IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_582_24

Amrita Bhattacharyya, Raja Dhar, Shyam Krishnan, Arup Halder, Beauty Biswas, Aditya Satpati, Ishita Chattopadhyay

{"title":"Aminophylline in acute exacerbation of COPD: Utility and treatment effects in hypercapnic respiratory failure (ACUTE): A pilot observational study.","authors":"Amrita Bhattacharyya, Raja Dhar, Shyam Krishnan, Arup Halder, Beauty Biswas, Aditya Satpati, Ishita Chattopadhyay","doi":"10.4103/lungindia.lungindia_582_24","DOIUrl":"10.4103/lungindia.lungindia_582_24","url":null,"abstract":"Background and objective: Aminophylline may play a role in managing both stable and exacerbating COPD, but its use is controversial due to its narrow therapeutic window. We aimed to evaluate the role of aminophylline in acute exacerbations of COPD under monitored conditions in patients who remained acidotic and hypercapnic after 48 hours of maximal treatment.Methods: We conducted a prospective, nonrandomized cohort study with 30 patients receiving aminophylline infusion in addition to standard care, matched to 20 historical controls. The primary outcome was the length of hospital stay, with secondary outcomes including improvements in oxygenation, PaCO2, and dyspnea severity.Results: There was no significant difference in hospital stay (11.23 vs. 12.65 days, P = 0.234) or ICU stay between the two groups. However, aminophylline significantly improved dyspnea severity (P = 0.0081), P/F ratio (P = 0.0014), and PaCO2 levels (P = 0.00001). Both groups showed improvements in oxygenation, but only the aminophylline group demonstrated a significant reduction in CO2 levels.Conclusion: Aminophylline did not affect the length of hospital or ICU stay but improved hypercapnia and dyspnea severity in patients with refractory COPD exacerbations. We believe it should be used in severe acidotic COPD exacerbations unresponsive to conventional therapies, with an aim to correct hypercapnia.","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 5","pages":"399-407"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144974106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent pulmonary embolism with haemoptysis, a challenging case. 复发性肺栓塞伴咯血，一个具有挑战性的病例。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_26_25

Nilay Tripathi, Jyoti Bajpai, Pravesh Vishwakarma, Sourabh Kumar, Akshyaya Pradhan

引用次数: 0

Altitude sickness: A neglected form of pulmonary edema. 高原反应：一种被忽视的肺水肿。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_356_25

Elcio Bakowski, Edson Marchiori

引用次数: 0

Mediastinal mass: Diagnostic dilemma on acute medical take. 纵隔肿块：急诊诊断困境。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_317_25

Amit Badshah, Abir Aijaz, Abdul Bhat, Shovan Rahman

引用次数: 0

Atypical lung emphysematous changes in systemic sclerosis. 系统性硬化症的非典型肺气肿改变。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_270_25

Augusto Kreling Medeiros, Eduardo Medeiros de Araújo, Felipe Marques da Costa, Ulysses S Torres, Edson Marchiori

引用次数: 0

Phenotyping of asthma population based on inflammatory blood biomarkers and characterisation of phenotypes depending on asthma control, frequency of exacerbations, and associated comorbidities. 基于炎症性血液生物标志物的哮喘人群表型，以及哮喘控制、发作频率和相关合并症的表型特征。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_594_24

Bony Francis, Deepak Phalgune, Sanjay Mehendale, Jai Mullerpattan

{"title":"Phenotyping of asthma population based on inflammatory blood biomarkers and characterisation of phenotypes depending on asthma control, frequency of exacerbations, and associated comorbidities.","authors":"Bony Francis, Deepak Phalgune, Sanjay Mehendale, Jai Mullerpattan","doi":"10.4103/lungindia.lungindia_594_24","DOIUrl":"10.4103/lungindia.lungindia_594_24","url":null,"abstract":"Background and objective: There are very few studies in the Indian population on the prevalence of phenotypes in asthma patients. To phenotype patients with bronchial asthma and characterise the phenotypes based on asthma control, exacerbation frequency, and associated comorbidities.Methods: The current cross-observational study was conducted between January 2022 and June 2022 in the department of pulmonary medicine in a tertiary care hospital. One hundred and seventeen patients aged 13 or above of both genders diagnosed with asthma as per Global Initiative for Asthma guidelines were enrolled. The blood eosinophil count and serum immunoglobulin E were measured. The Asthma Control Test (ACT) Questionnaire was used to calculate the ACT score. The patients were categorised into various asthma phenotypes such as atopic asthma, eosinophilic asthma, overlap phenotype, and biomarker-negative.Results: Phenotypes such as atopic, eosinophilic, overlap, and both negative were observed in 33.3%, 20.5%, 42.7%, and 3.4% patients, respectively. The mean BMI was significantly lower in both negative patients. There was no statistically significant association observed between allergic rhinitis, chronic rhinosinusitis, and eczema with various phenotypes, whereas nasal polyposis had a significant association with eosinophilic phenotype and overlap. The median asthma exacerbations per year were significantly higher in patients of bronchial asthma, atopic and overlap phenotypes. The percentage of patients who required baseline corticosteroid support was significantly less in both negative phenotypes.Conclusion: There is a substantial overlap of inflammatory blood biomarkers, suggesting that a more comprehensive approach is needed to identify the optimal therapy for individual patients.","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 5","pages":"408-413"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144974182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An RCT to compare high flow nasal cannula with standard nasal cannula to prevent desaturation in subjects undergoing EBUS-TBNA: HIFLO-EBUS trial. 一项比较高流量鼻插管与标准鼻插管预防EBUS-TBNA受试者去饱和的RCT: hifl - ebus试验。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_128_25

Inderpaul Singh Sehgal, Shivakshi Jaiswal, Nalini Gupta, Sahajal Dhooria, Kuruswamy Thurai Prasad, Amanjit Bal, Parikshaa Gupta, Ashutosh Nath Aggarwal, Valliappan Muthu, Ritesh Agarwal

{"title":"An RCT to compare high flow nasal cannula with standard nasal cannula to prevent desaturation in subjects undergoing EBUS-TBNA: HIFLO-EBUS trial.","authors":"Inderpaul Singh Sehgal, Shivakshi Jaiswal, Nalini Gupta, Sahajal Dhooria, Kuruswamy Thurai Prasad, Amanjit Bal, Parikshaa Gupta, Ashutosh Nath Aggarwal, Valliappan Muthu, Ritesh Agarwal","doi":"10.4103/lungindia.lungindia_128_25","DOIUrl":"10.4103/lungindia.lungindia_128_25","url":null,"abstract":"Background and objective: Oxygen desaturation events occur commonly during Endobronchial endobronchial ultrasound (EBUS) guided-transbronchial needle aspiration (TBNA) performed under conscious sedation. We hypothesized that high-flow nasal cannula (HFNC) would be superior to conventional nasal cannula (NC) in preventing these hypoxemic episodes.Methods: We randomized consecutive subjects ≥18 years undergoing EBUS-TBNA to receive oxygen with HFNC or NC. The primary objective was to compare the proportion of subjects experiencing oxygen desaturation events (defined as SPO2 < 90% for at least 30 sec) during the EBUS-TBNA procedure between the two study arms. The key secondary outcomes were the number of desaturation events during the procedure and patient comfort on a visual analogue scale (VAS [0 mm-100 mm]).Results: We randomized 300 subjects (150 in each arm). The mean ± SD age of the study population (129 [43%] females) was 46.5 ± 14 years. The proportion of subjects experiencing clinically significant hypoxemic episodes was significantly (P < 0.0001) higher in NC (42.7% [64/150]) than in the HFNC (20% [30/150]) arm. The median nadir SPO2 was significantly lower in the NC arm than in HFNC (91% vs. 93%, P < 0.0001). The use of HFNC during EBUS-TBNA resulted in fewer desaturation events (mean difference [95% confidence interval], 0.55 [0.22-0.88]) and better patient comfort (mean difference in VAS, 7.1 [4.3 mm-9.9 mm]). We found no difference in the complication rates.Conclusion: HFNC during EBUS reduced the number of subjects experiencing clinically significant hypoxemia, the number of desaturation events, and improved patient comfort compared to conventional oxygen therapy.","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 5","pages":"391-398"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144974138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-factorial analysis of smoking behaviour and cessation process. 吸烟行为与戒烟过程的多因素分析。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_546_24

Ahmet Gurbuzel, Nurgul Naurzvai, Can Ozturk

{"title":"Multi-factorial analysis of smoking behaviour and cessation process.","authors":"Ahmet Gurbuzel, Nurgul Naurzvai, Can Ozturk","doi":"10.4103/lungindia.lungindia_546_24","DOIUrl":"10.4103/lungindia.lungindia_546_24","url":null,"abstract":"Background and objectives: Tobacco use is a major global health concern, contributing to six of the eight most common causes of death worldwide. In Turkey, the average number of cigarettes smoked per day by individuals over 15 years old surpasses the global average. To mitigate this public health issue, it is crucial to develop strategic education models and state policies. Additionally, closely monitoring patients who seek smoking cessation services can improve outcomes by identifying specific smoking patterns and tailoring treatments accordingly. This study aimed to analyze the smoking behavior, characteristics, and cessation outcomes of patients aged 25-65 years who visited the smoking cessation outpatient clinic.Methods: This cross-sectional prospective study included 307 patients. We collected socio-demographic data, prior smoking cessation experiences, addiction levels, and conducted medical examinations to assess health status and medical history. This information was used to develop personalized treatment and follow-up plans.Results: The mean age of the patients was 42±11 years, with 74% being married and 55% being male. At the end of a three-month period, the smoking cessation rate was 49% for women and 33% for men. Notably, patients who started smoking at a median age of 19±5 years had higher cessation rates compared to those who started at 17±4 years. The most common reasons cited for starting smoking were environmental, social, and curiosity factors.Conclusion: Our findings suggest that a personalized approach to smoking cessation, which takes into account factors such as age, gender, and comorbidities, may be more effective in helping patients quit smoking. Future research should focus on long-term outcomes and the impact of specific interventions tailored to individual patient characteristics.","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 5","pages":"429-437"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144974200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue sample taken by transbronchial biopsy in the diagnosis of tuberculosis; benefits-risks. 经支气管活检组织标本在肺结核诊断中的价值benefits-risks。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_653_24

Bilal Rabahoğlu, Nuri Tutar, Burcu Baran, Nur A Yetkin, Fatma S Oymak, İnci Gülmez

{"title":"Tissue sample taken by transbronchial biopsy in the diagnosis of tuberculosis; benefits-risks.","authors":"Bilal Rabahoğlu, Nuri Tutar, Burcu Baran, Nur A Yetkin, Fatma S Oymak, İnci Gülmez","doi":"10.4103/lungindia.lungindia_653_24","DOIUrl":"10.4103/lungindia.lungindia_653_24","url":null,"abstract":"Objectives: Tuberculosis (TB) poses a serious health risk in Turkey and globally and is often difficult to diagnose. It may be sometimes necessary to obtain bronchoalveolar lavage (BAL) and, in some cases, biopsy samples via bronchoscopy to acquire an adequate sample. Our aim is to assess the contribution of transbronchial lung biopsy (TBLB) alongside BAL in diagnosing TB. In addition, we will evaluate the risk of pneumothorax associated with TBLB and determine the overall risk-benefit ratio.Methods: Flexible fiberoptic bronchoscopy (FFB) reports performed for suspected TB between March 2011 and July 2018 were retrospectively reviewed. Patients who had both BAL and tissue samples taken via TBLB were included in the study. Of the 606 patients included, age, sex, the lung area where the biopsy was taken, BAL and biopsy AFB and culture results, and complications such as pneumothorax and chest tube application were recorded.Results: A total of 606 patients were included in the study. Of these, 391 patients were male (64.5%) and 215 were female (35.5%). A total of 37 (6.1%) patients had a positive culture for TB. Nineteen (59.4%) patients were positive on both BAL and tissue culture, while 5 patients were only positive on tissue culture. Pneumothorax developed in 34 patients (5.6%), 28 of whom required a chest tube.Conclusion: Using various modalities such as BAL and TBLB together for diagnosing pulmonary TB can be advantageous when appropriate, particularly given the absence of significant complications during the procedure. Our findings indicate that incorporating TBLB alongside BAL impacted the diagnosis of pulmonary TB.","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 5","pages":"438-442"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144974237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High altitude: A forgotten cause of pulmonary oedema. 高海拔：肺水肿的一个被遗忘的原因。

IF 1.2

Lung India Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.4103/lungindia.lungindia_577_25

Jihyun Song, Ricardo Amaru, Josef T Prchal

引用次数: 0

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