Spatial Transcriptomics to Study Virus-Host Interactions.

IF 8.1 1区医学 Q1 VIROLOGY

Annual Review of Virology Pub Date : 2025-06-16 DOI:10.1146/annurev-virology-092623-104926

Chase Holdener, Shaowen Jiang, Danica M Sutherland, Kira A Griswold, Terence S Dermody, John S L Parker, Iwijn De Vlaminck

引用次数: 0

Abstract

The morbidity and mortality associated with viral diseases in plants, animals, and humans are significant concerns. Understanding how viruses cause disease and identifying the viral and host factors that determine the outcome of infection are essential to develop new antiviral therapeutics and strategies to induce protective immunity. In this review, we focus on the transformative potential of spatial transcriptomics for studies of viral pathogenesis and some of the intricacies of corresponding technologies and how to implement them.

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空间转录组学研究病毒-宿主相互作用。

在植物、动物和人类中，与病毒性疾病相关的发病率和死亡率是值得关注的重大问题。了解病毒如何引起疾病以及确定决定感染结果的病毒和宿主因素对于开发新的抗病毒治疗方法和诱导保护性免疫的策略至关重要。在这篇综述中，我们重点介绍了空间转录组学在研究病毒发病机制方面的变革潜力，以及相应技术的一些复杂性和如何实现它们。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Virology VIROLOGY-

CiteScore

19.40

自引率

0.90%

发文量

期刊介绍： The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.