Pan African Medical Journal最新文献

{"title":"[Precocious puberty in the McCune-Albright Syndrome: a case report].","authors":"Kaoutar Rifai, Kaoutar El Moatamid, Hinde Iraqi, Dounia Talbi, Mohamed El Hassan Gharbi","doi":"10.11604/pamj.2025.51.20.44747","DOIUrl":"10.11604/pamj.2025.51.20.44747","url":null,"abstract":"<p><p>McCune-Albright Syndrome is a rare condition with a clinical diagnosis, typically suspected when the classic triad is present: café-au-lait spots, fibrous dysplasia of bone and endocrinopathy. Therapeutic management depends on the endocrine involvement and the severity of bone disease. We here report an original case of a 2-year and 8-month-old girl presenting with precocious puberty revealing McCune-Albright syndrome. The diagnosis was suspected due to premature menarche and premature thelarche associated with café-au-lait spots. Biochemically, estradiol levels were elevated at 179 ng/ml with low FSH and LH levels. ALHRH test demonstrated a flat FSH LH profile with a peak LH/FSH ratio < 1, confirming the peripheral origin of precocious puberty. X-ray of the wrist showed a heterogeneous bone texture suggestive of fibrous dysplasia. To control vaginal bleeding and reduce hyperestrogenism, treatment with third-generation aromatase inhibitors \"Letrozole\" was prescribed with good clinical and biochemical outcome. This study highlights the importance of thorough clinical examination including skin and mucosal examination in any case of precocious puberty to ensure accurate etiological diagnosis and appropriate treatment.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"51 ","pages":"20"},"PeriodicalIF":1.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impacted subglottic fish vertebra in an infant: an unusual case report].","authors":"Aminata Diop Nakoulima, Khadidia Fall, Mame Rouba Ndiaye, Mame Diarra Mbacke, Mame Diarra Bousso Ndao, Cheikh Ahmédou Lame","doi":"10.11604/pamj.2025.51.19.47322","DOIUrl":"10.11604/pamj.2025.51.19.47322","url":null,"abstract":"<p><p>Inhalation of foreign bodies, a common occurrence in children, can be life-threatening. Different types of foreign bodies can be found, but laryngeal localization is rare. We here report the case of an 8-month-old male infant who presented with respiratory distress, dysphonia, and stridor. On admission, the child exhibited severe laryngeal dyspnea. Cervical CT scan revealed a radiopaque foreign body in the larynx. Endoscopic extraction revealed an impacted fish vertebra in the subglottis. Foreign bodies located in the laryngeal area of the lower airways are rare, and the discovery of a fish vertebra is exceptional.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"51 ","pages":"19"},"PeriodicalIF":1.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokines in HIV-1 patients on combination antiretroviral therapy with persistent low-level viremia at a tertiary hospital in Western Kenya.","authors":"Rose Undisa, Isaac Ndede, Lameck Oteko Diero","doi":"10.11604/pamj.2025.51.18.47628","DOIUrl":"10.11604/pamj.2025.51.18.47628","url":null,"abstract":"<p><strong>Introduction: </strong>persistent low-level viremia (pLLV) in HIV-1 participants on combination antiretroviral therapy (cART) is a significant predictor of immune activation and virologic rebound. Elevated cytokine levels are linked to pLLV, yet the roles of pro- and anti-inflammatory cytokines remain unclear in settings such as Kenya. This study assessed IL-17, IFN-γ, IL-10, and TGF-β in HIV-1 pLLV and virally suppressed participants at Moi Teaching and Referral Hospital (MTRH) to explore alternative biomarkers for virologic monitoring in resource-limited settings.</p><p><strong>Methods: </strong>cross-sectional study of 82 age- and gender-matched HIV-1 participants on first-line cART, -41 pLLV (50-500 copies/ml), and 41 virally suppressed (<50 copies/ml) was conducted using MTRH database data. Plasma cytokines (IL-17, IFN-γ, IL-10, TGF-β) were measured by ELISA (Zeptometrix, USA), and viral loads by RT-PCR (Abbott, USA). Data were analyzed using Mann-Whitney U, Chi-squared, and logistic regression tests.</p><p><strong>Results: </strong>the median (IQR) levels of IL-17, IFN-γ, IL-10, and TGF-β (pg/ml) were significantly higher in pLLV participants on first-line cART compared to virally suppressed participants: 23.8 (21.3-25.8) vs. 15.5 (12.7-18.2); 28.3 (23.5-31.2) vs. 11.4 (8.8-14.8); 45.2 (34.0-53.7) vs. 28.4 (22.6-31.6); and 56.9 (50.0-67.8) vs. 27.7 (19.5-34.7) p<.001. The odds (95% CI) of being suppressed were reduced by TGF-β 0.329 (0.035-0.361), IFN-γ, 0.360 (0.270-1.501, and IL-17 0.938 (0.691-1.273), but increased by IL-10 1.106 (0.675-1.811), though not statistically significant.</p><p><strong>Conclusion: </strong>persistent low-level viremia (pLLV) presents with elevated pro-inflammatory (IL-17, IFN-γ) and anti-inflammatory cytokines (IL-10, TGF-β) levels. Recommendation: exploring other cytokines in pLLV could enhance understanding of cytokine levels and viral suppression and may help refine HIV-1 treatment.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"51 ","pages":"18"},"PeriodicalIF":1.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern and correlates of coronary artery disease among patients referred for coronary angiography at Abuad Multisystem Hospital, Ado-Ekiti, Nigeria: a descriptive cross-sectional study.","authors":"Oladipo Ayoola Olanipekun, Stephen Olawale Oguntola, Adekunle Kayode Agoke, Adedayo Hakeem Oyebanji, Olamide Nelson Ogidan, Akinola Akinmade, Dhirendrakumar Jayantilal Dave, Anthony Olubunmi Akintomide, Michael Sanusi, Kamar Tayo Adeleke","doi":"10.11604/pamj.2025.50.55.45726","DOIUrl":"10.11604/pamj.2025.50.55.45726","url":null,"abstract":"<p><strong>Introduction: </strong>coronary artery disease (CAD) is a common cardiovascular disease (CVD) and a notable cause of mortality worldwide. Angiographic diagnosis of CAD is not widely available in sub-Saharan Africa. We assessed the pattern and correlates of CAD among patients referred for coronary angiography in Ado-Ekiti, Nigeria.</p><p><strong>Methods: </strong>patients with clinical suspicion of CAD who were referred for coronary angiography at Afe Babalola University Multi-System Hospital (AMSH) from August 2019 to December 2020 were recruited into the study after a written informed consent was obtained. Serum fasting lipids, electrolytes, urea and creatinine and erythrocyte sedimentation rate (ESR) were assessed. All patients had coronary angiography.</p><p><strong>Results: </strong>forty-six (46) patients were recruited into the study. The mean age among patients who had CAD was 52.12 years (±10.34). There were 15 (32.6%) females in the study population. CAD was confirmed in 18/46 (39.1%) patients. Triple vessel disease (TVD) was seen in 9/18 (50.0%) of patients who had CAD, hence, the most prevalent CAD disease pattern. ESR was significantly prolonged among patients who had CAD compared to patients who did not have CAD on univariate analysis while diabetes mellitus was an independent risk factor for CAD and conferred a greater than 7-fold risk for CAD (aOR: 7.28, 95% CI 1.15-46.16; p = 0.035).</p><p><strong>Conclusion: </strong>diabetes mellitus was an independent risk factor for CAD. Triple vessel disease was the most common pattern of CAD in our study. ESR was associated with CAD.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"50 ","pages":"55"},"PeriodicalIF":0.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco and alcohol use among adolescents and young adults in aspirational districts in India: NFHS-5 based secondary analysis.","authors":"Shiv Kumar Mudgal, Vipin Patidar, Suresh Kumar Sharma, Rakhi Gaur, Ramesh Kumar Huda, Jayvardhan Singh, Saurabh Varshney","doi":"10.11604/pamj.2025.51.17.46828","DOIUrl":"10.11604/pamj.2025.51.17.46828","url":null,"abstract":"<p><strong>Introduction: </strong>an early initiation of alcohol and tobacco use is associated with addiction and significant health complications. This study aimed to determine the prevalence and associated factors of tobacco and alcohol usage among adolescents (15-19 years) and young adults (20-24 years) in India's aspirational districts.</p><p><strong>Methods: </strong>data from India's biggest demographic and health survey, the National Family Health Survey-5 (NHFS-5), 2019-21, were reviewed. Alcohol and tobacco (in any form) usage were measured using the self-reported binary responses. Multivariate binary logistic regression was used to examine relationships with different demographic variables.</p><p><strong>Results: </strong>among the 47,343 individuals, tobacco usage was substantially higher in men than women (adolescents: 15.9% versus 1.2%; young adults: 31.8% versus 2.2%). The prevalence of alcohol usage was also higher among men (adolescents: 8.1% versus 0.4%; young adults: 21.8% versus 1.0%), with statistical significance (p < 0.0001) for all sex-related differences. Use of tobacco and alcohol was significantly associated with illiteracy, male gender, and young adults. A higher prevalence was observed among Christians in rural areas and lower socio-economic settings.</p><p><strong>Conclusion: </strong>the results highlight the necessity of targeted efforts by appropriate stakeholders and governmental agencies to lower alcohol and tobacco usage, particularly among vulnerable populations. More research is required to determine the root causes of these habits and the related health risk behaviours.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"51 ","pages":"17"},"PeriodicalIF":1.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management of bilateral and multiple semicircular canal dehiscence: a case report.","authors":"Taha Benatiya Andaloussi, Mohamed Bouqes, Naouar Ouattassi, Mohamed Afellah, Mohammed Ridal, Najib Benmansour, Zouheir Zaki, Abdellatif Oudidi, Mohamed Noureddine El Amine El Alami","doi":"10.11604/pamj.2025.51.12.47421","DOIUrl":"10.11604/pamj.2025.51.12.47421","url":null,"abstract":"<p><p>Semicircular canal dehiscence (SCCD) is a rare inner ear disease caused by an anatomical defect in the bony covering of the semicircular canal (SCC). This condition most commonly affects the superior semicircular canal, and less frequently involves multiple canals in one or both ears. Although the clinical and physiological features of a single SCCD are well known, there are only a few reported cases of multiple semicircular canal dehiscences. Thus, their clinical and physiological characteristics require further investigation. We present the case of a 59-year-old male patient of Moroccan ethnicity who presented with chronic imbalance and mild dizziness, induced by loud noises. As a dentist, he experienced extreme difficulty while drilling his patients' teeth, exhibiting nausea, tachycardia, and sweating. Clinical oto-vestibular and neurological examinations, tonal audiometry, and videonystagmography (VNG) revealed peripheral vestibular syndrome. Bilateral multiple SCCD was subsequently confirmed using high-resolution computed tomography imaging of the temporal bone. The clinical manifestations in this case were primarily neurovegetative symptoms of vestibular dysfunction. Functional assessments revealed vibratory-induced down-beating nystagmus and left preponderance on caloric testing. Computed tomography (CT) imaging confirmed dehiscence in the posterior and superior semicircular canals on the right side, and posterior semicircular canal dehiscence on the left side.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"51 ","pages":"12"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Severe congenital Factor VII deficiency discovered incidentally in the peripartum period: a case report].","authors":"Youssef Aarjouni, Oumayma Elbouni, Chikhi Brahim, Mohamed Benani, Houmed Housein, Laila Drouzi, Nezha Oudghiri, Sofia Lahbabi, Rajaa Tachinante","doi":"10.11604/pamj.2025.51.15.47005","DOIUrl":"10.11604/pamj.2025.51.15.47005","url":null,"abstract":"<p><p>Factor VII, also known as proconvertin, is a vitamin K-dependent coagulation protein involved in the extrinsic coagulation pathway. It is a congenital deficiency that is a rare autosomal recessive disorder that can manifest as bleeding episodes of varying severity. We here report the case of a 22-year-old primigravida patient in whom a coagulation disorder was incidentally discovered during the peripartum period, following an episode of epistaxis. Biological investigations revealed a significant decrease in prothrombin time and a markedly prolonged INR, leading to the diagnosis of severe factor VII deficiency. Given the high risk of hemorrhage, a specific obstetric management plan was implemented. Delivery was performed by cesarean section under general anesthesia, following preoperative preparation that included a transfusion of fresh frozen plasma and the administration of an antifibrinolytic agent. The procedure was uneventful, and the postoperative course was favorable, with no significant bleeding episodes. This study highlights the importance of early detection and appropriate management of factor VII deficiency in an obstetric context to minimize hemorrhagic risks for both mother and newborn.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"51 ","pages":"15"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences with facility delivery services within the context of a maternal neonatal health project in Gombe State, Northeast Nigeria: a qualitative study.","authors":"Maryam Al-Mujtaba, Olukolade Shobo, Bolanle Christy Oyebola, Benson Ohemu, Isaac Omale, Abdulrahman Shuaibu, Jennifer Anyanti","doi":"10.11604/pamj.2025.51.16.43132","DOIUrl":"10.11604/pamj.2025.51.16.43132","url":null,"abstract":"<p><strong>Introduction: </strong>a maternal neonatal health (MNH) project implemented in Gombe State improved uptake of facility delivery services from 27% to 65%. The project supplied health commodities to health facilities, provided women with cost-free transportation, and implemented the Village Health Worker program. Village health workers are lay indigenous women trained to provide community-based maternal and newborn care and to facilitate linkage to health facilities. We explored women's experiences with facility delivery services within the context of the MNH project.</p><p><strong>Methods: </strong>qualitative data were obtained through focus group discussions with women who delivered within the last 12 months. Participants were asked questions related to their experiences with the access and use of facility delivery services. Data were organized with NVivo 12 (Pro for Windows) and analyzed using directed content analysis.</p><p><strong>Results: </strong>six focus group discussions were conducted with 58 participants. Mean age was 25.1 (± 5.3) years old. All the women preferred facility delivery over home delivery for quality care. Most women reported experiencing immediate and respectful care with facility delivery services, and healthcare workers' competence and attitude were more important than the gender of the healthcare worker. However, for some women use of facility delivery services was limited due to the use of traditional birth attendants, absent husbands at the onset of labor, imminent delivery, long distance to the facility, expensive transportation fees, healthcare worker absenteeism and long clinic wait times.</p><p><strong>Conclusion: </strong>maternal neonatal health projects should be designed to ameliorate the effects of socio-economic and facility level factors that limit use of facility delivery services.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"51 ","pages":"16"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of endothelial dysfunction in rheumatoid arthritis in Black African subjects in the Physiology Department of the Faculty of Medicine of Dakar: a cross-sectional study.","authors":"Maïmouna Touré, Ibrahima Diouf, Fatou Bintou Sar, Coumba Diouf, Modou Oumy Kane, Abdoulaye Ba, Lamine Gueye, Abdoulaye Samb, Mamadou Sarr","doi":"10.11604/pamj.2025.50.75.40822","DOIUrl":"10.11604/pamj.2025.50.75.40822","url":null,"abstract":"<p><strong>Introduction: </strong>the vascular endothelium plays an essential role in many basic physiological vascular regulations. Endothelial dysfunction is the first stage of atherosclerosis. The latter would be the main basis of the cardiovascular events responsible for the high mortality of rheumatoid arthritis. The aim of this study was to screen for subclinical endothelial dysfunction in rheumatoid arthritis in a quick, easy and non-operator dependent way.</p><p><strong>Methods: </strong>this is a cross-sectional and prospective study conducted in the department of physiology and functional explorations from the Faculty of Medicine, of Pharmacy and of Odontostomatology (FMPOS) of the Cheikh Anta Diop University (UCAD) of Dakar in Senegal. Were excluded patients under 18 years and those with rheumatoid arthritis was associated with severe complications or other medical conditions or pregnancy. Therefore, we included subjects, aged 18 and over, with rheumatoid arthritis without clinically detectable cardiovascular complications. The reactive hyperemia index (RHI) was measured by an EndoPAT2000® (Itamar Medical Ltd-Israel) to explore endothelial function. Biochemical parameters were analyzed from fasting serum and plasma using an automated Abbott device. We used SPSS software to study endothelial dysfunction and the factors associated with it for simple and multiple linear regression calculations.</p><p><strong>Results: </strong>the mean age of the study population was 42.84 ± 12.80 years. The sex ratio (M/F) was 0.19. The reactive hyperemic index was significantly lower than the normal value in more than half of the patients with rheumatoid arthritis (11 subjects out of the 19 patients, i.e. 57.89%), indicating endothelial dysfunction in these patients. After Spearman correlation tests, a positive correlation was found between reactive hyperemic index and systolic blood pressure (rho=0.753 p=0.0002), mean blood pressure (rho= 0.660 p= 0.002), hs-CRP (rho= 0.486 p= 0.035) and uremia (rho= 0.476 p= 0.039). After a multiple linear regression test, a positive association was noted between the reactive hyperemia index and the systolic blood pressure (β 0.049, 95% CI [0.011 - 0.087]; p= 0.015).</p><p><strong>Conclusion: </strong>the endothelial dysfunction is a new concept in the management of rheumatoid arthritis. Screening and detection of this endothelial dysfunction in the subclinical state is possible thanks to new tools including EndoPATH2000. This could make it possible to predict the risk of cardiovascular events notably high blood pressure in general, and high systolic blood pressure in particular.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"50 ","pages":"75"},"PeriodicalIF":0.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stakeholders' perspectives on addressing climate change and respiratory health impacts in Nigeria.","authors":"Olayemi Oluseun Akinnola, Alexander Iseolorunkanmi, Faatihah Adeyinka Niyi-Odumosu, Temitope Eyitayo Akinnola, Boni Maxime Ale, Davies Adeloye, Obianuju Beatrice Ozoh","doi":"10.11604/pamj.2025.51.14.47414","DOIUrl":"10.11604/pamj.2025.51.14.47414","url":null,"abstract":"<p><p>The impacts of climate change on respiratory health are increasingly becoming a significant challenge in Nigerian cities, particularly in Lagos and Ogun States. Engaging stakeholders in discussions about climate change and health is crucial for addressing these challenges. The climate change and respiratory health (C2Rest) Nigeria Study team facilitated a stakeholder engagement to discuss climate change and health impacts in Nigeria, aiming to explore feasible solutions relevant to research, policy, and practice. A stakeholder meeting was conducted on April 23^rd, 2024, involving participants from Lagos and Ogun States. The framework for the activities was adapted from Gardner´s climate change engagement pathways, which examine key drivers (8 questions), barriers (7 questions), and adaptation pathways (3 questions). Data were collected through note-taking, written contributions, audio and video recording, and subsequently transcribed and analysed thematically. A total of 42 registered participants, comprising government officials, academicians, healthcare professionals, community and religious leaders, attended the stakeholder engagement meeting. Participants made group presentations and submitted a total of 380 written contributions. There were varying views on the drivers of climate change, but there was consensus that the most vulnerable populations include the poor, homeless, pregnant women, children, the elderly, and individuals with underlying health conditions. An important barrier identified was the sociocultural belief that climate change is an act of God or spirits. Financial constraints were a recurrent theme in discussions about mitigation and adaptation to climate change. This report provides valuable information on the most vulnerable population to the effects of climate change in Nigeria and identifies sociocultural beliefs and financial constraints as key barriers to the adoption of effective mitigation and adaptation behaviors.</p>","PeriodicalId":48190,"journal":{"name":"Pan African Medical Journal","volume":"51 ","pages":"14"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}