Biosensors-Basel最新文献_第6页

Measurement of Salivary Cortisol for Revealing Age-Specific Dependence of Cortisol Levels on Time, Feeding, and Oxygen Metabolism in Newborn Infants. 测量唾液皮质醇揭示年龄特异性皮质醇水平对时间，喂养和新生儿氧代谢的依赖。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-07-01 DOI: 10.3390/bios15070420

Tomoko Suzuki, Sachiko Iwata, Chinami Hanai, Satoko Fukaya, Yuka Watanabe, Shigeharu Nakane, Hisayoshi Okamura, Shinji Saitoh, Osuke Iwata

{"title":"Measurement of Salivary Cortisol for Revealing Age-Specific Dependence of Cortisol Levels on Time, Feeding, and Oxygen Metabolism in Newborn Infants.","authors":"Tomoko Suzuki, Sachiko Iwata, Chinami Hanai, Satoko Fukaya, Yuka Watanabe, Shigeharu Nakane, Hisayoshi Okamura, Shinji Saitoh, Osuke Iwata","doi":"10.3390/bios15070420","DOIUrl":"10.3390/bios15070420","url":null,"abstract":"Salivary cortisol is widely used to assess stress and circadian rhythms, yet its control variables in neonates, particularly regarding postnatal age, remain poorly understood. To elucidate age-specific effects of clinical variables on cortisol levels, 91 neonates with a mean (standard deviation) gestational age of 34.2 (3.8) weeks and postnatal age of 38.3 (35.4) days were categorised into Early, Medium, and Late groups by quartiles (days 10 and 56). Interactions with postnatal age were evaluated by comparing Early-to-Medium or Early-to-Late differences in regression coefficients between independent variables and cortisol levels. In the whole cohort, maternal hypertensive disorders of pregnancy and morning sampling were associated with reduced cortisol levels (both p = 0.001). Mean regression coefficients (95% CI) between variables and cortisol levels were as follows: for postconceptional age, Early, -0.102 (-0.215, 0.010) and Late, 0.065 (-0.203, 0.332) (p = 0.035); for feeding duration, Early, 0.796 (-0.134, 1.727) and Late, -0.702 (-2.778, 1.376) (p = 0.010); for time elapsed since feeding, Early, -0.748 (-1.275, -0.221) and Late, -0.071 (-1.230, 1.088) (p = 0.036); and for blood lactate, Early, 0.086 (0.048 to 0.124), Medium, 0.022 (-0.063, 0.108), and Late, -0.018 (-0.106, 0.070) (p = 0.008 and <0.001 vs. Medium and Late, respectively). The influence of postconceptional age, oral feeding, and anaerobic metabolism on salivary cortisol levels was observed during the birth transition period but not beyond 10 days of life. Given the age-specific dependence of cortisol levels on clinical variables, including postconceptional age, feeding, and oxygen metabolism, caution is warranted when interpreting findings from studies on salivary cortisol in newborn infants.","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 7","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Droplet-Based Measurements of DNA-Templated Nanoclusters-Towards Point-of-Care Applications. 基于液滴的dna模板纳米簇测量-面向护理点应用。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-07-01 DOI: 10.3390/bios15070417

Jonas Kluitmann, Stefano Di Fiore, Greta Nölke, Klaus Stefan Drese

{"title":"Droplet-Based Measurements of DNA-Templated Nanoclusters-Towards Point-of-Care Applications.","authors":"Jonas Kluitmann, Stefano Di Fiore, Greta Nölke, Klaus Stefan Drese","doi":"10.3390/bios15070417","DOIUrl":"10.3390/bios15070417","url":null,"abstract":"In this work, we investigate the fundamental usability of fluorescent DNA-templated silver nanoclusters (DNA-AgNCs) as sensors for Point-of Care-Testing (PoCT) applications. We developed a microfluidic platform for the generation of droplets containing DNA-AgNCs in defined, different chemical environments. The droplets are read out fluorescently at two different emission wavelengths. For the pre-evaluation for the usage of biologically relevant matrices with DNA-AgNCs, the response of two different DNA-AgNCs to a variation in pH and sodium chloride concentration was acquired. Our compact and simple setup can detect DNA-AgNCs well below 100 nM and allows the characterization of the fluorescence response of DNA-based biohybrid nanosensors to changes in the chemical environment within short measurement times. The model DNA-AgNCs remain fluorescent throughout the physiologically relevant chloride concentrations and up to 150 mM. Upon shifts in pH, the DNA-AgNCs showed a complex fluorescence intensity response. The model DNA-AgNCs differ strongly in their response characteristics to the applied changes in their environments. With our work, we show the feasibility of the use of DNA-AgNCs as sensors in a simple microfluidic setup that can be used as a building block for PoCT applications while highlighting challenges in their adaption for use with biologically relevant matrices.","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 7","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary Biosensing Opportunities for Predicting Cognitive and Physical Human Performance. 唾液生物传感预测人类认知和身体表现的机会。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-07-01 DOI: 10.3390/bios15070418

Sara Anne Goring, Evan D Gray, Eric L Miller, Tad T Brunyé

{"title":"Salivary Biosensing Opportunities for Predicting Cognitive and Physical Human Performance.","authors":"Sara Anne Goring, Evan D Gray, Eric L Miller, Tad T Brunyé","doi":"10.3390/bios15070418","DOIUrl":"10.3390/bios15070418","url":null,"abstract":"Advancements in biosensing technologies have introduced opportunities for non-invasive, real-time monitoring of salivary biomarkers, enabling progress in fields ranging from personalized medicine to public health. Identifying and prioritizing the most critical analytes to measure in saliva is essential for estimating physiological status and forecasting performance in applied contexts. This study examined the value of 12 salivary analytes, including hormones, metabolites, and enzymes, for predicting cognitive and physical performance outcomes in military personnel (N = 115) engaged in stressful laboratory and field tasks. We calculated a series of features to quantify time-series analyte data and applied multiple regression techniques, including Elastic Net, Partial Least Squares, and Random Forest regression, to evaluate their predictive utility for five outcomes of interest: the ability to move, shoot, communicate, navigate, and sustain performance under stress. Predictive performance was poor across all models, with R-squared values near zero and limited evidence that salivary analytes provided stable or meaningful performance predictions. While certain features (e.g., post-peak slopes and variance metrics) appeared more frequently than others, no individual analyte emerged as a reliable predictor. These results suggest that salivary biomarkers alone are unlikely to provide robust insights into cognitive and physical performance outcomes. Future research may benefit from combining salivary and other biosensor data with contextual variables to improve predictive accuracy in real-world settings.","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 7","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photonics for Bioapplications: Sensors and Technology. 生物应用光子学：传感器与技术。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-07-01 DOI: 10.3390/bios15070416

Nélia Alberto, Maria Fátima Domingues, Nunzio Cennamo, Adriana Borriello

引用次数: 0

Biosensing Strategies to Monitor Contaminants and Additives on Fish, Meat, Poultry, and Related Products. 监测鱼、肉、禽及相关产品中污染物和添加剂的生物传感策略。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-06-30 DOI: 10.3390/bios15070415

Zenebe Tadesse Tsegay, Elahesadat Hosseini, Teresa D'Amore, Slim Smaoui, Theodoros Varzakas

引用次数: 0

Wearable Glove with Enhanced Sensitivity Based on Push-Pull Optical Fiber Sensor. 基于推拉式光纤传感器的高灵敏度可穿戴手套。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-06-27 DOI: 10.3390/bios15070414

Qi Xia, Xiaotong Zhang, Hongye Wang, Libo Yuan, Tingting Yuan

{"title":"Wearable Glove with Enhanced Sensitivity Based on Push-Pull Optical Fiber Sensor.","authors":"Qi Xia, Xiaotong Zhang, Hongye Wang, Libo Yuan, Tingting Yuan","doi":"10.3390/bios15070414","DOIUrl":"10.3390/bios15070414","url":null,"abstract":"Hand motion monitoring plays a vital role in medical rehabilitation, sports training, and human-computer interaction. High-sensitivity wearable biosensors are essential for accurate gesture recognition and precise motion analysis. In this work, we propose a high-sensitivity wearable glove based on a push-pull optical fiber sensor, designed to enhance the sensitivity and accuracy of hand motion biosensing. The sensor employs diagonal core reflectors fabricated at the tip of a four-core fiber, which interconnect symmetric fiber channels to form a push-pull sensing mechanism. This mechanism induces opposite wavelength shifts in fiber Bragg gratings positioned symmetrically under bending, effectively decoupling temperature and strain effects while significantly enhancing bending sensitivity. Experimental results demonstrate superior bending-sensing performance, establishing a solid foundation for high-precision gesture recognition. The integrated wearable glove offers a compact, flexible structure and straightforward fabrication process, with promising applications in precision medicine, intelligent human-machine interaction, virtual reality, and continuous health monitoring.","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 7","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Wearable Device for Continuous Blood Pressure Monitoring Utilizing Strain Gauge Technology. 一种基于应变计技术的新型可穿戴血压连续监测装置。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-06-27 DOI: 10.3390/bios15070413

Justin P McMurray, Aubrey DeVries, Kendall Frazee, Bailey Sizemore, Kimberly L Branan, Richard Jennings, Gerard L Coté

{"title":"A Novel Wearable Device for Continuous Blood Pressure Monitoring Utilizing Strain Gauge Technology.","authors":"Justin P McMurray, Aubrey DeVries, Kendall Frazee, Bailey Sizemore, Kimberly L Branan, Richard Jennings, Gerard L Coté","doi":"10.3390/bios15070413","DOIUrl":"10.3390/bios15070413","url":null,"abstract":"Cardiovascular disease (CVD) is the leading cause of global mortality, with hypertension affecting over one billion people. Current noninvasive blood pressure (BP) systems, like cuffs, suffer from discomfort and placement errors and lack continuous monitoring. Wearable solutions promise improvements, but technologies like photoplethysmography (PPG) and bioimpedance (BIOZ) face usability and clinical accuracy limitations. PPG is sensitive to skin tone and body mass index (BMI) variability, while BIOZ struggles with electrode contact and reusability. We present a novel, strain gauge-based wearable BP device that directly quantifies pressure via a dual transducer system, compensating for tissue deformation and external forces to enable continuous, accurate BP measurement. The reusable, energy-efficient, and compact design suits long-term daily use. A novel leg press protocol across 10 subjects (systolic: 71.04-241.42 mmHg, diastolic: 53.46-123.84 mmHg) validated its performance under dynamic conditions, achieving mean absolute errors of 2.45 ± 3.99 mmHg (systolic) and 1.59 ± 2.08 mmHg (diastolic). The device showed enhanced robustness compared to the Finapres, with less motion-induced noise. This technology significantly advances current methods by delivering continuous, real-time BP monitoring without reliance on electrodes, independent of skin tone, while maintaining a high accuracy and user comfort.","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 7","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanically Tunable Composite Hydrogel for Multi-Gesture Motion Monitoring. 用于多手势运动监测的机械可调复合水凝胶。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-06-27 DOI: 10.3390/bios15070412

Jiabing Zhang, Zilong He, Bin Shen, Jiang Li, Yongtao Tang, Shuhuai Pang, Xiaolin Tian, Shuang Wang, Fengyu Li

{"title":"Mechanically Tunable Composite Hydrogel for Multi-Gesture Motion Monitoring.","authors":"Jiabing Zhang, Zilong He, Bin Shen, Jiang Li, Yongtao Tang, Shuhuai Pang, Xiaolin Tian, Shuang Wang, Fengyu Li","doi":"10.3390/bios15070412","DOIUrl":"10.3390/bios15070412","url":null,"abstract":"Intrinsic conductive ionic hydrogels, endowed with excellent mechanical properties, hold significant promise for applications in wearable and implantable electronics. However, the complexity of exercise and athletics calls for mechanical tunability, facile processability and high conductivity of wearable sensors, which remains a persistent challenge. In this study, we developed a mechanically tunable and high ionic conductive hydrogel patch to approach multi-gesture or motion monitoring. Through adjustment of the ratio of amino trimethylene phosphonic acid (ATMP) and poly(vinyl alcohol) (PVA), the composite hydrogel attains tunable mechanical strength (varying from 50 kPa to 730 kPa), remarkable stretchability (reaching up to 1900% strain), high conductivity (measuring 15.43 S/m), and strong linear sensitivity (with a gauge factor of 2.34 within 100% strain). Benefitting with the tunable mechanical sensitivity, the composite hydrogel patch can perform subtle movement monitoring, such as epidermal pulses or pronounced muscle vibrations; meanwhile, it can also recognize and detect major motions, such as hand gestures. The mechanically tunable composite hydrogel contributes a versatile sensing platform for health or athletic monitoring, with wide and sensitive adoptability.","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 7","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn-Doped CeO₂ Nanozyme-Integrated Mesoporous Interfaces for High-Sensitivity Antifouling Electrochemiluminescence Biosensing. mn掺杂CeO2纳米酶集成介孔界面用于高灵敏度防污电化学发光生物传感。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-06-27 DOI: 10.3390/bios15070411

Guanze Huang, Haiyan Qiu, Huiping Chen, Wanxuan Li, Yufei Zhang, Minfang Huang, Tingting Zhang, Xiaoxin Xu, Shanwen Hu

{"title":"Mn-Doped CeO2 Nanozyme-Integrated Mesoporous Interfaces for High-Sensitivity Antifouling Electrochemiluminescence Biosensing.","authors":"Guanze Huang, Haiyan Qiu, Huiping Chen, Wanxuan Li, Yufei Zhang, Minfang Huang, Tingting Zhang, Xiaoxin Xu, Shanwen Hu","doi":"10.3390/bios15070411","DOIUrl":"10.3390/bios15070411","url":null,"abstract":"To address the challenges of nonspecific adsorption interference and low mass transfer efficiency encountered by electrochemiluminescence (ECL) sensors in complex biological matrices, this study developed a Mn@CeO2 nanozyme-based sensing interface. The Mn-doped CeO2 enhanced electron transfer efficiency, increased oxygen vacancy concentration, and stabilized the Mn-O-Ce structure, collectively enabling highly efficient peroxidase (POD)-like activity. The design significantly improved ECL reaction efficiency, which simultaneously conferred synergistic antifouling and mass transport enhancing properties. The mesoporous silica nanoparticle on the sensing interface accelerated mass transfer processes, thereby overcoming the limitations of traditional diffusion-controlled kinetics. The Mn@CeO2 nanozyme and mesoporous silica nanoparticle synergistically improved electron transfer and reactant enrichment, thereby significantly enhancing the signal response. Concurrently, a biomimetic anti-fouling coating was introduced at the interface to effectively suppress nonspecific adsorption of interferents. The constructed nanozyme-enhanced ECL sensing platform was demonstrated through the detection of dopamine (DA) as a model neurotransmitter, exhibiting favorable detection performance while maintaining high-accuracy detection in complex biological samples. This strategy offers a novel approach to developing highly sensitive and interference-resistant ECL sensors, with promising applications in disease biomarker monitoring and live physiological sample analysis.","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 7","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-Driven Wearable Bioelectronics in Digital Healthcare. 数字医疗中人工智能驱动的可穿戴生物电子设备。

IF 5.6 3区工程技术

Biosensors-Basel Pub Date : 2025-06-26 DOI: 10.3390/bios15070410

Guangqi Huang, Xiaofeng Chen, Caizhi Liao

{"title":"AI-Driven Wearable Bioelectronics in Digital Healthcare.","authors":"Guangqi Huang, Xiaofeng Chen, Caizhi Liao","doi":"10.3390/bios15070410","DOIUrl":"10.3390/bios15070410","url":null,"abstract":"The integration of artificial intelligence (AI) with wearable bioelectronics is revolutionizing digital healthcare by enabling proactive, personalized, and data-driven medical solutions. These advanced devices, equipped with multimodal sensors and AI-powered analytics, facilitate real-time monitoring of physiological and biochemical parameters-such as cardiac activity, glucose levels, and biomarkers-allowing for early disease detection, chronic condition management, and precision therapeutics. By shifting healthcare from reactive to preventive paradigms, AI-driven wearables address critical challenges, including rising chronic disease burdens, aging populations, and healthcare accessibility gaps. However, their widespread adoption faces technical, ethical, and regulatory hurdles, such as data interoperability, privacy concerns, algorithmic bias, and the need for robust clinical validation. This review comprehensively examines the current state of AI-enhanced wearable bioelectronics, covering (1) foundational technologies in sensor design, AI algorithms, and energy-efficient hardware; (2) applications in continuous health monitoring, diagnostics, and personalized interventions; (3) key challenges in scalability, security, and regulatory compliance; and (4) future directions involving 5G, the IoT, and global standardization efforts. We highlight how these technologies could democratize healthcare through remote patient monitoring and resource optimization while emphasizing the imperative of interdisciplinary collaboration to ensure equitable, secure, and clinically impactful deployment. By synthesizing advancements and critical gaps, this review aims to guide researchers, clinicians, and policymakers toward responsible innovation in the next generation of digital healthcare.","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 7","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0