A Review of the Role of ERp57 in Cancerous and Non-Cancerous Cell Physiology and its Potential as a Therapeutic Target

Q4 Biochemistry, Genetics and Molecular Biology

Molecular & Cellular Biomechanics Pub Date : 2021-01-01 DOI:10.32604/mcb.2021.017750

F. Rahbar, Avid Farhang Fagheh, A. Khosravi, Siavash Shariatzadeh, R. Akhavan-Sigari

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Abstract

The protein ERp57 is a stress-responsive protein, mainly exists in the endoplasmic reticulum (ER), and a small amount in the cell membrane, cytoplasm, nucleus and mitochondria, which is involved in the signal transduction from the cell surface, the regulation process that occurs in the nucleus, and the formation of polymer protein complexes involved in DNA repair. Various degrees of ERp57 dysregulation has been observed in many types of non-communicable diseases especially in cancers. Previous studies showed that the expression of ERp57 could play a key role in occurrence and development of cancers such as breast cancer, gastric cancer, ovarian cancer, etc.; in addition, it has been suggested to play a pivotal role in disease progression of non-cancerous diseases such as neurodegeneration, liver disease, kidney disease, intestinal irritability syndrome and airway hypersensitivity. Thus, abnormal expression of ERp57 could be used as promising biomarker for cancer diagnosis and prognosis based on the previous studies. In this regard, current study was aimed to review the literature, which have been elucidate the role of ERp57 protein expression in both non-cancer and cancer disease. Overall, most studies have shown that inhibiting/knocking out of ERp57 could inhibit the cell proliferation and also induce apoptosis in both human cancerous and non-cancerous cells. Also, it has been suggested that the overexpression of ERp57 could intensify the cancer development. Therefore, it could be hypothesized that targeting of ERp57 might be a potential treatment in cancerous and non-cancerous diseases.

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ERp57在癌变和非癌变细胞生理中的作用及其作为治疗靶点的潜力综述

ERp57蛋白是一种应激反应蛋白，主要存在于内质网(endoplasmic reticulum, ER)中，少量存在于细胞膜、细胞质、细胞核和线粒体中，参与细胞表面的信号转导、细胞核内发生的调控过程以及参与DNA修复的聚合物蛋白复合物的形成。在许多类型的非传染性疾病中，特别是在癌症中，观察到不同程度的ERp57失调。既往研究表明，ERp57的表达在乳腺癌、胃癌、卵巢癌等癌症的发生发展中发挥关键作用;此外，它被认为在非癌性疾病的疾病进展中起关键作用，如神经退行性疾病、肝脏疾病、肾脏疾病、肠易激综合征和气道过敏。因此，基于以往的研究，ERp57的异常表达可以作为癌症诊断和预后的有希望的生物标志物。在这方面，本研究旨在回顾已经阐明ERp57蛋白表达在非癌症和癌症疾病中的作用的文献。总的来说，大多数研究表明，抑制/敲除ERp57可以抑制人类癌细胞和非癌细胞的细胞增殖，并诱导细胞凋亡。此外，有人认为ERp57的过表达可能会加剧癌症的发展。因此，可以假设靶向ERp57可能是一种潜在的治疗癌性和非癌性疾病的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular & Cellular Biomechanics CELL BIOLOGYENGINEERING, BIOMEDICAL&-ENGINEERING, BIOMEDICAL

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications.