Lung India最新文献

{"title":"Acquired unilateral bronchomegaly secondary to pulmonary carcinoid tumour.","authors":"Nipun Malhotra, Pawan Tiwari, Saurabh Mittal, Anant Mohan, Karan Madan","doi":"10.4103/lungindia.lungindia_778_25","DOIUrl":"10.4103/lungindia.lungindia_778_25","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"459-461"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of nebulised vs intravenous tranexamic acid in management of non-massive haemoptysis: A randomised controlled trial.","authors":"Khan Noman Zulfikar Ali, Komatineni H Ravikumar, Sarbari Swaika","doi":"10.4103/lungindia.lungindia_130_26","DOIUrl":"10.4103/lungindia.lungindia_130_26","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"478-479"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uniportal midline subxiphoid thymectomy: Our experience from a single oncology centre in India.","authors":"Naveen Kumar, Rohan Kapoor, Jyoutishman Saikia, Tejas Saha, Sachidanand Jee Bharati, Rakesh Garg, Prashant Sirohiya, Saurabh Vig, Deepali Jain, Sunil Kumar","doi":"10.4103/lungindia.lungindia_674_25","DOIUrl":"10.4103/lungindia.lungindia_674_25","url":null,"abstract":"<p><strong>Background: </strong>Thymoma is the most common anterior mediastinal neoplasm in adults and often requires surgical resection for curative treatment. Traditional approaches, including open surgery and multiportal thoracoscopic techniques, are associated with significant morbidity. The uniportal subxiphoid approach offers a minimally invasive, patient-friendly alternative, with potential benefits in operative efficiency and post-operative recovery. This technique may be particularly advantageous in low-resource settings, given its simplicity and reduced need for specialized equipment or personnel.</p><p><strong>Methods: </strong>This study included 27 patients who underwent uniportal subxiphoid thymectomy at our institution between January 2022 and December 2024. The technique involves pre-operative planning based on tumour staging, with resections possible for tumours up to 15 cm. The patient is placed supine, with no carbon dioxide insufflation or epidural anaesthesia used. An incision below the xiphoid process provides access for tumour dissection, utilizing a thoracoscope. The thymoma is carefully removed through the incision, followed by a mediastinal drain placement.</p><p><strong>Results: </strong>In 27 patients, tumour sizes ranged from 2 to 15 cm. The mean operative time was 106.9 min, with minimal blood loss (46.7 mL). All procedures were R0 resections, with no conversions to open surgery. Post-operative pain was minimal, and the mean hospital stay was 2.6 days.</p><p><strong>Conclusions: </strong>The uniportal subxiphoid thymectomy is an effective, minimally invasive technique, offering excellent outcomes in terms of operative time, blood loss, and recovery. It provides a safe, efficient, and cost-effective alternative, especially for low-resource settings.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"371-378"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pragmatic workflow for advanced NSCLC diagnosis in routine practice: Integrating histopathology, PD-L1 scoring, and EGFR testing.","authors":"Ashmeet Kaur, Ranjana Solanki, Ravindra Singh Gothwal, Arpita Jindal","doi":"10.4103/lungindia.lungindia_835_25","DOIUrl":"10.4103/lungindia.lungindia_835_25","url":null,"abstract":"<p><strong>Background: </strong>Precision treatment of advanced non-small cell lung carcinoma (NSCLC) requires early biomarker availability, yet routine practice is constrained by small biopsies, sequential testing, and limited resources. We assessed whether PD-L1 and EGFR testing were completed from the initial biopsy using a tissue-efficient reflex workflow integrating histologic subtyping, PD-L1 scoring, EGFR analysis, and tumour-infiltrating lymphocyte (TIL) assessment.</p><p><strong>Methods: </strong>In this prospective single-arm feasibility study, 50 stage III or IV NSCLC cases were evaluated. Tumours were subtyped using morphology and minimal immunohistochemistry (TTF-1, Napsin A, p40). PD-L1 immunohistochemistry was performed using a locally validated CAL10-based laboratory-developed test and scored by tumour proportion score (TPS) and combined positive score (CPS). Reflex EGFR testing was attempted in adenocarcinomas with adequate tissue. TILs were graded morphologically. Tissue adequacy and biomarker associations were analysed.</p><p><strong>Results: </strong>Squamous cell carcinoma comprised 56% and adenocarcinoma 44% of cases. Adequate tissue to complete PD-L1 and EGFR testing was available in 59% (13/22) of adenocarcinomas, and was reported within 30 days. EGFR mutations were detected in 31% of tested adenocarcinomas and were associated with TPS <50% and absent TILs. High PD-L1 expression (TPS ≥50%) was observed in 14% of tumours, exclusively in EGFR wild-type cases. TILs were present in 12% of cases and were significantly associated with higher CPS ( P = 0.002), exceeding TPS.</p><p><strong>Conclusion: </strong>A biopsy-level reflex workflow enables feasible, tissue-efficient concurrent molecular and immune profiling in advanced NSCLC. Integration of TPS, CPS, TIL assessment, and EGFR testing within a reflex workflow demonstrates the feasibility of coordinated immuno-molecular profiling from limited biopsy tissue in advanced NSCLC.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"404-411"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VICTOR-CPA: Oral itraconazole versus oral voriconazole for treatment-naive patients with chronic pulmonary aspergillosis in India.","authors":"Asmita A Mehta","doi":"10.4103/lungindia.lungindia_800_25","DOIUrl":"10.4103/lungindia.lungindia_800_25","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"357-359"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masked invaders: A case series on uncommon manifestations of extrapulmonary tuberculosis.","authors":"Robin Choudhary, Neeraj Sharma, Debaseesh Sr Das, Kavita Sinha, Shipra Verma","doi":"10.4103/lungindia.lungindia_543_25","DOIUrl":"10.4103/lungindia.lungindia_543_25","url":null,"abstract":"<p><strong>Abstract: </strong>Extrapulmonary tuberculosis (EPTB) is a challenging clinical entity due to its diverse and often atypical presentations. This case series discusses five rare manifestations of EPTB: tubercular arthritis of the wrist, sternoclavicular joint tuberculosis, mandibular osteomyelitis, epididymo-orchitis with scrotal abscess, and tuberculosis-associated Tolosa-Hunt syndrome. All patients were immunocompetent and did not exhibit typical systemic symptoms. Diagnosis was established through a combination of imaging, histopathology, and molecular testing (CBNAAT/GeneXpert). The cases were successfully managed with anti-tubercular therapy (ATT), resulting in favourable outcomes. This report emphasises the necessity for high clinical suspicion, especially in endemic areas, and highlights EPTB's ability to mimic more common inflammatory or neoplastic conditions.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"449-454"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of bronchodilator response using forced oscillation technique in paediatric asthmatic patients from Central India: A cross-sectional study.","authors":"Sandhya Saini, Kanika Kanika","doi":"10.4103/lungindia.lungindia_165_26","DOIUrl":"10.4103/lungindia.lungindia_165_26","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"473-474"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare convergence: Pleural amyloidosis in H syndrome - A diagnostic surprise in a young Indian male.","authors":"Irfan Shekh, Aditi Singh, Shubhi Singhal, Ashish Kumar Prakash, Dheeraj Gautam, Randeep Guleria","doi":"10.4103/lungindia.lungindia_727_25","DOIUrl":"10.4103/lungindia.lungindia_727_25","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"471-473"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral diaphragmatic palsy following Nivolumab-Ipilimumab therapy: A rare respiratory complication of immune checkpoint inhibitors.","authors":"Vikas Marwah, Narayanan Subramanian, Sharanpreet Kaur Aulakh, Suresh Pandalanghat, Prafull Sharma","doi":"10.4103/lungindia.lungindia_38_26","DOIUrl":"10.4103/lungindia.lungindia_38_26","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"467-469"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the lung reaches the eye: Ocular metastasis from large-cell neuroendocrine carcinoma.","authors":"Ana Luis Correia, Tito A Abrantes, Joana M Correia, Mariana S Conceição","doi":"10.4103/lungindia.lungindia_199_26","DOIUrl":"10.4103/lungindia.lungindia_199_26","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"43 4","pages":"474-476"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}