Journal of Taibah University Medical Sciences最新文献_第9页

Design, synthesis, and molecular docking studies of N-substituted sulfonamides as potential anticancer therapeutics n -取代磺酰胺作为潜在抗癌药物的设计、合成和分子对接研究

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-11-04 DOI: 10.1016/j.jtumed.2023.10.006

Ibrahim T. Babalola Ph.D, Garba Suleiman M.Sc.

引用次数: 0

Stair-climbing interventions on cardio-metabolic outcomes in adults: A scoping review 爬楼梯对成人心脏代谢结果的干预:一项范围综述

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-11-01 DOI: 10.1016/j.jtumed.2023.10.003

Anang M. Ghosal BSc, Baskaran Chandrasekaran MPT

引用次数: 0

Evolution of the accreditation program for healthcare organizations in KSA: From present to future 沙特阿拉伯医疗机构认证计划的演变:从现在到未来

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-10-21 DOI: 10.1016/j.jtumed.2023.10.002

Dalal M. Alshathri MSc , Abdulmunim F. Alsuhaimi MD , Salem A. Alwahabi MD , Majed M. Elmaghrabi MD , Mohammed A. Hussein PhD

引用次数: 0

The urgency of cautious prescription for fluoride toothpaste: Recommendations for the stakeholders 含氟牙膏谨慎处方的紧迫性:给利益相关者的建议

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-10-12 DOI: 10.1016/j.jtumed.2023.09.008

Rizwan Ullah MSc , Syed K. Iqbal PhD , Muhammad S. Zafar PhD

引用次数: 0

Validity of self-reported number of teeth among Saudi older adults: A public health perspective 沙特老年人自我报告牙齿数量的有效性:公共卫生视角

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-10-12 DOI: 10.1016/j.jtumed.2023.10.001

Faisal F. Hakeem PhD , Lina AlQobaly DClinDent , Arwa M. Mubarak BDS , Sarah A. Almuzaini BDS

引用次数: 0

Morphometric measurements of mandible to determine stature and sex: A postmortem study 下颌骨形态测量以确定身高和性别：尸检研究。

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-10-11 DOI: 10.1016/j.jtumed.2023.09.007

Nehala C Hamza , Chandni Gupta MD , Vikram Palimar MD

引用次数: 0

Pulmonary fibrosis: Is stem cell therapy the way forward? 肺纤维化:干细胞治疗是未来的方向吗?

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-10-11 DOI: 10.1016/j.jtumed.2023.09.009

Muhammad Ikrama MBBS, Muhammad Usama MBBS, Shifa Israr MBBS, Maryam Humayon MBBS

{"title":"Pulmonary fibrosis: Is stem cell therapy the way forward?","authors":"Muhammad Ikrama MBBS, Muhammad Usama MBBS, Shifa Israr MBBS, Maryam Humayon MBBS","doi":"10.1016/j.jtumed.2023.09.009","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.09.009","url":null,"abstract":"<div><p>Pulmonary fibrosis, a chronic and fatal lung disease affecting millions of people worldwide, is characterized by the scarring of lung tissue, thereby impairing oxygen exchange between the lungs and blood. The etiology of pulmonary fibrosis is multifactorial, involving environmental exposures, comorbidities, and genetic mutations. Current pharmacological treatments can only slow the disease progression, and lung transplantation is limited by donor availability and complications. Stem cell therapy has emerged as a potential alternative treatment for pulmonary fibrosis, in which stem cells modulate the inflammatory response, differentiate into lung epithelial cells, secrete growth factors and extracellular matrix components, and enhance vascularization and tissue regeneration. Various sources of stem cells, such as endogenous lung stem cells, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells, have been investigated in animal models and human trials. Various delivery routes, such as intravenous injection, intratracheal instillation, and inhalation, have been tested for safety and efficacy. However, several challenges and limitations remain to be overcome, such as high costs, ethical issues, immunological compatibility, cell survival and homing, and long-term outcomes. Further research is needed to optimize the protocols and parameters in stem cell therapy for pulmonary fibrosis, and to evaluate the clinical benefits and risks for patients.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49873247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study 维生素D受体在葡萄胎和妊娠滋养细胞瘤中的表达:横断面研究

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-10-07 DOI: 10.1016/j.jtumed.2023.09.006

RM Sonny Sasotya MD , Arieff Kustiandi MD , Yudi Mulyana Hidayat MD , Jusuf Sulaeman Effendi MD , Wiryawan Permadi MD , Ali Budi Harsono MD , Ayu Insafi Mulyantari MD , Bethy S. Hernowo MD

{"title":"Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study","authors":"RM Sonny Sasotya MD , Arieff Kustiandi MD , Yudi Mulyana Hidayat MD , Jusuf Sulaeman Effendi MD , Wiryawan Permadi MD , Ali Budi Harsono MD , Ayu Insafi Mulyantari MD , Bethy S. Hernowo MD","doi":"10.1016/j.jtumed.2023.09.006","DOIUrl":"10.1016/j.jtumed.2023.09.006","url":null,"abstract":"<div><h3>Objective</h3><p>Vitamin D receptor (VDR) exerts anti-cancer properties in a variety of cancers. The purpose of this study was to investigate the expression of VDR in patients with hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN).</p></div><div><h3>Methods</h3><p>This is a cross-sectional study involved 61 specimens of HM (n = 37, 60.7%) and GTN (n = 24, 39.3%) was collected from the biopsy. An immunohistochemistry was used to asses the VDR expression. Student's t-test and Mann–Whitney test were used to compare the expression of VDR, including VDR staining intensity, VDR distribution, and histoscore, between HM and GTN tissue specimens.</p></div><div><h3>Results</h3><p>No significant differences in age and parity were noted between patients with HM or GTN (p > 0.05). The VDR staining intensity of GTN tissue specimens was significantly lower than that of HM tissue specimens (2.3 ± 0.8 vs. 2.8 ± 0.5, p = 0.008). In addition, the histoscore for GTN tissues was significantly lower than that for HM tissues (7.3 ± 3.2 vs. 9.4 ± 28, p = 0.016). However, no significant differences in VDR distribution between GTN and HM tissues were observed (3.3 ± 0.8 vs. 3.3 ± 1.0, p = 0.525).</p></div><div><h3>Conclusion</h3><p>Low VDR expression is associated with GTN, whereas high VDR expression is associated with HM, suggesting that the expression of VDR may regulate the severity of gestational trophoblastic disease.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223001464/pdfft?md5=d97e11dffe8ff4aadd98940d5160b254&pid=1-s2.0-S1658361223001464-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135605573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical variation in the sphenoidal sinuses in patients with chronic rhinosinusitis: A CT scan study 慢性鼻窦炎患者蝶窦解剖变异的CT扫描研究

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-10-07 DOI: 10.1016/j.jtumed.2023.09.005

Vinodhini Periyasamy PhD , Radhakrishnan Sumana M.D , Anupama Doddappaiah M.D , Rathinasabapathy Mythilikrishnan M.D

{"title":"Anatomical variation in the sphenoidal sinuses in patients with chronic rhinosinusitis: A CT scan study","authors":"Vinodhini Periyasamy PhD , Radhakrishnan Sumana M.D , Anupama Doddappaiah M.D , Rathinasabapathy Mythilikrishnan M.D","doi":"10.1016/j.jtumed.2023.09.005","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.09.005","url":null,"abstract":"<div><p>Computerized tomography (CT) of the skull base region has become an indispensable tool for endoscopic sinonasal surgery.</p></div><div><h3>Objectives</h3><p>Fundamental knowledge of the sinus anatomy is crucial for preoperative surgical planning. The aim of this research was to evaluate associations between the anatomical variations sphenoidal sinuses and chronic rhinosinusitis (CRS) by using CT.</p></div><div><h3>Methods</h3><p>A descriptive study was performed on patients with CRS, who were referred to the department of radiodiagnosis and imaging for CT scanning. Parameters were compared between the study and control groups.</p></div><div><h3>Results</h3><p>Among the anatomical variations, the presence of bilateral accessory septa within the sphenoidal sinus, and dehiscence and protrusion of the internal carotid artery and optic nerve (ON), were high in men and women in the case group compared with the control group. Among the anatomical variations in the sinonasal region of the male participants, a significant association (p < 0.05) was observed with ON protrusion and ON dehiscence. ON protrusion (OR = 2.168) in men was associated with elevated risk of CRS in the study population.</p></div><div><h3>Conclusion</h3><p>Knowledge of the anatomical variations in the sphenoid sinuses enables better understanding of the limits of surgical dissection during the treatment of sphenoid sinus surgeries.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49873248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Euphorbia hirta nanoextract as a piezoelectric ultrasonic scaler coolant in gingivitis treatment in a Wistar rat model 大戟纳米提取物作为压电超声清洗剂在Wistar大鼠牙龈炎模型中的治疗作用

IF 2.2

Journal of Taibah University Medical Sciences Pub Date : 2023-10-06 DOI: 10.1016/j.jtumed.2023.09.004

Archadian Nuryanti PhD , Andari Sarasati DDS , Latifah Ulfahastika DDS , Maria Ditya Wartadiani DDS , Muhammad Hidayat Syahruddin DDS , Rachma Nissa Sitho Qurota A'yun DDS

引用次数: 0