乳酸代谢:胰腺癌发展的幕后推手。

IF 3.5 3区 生物学 Q1 BIOLOGY
Lan Yang, Dong Guo, Kangli Wu, Yiqi Li, Yue Xi, Wenying Qin, Xingzhen Chen, Cefan Zhou, Jingfeng Tang
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引用次数: 0

摘要

自从在癌症中发现了“华宝效应”,乳酸不再仅仅被认为是一种代谢副产物。它既是参与能量循环的代谢燃料,又是调节细胞信号转导的信号分子。近年来的研究表明,乳酸参与蛋白质乳酸化,调节能量代谢,重塑肿瘤微环境,促进胰腺癌转移。因此,靶向乳酸代谢已成为提高胰腺癌治疗疗效和生存率的一种有前景的策略。在这篇综述中,我们概述了乳酸代谢异常和乳酸化的最新进展,并阐明了乳酸代谢在胰腺癌中的生物学功能,重点是代谢重编程,血管生成和免疫逃避。此外,我们还讨论了针对胰腺癌乳酸代谢的诊断和治疗方法。该领域的研究对于理解驱动胰腺癌进展的机制至关重要,并有望为临床实践开发新的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lactate Metabolism: The String-Puller for the Development of Pancreatic Cancer.

Since the discovery of the 'Warburg effect' in cancer, lactate is no longer considered merely a metabolic byproduct. It serves as both a metabolic fuel involved in the energy cycle and a signaling molecule that modulates cellular signal transduction. Recent studies have demonstrated that lactate participates in protein lactylation, regulates energy metabolism, reshapes the tumor microenvironment, and facilitates the metastasis of pancreatic cancer. Therefore, targeting lactate metabolism has emerged as a promising strategy to improve therapeutic efficacy and survival rates in pancreatic cancer. In this review, we outline aberrant lactate metabolism and recent advancements in lactylation, and elucidate the biological functions of lactate metabolism in pancreatic cancer, focusing on metabolic reprogramming, angiogenesis, and immune evasion. Additionally, we discuss diagnostic and therapeutic approaches targeting lactate metabolism in pancreatic cancer. Research in this field is critical for understanding the mechanisms driving pancreatic cancer progression and is anticipated to develop novel therapeutic strategies for clinical practice.

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来源期刊
Biology-Basel
Biology-Basel Biological Science-Biological Science
CiteScore
5.70
自引率
4.80%
发文量
1618
审稿时长
11 weeks
期刊介绍: Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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