Biology-Basel最新文献_第4页

Evaluation of the Anti-Inflammatory/Immunomodulatory Effect of Teucrium montanum L. Extract in Collagen-Induced Arthritis in Rats. 评估柚木提取物对胶原蛋白诱发的大鼠关节炎的抗炎/免疫调节作用

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-12 DOI: 10.3390/biology13100818

Biljana Bufan, Mirjana Marčetić, Jasmina Djuretić, Ivana Ćuruvija, Veljko Blagojević, Dragana D Božić, Violeta Milutinović, Radmila Janković, Jelena Sopta, Jelena Kotur-Stevuljević, Nevena Arsenović-Ranin

{"title":"Evaluation of the Anti-Inflammatory/Immunomodulatory Effect of Teucrium montanum L. Extract in Collagen-Induced Arthritis in Rats.","authors":"Biljana Bufan, Mirjana Marčetić, Jasmina Djuretić, Ivana Ćuruvija, Veljko Blagojević, Dragana D Božić, Violeta Milutinović, Radmila Janković, Jelena Sopta, Jelena Kotur-Stevuljević, Nevena Arsenović-Ranin","doi":"10.3390/biology13100818","DOIUrl":"https://doi.org/10.3390/biology13100818","url":null,"abstract":"The anti-inflammatory/immunomodulatory effects of Teucrium montanum L. (TM), a plant distributed in the Mediterranean region, have been insufficiently examined. The effects of the TM ethanol extract were tested in a rat collagen-induced arthritis (CIA) model of rheumatoid arthritis. LC-MS was used for the phytochemical analysis of the TM extract. Dark Agouti rats were immunized with bovine type II collagen (CII) in incomplete Freund's adjuvant for CIA, and treated with 100 or 200 mg/kg of TM extract daily via oral administration. Clinical and histopathological evaluations and a flow cytometric analysis of the phenotypic and functional characteristics of splenocytes and draining lymph node cells were performed. The cytokines in the paw tissue culture supernatants and anti-CII antibodies in serum were determined by ELISA. The TM extract, with the dominant components verbascoside and luteolin 7-O-rutinoside, reduced the arthritic score and ankle joint inflammation in CIA rats, promoted the antioxidant profile in serum, and lowered pro-inflammatory TNF-α, IL-6 and IL-1β production. It suppressed the activation status of CD11b+ cells by lowering CD86, MHCII and TLR-4 expression, and promoted the Th17/T regulatory cell (Tregs) balance towards Tregs. A lower frequency of B cells was accompanied by a lower level of anti-CII antibodies in treated rats. These findings imply the favorable effect of TM extract on the clinical presentation of CIA, suggesting its anti-inflammatory/immunomodulatory action and potential therapeutic effect.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of Traumatic Brain Injury in Modern Rodent Models: Current Status and Future Prospects. 现代啮齿动物模型中创伤性脑损伤的系统回顾：现状与前景

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-11 DOI: 10.3390/biology13100813

Evgenii Balakin, Ksenia Yurku, Tatiana Fomina, Tatiana Butkova, Valeriya Nakhod, Alexander Izotov, Anna Kaysheva, Vasiliy Pustovoyt

引用次数: 0

The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation. 高草酸盐刺激下肾小管上皮细胞蛋白质组景观的改变

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-11 DOI: 10.3390/biology13100814

Sen-Yuan Hong, Bao-Long Qin

{"title":"The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation.","authors":"Sen-Yuan Hong, Bao-Long Qin","doi":"10.3390/biology13100814","DOIUrl":"https://doi.org/10.3390/biology13100814","url":null,"abstract":"Our study aimed to apply a proteomic approach to investigate the molecular mechanisms underlying the effects of oxalate on rat renal tubular epithelial cells. NRK-52E cells were treated with or without oxalate and subjected to quantitative proteomics to identify key proteins and key pathological changes under high oxalate stimulation. A total of 268 differentially expressed proteins (DEPs) between oxalate-treated and control groups were identified, with 132 up-regulated and 136 down-regulated proteins. Functional enrichment analysis revealed that DEPs are associated with oxidative stress, apoptosis, ferroptosis, pro-inflammatory cytokines, vitamin D, and biomineralization. SPP1, MFGE8, ANKS1A, and NAP1L1 were up-regulated in the oxalate-treated cells and the hyperoxaluric stone-forming rats, while SUB1, RNPS1, and DGLUCY were down-regulated in both cases. This altered proteomic landscape sheds light on the pathological processes involved in oxalate-induced renal damage and identifies potential biomarkers and therapeutic targets to mitigate the effects of hyperoxaluria and reduce the risk of CaOx stone formation.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Nanoemulsified Clinacanthus nutans Extract: Synergistic Anti-Pathogenic, Anti-Biofilm, Anti-Inflammatory, and Metabolic Modulation Effects against Periodontitis. 多功能纳米乳化 Clinacanthus nutans 提取物：对牙周炎具有抗病原、抗生物膜、抗炎症和调节代谢的协同作用。

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-11 DOI: 10.3390/biology13100815

Sirintip Pechroj, Thida Kaewkod, Pachara Sattayawat, Angkhana Inta, Sureeporn Suriyaprom, Teerapong Yata, Yingmanee Tragoolpua, Itthayakorn Promputtha

{"title":"Multifunctional Nanoemulsified Clinacanthus nutans Extract: Synergistic Anti-Pathogenic, Anti-Biofilm, Anti-Inflammatory, and Metabolic Modulation Effects against Periodontitis.","authors":"Sirintip Pechroj, Thida Kaewkod, Pachara Sattayawat, Angkhana Inta, Sureeporn Suriyaprom, Teerapong Yata, Yingmanee Tragoolpua, Itthayakorn Promputtha","doi":"10.3390/biology13100815","DOIUrl":"https://doi.org/10.3390/biology13100815","url":null,"abstract":"This study investigates the therapeutic potential of Clinacanthus nutans extracts, focusing on the 95% ethanol (95E) extract and its nanoemulsified form, against oral pathogens and their bioactive effects. The findings demonstrate potent antibacterial activity against Streptococcus mutans and Staphylococcus aureus, essential for combating periodontal diseases, and significant anti-biofilm properties crucial for plaque management. Additionally, the extracts exhibit promising inhibitory effects on α-glucosidase enzymes, indicating potential for diabetes management through glucose metabolism regulation. Their anti-inflammatory properties, evidenced by reduced nitric oxide production, underscore their potential for treating oral infections and inflammation. Notably, the nanoemulsified 95E extract shows higher efficiency than the conventional extract, suggesting a multifunctional treatment approach for periodontal issues and metabolic disorders. These results highlight the enhanced efficacy of the nanoemulsified extract, proposing it as an effective treatment modality for periodontal disease in diabetic patients. This research offers valuable insights into the development of innovative drug delivery systems using natural remedies for improved periodontal care in diabetic populations.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to Gold Induces Autoantibodies against Nuclear Antigens in A.TL Mice. 金诱导 A.TL 小鼠产生针对核抗原的自身抗体

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-11 DOI: 10.3390/biology13100812

Sara Puente-Marin, Said Havarinasab

{"title":"Exposure to Gold Induces Autoantibodies against Nuclear Antigens in A.TL Mice.","authors":"Sara Puente-Marin, Said Havarinasab","doi":"10.3390/biology13100812","DOIUrl":"https://doi.org/10.3390/biology13100812","url":null,"abstract":"To demonstrate causation or/and assess pathogenic mechanisms of environment-induced autoimmunity, various animal models that mimic the characteristics of the human autoimmune diseases need to be developed. Experimental studies in mice reveal the genetic factors that contribute to autoimmune diseases. Here, the immune response of two mouse strains congenic for non-H-2 genes, A.TL (H-2tl) and A.SW (H-2s), was evaluated after 15 weeks' exposure to gold aurothiomalate (AuTM). AuTM-treated A.TL mice showed anti-nuclear antibodies (ANA) with homogenous and/or fine speckled staining patterns and serum autoantibodies to ds-DNA, chromatin, histones, and ribonucleoproteins (RNP). Female A.TL mice showed a stronger immune response than males, as well as an increase of B cells in their spleen after 15 weeks of gold exposure. A.SW exposed for AuTM showed the induction of anti-nucleolar antibodies (ANoA) with a clumpy staining pattern, as well as an increase in splenic B and T cells. The serum autoantibodies levels in A.SW mice were limited compared to those of A.TL mice. Overall, A.TL presents a stronger immune response after gold exposure than A.SW. The immune response developed in A.TL presents similarities with the clinical manifestations in human autoimmune diseases. Thus, gold-exposed A.TL could constitute a potential experimental mouse model for the study of autoimmunity.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Omics Profiling Unveils the Complexity and Dynamics of Immune Infiltrates in Intrahepatic Cholangiocarcinoma. 多指标图谱分析揭示肝内胆管癌免疫浸润的复杂性和动态性

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-11 DOI: 10.3390/biology13100816

Xuan Li, Yan Wang, Renchu Guan, Nan Sheng, Shuangquan Zhang

{"title":"Multi-Omics Profiling Unveils the Complexity and Dynamics of Immune Infiltrates in Intrahepatic Cholangiocarcinoma.","authors":"Xuan Li, Yan Wang, Renchu Guan, Nan Sheng, Shuangquan Zhang","doi":"10.3390/biology13100816","DOIUrl":"https://doi.org/10.3390/biology13100816","url":null,"abstract":"Intrahepatic cholangiocarcinoma (ICC) is a highly heterogeneous malignancy. The reasons behind the global rise in the incidence of ICC remain unclear, and there exists limited knowledge regarding the immune cells within the tumor microenvironment (TME). In this study, a more comprehensive analysis of multi-omics data was performed using machine learning methods. The study found that the immunoactivity of B cells, macrophages, and T cells in the infiltrating immune cells of ICC exhibits a significantly higher level of immunoactivity in comparison to other immune cells. During the immune sensing and response, the effect of antigen-presenting cells (APCs) such as B cells and macrophages on activating NK cells was weakened, while the effect of activating T cells became stronger. Simultaneously, four distinct subpopulations, namely BLp, MacrophagesLp, BHn, and THn, have been identified from the infiltrating immune cells, and their corresponding immune-related marker genes have been identified. The immune sensing and response model of ICC has been revised and constructed based on our current comprehension. This study not only helps to deepen the understanding the heterogeneity of infiltrating immune cells in ICC, but also may provide valuable insights into the diagnosis, evaluation, treatment, and prognosis of ICC.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of Mercury in an Arid Zone of Mexico: A Perspective Based on Biomonitoring of Mammals from Three Trophic Guilds. 墨西哥干旱地区汞的存在：基于对三个营养群哺乳动物的生物监测的视角。

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-11 DOI: 10.3390/biology13100811

Leticia Anaid Mora-Villa, Livia León-Paniagua, Rocío García-Martínez, Joaquín Arroyo-Cabrales

{"title":"Presence of Mercury in an Arid Zone of Mexico: A Perspective Based on Biomonitoring of Mammals from Three Trophic Guilds.","authors":"Leticia Anaid Mora-Villa, Livia León-Paniagua, Rocío García-Martínez, Joaquín Arroyo-Cabrales","doi":"10.3390/biology13100811","DOIUrl":"https://doi.org/10.3390/biology13100811","url":null,"abstract":"Mercury (Hg) has been extensively studied due to its impact on the environment and health, but its effects on wild mammal populations are still poorly known. Therefore, the use of biomonitors has gained importance. Our objective was to report and compare, for the first time, the amount of mercury in small mammals belonging to three trophic guilds and to provide an initial toxicology perspective in the Mezquital Valley, a critically polluted area of Central Mexico. We quantified total Hg from the hair and liver of a nectarivorous bat (Leptonycteris yerbabuenae), an insectivorous bat (Corynorhinus townsendii) and a granivorous mouse (Peromyscus melanophrys) using atomic absorption spectrometry during the dry and rainy seasons. We compared the mercury concentrations between seasons, species and matrices. In all species, the average mercury content was higher in hair than liver, and there was no correlation between matrices. There was no difference in mercury content among species. Hg concentrations in the livers of P. melanophrys and C. townsendii were lower during the dry season than the rainy season, suggesting a seasonal decline in mercury availability. All of the values detected were below the neurotoxicity threshold reported in small mammals (10 ppm); however, we propose constant monitoring of Hg in their environment and confirm the utility of these species as biomonitors.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purifying Selection Influences the Comparison of Heterozygosities between Populations. 纯化选择影响种群间杂合度的比较

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-10 DOI: 10.3390/biology13100810

Sankar Subramanian

{"title":"Purifying Selection Influences the Comparison of Heterozygosities between Populations.","authors":"Sankar Subramanian","doi":"10.3390/biology13100810","DOIUrl":"https://doi.org/10.3390/biology13100810","url":null,"abstract":"Heterozygosity is a fundamental measure routinely used to compare between populations to infer the level of genetic variation and their relative effective population sizes. However, such comparison is highly influenced by the magnitude of selection pressure on the genomic regions used. Using over 2 million Single Nucleotide Variants (SNVs) from chimpanzee and mouse populations, this study shows that the heterozygosities estimated using neutrally evolving sites of large populations were two times higher than those of small populations. However, this difference was only ~1.6 times for the heterozygosities estimated using nonsynonymous sites. This suggests an excess in the nonsynonymous heterozygosities due to the segregation of deleterious variants in small populations. This excess in the nonsynonymous heterozygosities of the small populations was estimated to be 23-31%. Further analysis revealed that the magnitude of the excess is modulated by effective population size (Ne) and selection intensity (s). Using chimpanzee populations, this investigation found that the excess in nonsynonymous diversity in the small population was little (6%) when the difference between the Ne values of large and small populations was small (2.4 times). Conversely, this was high (23%) when the difference in Ne was large (5.9 times). Analysis using mouse populations showed that the excess in the nonsynonymous diversity of highly constrained genes of the small population was much higher (38%) than that observed for the genes under relaxed selective constraints (21%). Similar results were observed when the expression levels of genes were used as a proxy for selection intensity. These results emphasize the use of neutral regions, less constrained genes, or lowly expressed genes when comparing the heterozygosities between populations.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Stocking Density on the Survival, Growth, and Stress Levels of the Juvenile Lined Seahorse (Hippocampus erectus) in Recirculating Aquaculture Systems. 放养密度对循环水养殖系统中幼年直立海马（Hippocampus erectus）的存活、生长和应激水平的影响。

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-10 DOI: 10.3390/biology13100807

Tingting Lin, Siping Li, Dong Zhang, Xin Liu, Yuanhao Ren

{"title":"Effects of Stocking Density on the Survival, Growth, and Stress Levels of the Juvenile Lined Seahorse (Hippocampus erectus) in Recirculating Aquaculture Systems.","authors":"Tingting Lin, Siping Li, Dong Zhang, Xin Liu, Yuanhao Ren","doi":"10.3390/biology13100807","DOIUrl":"https://doi.org/10.3390/biology13100807","url":null,"abstract":"Seahorses are increasingly regarded as a promising farming object suitable for recirculating aquaculture systems (RASs) due to their high economic value. However, reports on the large-scale farming of seahorses in RASs are rare, and some key parameters, such as stocking densities, are still unclear. In the present study, we employed the lined seahorse (Hippocampus erectus), for which large-scale farming has been achieved, to determine the suitable stocking density for three different-sized juveniles in RASs. The three different-sized juveniles had body heights of 4.0, 7.0, and 9.0 cm, and their test density gradients were 1.0, 0.8, 0.6, and 0.4 inds/L; 0.6, 0.5, 0.4, and 0.3 inds/L; and 0.4, 0.3, 0.2, and 0.1 inds/L, respectively. The juveniles were cultivated for one month, and then their survival, growth, and plasma cortisol and brain serotonin contents (two stress-related indicators) were analyzed. The results show that, regardless of the size of the juveniles, a high density can inhibit growth and trigger stress responses. In addition, for small- (4.0 cm) and medium-sized (7.0 cm) juveniles, a high density can also exacerbate size heterogeneity and cause death. Taking into account the welfare and yield of farmed seahorses, the present study suggests that the suitable stocking densities for 4.0, 7.0, and 9.0 cm juveniles in RASs are 0.6, 0.4, and 0.2 inds/L, respectively.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of 4.9 GHz Radiofrequency Field Exposure on Brain Metabolomic and Proteomic Characterization in Mice. 4.9 GHz 射频场暴露对小鼠脑代谢组和蛋白质组特征的影响

IF 3.6 3区生物学

Biology-Basel Pub Date : 2024-10-10 DOI: 10.3390/biology13100806

Xing Wang, Guiqiang Zhou, Jiajin Lin, Zhaowen Zhang, Tongzhou Qin, Ling Guo, Haonan Wang, Zhifei Huang, Guirong Ding

{"title":"Effects of 4.9 GHz Radiofrequency Field Exposure on Brain Metabolomic and Proteomic Characterization in Mice.","authors":"Xing Wang, Guiqiang Zhou, Jiajin Lin, Zhaowen Zhang, Tongzhou Qin, Ling Guo, Haonan Wang, Zhifei Huang, Guirong Ding","doi":"10.3390/biology13100806","DOIUrl":"https://doi.org/10.3390/biology13100806","url":null,"abstract":"Electromagnetic exposure has become increasingly widespread, and its biological effects have received extensive attention. The purpose of this study was to explore changes in the metabolism profile of the brain and serum and to identify differentially expressed proteins in the brain after exposure to the 4.9 GHz radiofrequency (RF) field. C57BL/6 mice were randomly divided into a Sham group and an RF group, which were sham-exposed and continuously exposed to a 4.9 RF field for 35 d, 1 h/d, at an average power density (PD) of 50 W/m2. After exposure, untargeted metabolomics and Tandem Mass Tags (TMT) quantitative proteomics were performed. We found 104 and 153 up- and down-regulated differentially expressed metabolites (DEMs) in the RF_Brain group and RF_Serum group, and the DEMs were significantly enriched in glycerophospholipid metabolism. Moreover, 10 up-regulated and 51 down-regulated differentially expressed proteins (DEPs) were discovered in the RF group. Functional correlation analysis showed that most DEMs and DEPs showed a significant correlation. These results suggested that 4.9 GHz exposure induced disturbance of metabolism in the brain and serum, and caused deregulation of proteins in the brain.","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0