Lung India最新文献

{"title":"Evaluating lung transplant referral and listing in chronic respiratory disease: A single-center experience from a tertiary care centre in India.","authors":"Gaurav Jain, Amita Athavale","doi":"10.4103/lungindia.lungindia_559_25","DOIUrl":"10.4103/lungindia.lungindia_559_25","url":null,"abstract":"<p><strong>Background: </strong>Patients with advanced chronic respiratory diseases experience severe functional limitation, limited therapeutic options, and high mortality risk. Lung transplantation (LTx) offers potential survival benefit in carefully selected candidates. However, Indian data describing the severity profile and eligibility of such patients are scarce. This study assessed the proportion and characteristics of patients meeting International Society for Heart and Lung Transplantation (ISHLT) referral and listing criteria, along with disease severity, contraindications, and risk factors.</p><p><strong>Methods: </strong>This retrospective observational study included adults admitted between January 2020 and October 2023 with interstitial lung disease, chronic obstructive pulmonary disease, bronchiectasis, or pulmonary vascular disease. Eligibility for LTx was evaluated using 2021 ISHLT consensus criteria. Lung Allocation Score was calculated as per OPTN/UNOS guidelines. ISHLT-defined risk factors, substantially increased risk, and absolute contraindications were recorded.</p><p><strong>Results: </strong>Among 401 patients, 105 (26.2%) met referral and 97 (24.2%) listing criteria. Most demonstrated advanced physiological limitation (mean FVC 44.1% predicted; median ECOG 3). ILD was the leading indication among listing-eligible patients (48.6%), followed by COPD (32.4%) and bronchiectasis (18.1%). LAS was highest in ILD (mean 47.8). ISHLT-defined risk factors were present in 90.5% of referral-eligible patients, with 25.7% showing substantially increased risk and 32.4% absolute contraindications. Findings may overestimate eligibility and severity given the inclusion of only hospitalized patients, limiting broader generalizability to ambulatory patients.</p><p><strong>Conclusion: </strong>A considerable proportion of hospitalized patients with advanced respiratory disease are LTx-eligible, though many have comorbidities or modifiable risks. Early referral and multidisciplinary optimization are essential to improve candidacy.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 3","pages":"283-290"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep medicine practices in India: Insights from a national survey.","authors":"Sasha Scadding, Saurabh Mittal, Amar Shah, Karan Madan, Anant Mohan, Swapna Mandal","doi":"10.4103/lungindia.lungindia_101_26","DOIUrl":"10.4103/lungindia.lungindia_101_26","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 3","pages":"345-346"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term outcome of veno-venous extracorporeal membrane oxygenation in patients of acute respiratory distress syndrome presenting at a tertiary care centre - An observational study.","authors":"Khuram Maqbool, Munish Chauhan, Sandeep Dewan","doi":"10.4103/lungindia.lungindia_451_25","DOIUrl":"10.4103/lungindia.lungindia_451_25","url":null,"abstract":"<p><strong>Background and objective: </strong>Acute respiratory distress syndrome (ARDS) is a severe and potentially fatal condition characterised by inflammation and damage to the lungs. Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) is a form of life support that can be used in the management of ARDS. This study was done to evaluate the short-term outcome of VV ECMO in patients of ARDS presenting at our institute.</p><p><strong>Materials: </strong>This ambispective observational study was carried out on patients with severe ARDS on VV ECMO admitted to the intensive care unit (ICU). Parameters studied included duration of pre-ECMO and total duration of mechanical ventilation, duration of ECMO, length of stay in ICU, length of hospital stay, and in-hospital mortality from the case records. The APACHE II, SOFA, and Murray scores were also recorded.</p><p><strong>Results: </strong>The mean age of the ARDS patients in our study was 48.70 ± 12.06 years. Out of 70 study patients, 41 were male and 29 were female. The most common underlying causes of ARDS requiring VV ECMO were pneumonia and sepsis. The primary indication for ECMO initiation in all patients was refractory hypoxemia despite optimal conventional ventilation. The rate of mortality was significantly higher in patients with pneumonia (44.7%) and sepsis (44.4%). The mean duration of mechanical ventilation and the mean duration of ECMO were 21.86 ± 13.19 days and 16.35 ± 10.11 days, respectively. The mean duration of ICU and hospital stay in our study was 23.26 ± 12.25 days and 27.33 ± 14.44 days, respectively. The proportion of survivors (58.6%) was higher than that of non-survivors (41.4%).</p><p><strong>Conclusion: </strong>VV ECMO can be used as a treatment option for patients with severe ARDS who are failing conventional mechanical ventilation.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 3","pages":"297-303"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doege-Potter syndrome in benign relapse of solitary fibrous tumour of the pleura: An exotic clinical setting.","authors":"Julián Rondón-Carvajal, Luis Ernesto Rodríguez-Month, Andrés García-Montoya, José Julián Venegas-Sánchez, Luis Antonio Rodríguez-Arrieta","doi":"10.4103/lungindia.lungindia_535_24","DOIUrl":"10.4103/lungindia.lungindia_535_24","url":null,"abstract":"<p><p>Solitary fibrous tumors are mesenchymal neoplasms that make up 2% of soft tissue tumors. Doege-Potter syndrome (DPS) occurs between 5-10% of patients with solitary fibrous tumor of the pleura (SFTP). Little is mentioned about DPS in the relapse setting, where malignant transformation should always be ruled out (until 12% of cases) according to tumor size, histopathologic aspects (including mitotic index) and immunohistochemical markers. This is the first case of Doege-Potter syndrome in the setting of a fibrous tumor relapse of the pleura without malignant transformation described in Colombia.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 3","pages":"333-336"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of bronchodilator response using forced oscillation technique in paediatric asthmatic patients from Central India: A cross-sectional study.","authors":"Sachin B Rathod, Smita R Sorte, Mrunal S Phatak, Abhishek D Madhura, Vinu A Vij","doi":"10.4103/lungindia.lungindia_337_25","DOIUrl":"10.4103/lungindia.lungindia_337_25","url":null,"abstract":"<p><strong>Introduction: </strong>Paediatric asthma diagnosis and monitoring often face challenges due to children's inability to perform effort-dependent tests like spirometry. The forced oscillation technique (FOT) offers a non-invasive, effort-independent alternative for assessing airway function. We set out to evaluate bronchodilator response (BDR) using FOT parameters in asthmatic children aged 2 to 12 years and to assess age- and gender-related differences in airway reversibility.</p><p><strong>Material and methods: </strong>This cross-sectional observational study was conducted at a tertiary care center in Central India. Forty-eight paediatric asthma patients (26 aged 2 to 6 years and 22 aged 7 to 12 years) were recruited. Respiratory impedance parameters (R5, R20, R5-20, X5, X20, Ax, and Fres) were measured before and after BDR. The percentage change post-bronchodilator was calculated using the mean or median based on distribution. Data analysis was performed using Python (with Pandas, NumPy, SciPy, and matplotlib) and Jamovi (v2.3.28).</p><p><strong>Results: </strong>R5-20% change demonstrated improvement, particularly in older males (mean: 81.83%, median: 93.74%). X5 and Ax also showed significant reductions. No statistically significant differences were observed between genders for R5, R20, R5-20%, X5%, and X20% change after BDR after adjusting covariate: age, weight, height, and BMI.</p><p><strong>Conclusions: </strong>In the absence of central Indian paediatric FOT values for BDR, we adopted an internal, data-driven approach to describe response values stratified by age and gender for central Indian asthmatic children. R5-20 and Ax are sensitive markers of airway reversibility and may serve as valuable tools for clinical decision-making in children.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 2","pages":"130-142"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of baseline serum angiotensin-converting enzyme (sACE) levels for steroid response in sarcoidosis.","authors":"Asmita A Mehta, V P Lakshmi Priya, G Gokulakrishnan, Liya Anil","doi":"10.4103/lungindia.lungindia_461_25","DOIUrl":"10.4103/lungindia.lungindia_461_25","url":null,"abstract":"<p><strong>Background and objective: </strong>Sarcoidosis is a systemic granulomatous disease that primarily affects the lungs. Corticosteroids are the first-line therapy, but steroid resistance remains a major clinical challenge. This study evaluates baseline serum angiotensin-converting enzyme (sACE) levels as a potential biomarker for predicting steroid resistance in sarcoidosis.</p><p><strong>Methods: </strong>In this prospective single-centre study, 188 patients with biopsy-confirmed sarcoidosis had baseline sACE levels measured before corticosteroid initiation using the Kasahara colorimetric technique. Associations between sACE levels and treatment response were analysed using logistic regression and ROC analysis (SPSS v21; significance at P < 0.05).</p><p><strong>Results: </strong>The mean age of the cohort was 54 years, with 62% women. Common symptoms included cough, dyspnoea, fatigue, and arthralgia; hypercalcemia was seen in 11%. Elevated baseline sACE > 64 U/L was found in 41% of cases. ROC analysis yielded an (AUC) of 0.788 (95% CI: 0.685-0.891), with 83% sensitivity and 73% specificity for predicting steroid resistance. On multi-variate analysis, elevated sACE (P < 0.001), age > 54 years (P < 0.001), fatigue (P = 0.002), hypercalcemia (P = 0.019), and mediastinal lymph node involvement on CECT (P = 0.036) were independent predictors of poor steroid response.</p><p><strong>Conclusion: </strong>Elevated baseline sACE levels show potential as an adjunctive biomarker for identifying patients at risk of steroid resistance in sarcoidosis. However, given its moderate specificity and absence of longitudinal validation, sACE should be interpreted cautiously and in conjunction with clinical and radiological parameters. Multi-centre studies with longer follow-up are warranted to confirm these findings.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 2","pages":"163-171"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling MicroRNA-21 as a non-invasive diagnostic biomarker in chronic obstructive pulmonary disease-associated pulmonary hypertension: Comparative insights with NT-proBNP.","authors":"Hoda A Eid, Rehab M Hamdy, Mona A Eldosoky, Sally S Abd Elhamed, Omaima I Abo-Elkheir, Shahinaz El Attar, Walaa Shipl, Esraa M Ali, Eman S Albeltagy, Mohamed A Heiba, Asmaa A Elmadbouly","doi":"10.4103/lungindia.lungindia_413_25","DOIUrl":"10.4103/lungindia.lungindia_413_25","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hypertension (PH) is a fatal complication of chronic obstructive pulmonary disease (COPD) that worsens its prognosis. However, the associated diagnostic markers are uncertain. We assess the diagnostic utility of microRNA-21 (miR-21) and NT-proBNP for PH diagnosis in COPD patients.</p><p><strong>Methods: </strong>We selected three groups of participants: Group 1 consisted of 25 patients with COPD who did not have PH (COPD); Group 2 included 35 patients with COPD and PH (COPD-PH); and Group 3 comprised 30 healthy controls. Demographic, spirometric, echocardiographic-Doppler study, and biochemical variables were recorded and compared among these three groups. Serum miR-21 was measured by quantitative real-time PCR.</p><p><strong>Results: </strong>Serum miR-21 level in COPD-PH patients was significantly higher compared with that in COPD patients and controls (P < 0.001). Compared with the COPD group, the COPD-PH group had greater miR-21 and brain natriuretic peptide (BNP) levels but significantly reduced forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), tricuspid annular plane systolic excursion (TAPSE), 6-minute walk test, and right ventricular (RV) functional parameters. Receiver Operating Characteristic curve analysis revealed that miRNA-21 had good diagnostic value for PH diagnosis in COPD patients, with an area under the curve (AUC) of 1.000, 100% sensitivity, and 100% specificity at a cutoff >7.94. While NT-proBNP demonstrated good accuracy, with an AUC of 0.936, sensitivity of 88.6%, and specificity of 88% at a cutoff >390.1 pg/mL.</p><p><strong>Conclusion: </strong>miR-21 may serve as a useful and reliable biomarker for diagnosing PH in COPD patients, outperforming the traditional biomarker NT-proBNP.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 2","pages":"178-184"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute respiratory distress syndrome after administration of lidocaine in bronchoscopy.","authors":"Stephany I Briones Alvarado, Javier García López, Luis Puente Maestu","doi":"10.4103/lungindia.lungindia_191_25","DOIUrl":"10.4103/lungindia.lungindia_191_25","url":null,"abstract":"<p><strong>Abstract: </strong>Lidocaine is the most commonly used local anaesthetic agent for bronchoscopy, and adverse reactions secondary to its use have rarely been reported. Among the possible adverse reactions, the most common is lidocaine toxicity. Secondary reactions to the use of nontoxic doses of lidocaine are infrequent, and acute respiratory distress syndrome following its administration is exceptional.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 2","pages":"197-200"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The vanishing lesion: A procedural clue to pneumothorax during endobronchial ultrasound.","authors":"Chun I Soo, Wai L Leong, Yeh H Poh, Hema Y Ramarmuty","doi":"10.4103/lungindia.lungindia_640_25","DOIUrl":"10.4103/lungindia.lungindia_640_25","url":null,"abstract":"<p><strong>Abstract: </strong>Endobronchial ultrasound (EBUS) has become an essential tool in lung cancer staging and the diagnosis of centrally located pulmonary lesions. Vigilance during EBUS-guided biopsy is crucial. The disappearance of a previously visualised lesion should raise suspicion of a developing pneumothorax. We present our experience with an intra-procedural pneumothorax following EBUS-guided biopsy and discuss the procedural considerations relevant to its prompt recognition and management.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 2","pages":"211-213"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FRED scoring system for interstitial lung disease: Predicting exacerbations requiring admissions need for long-term oxygen therapy and mortality.","authors":"C Padashetti Vaibhav, Gothi Dipti, Malhotra Nipun, C Ohja Umesh, S Arora Ruchi","doi":"10.4103/lungindia.lungindia_422_25","DOIUrl":"10.4103/lungindia.lungindia_422_25","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 2","pages":"224-227"},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}