Molecular & Cellular Biomechanics最新文献

{"title":"Research on the antistatic performance of peanut shells @ glucose biochar/epoxy composites","authors":"Mengxiao Guo, Heyi Ge, Boming Zhang, Jinman Liu","doi":"10.62617/mcb1348","DOIUrl":"https://doi.org/10.62617/mcb1348","url":null,"abstract":"In this work, the glucose nanocarbon spheres (GC) were in situ decorated on the surface of lamellar peanut shell biochar (PSAC) to construct the self-modified conductive function unit of biomass (PSAC@GC). The effects of PSAC@GC at different carbonization temperatures on the conductivity, the antistatic properties, and the thermal stability of epoxy composites were investigated. This unique structure not only improves the dispersion of GC nanospheres in the epoxy resin, but the larger carbon framework of PSAC also contributed to forming a continuous conductive network. Moreover, the well-dispersed GC nanospheres on PSAC facilitate the transfer of surface free electrons, effectively improving the electrical conductivity and ultimately strengthening the antistatic properties of the composites. The results show that when the carbonization temperature was 900 ℃, the conductivity of PSAC@GC with a mass ratio of 1:1 was 41.19 S/m, which represents an increase of 135% and 43% compared to PSAC and GC, respectively. When 5 wt.% PSAC@GC was added, it showed good dispersion in the epoxy resin, and the surface resistivity of the composites was reduced to 1.89 × 108 Ω. The work provides a new approach for the development of environmentally friendly and cost-effective novel antistatic carbon material.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"22 3","pages":"1348-1348"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ojs.sin-chn.com/index.php/mcb/article/download/1348/771","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-6747-5p suppresses angiogenesis in esophageal squamous cell carcinoma by targeting EGFL6","authors":"Jiawen Huang, Yuxin Xiao, Cunjie Li, Shifeng Liu, Jieling Zhou, Qifang Song, Ting Wang, Ning Deng","doi":"10.62617/mcb1047","DOIUrl":"https://doi.org/10.62617/mcb1047","url":null,"abstract":"Epidermal growth factor-like domain 6 (EGFL6) plays a crucial role in angiogenesis in various malignant tumors. This study aimed to screen microRNAs (miRNAs) targeting EGFL6 and explore their mechanisms in regulating angiogenesis in esophageal squamous cell carcinoma (ESCC) cells. After analyzing the miRNA expression profiles of ESCC and using the target prediction algorithm, we screened three miRNAs that could potentially target EGFL6. By dual luciferase reporter gene assay and western blot, we found that miR-6747-5p could directly target EGFL6 and down-regulate EGFL6 expression in ESCC cells. The results of clone formation, CCK-8, Transwell, wound healing, and endothelial cell tube formation assay showed that miR-6747-5p exerted a significant inhibitory effect on the proliferation, migration, invasion, and angiogenesis of ESCC cells. At the same time, we observed that the phosphorylation levels of AKT and MAPK were decreased, the epithelial-mesenchymal transition (EMT) related E-cadherin expression was downregulated while N-cadherin was upregulated, and the protein expression of the pro-angiogenic factors, including platelet-derived growth factor subunit B (PDGFB), fibroblast growth factor 2 (FGF2), and angiogenin (ANG) were inhibited transfected with miR-6747-5p mimics. Further studies showed that the overexpression vectors of EGFL6 transfected into ESCC cells could reverse the inhibitory effects induced by miR-6747-5p. These findings reveal that miR-6747-5p could target EGFL6 and inhibit tumor angiogenesis and ESCC progression. miR-6747-5p may be a promising biomarker for the anti-angiogenic treatment of ESCC.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"22 2","pages":"1047-1047"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ojs.sin-chn.com/index.php/mcb/article/download/1047/575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality analysis report of Cistanche tubulosa and Cistanche deserticola","authors":"Xianzhi Li, Qiongli Mao, Qiang Yang, Qifu Li, Zhian Huang, Jinpeng Zhu, Yan Zhu, Yang Hu, Hao Shi","doi":"10.62617/mcb633","DOIUrl":"https://doi.org/10.62617/mcb633","url":null,"abstract":"The medicinal materials of Cistanche tubulosa (CW) and Cistanche deserticola (CD) were selected to carry out the determination of bioactive substances and antioxidant activity and multivariate statistical analysis. The results of active substance analysis showed that there were significant differences in the content of total polysaccharides between the two varieties, and there were significant differences in the contents of total polyphenols, total flavonoids, total triterpenoids, proanthocyanidins, phenylethanoid glycosides, amino acids, proteins and heavy metals. The total polysaccharides in CW were higher than those in CD. The contents of total polyphenols, total flavonoids, total triterpenes and phenylethanoid glycosides in CW were significantly higher than those in CD. The contents of amino acids, proteins and heavy metals in CD were higher than those in CW. The results of antioxidant analysis showed that the DPPH free radical scavenging ability, ABTS free radical scavenging ability and ORAC superoxide radical scavenging ability of CW were significantly higher than those of CD, and there was a significant difference between the two varieties. Correlation analysis showed that the antioxidant capacity of Cistanches herba was closely related to the contents of total polyphenols, total flavonoids, total triterpenes, total polysaccharides, phenylethanoid glycosides, proanthocyanidins, amino acids, proteins and heavy metals. The samples were divided into two groups by cluster analysis. Four principal components were extracted by principal component analysis, and the cumulative variance contribution rate was 94.15%.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"22 1","pages":"633-633"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ojs.sin-chn.com/index.php/mcb/article/download/633/483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of human-computer interaction technology integrating biomimetic vision system in animation design with a biomechanical perspective","authors":"Jing Han","doi":"10.62617/mcb468","DOIUrl":"https://doi.org/10.62617/mcb468","url":null,"abstract":"The combination of Human-Computer Interaction (HCI) technology with biomimetic vision systems has transformational potential in animation design, particularly by incorporating biomechanical principles to create immersive and interactive experiences. Traditional animation approaches frequently lack sensitivity to real-time human motions, which can restrict engagement and realism. This study addresses this constraint by creating a framework that uses Virtual Reality (VR) and Augmented Reality (AR) to generate dynamic settings that include a variety of human activities, informed by biomechanical analysis. A biomimetic vision system is used to record these motions with wearable sensors, allowing for precise monitoring of user activity while considering biomechanical factors such as joint angles, force distribution, and movement patterns. The recorded data is preprocessed using Z-score normalization methods and extracted using Principal Component Analysis (PCA). This study proposed an Egyptian Vulture optimized Adjustable Long Short-Term Memory Network (EVO-ALSTM) technique for motion classification, specifically tailored to recognize biomechanical characteristics of human movements. Results demonstrate a significant improvement in precision (93%), F1-score (91%), accuracy (95%), and recall (90%) for the motion recognition system, highlighting the effectiveness of biomechanical insights in enhancing animation design. The findings indicate that integrating real-time biomechanical data into the animation process leads to more engaging and realistic user experiences. This study not only advances the subject of HCI but also provides the framework for future investigations into sophisticated animation technologies that use biomimetic and biomechanical systems.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"21 4","pages":"468-468"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ojs.sin-chn.com/index.php/mcb/article/download/468/428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocyte growth factor and insulin-like growth factor-1 were used to repair bone-cartilage defects in bone marrow mesenchymal stem cells in a rabbit model of postmenopausal","authors":"Jia-Qi Guan, Chuan-Bo Zang, Jun-Cen Li, Feifan Chen, Ya‐Hui Wang, Guangdong Zhou, Yu Liu, Yilin Cao","doi":"10.62617/mcb.v21.72","DOIUrl":"https://doi.org/10.62617/mcb.v21.72","url":null,"abstract":"In postmenopausal osteoporosis (PMOP), an imbalance exists in the differentiation of bone marrow mesenchymal stem cells (BMSCs), with a decrease in osteogenic differentiation and an increase in adipogenic differentiation. This imbalance leads to bone marrow adiposity, bone loss, bone fragility, and a substantial rise in fracture risk. After a patient experiences an osteochondral defect due to trauma, it struggles to heal naturally, presenting a clinical challenge for treatment. Our study delved into the abnormal differentiation of BMSCs in PMOP by conducting transcriptome sequencing on BMSCs from a PMOP model (PMOP-BMSCs) and a healthy control model (Normal-BMSCs). We identified insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) genesas significantly low-expressed protein-coding genes during the osteogenic cartilage differentiation process of PMOP-BMSCs. Due to the downregulation of its expression, it leads to the deletion of the proteins it encodes IGF-1 and HGF. In order to verify the sequencing results, the feasibility of co-culture the above two growth factors with PMOP-BMSCs to repair osteochondral defects was discussed. The findings indicated that the inclusion of elements enhanced the DNA replication activity and extracellular matrix mineralization of PMOP-BMSCs. It also promoted the construction of tissue-engineered bone in vitro and the up- regulation of Runx2, BMP4, OCN, ACAN, collagen type Ⅰ, II, and Sox9 osteochondral differentiation markers. In the rabbit model of knee osteochondral injury with PMOP, the group treated with both growth factors and PMOP-BMSCs showed superior outcomes in repairing cartilage and subchondral bone defects compared to the other groups. We suggest that the addition of HGF and IGF-1 increases the expression of osteoblast and cartilage-related genes and proteins, promoting the proliferation and differentiation of osteochondrous bone in PMOP-BMSCs. These findings could offer a novel cell therapy strategy for treating postmenopausal osteoporosis, utilizing growth factors.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"21 1","pages":"72-72"},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ojs.sin-chn.com/index.php/mcb/article/download/72/72","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hot Topics of Molecular and Cellular Biomechanics in 2022","authors":"Guixue Wang","doi":"10.32604/mcb.2023.044564","DOIUrl":"https://doi.org/10.32604/mcb.2023.044564","url":null,"abstract":"The analysis of biomechanical characteristics plays an important role in mastering the technical characteristics of athletes, providing guidance for the formulation and prevention of sports injury training plans and providing theoretical support for research on injury prevention and stability control in the sports field. With the importance of data analysis, the application scope of artificial intelligence methods is more extensive. For example, intelligent training systems can be used for athletes’ personalized and professional training, real-time monitoring and feedback of training data, and further reduce the risk of sports injury. However, deep learning methods process a large number of medical images to identify and predict diseases such as cancer.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135131883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CFD Study on Hemodynamic Characteristics of Inferior Vena Cava Filter Affected by Blood Vessel Diameter","authors":"Shiyue Zhang, Xue Song, Jingying Wang, Wen Huang, Yue Zhou, Mingrui Li","doi":"10.32604/mcb.2023.044445","DOIUrl":"https://doi.org/10.32604/mcb.2023.044445","url":null,"abstract":"Pulmonary embolism (PE), caused by deep venous thrombosis (DVT), is a disease with high morbidity and mortality. Implantation of inferior vena cava filters is an important method for the clinical prevention of PE. The hemodynamic characteristics of filters implanted in the inferior vena cava (IVC) have a significant impact on their performance. However, IVC diameters vary among patients. This may have a direct impact on the hemodynamic properties of the filter. At present, there is no research on this kind of problem to be investigated. In this paper, the hemodynamic properties of the VenaTech convertible filter were simulated in three different IVC models of 15, 20 and 25 mm diameters, using computational fluid dynamics (CFD) as a control variable (only the IVC diameter is varied). The results showed that the diameter has a significant impact on the hemodynamic characteristics after filter implantation. The IVC diameter has a great influence on the stagnation zone of the blood flow, the maximum wall shear stress (WSS) on the upstream side along the filter wire, and the flow resistance. The case of 15 mm diameter was the most prone to thrombus formation downstream of the filter head in the IVC, but the larger WSS on the upstream along the filter wire may facilitate thrombus lysis. Therefore, the change in vessel diameter should be considered when performing filter implantation for patients.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135213034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of the Hindlimb Locomotion of Confuciusornis (Aves) and Its Implication for the Origin of Avian Flight","authors":"Xinsen Wei, Ying Guo, Yan Zhao","doi":"10.32604/mcb.2023.041173","DOIUrl":"https://doi.org/10.32604/mcb.2023.041173","url":null,"abstract":"As one of the most basal avian clades, the Confuciusornithids are ideal in revealing the early evolution of avian flight. Birds’ hindlimbs are functionally diverse and contain a wealth of information about their behavior. The hindlimb of <i>Confuciusornis</i>, however, has only been studied in detail in terms of functional morphology, and quantitative studies that directly assess locomotor ability are relatively lacking. This has led to certain controversies on the behavior of <i>Confuciusornis</i>. This paper reviews the debates over the life habits and take-off ability of <i>Confuciusornis</i>, which are closely related to their hindlimb function. Several methodologies adopted engineering techniques, including the geometrical analysis of long bones, physiological reconstruction of muscles, kinematic and kinetic characteristics estimating, and appendage locomotor mechanism analysis, are recommended for estimating the hindlimb functions of <i>Confuciusornis</i>. Considering that the fossil bones are fragile, irregular in shape, and usually deformed, it is appropriate to apply computer numerical simulation techniques to such studies. A sufficient functional quantitative study will help clarify early bird locomotor behavior, which will provide clues and evidence for further exploration of the origin of bird flight and early bird movement.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135402661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can PAPE-Induced Increases in Jump Height Be Explained by Jumping Kinematics?","authors":"Xiaojie Jiang, Xin Li, Yining Xu, Dong Sun, Julien S. Baker, Yaodong Gu","doi":"10.32604/mcb.2023.042910","DOIUrl":"https://doi.org/10.32604/mcb.2023.042910","url":null,"abstract":"The aim of this study was to investigate whether kinematic data during a countermovement jump (CMJ) could explain the post-activation performance enhancement (PAPE) effects following acute resistance exercise. Twenty-four male participants with resistance training and jumping experience were recruited and randomly assigned to either the experimental group (PAPE-stimulus) (n = 12) or the control group (n = 12). In the experimental group, participants performed 5 reps of squats at 80% 1RM to induce PAPE, while the control group received no intervention. Both groups performed three CMJ tests before (PRE) and at immediate (POST0), 4 (POST4), 8 (POST8), and 12 (POST12) min after the intervention, with kinematic data recorded during the CMJ. Kinematic parameters analyzed in this study included jump height, hip-knee-ankle flexion angles at the lowest position of the countermovement, eccentric and concentric time durations, and the temporal changes of hip-knee-ankle flexion angles during the entire jumping phase. The presence of PAPE was determined by the change in jump height. The results showed that in the experimental group, jump height significantly increased at POST4 (<i>p</i> < 0.001) and POST8 (<i>p</i> < 0.001) and significantly decreased at POST0 (<i>p</i> = 0.008), with no significant change at POST12. The control group showed no significant changes at any measured time point. Kinematic parameters showed that there was no significant difference in joint flexion angle of the lower body during the CMJ between pre- and post-intervention, regardless of PAPE or fatigue. However, eccentric time significantly decreased at 4 and 8 min (<i>p</i> = 0.013 and <i>p</i> = 0.001, respectively) after the intervention. These findings suggest that PAPE-induced increases in jump height after acute resistance exercise can be attributed to the decrease in eccentric phase duration, but not joint flexion angle. Additionally, the fatigue-induced decrease in jump height cannot be reflected by jumping kinematics. Based on these findings, coaches may use complex training to utilize the PAPE effects to increase jump height while reducing the eccentric time during vertical jumps. This method can enhance an athlete’s eccentric ability to generate force in a short amount of time which is crucial for performance enhancement.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135214871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear Stress-Strain State over Micropillars: A Mechanical In silico Study","authors":"R. Allena, D. Aubry","doi":"10.32604/mcb.2022.018958","DOIUrl":"https://doi.org/10.32604/mcb.2022.018958","url":null,"abstract":"Cells adapt to their environment and stimuli of different origin. During confined migration through sub-cellular and sub-nuclear pores, they can undergo large strains and the nucleus, the most voluminous and the stiffest organelle, plays a critical role. Recently, patterned microfluidic devices have been employed to analyze the cell mechanical behavior and the nucleus self-deformations. In this paper, we present an in silico model to simulate the interactions between the cell and the underneath microstructured substrate under the effect of the sole gravity. The model lays on mechanical features only and it has the potential to assess the contribution of the nuclear mechanics on the cell global behavior. The cell is constituted by the membrane, the cytosol, the lamina, and the nucleoplasm. Each organelle is described through a constitutive law defined by specific mechanical parameters, and it is composed of a fluid and a solid phase leading to a viscoelastic behavior. Our main objective is to evaluate the influence of such mechanical components on the nucleus behavior. We have quantified the stress and strain distributions in the nucleus, which could be responsible of specific phenomena such as the lamina rupture or the expression of stretch-sensitive proteins.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82460773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}