Membrane Fusion: A Dance Between Proteins and Lipids.

There are at least 21 families of enveloped viruses that infect mammals, and many contain members of high concern for global human health. All enveloped viruses have a dedicated fusion protein or fusion complex that enacts the critical genome-releasing membrane fusion event that is essential before viral replication within the host cell interior can begin. Because all enveloped viruses enter cells by fusion, it behooves us to know how viral fusion proteins function. Viral fusion proteins are also major targets of neutralizing antibodies, and hence they serve as key vaccine immunogens. Here we review current concepts about viral membrane fusion proteins focusing on how they are triggered, structural intermediates between pre- and postfusion forms, and their interplay with the lipid bilayers they engage. We also discuss cellular and therapeutic interventions that thwart virus-cell membrane fusion.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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