Lung India最新文献

{"title":"A critical appraisal of the clinico-radiological, histopathological and immunohistochemical profile of CT-guided and bronchoscopy-guided biopsies in lung lesions.","authors":"Mukta Pujani, Ruchi Arora Sachdeva, S Zafar Abbas, Charu Agarwal, Minakshi Bhardwaj, Varsha Chauhan, Jyoti Rajpoot, Dipti Sidam, Aniruna Dey","doi":"10.4103/lungindia.lungindia_496_24","DOIUrl":"10.4103/lungindia.lungindia_496_24","url":null,"abstract":"<p><strong>Background: </strong>Lung biopsies are obtained by bronchoscopy or by percutaneous route under image guidance and usually have limited tissue material. It is quite challenging for a pathologist to make an accurate diagnosis of lung cancer using only a limited panel of immunohistochemical markers and mucin stains as well as spare as much tissue for molecular testing.Molecular testing for specific genetic mutations or biomarkers serves as an adjunct for more rational, targeted treatment regimens.</p><p><strong>Methods: </strong>All the consecutive image-guided lung biopsies (both computed tomography [CT] guided and bronchoscopy-guided) for a period of 3 years (2021-2024) were included in the study. The clinicopathological data was compiled from the hospital records, and histopathology and immunohistochemistry (IHC) were analysed critically for all lung carcinomas. Sensitivity, specificity, negative predictive value, positive predictive value and diagnostic accuracy were calculated for IHC markers.</p><p><strong>Results: </strong>There were 127 lung biopsies (117 bronchoscopic and 10 CT-guided biopsies) comprise of adenocarcinoma (30%), squamous cell carcinoma (25.2%), small-cell carcinoma (13.4%) and poorly differentiated carcinoma (6.3%). The concordance between clinico-radiological and pathological diagnosis was 85%. P40 (22/22 cases) and CK5/6 (10/10) were the most sensitive and specific markers for squamous cell carcinoma, while TTF-1 (35/36) and Napsin A (18/22) were the most sensitive IHC markers for adenocarcinoma. The most sensitive markers for small-cell carcinoma lung were synaptophysin (17/17), CD 56, NSE followed by chromogranin A (11/15).</p><p><strong>Conclusion: </strong>Integrating conventional histopathology with IHC results in accurate diagnosis, thereby avoiding a broad diagnosis of non-small-cell lung carcinoma (NSCLC). Subclassification of NSCLC has significant treatment implications, especially for advanced-stage tumours for which chemotherapy or targeted therapy is being considered. The focus should be on the judicious use of IHC based on histological type because of the limited availability of tissues in bronchoscopic and CT-guided biopsy specimens.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 3","pages":"218-224"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric mediastinal tuberculosis: Exploring the diagnostic precision of endobronchial ultrasound and ancillary investigations.","authors":"Manoj Madhusudan, Priyanka Potti, Kaustubh Mohite, Tejaswi Chandra, J T Srikanta","doi":"10.4103/lungindia.lungindia_288_24","DOIUrl":"10.4103/lungindia.lungindia_288_24","url":null,"abstract":"<p><strong>Background: </strong>Mediastinal Tuberculosis (TB), although a common presentation of TB in children, has a very low rate of microbiological confirmation. This is because of the difficulty in acquiring appropriate tissue samples for microbiological confirmation. Endobronchial ultrasound (EBUS) and esophageal ultrasound with a bronchoscope (EUS-B) offer a safe, effective, and minimally invasive modality of sampling in these children. We present our institutional experience on EBUS/EUSB and the various ancillary investigations for mediastinal TB.</p><p><strong>Methods: </strong>This is a single-center retrospective study among children who underwent EBUS/EUS-B for a mediastinal nodal lesion. The primary objective of the study was to analyze the diagnostic accuracy of histopathology and various microbiological investigations, through EBUS/EUS-B guided TBNA, in the diagnosis of mediastinal TB. The secondary objective was to ascertain the safety of EBUS/EUS-B.</p><p><strong>Results: </strong>A total of 50 children underwent EBUS/EUS-B at our center, of those 26 (17 girls, mean age 11.7 years) were diagnosed with mediastinal TB. Fever was the most common presenting symptom (85%) and only seven children (26%) had a concomitant pulmonary involvement. The diagnostic performance of various investigations was as follows: Acid-fast bacilli (AFB) smear (sensitivity - 86.6%, specificity - 82.9%, NPV-93.5%, PPV - 68.4%), Xpert Ultra (sensitivity -100%, specificity - 68.5%, NPV - 100%, PPV - 57.7%), and cytology (sensitivity - 100%, specificity - 82.9%, NPV - 100%, PPV - 71.4%). A microbiological confirmation was attained in 81% of the children. There were no major complications in any of the procedures.</p><p><strong>Conclusion: </strong>EBUS/EUSB is an effective and safe investigation for the diagnosis of mediastinal TB in children.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 3","pages":"199-203"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histoplasmosis presenting as fibrosing mediastinitis and superior vena cava obstruction.","authors":"Sagar Poudel, Sanjeev Kumar, Saurabh Mittal, Preyas Sethi, Karan Madan","doi":"10.4103/lungindia.lungindia_485_24","DOIUrl":"10.4103/lungindia.lungindia_485_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 3","pages":"264-265"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleural fluid refractometry.","authors":"René A Flores-Franco, David R Flores-Aguilar","doi":"10.4103/lungindia.lungindia_30_25","DOIUrl":"10.4103/lungindia.lungindia_30_25","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 3","pages":"268-269"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An uncommon cause of acute hypercapnic respiratory failure managed with endoscopic ultrasound.","authors":"Vishal Raj, Aman Ahuja, Monika Gupta, Dhruva Chaudhry, Pawan Kumar Singh","doi":"10.4103/lungindia.lungindia_423_24","DOIUrl":"10.4103/lungindia.lungindia_423_24","url":null,"abstract":"<p><strong>Abstract: </strong>Mediastinal cysts can occasionally cause severe respiratory symptoms. A 60-year-old female smoker presented with acute hypercapnic respiratory failure. Imaging revealed a posterior mediastinal cyst compressing the trachea. Bronchoscopic ultrasound-guided fine needle aspiration (EUS-B FNA) provided both diagnostic clarity and symptomatic relief. This case underscores the importance of considering mediastinal cysts in differential diagnoses of acute respiratory distress and demonstrates the efficacy of EUS-B FNA for both diagnosis and immediate therapeutic intervention.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"151-154"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series of Y shaped self-expanding metallic stents (Y-SEMS) for central airway obstruction - Experience of deployment with 'Single Guide Wire' technique.","authors":"Rajiv Goyal, Manish Kumar Aggarwal, Chetan Nemani, Kedar Hibare, Jeenam Shah, Dhammdeep Kadam, Sagar Raiya, Abhijit Ahuja, Ajay Ravi, Anurag Deshpande, Ramasubramaniam Kottasiamy, Akhilesh Jain, Eshita Shah, Amit Jain, Sankar N Raman, Pankul Mangla, Arushi Chokhani, Avinash Murugan","doi":"10.4103/lungindia.lungindia_482_24","DOIUrl":"10.4103/lungindia.lungindia_482_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"166-170"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of long-term inhaled corticosteroids therapy on cognitive function in patients with bronchial asthma and chronic obstructive pulmonary disease.","authors":"Swapnil N Deshmukh, Navothna Somireddy, Manosri Mandadi","doi":"10.4103/lungindia.lungindia_483_24","DOIUrl":"10.4103/lungindia.lungindia_483_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"175-176"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2024 International Society for Human and Animal Mycology (ISHAM)-ABPA working group guidelines: Transforming diagnosis and management of ABPA.","authors":"Ritesh Agarwal, Inderpaul S Sehgal, Valliappan Muthu","doi":"10.4103/lungindia.lungindia_28_25","DOIUrl":"10.4103/lungindia.lungindia_28_25","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"79-83"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrarater and interrater reliability of respiratory muscle strength measuring aneroid manometer.","authors":"Tvisha K Patel, Arvind Kumar, Zarana K Khamar, Neelam K Rathod, Kartik G Patel","doi":"10.4103/lungindia.lungindia_345_24","DOIUrl":"10.4103/lungindia.lungindia_345_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"171-172"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bronchial anthracofibrosis beyond bronchial involvement causing pulmonary artery stenosis.","authors":"Luis Gorospe, Paola Arrieta, Ignacio Barbolla-Díaz, Rosa M Mirambeaux-Villalona, Adela Montelongo-Martín","doi":"10.4103/lungindia.lungindia_99_24","DOIUrl":"10.4103/lungindia.lungindia_99_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"161-162"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}