Lung India最新文献

{"title":"Follow-up study of COVID-19 sequelae (FOSCO study).","authors":"Mahismita Patro, Dipti Gothi, Shweta Anand, Dweepala P D K Priyadarshini, Umesh C Ojha, Ramesh S Pal, Nipun Malhotra, Rahul Kumar, Anshul Jain, Sunil Kumar, Pranzal Agarwal","doi":"10.4103/lungindia.lungindia_400_23","DOIUrl":"10.4103/lungindia.lungindia_400_23","url":null,"abstract":"<p><strong>Introduction: </strong>We undertook the first study from India to evaluate the long-term health effects of coronavirus disease 2019 (COVID-19).</p><p><strong>Methods: </strong>The patients enrolled in our post-COVID-19 clinic were followed up for assessment at 1, 3, 6 and 12 months after recovery from acute disease prospectively.</p><p><strong>Results: </strong>200 patients with mean age of 50.72 years and 57.5% males were analysed. 42.5% had severe and 17% had moderate disease at the time of diagnosis. The persistence of symptoms beyond 1 month of diagnosis was seen in 72.5% (145/200) patients. 8% (16/200) of the patients had post-COVID-19 complications that required rehospitalisation after discharge or recovery from acute COVID-19. The complications included respiratory failure (2%), lung cavities (3.5%), fungal infection, pericardial effusion, pneumothorax and death. The symptoms were persistent beyond 3 months in 51% (102/200) and beyond 6 months in 17.5% (35/200) of cases. The patients with persistent symptoms beyond 3 months and 6 months had significantly higher intensive care unit (ICU) admission during acute COVID-19, severe disease during acute COVID-19, and higher prevalence of comorbidities compared to the recovered patients. The clinical recovery was attained in 95.5% (91/200) patients, and the radiological recovery was attained in 97.92% patients at 1 year. The mean duration to clinical recovery was 174.2 days.</p><p><strong>Conclusions: </strong>COVID-19 recovery takes longer time. However, clinico-radiological recovery is attained in >95% cases by one year.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"103-109"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicentre, double-blind, placebo-controlled randomized trial of Mycobacterium w in critically ill patients with COVID-19 (ARMY-2).","authors":"Inderpaul S Sehgal, Ritesh Agarwal, Atul Jindal, Md Sabah Siddiqui, Anant Mohan, Arnab Pal, Randeep Guleria, Ashish Bhalla, Kamal Kajal, Pankaj Malhotra, Goverdhan Dutt Puri, Sagar Khadanga, Rajnish Joshi, Sarman Singh, Saurabh Saigal, Nitin M Nagarkar, Vikas Suri, Sushma Bhatnagar, Pawan Tiwari, Mini P Singh, Laxmi Narayana Yaddanapudi, Saurabh Mittal, Anshika Chauhan, Gaurab Banerjee, Deependra K Rai, Bikram K Gupta","doi":"10.4103/lungindia.lungindia_426_23","DOIUrl":"10.4103/lungindia.lungindia_426_23","url":null,"abstract":"<p><strong>Background: </strong>Mycobacterium w (Mw), an immunomodulator, resulted in better clinical status in severe coronavirus infectious disease 19 (COVID-19) but no survival benefit in a previous study. Herein, we investigate whether Mw could improve clinical outcomes and survival in COVID-19.</p><p><strong>Materials and methods: </strong>In a multicentric, randomized, double-blind, parallel-group, placebo-controlled trial, we randomized hospitalized subjects with severe COVID-19 to receive either 0.3 mL/day of Mw intradermally or a matching placebo for three consecutive days. The primary outcome was 28-day mortality. The co-primary outcome was the distribution of clinical status assessed on a seven-point ordinal scale ranging from discharged (category 1) to death (category 7) on study days 14, 21, and 28. The key secondary outcomes were the change in sequential organ failure assessment (SOFA) score on days 7 and 14 compared to the baseline, treatment-emergent adverse events, and others.</p><p><strong>Results: </strong>We included 273 subjects (136 Mw, 137 placebo). The use of Mw did not improve 28-day survival (Mw vs. placebo, 18 [13.2%] vs. 12 [8.8%], P = 0.259) or the clinical status on days 14 (odds ratio [OR], 1.33; 95% confidence intervals [CI], 0.79-2.3), 21 (OR, 1.49; 95% CI, 0.83-2.7) or 28 (OR, 1.49; 95% CI, 0.79-2.8) between the two study arms. There was no difference in the delta SOFA score or other secondary outcomes between the two groups. We observed higher injection site reactions with Mw.</p><p><strong>Conclusion: </strong>Mw did not reduce 28-day mortality or improve clinical status on days 14, 21 and 28 compared to placebo in patients with severe COVID-19. [Trial identifier: CTRI/2020/04/024846].</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"84-92"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An uncommon cause of dyspnea after trauma in an adult male.","authors":"Vikram Damaraju, Adimulam G Ravindra, Satvinder S Bakshi, R Sripriya, Vineet T Abraham","doi":"10.4103/lungindia.lungindia_476_23","DOIUrl":"10.4103/lungindia.lungindia_476_23","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"147-148"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza vaccination: A case for removal of B/Yamagata from the quadrivalent vaccine.","authors":"Parvaiz A Koul","doi":"10.4103/lungindia.lungindia_66_24","DOIUrl":"10.4103/lungindia.lungindia_66_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":" ","pages":"149-150"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chest X-ray: Routine follow-up in community-acquired pneumonia?","authors":"Vasileios Papavasileiou, Stelios Loukides, Ilektra Voulgareli","doi":"10.4103/lungindia.lungindia_490_23","DOIUrl":"10.4103/lungindia.lungindia_490_23","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"146-147"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific differences in presenting symptoms of obstructive sleep apnea.","authors":"Abhishek Goyal, Rishikesh Meena, Suruchi Gupta, Avishek Kar, Rashida Ali, Arwa Bohra, Vindhya Solanki, Poonam Chaudhary, Abhijit Pakhare","doi":"10.4103/lungindia.lungindia_235_22","DOIUrl":"10.4103/lungindia.lungindia_235_22","url":null,"abstract":"<p><strong>Objectives: </strong>Scant data from India are available on the gender differences in presenting features of Obstructive Sleep Apnea (OSA) in India. This study aims to compare male and female patients with OSA for general characteristics and presenting symptoms.</p><p><strong>Methodology: </strong>Retrospective study was done in OSA patients diagnosed in our sleep lab. History, biochemical reports, and polysomnography variables were retrieved from the sleep registry and were compared between males and females.</p><p><strong>Results: </strong>Out of 514 patients of OSA (367 males; 147 females). Females were older (55.97 ± 9.73 v/s 50.2 + 12.70 years, P<0.001) and more obese (BMI 35.26 ± 7.17 v/s 29.58 ± 5.49 Kg/m2; P<0.001). Waist and hip circumference were significantly higher in the female patients (P = 0.009 and <0.001 respectively). Morning headache, nocturia, fatigability (P < 0.001), and depression (P = 0.005) was more common in females (P = 0.036). Hypersomnia was more commonly seen in males (P < 0.001). Mean diastolic blood pressure was significantly higher in males, although no difference was seen in Systolic BP. Females had higher mean Fasting Blood glucose (FBS) (P = 0.02). Apnea hypopnea index was significantly higher in females {P = 0.01}.</p><p><strong>Conclusion: </strong>Women with OSA are more obese, elderly, and with higher fasting blood glucose than males at the time of diagnosis. Females have a higher prevalence of symptoms like fatigability, depression, nocturia and early morning headache and had more severe AHI than males.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"115-120"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the accuracy of pleural puncture sites in patients with pleural effusion as determined by clinical examination versus ultrasound-A single-centre prospective study.","authors":"Shahir Asfahan, Abhishek Tandon, Nishant K Chauhan, Ram N Jalandra, Mahendra K Garg, Gopal K Bohra, Pawan K Garg, Nitin K Bajpai, Pradeep Bajad, Avinash Babu, Naveen Dutt","doi":"10.4103/lungindia.lungindia_270_23","DOIUrl":"10.4103/lungindia.lungindia_270_23","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to ascertain the accuracy of clinical examination for the determination of pleural puncture sites as compared to the use of ultrasonography in patients with pleural effusion.</p><p><strong>Material and methods: </strong>A single-centre, prospective, observational study was carried out amongst 115 patients with pleural effusion in a tertiary care hospital in western India. Patients were subjected to clinical assessment for determination of pleural puncture sites and the same were confirmed with ultrasonography. All physicians were blinded to the marking of the previous physician to prevent any influence on their assessment.</p><p><strong>Results: </strong>The study had 345 physician observations. The overall accuracy of the clinical examination was 94.8%. Multivariate logistic regression of the factors responsible for the accuracy of clinical examination demonstrated a significant role of higher body mass index (BMI) (OR-1.19) and lower zone pleural effusions (OR-4.99) when adjusted for age, gender, side of effusion, and experience of examining doctors. When the effusions were classified according to their location, lower zone pleural effusions and loculated pleural effusions had an error rate of 15.9% and 8.33%, respectively.</p><p><strong>Conclusion: </strong>An ultrasound is the standard of care to assess all pleural effusions and guide the best point for aspiration.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"98-102"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NCCP-ICS joint consensus-based clinical practice guidelines on medical thoracoscopy.","authors":"Rakesh K Chawla, Mahendra Kumar, Arun Madan, Raja Dhar, Richa Gupta, Dipti Gothi, Unnati Desai, Manoj Goel, Rajesh Swarankar, Amita Nene, Radha Munje, Dhruv Chaudhary, Randeep Guleria, Vijay Hadda, Vivek Nangia, Girish Sindhwani, Rajesh Chawla, Naveen Dutt, Yuvarajan, Sonia Dalal, Shailendra Nath Gaur, Subodh Katiyar, Jai Kumar Samaria, K B Gupta, Parvaiz A Koul, Suryakant, D J Christopher, Dhrubajyoti Roy, Basant Hazarika, Shanti Kumar Luhadia, Anand Jaiswal, Karan Madan, Prem Parkash Gupta, B N B M Prashad, Nasser Yusuf, Prince James, Amit Dhamija, Veerotam Tomar, Ujjwal Parakh, Ajmal Khan, Rakesh Garg, Sheetu Singh, Vinod Joshi, Nikhil Sarangdhar, Sushmita Roy Chaudhary, Sandeep Nayar, Anand Patel, Mansi Gupta, Rama Kant Dixit, Sushil Jain, Pratibha Gogia, Manish Agarwal, Sandeep Katiyar, Aditya Chawla, Hari Kishan Gonuguntala, Ravi Dosi, Vijya Chinnamchetty, Apar Jindal, Shubham Sharma, Vaibhav Chachra, Utsav Samaria, Avinash Nair, Shruti Mohan, Gargi Maitra, Ashish Sinha, Rishabh Kochar, Ajit Yadav, Gaurav Choudhary, M Arunachalam, Amith Rangarajan, Ganesh Sanjan","doi":"10.4103/lungindia.lungindia_5_24","DOIUrl":"10.4103/lungindia.lungindia_5_24","url":null,"abstract":"<p><strong>Abstract: </strong>Medical Thoracoscopy (MT) is commonly performed by respiratory physicians for diagnostic as well as therapeutic purposes. The aim of the study was to provide evidence-based information regarding all aspects of MT, both as a diagnostic tool and therapeutic aid for pulmonologists across India. The consensus-based guidelines were formulated based on a multistep process using a set of 31 questions. A systematic search of published randomized controlled clinical trials, open labelled studies, case reports and guidelines from electronic databases, like PubMed, EmBase and Cochrane, was performed. The modified grade system was used (1, 2, 3 or usual practice point) to classify the quality of available evidence. Then, a multitude of factors were taken into account, such as volume of evidence, applicability and practicality for implementation to the target population and then strength of recommendation was finalized. MT helps to improve diagnosis and patient management, with reduced risk of post procedure complications. Trainees should perform at least 20 medical thoracoscopy procedures. The diagnostic yield of both rigid and semirigid techniques is comparable. Sterile-graded talc is the ideal agent for chemical pleurodesis. The consensus statement will help pulmonologists to adopt best evidence-based practices during MT for diagnostic and therapeutic purposes.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"151-167"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 61-year-old lady with acute-onset wheeze and hypoxemia.","authors":"Sandeep Kumar, Arun Sharma, Kuruswamy Thurai Prasad, Inderpaul S Sehgal, Sahajal Dhooria, Ritesh Agarwal, Valliappan Muthu","doi":"10.4103/lungindia.lungindia_556_23","DOIUrl":"10.4103/lungindia.lungindia_556_23","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"143-145"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle relaxants in ARDS - The final verdict with the updated evidence.","authors":"Vidushi Rathi, Pranav Ish, Nipun Malhotra","doi":"10.4103/lungindia.lungindia_605_23","DOIUrl":"10.4103/lungindia.lungindia_605_23","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"81-83"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}