Lung India最新文献

{"title":"Chest radiology quiz in an unusual case of chronic cough.","authors":"Giacomo Ghinassi, Simone Ielo, Magda Viani, Raffaele Scala","doi":"10.4103/lungindia.lungindia_280_24","DOIUrl":"10.4103/lungindia.lungindia_280_24","url":null,"abstract":"<p><strong>Abstract: </strong>Welcome to this radiology challenge. Follow the clues to diagnose a young woman presenting with an unusual and persistent cough. Let us dive into the clinical case and see if you can figure out the cause.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"159-160"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small airway disease (SAD) in asthma in pregnancy evaluated by impulse oscillometry: A cross-sectional study.","authors":"Mita Mandal, Indranil Halder, Subhankar Sarkar, Arman Haque, Manidip Pal","doi":"10.4103/lungindia.lungindia_413_24","DOIUrl":"10.4103/lungindia.lungindia_413_24","url":null,"abstract":"<p><strong>Background and objective: </strong>Asthma is a common respiratory disease in pregnancy, with approximately 18% of cases worsening. Small airway disease (SAD) with a reported prevalence of up to 70% is now recognised as a principal indicator of poor asthma control. Impulse oscillometry (IOS) is a non-invasive, technically easier, and patient-friendly tool for detecting SAD. We aimed to assess the prevalence of SAD in pregnant women with asthma and the acceptance of the IOS across different trimesters of pregnancy.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among pregnant women aged ≥18 years with clinically diagnosed asthma. All patients underwent IOS following manufacturer and European Respiratory Society guidelines. A questionnaire was used to assess their satisfaction with the technique.</p><p><strong>Results: </strong>Out of 78 patients who underwent IOS, SAD was present in 55.1% (95% CI = 43.4 to 66.4%). Post-bronchodilator reversibility was observed in 37.2% of patients. Abnormal total (R5) and larger (R20) airway resistance were found in 79.5% and 64.1% of patients, respectively. Other IOS parameters (Fres, AX, and X5) were abnormal in 58.9%, 30.7%, and 39.7% of patients, respectively. Bivariate and multivariate logistic regression analyses indicated longer duration of asthma (OR = 1.1; 95% CI = 1.05-1.18; P < 0.001) and passive smoking (OR = 4.2; 95% CI = 1.58-11.1; P = 0.004) were significantly associated with SAD. All participants tolerated the IOS well, with a satisfaction score of 4.75 ± 0.72.</p><p><strong>Conclusion: </strong>The IOS is a helpful tool for the evaluation of SAD, a significant comorbidity in pregnant women with asthma. Factors such as longer disease duration and exposure to passive smoking, akin to risk factors for chronic airflow obstruction, are significantly associated with SAD. Future research should explore SAD's impact on clinical management and overall asthma outcomes.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"87-90"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low occurrence of pulmonary lophomoniasis among cigarette smokers: An analysis of risk factors based on registry data.","authors":"Mahdi Fakhar, Zahra Hosseininejad, Ali Sharifpour, Fatemeh Z Hosseini, Zakaria Zakariaei","doi":"10.4103/lungindia.lungindia_518_24","DOIUrl":"10.4103/lungindia.lungindia_518_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Lophomonas blattarum is an emerging protozoan agent that mainly causes pulmonary lophomoniasis. Given that cigarette smokers are predisposed to various diseases while some conditions are less common among them, the current study aimed to compare the relationship between smoking status and the prevalence of pulmonary lophomoniasis in patients registered at the Iranian National Registry Center for Lophomoniasis (INRCL). Additionally, we examined common risk factors associated with Lophomonas infection among these registered subjects.</p><p><strong>Materials and methods: </strong>This descriptive-analytical cross-sectional registry-based study was conducted on 600 registered subjects through microscopic examination (wet mount smears) and conventional polymerase chain reaction assay between 2021 and 2023. We analysed the smoking status and smoking intensity of 135 Lophomonas-positive patients and 465 Lophomonas-negative patients who were referred to the INRCL. Baseline data were collected from participants using a questionnaire.</p><p><strong>Results: </strong>Our results showed the prevalence of Lophomonas infection among enrolled subjects was estimated to be 22.5% (135/600). Also, we studied 135 Lophomonas positive patients (male = 92, female = 43). Furthermore, most patients testing positive for Lophomonas (74.8%; 101/135) also had at least one comorbidity condition. Our findings showed a statistically significant occurrence of Lophomonas infection among non-smokers (70.4%; n = 95), in contrast to smokers (29.6%; n = 40) (P = 0.001). Correspondingly, among the 40 Lophomonas-positive smokers, the majority (62.5%) were classified as light smokers. Moreover, based on the multiple logistic regressions, Lophomonas infection was 2.123, 3.142, and 2.353 times higher in men compared to women, patients aged 51-70 years compared to other age groups, and non-smokers compared to cigarette smokers, respectively (P = 0.001).</p><p><strong>Conclusion: </strong>Our findings reveal that Lophomonas infection is significantly lower among cigarette smokers compared to nonsmokers. Our data shed light on a new hypothesis about lophomoniasis among smokers. Further research is needed to assess the role of smoking in the pathophysiology of lophomoniasis.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"109-114"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective initiative to beat tuberculosis from India: Revised Nikshay Mitra support policy.","authors":"Sameena Khan, Sahjid Mukhida, Rajashri Patil, Nikunja K Das","doi":"10.4103/lungindia.lungindia_522_24","DOIUrl":"10.4103/lungindia.lungindia_522_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"173-174"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary artery sling with total anomalous pulmonary venous return: Hitherto unreported association.","authors":"Saurabh Deshpande, Pratyaksha Rana, Megha M Sheth, Hit Jivani, Timiri Madhukaran Harishkar, Dinesh Patel","doi":"10.4103/lungindia.lungindia_465_24","DOIUrl":"10.4103/lungindia.lungindia_465_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"172-173"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life after lung lobectomy: The road to recovery and well-being - A descriptive study.","authors":"Nandita Ghosh, Neena V Singh, Sukhpal Kaur, Harkant Singh","doi":"10.4103/lungindia.lungindia_349_24","DOIUrl":"10.4103/lungindia.lungindia_349_24","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary lobectomy significantly impacts the quality of life (QOL) in lung cancer patients. This study investigates QOL in lung lobectomy patients, identifying challenges and influencing factors to inform strategies for improving care and outcomes and enhancing recovery and long-term well-being.</p><p><strong>Objective: </strong>To assess the quality of life of patients who underwent lung lobectomy.</p><p><strong>Methods: </strong>Using a descriptive study design, 50 patients who had undergone lung lobectomy at least 3 months before and were attending CTVS OPD at a tertiary hospital were enrolled consecutively. Apart from collecting the clinical and socio-demographic profiles of patients, the EORTC-QLQ-C30 scale was used to assess QOL of patients.</p><p><strong>Results: </strong>The mean (standard deviation [SD]) age of the patients was 45.34 (15.19) years. Male patients outnumbered females (62%). The most common diagnosis was non-small cell lung cancer (28%). Around 18% of patients had a history of treatment for pulmonary tuberculosis. The majority (76%) of patients had a higher QOL, with a mean (SD) score of 64.50 (19.27). Age and socioeconomic status were linked to fatigue and pain, respectively. Alcohol consumption history was associated with fatigue (P = 0.02), while smoking history was linked to pain (P = 0.04) and dyspnoea (P = 0.02), revealing significant correlations between lifestyle factors and postoperative symptoms. In addition, patients in the postoperative period of 3-6 months tended to have poorer QOL.</p><p><strong>Conclusion: </strong>There is a need to plan comprehensive support, considering the age, health habits and socioeconomic status of patients to optimise recovery and QOL. Proper care and education can help patients adapt and make positive outcomes in post-surgery rehabilitation.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"120-127"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and genetic profiles of paediatric patients with cystic fibrosis from Western India.","authors":"Parmarth Chandane, Avantika Chauhan, Alpa Bhosale, Mounnish Balaji, Nidhi Parekh","doi":"10.4103/lungindia.lungindia_404_24","DOIUrl":"10.4103/lungindia.lungindia_404_24","url":null,"abstract":"<p><strong>Background: </strong>Cystic fibrosis (CF) is a genetic disorder caused by genetic variant in the cystic fibrosis transmembrane regulator (CFTR) gene that affects around 89,000 people worldwide. Loss of the CFTR chloride channel due to pathogenic variants in the CFTR gene causes obstruction in the exocrine pancreas gland and reduced lung function.</p><p><strong>Objective: </strong>To determine the genotype and phenotype of patients with CF from western India.</p><p><strong>Materials and methods: </strong>This was a single-center retrospective cross-sectional study conducted in a tertiary care super speciality paediatric hospital of Mumbai, India, comprising patients aged 0 to 18 years visiting a paediatric pulmonology clinic with suspected or confirmed diagnosis of CF.</p><p><strong>Results: </strong>The mean (SD) age of onset of symptoms was 6.8 (10.2) months and the mean (SD) age at diagnosis was 32.5 (50.5) months. The two most common genetic variants found in our patients were c. 1521_1523delCTT (F508del) (n = 21) and c.1367T>C (V456A) (n = 10). There were nine novel genetic variants identified that have not been reported so far. The mean (SD) age of onset of symptoms was 6.8 (10.2) months and mean (SD) age at diagnosis was 32.5 (50.5) months. The most common presenting features were recurrent respiratory infections (83%), malabsorption (79%), and failure to thrive (79%). Sweat chloride testing was conducted to establish the CFTR gene dysfunction and was positive in 79% (46/58) of patients and intermediate in 15% (n = 9/58) of patients. The two most common genetic variants found in our group of patients were c. 1521_1523delCTT (F508del) (n = 21) and c.1367T>C (V456A) (n = 10). There were nine novel genetic variants identified that have not been reported so far.</p><p><strong>Conclusion: </strong>This study adds to the knowledge of genetic diversity in the pathogenic CFTR gene variants causing CF and highlights the importance of sequencing the entire CFTR gene as regional variations in the gene have been documented in India.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"103-108"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple post-intubation tracheal granulomas presenting as stridor.","authors":"Rakesh Kodati, Shanmukha Priya Satuluri, Narendra Kumar Narahari, Monalisa Hui, Paramjyothi Gongati","doi":"10.4103/lungindia.lungindia_450_24","DOIUrl":"10.4103/lungindia.lungindia_450_24","url":null,"abstract":"","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 2","pages":"162-164"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endobronchial stenting in a rare case of severe necrotic tracheal mucormycosis.","authors":"T H Deepak, Karan Deshmukh, S Santha Kumar, J Venugopal","doi":"10.4103/lungindia.lungindia_114_24","DOIUrl":"10.4103/lungindia.lungindia_114_24","url":null,"abstract":"<p><p>We present a case of tracheal necrosis due to mucormycosis in a young diabetic male. He presented with stridor due to airway obstruction from the necrosed tracheal wall. We used a silicon tracheal stent to maintain airway patency and support the airway. This case highlights the use of tracheal stenting to stabilize the airway in an extremely necrosed and friable trachea, which is not fit for surgical resection due to the involvement of the long segment of the trachea. To the best of our knowledge, the use of stents to stabilize necrosed tracheal walls in cases of mucormycosis has not been reported so far.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 1","pages":"47-48"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous treatment with benralizumab and ustekinumab in a patient with severe asthma and ulcerative colitis.","authors":"Lorenzo Carriera, Roberto Barone, Simone Ielo, Angelo Coppola","doi":"10.4103/lungindia.lungindia_337_24","DOIUrl":"10.4103/lungindia.lungindia_337_24","url":null,"abstract":"<p><p>The burden of autoimmune diseases is rising worldwide. The expansion of the population of patients eligible for severe asthma biological therapy we are seeing in clinical practice could lead to the simultaneous use of different monoclonal antibodies. We present the case of biological combination therapy with ustekinumab and benralizumab in a patient with ulcerative colitis and severe eosinophilic asthma. The patient, already undergoing biological treatment for colitis, began to suffer from uncontrolled severe asthma. Since benralizumab was administered, the patient has not experienced any exacerbations requiring oral corticosteroids, emergency department visits, or hospital admissions, and the control of asthma symptoms and respiratory function considerably improved. Twelve months after the initiation of the combination, both diseases are well controlled, without any side effects or blood test abnormalities. To our knowledge, this is one of the first reported cases of patients simultaneously receiving a combination of biological therapy for ulcerative colitis and asthma.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"42 1","pages":"49-52"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}