Biology-Basel最新文献

{"title":"Using the Constrained Disorder Principle to Navigate Uncertainties in Biology and Medicine: Refining Fuzzy Algorithms.","authors":"Yaron Ilan","doi":"10.3390/biology13100830","DOIUrl":"https://doi.org/10.3390/biology13100830","url":null,"abstract":"<p><p>Uncertainty in biology refers to situations in which information is imperfect or unknown. Variability, on the other hand, is measured by the frequency distribution of observed data. Biological variability adds to the uncertainty. The Constrained Disorder Principle (CDP) defines all systems in the universe by their inherent variability. According to the CDP, systems exhibit a degree of variability necessary for their proper function, allowing them to adapt to changes in their environments. Per the CDP, while variability differs from uncertainty, it can be viewed as a regulated mechanism for efficient functionality rather than uncertainty. This paper explores the various aspects of un-certainties in biology. It focuses on using CDP-based platforms for refining fuzzy algorithms to address some of the challenges associated with biological and medical uncertainties. Developing a fuzzy decision tree that considers the natural variability of systems can help minimize uncertainty. This method can reveal previously unidentified classes, reduce the number of unknowns, improve the accuracy of modeling results, and generate algorithm outputs that are more biologically and clinically relevant.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Communities through Citizen Science: Dengue Prevention in Córdoba.","authors":"Elizabet L Estallo, Magali Isabel Madelon, Elisabet M Benítez, Doriam Camacho-Rodríguez, Mía E Martín, Anna M Stewart-Ibarra, Francisco F Ludueña-Almeida","doi":"10.3390/biology13100826","DOIUrl":"https://doi.org/10.3390/biology13100826","url":null,"abstract":"<p><p>Traditional mosquito vector control methods have proved ineffective in controlling the spread of dengue fever. This study aimed to assess the effectiveness of community engagement through student-led science in promoting dengue prevention and socioecological factors in the temperate urban city of Córdoba, Argentina. It assesses community perceptions, knowledge, attitudes, and preventive practices regarding dengue fever and its vector. Results showed a significant increase in knowledge about the vector and the disease and respondents' adoption of good preventive practices. Student-led science was identified as a valuable tool for reaching households and leading to behavior changes at home. Furthermore, the findings highlighted the need for school programs to address vector biology and vector-borne disease prevention all year round. This study provides invaluable insights into the effectiveness of community engagement through student-led science to promote dengue prevention and socioecological factors. The findings suggest that this approach could be used to control the spread in other regions affected by the disease.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dietary Digestible Protein Levels on Muscle Growth and Oxidative Stress in Amazonian Pintado (<i>Pseudoplatystoma reticulatum</i> × <i>Leiarius marmoratus</i>).","authors":"Stephane Vasconcelos Leandro, Daniel Rabello Ituassú, Valéria Dornelles Gindri Sinhorin, Danilo Henrique Aguiar, Paula Sueli Andrade Moreira, Ana Julia Lopes Braga Ferneda, Soraia Andressa Dall'Agnol Marques, Adilson Paulo Sinhorin, Anderson Corassa, Ana Paula Silva Ton, Leonardo Willian de Freitas, Maicon Sbardella","doi":"10.3390/biology13100825","DOIUrl":"https://doi.org/10.3390/biology13100825","url":null,"abstract":"<p><p>This study aimed to evaluate the effects of dietary digestible protein levels on the growth dynamics and oxidative stress status of white muscle fibers in Amazonian Pintado (<i>Pseudoplatystoma reticulatum</i> × <i>Leiarius marmoratus</i>). Four hundred and fifty-five juveniles of Amazonian Pintado were fed diets containing varying digestible protein levels (225, 250, 275, 300, 325, 350, or 375 g kg^-1) for 75 days. At the end of the experiment, the fish were fasted for 24 h, anesthetized, and euthanized to obtain muscle samples. The linear and quadratic effects of dietary digestible protein levels on white muscle fiber diameter, metabolite concentrations, and oxidative stress were assessed. The results revealed that increasing dietary digestible protein levels linearly raised the concentrations of free amino acids and total proteins in muscle tissue but also led to elevated levels of TBARS, indicating increased oxidative stress. Notably, the average area of muscle fibers with a cell area greater than 1133 µm² decreased, reflecting restricted muscle hypertrophy, whereas glycogen and glucose levels also declined. These findings suggest that although high dietary digestible protein enhances protein and free amino acid concentrations in muscle tissue, it may compromise muscle hypertrophy and increase oxidative damage in Amazonian Pintado, underscoring the complexity of optimizing diet formulation.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of New Btk-Based Formulations BLB1 and Lip on Aquatic Non-Target Organisms.","authors":"Sayda Dhaouadi, Rim El Jeni, Hazar Kraiem, Gul Ayyildiz, Cansu Filik-Iscen, Zeynep Yurtkuran-Ceterez, Balkiss Bouhaouala-Zahar","doi":"10.3390/biology13100824","DOIUrl":"https://doi.org/10.3390/biology13100824","url":null,"abstract":"<p><p>Integrated pest management based on the use of biopesticides is largely applied. Experimental bioassays are critical to assess biopesticide biosafety at the ecotoxicological level. In this study, we investigated the effects of the new <i>Bacillus thuringiensis subsp. kurstaki</i> (<i>Btk</i>)-formulated-based biopesticides BLB1 and Lip, efficiently tested in field assays (IPM-4-CITRUS EC project no. 734921) on two aquatic non-target organisms, precisely the water flea <i>Daphnia magna</i> and the bioluminescent bacteria <i>Aliivibrio fischeri</i>. Acute toxicity studies, carried out in a comparative manner with Delfin^® as the reference bioproduct and the lactose-based Blank formulation, show that no significant toxicity was observed up to 1 g/L. Our results indicated that BLB1- and Lip-formulated new bioproducts are far less toxic than the Delfin^® reference bioproduct.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity and Evolution of <i>NLR</i> Genes in <i>Citrus</i> Species.","authors":"Zhiwei Xiong, Wanshan Zhang, Hui Yin, Jiaxing Wan, Zhuozhuo Wu, Yuxia Gao","doi":"10.3390/biology13100822","DOIUrl":"https://doi.org/10.3390/biology13100822","url":null,"abstract":"<p><p><i>NLR</i> genes are crucial components of the effector-triggered immunity (ETI) system, responsible for recognizing pathogens and initiating immune responses. Although <i>NLR</i> genes in many plant species have been extensively studied, the diversity of <i>NLR</i> genes in <i>citrus</i> remains largely unknown. Our analysis revealed significant variations in the copy numbers of <i>NLR</i> genes among these species. Gene duplication and recombination were identified as the major driving forces behind this diversity. Additionally, horizontal gene transfer (HGT) emerged as the principal mechanism responsible for the increase in <i>NLR</i> gene copy number in <i>A. buxifolia</i>. The <i>citrus NLR</i> genes were classified into four categories: TIR-NBS-LRR (TNL), CC-NBS-LRR (CNL), RPW8-NBS-LRR (RNL), and NL. Our findings indicate that TNL, RNL, and CNL genes originated from NL genes through the acquisition of TIR and RPW8 domains, along with CC motifs, followed by the random loss of corresponding domains. Phylogenetic analysis suggested that <i>citrus NLR</i> genes originated alongside the species and underwent adaptive evolution, potentially playing crucial roles in the global colonization of <i>citrus</i>. This study provides important insights into the diversity of <i>citrus NLR</i> genes and serves as a foundational dataset for future research aimed at breeding disease-resistant <i>citrus</i> varieties.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Pirimiphos-Methyl on Non-Target Invertebrates.","authors":"Liudmyla Faly, Viktor Brygadyrenko","doi":"10.3390/biology13100823","DOIUrl":"https://doi.org/10.3390/biology13100823","url":null,"abstract":"<p><p>The effects of pirimiphos-methyl have previously been assessed on blood-sucking insect species, pollinating insects, and target crop pest species. The sensitivity of non-target zoophagous and saprophage species to this insecticide remains largely unstudied. In laboratory conditions, we assessed the susceptibility of 43 species of invertebrates to pirimiphos-methyl. The most tolerant species to this insecticide were <i>Pyrrhocoris apterus</i> (LC₅₀ measured over 60 mg/m²), <i>Cylindroiulus truncorum</i>, <i>Pterostichus niger</i>, <i>Harpalus rufipes</i>, <i>Lithobius forficatus</i>, and <i>Carabus hortensis</i> (LC₅₀ ranged from 25 to 50 mg/m²). Average tolerance to pirimiphos-methyl was displayed by <i>Ophonus rufibarbis</i>, <i>Teuchestes fossor</i>, <i>Silpha carinata</i>, <i>Badister sodalis</i>, <i>Rugilus rufipes</i>, <i>Phosphuga atrata</i>, <i>Porcellio laevis</i>, <i>Pterostichus oblongopunctatus</i>, <i>Aphodius foetens</i>, <i>Lasius fuliginosus</i>, <i>Oxypselaphus obscurus</i>, <i>Platydracus fulvipes</i>, <i>Myrmica ruginodis</i>, <i>Xantholinus tricolor</i>, and <i>Megaphyllum</i> sp. (LC₅₀ for those species ranged from 12 to 24 mg/m²). Higher sensitivity to this insecticide was seen for <i>Amara nitida</i>, <i>Leistus ferrugineus</i>, <i>Harpalus xanthopus winkleri</i>, <i>Philonthus nitidus</i>, <i>Pterostichus melanarius</i>, <i>Harpalus latus</i>, <i>Limodromus assimilis</i>, <i>Philonthus decorus</i>, <i>Tachinus signatus</i>, <i>Ponera coarctata</i>, <i>Carabus convexus</i>, <i>Philonthus coprophilus</i>, <i>Philonthus laevicollis</i>, <i>Platydracus latebricola</i>, <i>Labia minor</i>, and <i>Carabus granulatus</i> (LC₅₀ for those species ranged from 6 to 12 mg/m²). The greatest sensitivity to pirimiphos-methyl was observed in <i>Hister fenestus</i>, <i>Drusilla canaliculata</i>, <i>Bisnius fimetarius</i>, <i>Oxytelus sculptus</i>, <i>Lasius niger</i>, and <i>Lasius flavus</i> (LC₅₀ ranged from 0.4 to 6 mg/m²). We found a relationship between the parameters of bodies of invertebrates (the average body length and dry body mass) and sensitivity to pirimiphos-methyl. With an increase in body sizes of invertebrates, the tolerance to the insecticide increased (per each mm of body length, LC₅₀ increased by 0.82 mg/m² on average). We identified no relationship between the trophic specialization and sensitivity to the insecticide.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphiregulin Upregulation in Visfatin-Stimulated Colorectal Cancer Cells Reduces Sensitivity to 5-Fluororacil Cytotoxicity.","authors":"Wen-Shih Huang, Kuen-Lin Wu, Cheng-Nan Chen, Shun-Fu Chang, Ding-Yu Lee, Ko-Chao Lee","doi":"10.3390/biology13100821","DOIUrl":"https://doi.org/10.3390/biology13100821","url":null,"abstract":"<p><p>Colorectal cancer (CRC) has become a prevalent and deadly malignancy over the years. Drug resistance remains a major challenge in CRC treatment, significantly affecting patient survival rates. Obesity is a key risk factor for CRC development, and accumulating evidence indicates that increased secretion of adipokines, including Visfatin, under obese conditions contributes to the development of resistance in CRC to various therapeutic methods. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family, which activates the EGF receptor (EGFR), influencing multiple tumorigenic characteristics of cancers. Abnormal expression levels of AREG in cancer cells have been associated with resistance to anti-EGFR therapy in patients. However, it remains unclear whether this abnormal expression also impacts CRC resistance to other chemotherapeutic drugs. The aim of this study is to examine whether AREG expression levels could be affected in CRC cells under Visfatin stimulation, thereby initiating the development of resistance to 5-fluororacil (5-FU). Through our results, we found that Visfatin indeed increases AREG expression, reducing the sensitivity of HCT-116 CRC cells to 5-FU cytotoxicity. Moreover, AREG upregulation is regulated by STAT3-CREB transcription factors activated by JNK1/2 and p38 signaling. This study highlights the significant role of AREG upregulation in CRC cells in initiating chemotherapeutic resistance to 5-FU under Visfatin stimulation. These findings provide a deeper understanding of drug resistance development in CRC under obese conditions and offer new insights into the correlation between an abnormal increase in AREG levels and the development of 5-FU-resistance in CRC cells, which should be considered in future clinical applications.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vegetation Succession for 12 Years in a Pond Created Restoratively.","authors":"Chang-Seok Lee, Dong-Uk Kim, Bong-Soon Lim, Ji-Eun Seok, Gyung-Soon Kim","doi":"10.3390/biology13100820","DOIUrl":"https://doi.org/10.3390/biology13100820","url":null,"abstract":"<p><p>The Najeoer Pond was created in a rice paddy as a part of a plan to build the National Institute of Ecology. To induce the establishment of various plants, the maximum depth of the pond was 2.0 m, and diverse depths were created with a gentle slope on the pond bed. When introducing vegetation, littoral and emergent vegetation were first introduced to stabilize the space secured for the creation of the pond, whereas the introduction of other vegetation was allowed to develop naturally. In this pond, floating, emergent, wetland, and littoral plants have been established to various degrees, reflecting the water depth and water table. As a result of stand ordination, based on vegetation data obtained from the created Najeoer Pond and a natural lagoon selected as the reference site, the species' composition resembled that of the reference site. Diversity, based on vegetation type, community, and species, tended to be higher than that of the reference site. The proportion of exotic species increased due to the disturbance that occurred during the pond creation process but continued to decrease as the vegetation introduced during the creation of the pond became established. Considering these results comprehensively, the restorative treatment served to increase both the biological integrity and ecological stability of the pond and, thus, achieved the creation goal from the viewpoint of the pond structure.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen Receptor Beta Agonist Influences Presynaptic NMDA Receptor Distribution in the Paraventricular Hypothalamic Nucleus Following Hypertension in a Mouse Model of Perimenopause.","authors":"Garrett Sommer, Claudia Rodríguez López, Adi Hirschkorn, Gianna Calimano, Jose Marques-Lopes, Teresa A Milner, Michael J Glass","doi":"10.3390/biology13100819","DOIUrl":"https://doi.org/10.3390/biology13100819","url":null,"abstract":"<p><p>Women become susceptible to hypertension as they transition to menopause (i.e., perimenopause); however, the underlying mechanisms are unclear. Animal studies using an accelerated ovarian failure (AOF) model of peri-menopause (peri-AOF) demonstrate that peri-AOF hypertension is associated with increased postsynaptic NMDA receptor plasticity in the paraventricular hypothalamic nucleus (PVN), a brain area critical for blood pressure regulation. However, recent evidence indicates that presynaptic NMDA receptors also play a role in neural plasticity. Here, using immuno-electron microscopy, we examine the influence of peri-AOF hypertension on the subcellular distribution of the essential NMDA GluN1 receptor subunit in PVN axon terminals in peri-AOF and in male mice. Hypertension was produced by 14-day slow-pressor angiotensin II (AngII) infusion. The involvement of estrogen signaling was investigated by co-administering an estrogen receptor beta (ERß) agonist. Although AngII induced hypertension in both peri-AOF and male mice, peri-AOF females showed higher cytoplasmic GluN1 levels. In peri-AOF females, activation of ERß blocked hypertension and increased plasmalemmal GluN1 in axon terminals. In contrast, stimulation of ERß did not inhibit hypertension or influence presynaptic GluN1 localization in males. These results indicate that sex-dependent recruitment of presynaptic NMDA receptors in the PVN is influenced by ERß signaling in mice during early ovarian failure.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Hundred Years of Progress and Pitfalls: Maximising Heterosis through Increasing Multi-Locus Nuclear Heterozygosity.","authors":"Brendan F Hallahan","doi":"10.3390/biology13100817","DOIUrl":"https://doi.org/10.3390/biology13100817","url":null,"abstract":"<p><p>The improvement in quantitative traits (e.g., yield, size) in F₁ offspring over parent lines is described as hybrid vigour, or heterosis. There exists a fascinating relationship between parental genetic distance and genome dosage (polyploidy), and heterosis effects. The contribution of nuclear heterozygosity to heterosis is not uniform across diploid and polyploid crops, even within same species, thus demonstrating that polyploid crops should be part of any discussion on the mechanisms of heterosis. This review examines the records of correlating heterosis with parental genetic distance and the influence of adding supplementary genomes in wide crosses. Increasing nuclear heterozygosity through parental genetic distance has been shown to be an imperfect predictor for heterosis in a variety of commercial crops such as maize, rice, and pepper. However, increasing the ploidy level raises the maximum number of alleles that can be harboured at any one locus, and studies on crops such as oilseed rape, potato, alfalfa, maize, and rice have demonstrated that heterosis may be maximised upon increasing multi-locus nuclear heterozygosity. The novel heterotic phenotypes observed above the diploid level will contribute to our understanding on the mechanisms of heterosis and aid plant breeders in achieving the righteous goal of producing more food with fewer inputs.</p>","PeriodicalId":48624,"journal":{"name":"Biology-Basel","volume":"13 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}