Biology-Basel最新文献

{"title":"Deep into Cognition: The Neuropsychological Identikit of Younger and Older Individuals after COVID-19 Infection.","authors":"Maria Devita, Adele Ravelli, Anna Panzeri, Elisa Di Rosa, Pamela Iannizzi, Gioia Bottesi, Chiara Ceolin, Marina De Rui, Annamaria Cattelan, Silvia Cavinato, Chiara Begliomini, Biancarosa Volpe, Rossana Schiavo, Marta Ghisi, Daniela Mapelli","doi":"10.3390/biology13100754","DOIUrl":"https://doi.org/10.3390/biology13100754","url":null,"abstract":"<p><p>The literature on COVID-19 continues to increase daily. Cognitive sequelae associated with COVID-19 infection still draw the attention of the scientific community given the lack of consensus about their existence, etiology, characterization and reversibility. The aim of this study is to provide a neuropsychological identikit for younger (<65 years) and older (≥65 years) individuals diagnosed with COVID-19 infection, at baseline and after 3 and 6 months. In total, 226 individuals took part in a retrospective observational study and their cognitive performance was compared across groups (younger adults vs. older adults) and time (T0, T1, T2). The results highlighted differences between younger and older adults in the Montreal Cognitive Assessment (MoCA) global score, as expected in consideration of the different physiological conditions of the two populations. However, memory performance highlighted the two groups as characterized by a difference in patterns of recall that may move beyond a physiological explanation and provide information about COVID-19 cognitive sequelae. This study suggests that cognitive deficits observed in COVID-19 survivors may reflect a difficulty in attention and concentration that interferes mainly with retrieval processes. This result fits well with the concept of \"brain fog\" typical of post-COVID-19 syndrome and may also reflect the stress experienced while facing the pandemic.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhizobacteria Isolated from Amazonian Soils Reduce the Effects of Water Stress on the Growth of Açaí (<i>Euterpe oleracea</i> Mart.) Palm Seedlings.","authors":"Suania Maria do Nascimento Sousa, Josinete Torres Garcias, Marceli Ruani De Oliveira Farias, Allana Laís Alves Lima, Rosiane do Socorro Dos Reis de Sousa, Hellen Kempfer Philippsen, Lucimar Di Paula Dos Santos Madeira, Herve Rogez, Joana Montezano Marques","doi":"10.3390/biology13100757","DOIUrl":"https://doi.org/10.3390/biology13100757","url":null,"abstract":"<p><p><i>Euterpe oleracea</i> Mart., also known for its fruit açaí, is a palm native to the Amazon region. The state of Pará, Brazil, accounts for over 90% of açaí production. Demand for the fruit in national and international markets is increasing; however, climate change and diseases such as anthracnose, caused by the fungus <i>Colletotrichum</i> sp., lead to decreased production. To meet demand, measures such as expanding cultivation in upland areas are often adopted, requiring substantial economic investments, particularly in irrigation. Therefore, the aim of this study was to evaluate the potential of açaí rhizobacteria in promoting plant growth (PGPR). Rhizospheric soil samples from floodplain and upland açaí plantations were collected during rainy and dry seasons. Bacterial strains were isolated using the serial dilution method, and subsequent assays evaluated their ability to promote plant growth. Soil analyses indicated that the sampling period influenced the physicochemical properties of both areas, with increases observed during winter for most soil components like organic matter and C/N ratio. A total of 177 bacterial strains were isolated from rhizospheres of açaí trees cultivated in floodplain and upland areas across dry and rainy seasons. Among these strains, 24% produced IAA, 18% synthesized ACC deaminase, 11% mineralized organic phosphate, and 9% solubilized inorganic phosphate, among other characteristics. Interestingly, 88% inhibited the growth of phytopathogenic fungi of the genera <i>Curvularia</i> and <i>Colletotrichum</i>. Analysis under simulated water stress using Polyethylene Glycol 6000 revealed that 23% of the strains exhibited tolerance. Two strains were identified as <i>Bacillus proteolyticus</i> (PP218346) and <i>Priestia aryabhattai</i> (PP218347). Inoculation with these strains increased the speed and percentage of açaí seed germination. When inoculated in consortium, 85% of seeds germinated under severe stress, compared to only 10% in the control treatment. Therefore, these bacteria show potential for use as biofertilizers, enhancing the initial development of açaí plants and contributing to sustainable agricultural practices.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Expression Analysis of the C-Type Lectin Ladderlectin in <i>Litopenaeus vannamei</i> Post-WSSV Infection.","authors":"Qian Xue, Bingbing Yang, Kun Luo, Sheng Luan, Jie Kong, Qiang Fu, Jiawang Cao, Baolong Chen, Ping Dai, Qun Xing, Xupeng Li, Xianhong Meng","doi":"10.3390/biology13100758","DOIUrl":"https://doi.org/10.3390/biology13100758","url":null,"abstract":"<p><p>C-type lectins are known for agglutination activity and play crucial roles in regulating the prophenoloxidase (proPO) activation system, enhancing phagocytosis and encapsulation, synthesizing antimicrobial peptides, and mediating antiviral immune responses. This work cloned a C-type lectin, ladderlectin (<i>LvLL</i>), from <i>Litopenaeus vannamei</i>. <i>LvLL</i> comprised a 531 bp open reading frame (ORF) that encoded 176 amino acids. The predicted LvLL protein included a signal peptide and a CLECT domain. LvLL was predicted to feature a transmembrane region, suggesting it may be a transmembrane protein. <i>LvLL</i> was predominantly expressed in the shrimp's hepatopancreas. After WSSV infection, <i>LvLL</i> expression in the hepatopancreas increased significantly by 11.35-fold after 228 h, indicating a general upregulation. Knockdown of <i>LvLL</i> resulted in a significant decrease in WSSV viral load and a notable increase in shrimp survival rates. Additionally, knockdown of <i>LvLL</i> led to a significant downregulation of apoptosis-related genes <i>Bcl-2</i> and caspase 8 and a significant upregulation of <i>p53</i> and <i>proPO</i> in WSSV-infected shrimp. This study showed that <i>LvLL</i> played a vital role in the interaction between <i>L</i>. <i>vannamei</i> and WSSV.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Ventricular Hypertrophy in Spontaneously Hypertensive Rats (SHR/NHsd) Is Associated with Inter-Individual Variations of the Pulmonary Endothelin System.","authors":"Alicia Langer, Rolf Schreckenberg, Klaus-Dieter Schlüter","doi":"10.3390/biology13100752","DOIUrl":"https://doi.org/10.3390/biology13100752","url":null,"abstract":"<p><p>Spontaneously hypertensive rats (SHRs) develop severe hypertension and subsequently left ventricular hypertrophy. Whether they also develop right ventricular hypertrophy is not clear. We analyzed 76 female SHRs (strain SHR/NHsd) and observed severe right ventricular hypertrophy in 7% of these rats (SHR-RVH). Right ventricular hypertrophy did not correlate with the age of the rats and was already seen in one rat at the pre-hypertensive state. The current study investigated the molecular fingerprint of the lung and right ventricle from SHR-RVH and compared this first to SHRs that did develop left but not right ventricular hypertrophy, and second to normotensive rats without hypertrophy. Rats with right ventricular hypertrophy had a decreased expression of the endothelin-B receptor (<i>EDNRB</i>) in the lung, together with an increased protein content of endothelin-1 and an increased expression of <i>ACTA2A</i>. Furthermore, in the right ventricle, a down-regulation of the endothelin-A receptor (<i>EDNRA</i>) was found, consistent with a mild phenotype. The data suggest that in a sub-group of SHR/NHsd rats, low expression of the endothelin clearance receptor (endothelin-B receptor) in the lung triggers an increase in vascular resistance to the right ventricle that then triggers hypertrophy. Our study is the first description of a genetic variant in a defined SHR strain.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Migration-Proliferation Dichotomy in Cancer: Biological Fact or Experimental Artefact?","authors":"Abdulaziz Alfahed","doi":"10.3390/biology13100753","DOIUrl":"https://doi.org/10.3390/biology13100753","url":null,"abstract":"<p><p>The migration-proliferation dichotomy (MPD) has long been observed in cultured cancer cells. This phenomenon is not only relevant to tumour progression but may also have therapeutic significance in clinical cancer. However, MPD has rarely been investigated in primary cancer. This study aimed to either confirm or disprove the existence of MPD in primary cancer. Using primary gastric, colorectal and prostate cancer (GC, CRC and PCa) cohorts from the Cancer Genome Atlas and Memorial Sloan Kettering Cancer Center, this study interrogated the MPD phenomenon by utilising RNA-Seq-based proliferation (CIN70 signature) and migration (epithelial-mesenchymal transition) indices, as well as gene set enrichment analyses (GSEA). Alternative hypothetical migration-proliferation models-The simultaneous migration-proliferation (SMP) and phenotype-refractory (PR) models-were compared to the MPD model by probing the migration-proliferation relationships within cancer stages and between early- and late-stage diseases using chi-square and independent T tests, z-score statistics and GSEA. The results revealed an inverse relationship between migration and proliferation signatures overall in the GC, CRC and PCa cohorts, as well as in early- and late-stage diseases. Additionally, a shift in proliferation- to migration dominance was observed from early- to late-stage diseases in the GC and CRC cohorts but not in the PCa cohorts, which showed enhanced proliferation dominance in metastatic tumours compared to primary cancers. The above features exhibited by the cancer cohorts are in keeping with the MPD model of the migration-proliferation relationship at the cellular level and exclude the SMP and PR migration-proliferation models.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Santos et al. Early Peri-Implant Bone Healing on Laser-Modified Surfaces with and without Hydroxyapatite Coating: An In Vivo Study. <i>Biology</i> 2024, <i>13</i>, 533.","authors":"Ana Flávia Piquera Santos, Rodrigo Capalbo da Silva, Henrique Hadad, Laís Kawamata de Jesus, Maísa Pereira-Silva, Heloisa Helena Nímia, Sandra Helena Penha Oliveira, Antônio Carlos Guastaldi, Thallita Pereira Queiroz, Pier Paolo Poli, Debora de Barros Barbosa, André Luis da Silva Fabris, Idelmo Rangel Garcia Júnior, Reinhard Gruber, Francisley Ávila Souza","doi":"10.3390/biology13100756","DOIUrl":"https://doi.org/10.3390/biology13100756","url":null,"abstract":"<p><p>There were two errors in the original publication [...].</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of Seed Germination and Seedling Growth of Six Desert Shrubs to Different Moisture Levels under Greenhouse Conditions.","authors":"Yonghong Luo, Hui Yang, Xingfu Yan, Yongrui Ma, Shuhua Wei, Jiazhi Wang, Ziyu Cao, Zhong Zuo, Chunhui Yang, Jiming Cheng","doi":"10.3390/biology13090747","DOIUrl":"https://doi.org/10.3390/biology13090747","url":null,"abstract":"<p><p>Moisture is the most important environmental factor limiting seed regeneration of shrubs in desert areas. Therefore, understanding the effects of moisture changes on seed germination, morphological and physiological traits of shrubs is essential for vegetation restoration in desert areas. In March to June 2023, in a greenhouse using the potting method, we tested the effects of soil moisture changes (5%, 10%, 15%, 20% and 25%) on seed germination and seedling growth of six desert shrubs (<i>Zygophyllum xanthoxylum</i>, <i>Nitraria sibirica</i>, <i>Calligonum mongolicum</i>, <i>Corethrodendron scoparium</i>, <i>Caragana korshinskii</i>, and <i>Corethrodendron fruticosu</i>). Results showed that (1) seed germination percent and vigor index were significantly higher at 15 and 20% soil moisture content than at 5 and 10%; (2) shoot length, primary root length, specific leaf area and biomass of seedlings were significantly higher in the 15% and 20% soil moisture content treatments than in the 5% and 10% treatments; (3) superoxide dismutase activity (SOD) and soluble protein content (SP) decreased with decreasing soil water content, while peroxidase activity (POD) and catalase activity (CAT) showed a decreasing and then increasing trend with increasing soil water content; (4) the six seeds and seedling of shrubs were ranked in order of their survivability in response to changes in soil moisture: <i>Caragana korshinskii</i> > <i>Zygophyllum xanthoxylum</i> > <i>Calligonum mongolicum</i> > <i>Corethrodendron scoparium</i> > <i>Corethrodendron fruticosu</i> > <i>Nitraria sibirica</i>. Our study shows that shrub seedlings respond to water changes by regulating morphological and physiological traits together. More importantly, we found that <i>C. korshinskii</i>, <i>Z. xanthoxylum</i> and <i>C. mongolicum</i> were more survivable when coping with water deficit or extreme precipitation. The results of the study may provide a reference for the selection and cultivation of similar shrubs in desert areas under frequent extreme droughts in the future.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 9","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Causal Relationship between Ibuprofen Use and Osteoarthritis Risk: A Mendelian Randomization Study.","authors":"Yongzhi Jian, Yanmin Lyu, Said Hashemolhosseini","doi":"10.3390/biology13090748","DOIUrl":"https://doi.org/10.3390/biology13090748","url":null,"abstract":"<p><p>This study explored the potential causal relationship between ibuprofen (IBU) use and the risk of developing osteoarthritis, a prevalent joint disorder characterized by pain and stiffness. We conducted a two-sample MR analysis using four distinct OA GWAS datasets as outcomes and single-nucleotide polymorphisms (SNPs) associated with IBU metabolism as exposures. The inverse variance weighted (IVW) and weighted median methods were utilized to assess the causal association by meta-analysis, while pleiotropy and heterogeneity were evaluated using MR-Egger regression and Cochran's Q statistics. The MR analysis provided strong evidence for a causal association between IBU use and an increased risk of OA. A meta-analysis of the IVW and weighted median results across all datasets demonstrated an OR = 1.116 (95% CI = 1.063-1.170) and an OR = 1.110 (95% CI = 1.041-1.184). The consistency of the results obtained from different methods enhanced the reliability of the findings. Low pleiotropy and minimal heterogeneity were observed, further validating the results. The study supports a causal link between IBU use and an increased risk of OA, suggesting that IBU may accelerate the progression of OA while relieving symptoms. These findings highlight the importance of cautious use of IBU in clinical practice, especially considering its potential impact on long-term joint health.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 9","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Dynamics and mRNA Translation: A Local Synaptic Tale.","authors":"Marta Zaninello, Pedro Baptista, Filipe V Duarte","doi":"10.3390/biology13090746","DOIUrl":"https://doi.org/10.3390/biology13090746","url":null,"abstract":"<p><p>Mitochondria are dynamic organelles that can adjust and respond to different stimuli within a cell. This plastic ability allows them to effectively coordinate several cellular functions in cells and becomes particularly relevant in highly complex cells such as neurons. An imbalance in mitochondrial dynamics can disrupt mitochondrial function, leading to abnormal cellular function and ultimately to a range of diseases, including neurodegenerative disorders. Regulation of mRNA transport and local translation inside neurons is crucial for maintaining the proteome of distal mitochondria, which is vital for energy production and synaptic function. A significant portion of the axonal transcriptome is dedicated to mRNAs for mitochondrial proteins, emphasizing the importance of local translation in sustaining mitochondrial function in areas far from the cell body. In neurons, local translation and the regulation of mRNAs encoding mitochondrial-shaping proteins could be essential for synaptic plasticity and neuronal health. The dynamics of these mRNAs, including their transport and local translation, may influence the morphology and function of mitochondria, thereby affecting the overall energy status and responsiveness of synapses. Comprehending the mitochondria-related mRNA regulation and local translation, as well as its influence on mitochondrial morphology near the synapses will help to better understand neuronal physiology and neurological diseases where mitochondrial dysfunction and impaired synaptic plasticity play a central role.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 9","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Different Opening Diet on the Growth, the Structure of the Digestive Tract and Digestive Enzyme Activity of Larval and Juvenile <i>Mystus macropterus</i>.","authors":"Xiaoli Li, Xingbing Wu, Xuemei Li, Nian Wei, Ming Jiang, Yongjiu Zhu, Tingbing Zhu","doi":"10.3390/biology13090749","DOIUrl":"10.3390/biology13090749","url":null,"abstract":"<p><p>One of the crucial factors influencing the growth and viability of larvae and juveniles is their opening diets. The objective of this study was to identify suitable initial feed options for <i>M. macropterus</i> larvae and juveniles. A total of 1200 newly hatched <i>M. macropterus</i> with an average weight of 18.3 mg and an average length of 11.58 mm were selected and randomly divided into four groups. The fish were fed with different opening diets, including rotifer, <i>Artemia nauplii</i>, Tubifex, and micro-diet from six days after hatching (dahs), respectively. Growth indices and activities of digestive enzymes were assessed at 10, 15, 20, 25, 30, 35, and 40 dahs. Histological examination of the structure of the digestive tract was performed at 40 dahs, while survival rates were also documented. The results demonstrated that different diets had no effect on the survival rate of larvae and juveniles of <i>M. macropterus</i>. The growth performance indices were ranked as follows: Tubifex group > <i>Artemia nauplii</i> group > micro-diet group > rotifer group. Remarkably, the Tubifex group exhibited superior growth performance, which was also reflected in the structure of the digestive tract and digestive enzyme activity. Therefore, it is recommended to include Tubifex in the diet of <i>M. macropterus</i> larvae and juvenile during the standardized farming process.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 9","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}