Journal of Taibah University Medical Sciences最新文献

{"title":"Pharmacokinetic profiling of quinazoline-4(3H)-one analogs as EGFR inhibitors: 3D-QSAR modeling, molecular docking studies and the design of therapeutic agents","authors":"Sagiru Hamza Abdullahi PhD, Adamu Uzairu PhD, Gideon Adamu Shallangwa PhD, Sani Uba PhD, Abdullahi Bello Umar PhD","doi":"10.1016/j.jtumed.2023.02.015","DOIUrl":"10.1016/j.jtumed.2023.02.015","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/18/main.PMC10027554.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9178892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro bio-characterization of solid lipid nanoparticles of favipiravir in A549 human lung epithelial cancer cells","authors":"Alaa S. Tulbah Ph.D.","doi":"10.1016/j.jtumed.2023.02.014","DOIUrl":"10.1016/j.jtumed.2023.02.014","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/56/main.PMC10040896.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9219557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pakistan's healthcare preparedness after the NIH warned of a new diphtheria strain and Covid-19 variation","authors":"Muhammad Muzzamil MSPH ,&nbsp;Simra Naz MSCP ,&nbsp;Hassan Mumtaz MSPH ,&nbsp;Wajiha Omair FCPS","doi":"10.1016/j.jtumed.2023.03.002","DOIUrl":"10.1016/j.jtumed.2023.03.002","url":null,"abstract":"<div><h3>Objective</h3><p>In this paper, we examine the current crisis of regarding preparedness of healthcare industries in Pakistan, analyzing the causes, effects, and potential recommendations to this problem.</p></div><div><h3>Methods</h3><p>Highlighting the efforts and issues surrounding this topic is necessary for developing and implementing research-based solutions that accurately reflect the current state of the healthcare industry. This short overview is prepared in accordance with accepted practices in published studies around the world. Our findings were based on a search of the literature databases PubMed, Google Scholar, Journals Online, and the Internet Library.</p></div><div><h3>Results</h3><p>Searching for \"Healthcare Preparedness in Pakistan\" yielded the expected results. Particularly of interest to the researchers was the question of why, despite efforts to boost vaccination rates and emergency immunization response capacities in the event of epidemics, progress on SDG3 immunization indicators has been minimal. Immunization is critically important because vaccine-preventable diseases pose a significant risk to the general population. Pakistan's authorities and government should take deliberate action to increase immunization rates.</p></div><div><h3>Conclusion</h3><p>Particularly disadvantaged countries and regions are hit the worst by climate change. Pakistan continues to be hit hard by diseases like acute watery diarrhea, dengue fever, malaria, and COVID-19 are on the rise as a result of the flooding, especially in shelters and areas where water and sanitation systems have been affected. After devastating floods in KP, Sindh, and Punjab, over 70 suspected cases of diphtheria were reported. Diphtheria epidemics illustrate the precarious position of flood victims. It would be catastrophic if the newly found diphtheria strain or the covid-19 variation reached the underserved flood victims. Immunization protects against life-threatening illnesses so its government responsibility to improve immunization rates in Pakistan.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/6b/main.PMC10033978.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9560610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle medicine as a modality for prevention and management of chronic diseases","authors":"Idris Zubairu Sadiq M.Tech (Biotech.)","doi":"10.1016/j.jtumed.2023.04.001","DOIUrl":"10.1016/j.jtumed.2023.04.001","url":null,"abstract":"<div><p>Lifestyle medicine is an approach that focuses on modifying unhealthy behaviors and promoting healthy ones to prevent and manage chronic diseases. This modality addresses multiple risk factors such as physical inactivity, unhealthy diet, tobacco use, and stress. Evidence shows that adopting a healthy lifestyle can significantly reduce the incidence and progression of chronic diseases such as cardiovascular diseases, diabetes, and cancer. The implementation of Lifestyle medicine requires a multidisciplinary approach involving healthcare providers, patients, and communities. Healthcare providers play a pivotal role in educating and motivating patients to adopt healthy behaviors, while communities can provide a supportive environment that fosters healthy lifestyles. The aim of this letter to editor is to summarize the evidence supporting the use of Lifestyle medicine in the prevention and management of chronic diseases.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/0e/main.PMC10176046.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9477239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The synergistic effects of hydroxychavicol and amphotericin B towards yeast-hyphae transition and the germination of Candida albicans","authors":"Wan H.A.W. Harun PhD ,&nbsp;Che O.N. Zulaila MSc ,&nbsp;Ayesha Fahim PhD ,&nbsp;Nasar U.M. Allah MSc","doi":"10.1016/j.jtumed.2023.02.004","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.02.004","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49886688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of nurses to control beta thalassemia disease in Indonesia: A perspective","authors":"Henri Setiawan M.Si.Med. ,&nbsp;Andan Firmansyah M.Kep. ,&nbsp;Selvia D. Richard M.Kep.","doi":"10.1016/j.jtumed.2023.02.007","DOIUrl":"10.1016/j.jtumed.2023.02.007","url":null,"abstract":"<div><p>Thalassemia is the most common genetic disease in Indonesia and is passed on to the next generation following an autosomal recessive Mendelian inheritance pattern. The number of thalassemia sufferers in Indonesia increased from 4896 in 2012 to 8761 in 2018. The latest data in 2019 shows a significant increase to 10,500 patients. Community nurses who work at the Public Health Center, have full roles and responsibilities in carrying out promotive and preventive efforts against thalassemia cases. Promotive efforts that can be carried out are guided by government policies (Ministry of Health, Republic of Indonesia) which stipulate primary efforts in the form of education about thalassemia disease, prevention efforts, and diagnostic tests that can be taken. To optimize the promotive and preventive efforts, community nurses need to collaborate with midwives and cadres at integrated service posts. Interprofessional collaboration between stakeholders can strengthen the government's consideration in making policies for dealing with thalassemia cases in Indonesia.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10823924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of ever smoking and active smoking among school-aged children in Jeddah","authors":"Ahlam Mazi FRCPC","doi":"10.1016/j.jtumed.2023.03.005","DOIUrl":"10.1016/j.jtumed.2023.03.005","url":null,"abstract":"<div><h3>Objectives</h3><p>This study estimated the prevalence and investigated the determinants of ever-smoking and active smoking among school-aged children in Jeddah. Such data are crucial for developing optimal preventive and corrective strategies to address smoking among youth.</p></div><div><h3>Method</h3><p>A school-based, cross-sectional study was conducted in Jeddah City, KSA, from September 2020 to December 2020. It included 6770 children attending grades 4–12, who were selected from 60 public and private elementary, middle, and secondary schools through multistage random-cluster sampling. An Arabic version of the Global Youth Tobacco Survey questionnaire was used to assess the prevalence and predictors of tobacco use.</p></div><div><h3>Result</h3><p>The prevalence of ever smoking was 14.1% (95% CI = 13.2–14.9%), and the mean age at which children smoked their first cigarette or took any puffs was 13.76 years (SD = 2.23). The prevalence of active smoking was 3.8% (95% CI = 3.3–4.3%), and the amounts and frequency of cigarettes smoked in the past 30 days among smokers were relatively low. The most commonly consumed tobacco products were cigarettes (47.2%) and hookah (42.9%). In most cases, active smokers bought cigarettes by themselves from groceries or convenience stores, or received them from a person to whom they were close. Ever smoking was independently associated with older age, male gender, private school, the mother's working status, and exposure to passive smoking indoors or outdoors. Active smoking was independently associated with older age, male gender, private school, a high amount of pocket money, perceived ease of obtaining tobacco products, and exposure to passive smoking.</p></div><div><h3>Conclusion</h3><p>The observed smoking patterns among school-aged children in Jeddah corresponded to occasional smoking, and family-related determinants were significant contributors. The findings highlight the relevance of implementing smoking cessation interventions and awareness campaigns, at both the school and community levels, to achieve maximal benefit.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/ce/main.PMC10189269.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9867967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of physical activity breaks during prolonged sitting on vascular and executive function—A randomised cross-over trial","authors":"Obhuli Chandran MSc ,&nbsp;Poovitha Shruthi MSc ,&nbsp;Suresh Sukumar PhD ,&nbsp;Rajagopal Kadavigere DM ,&nbsp;Kalyana Chakravarthy PhD ,&nbsp;Chythra R. Rao DNB ,&nbsp;Baskaran Chandrasekaran MPT","doi":"10.1016/j.jtumed.2023.03.004","DOIUrl":"10.1016/j.jtumed.2023.03.004","url":null,"abstract":"<div><h3>Objectives</h3><p>High sedentary behaviour is associated with adverse effects on central vascular function and cognitive function. Although interventions to mitigate the adverse effects of workplace sitting are intriguing, evidence of the efficacy of such interventions remains lacking. This randomised cross-over trial was aimed at exploring the effectiveness of prolonged sitting, with or without physical activity breaks, on central, peripheral vascular and cognitive function in adults.</p></div><div><h3>Methods</h3><p>Twenty one healthy adults completed 4 h of simulated work conditions in three experimental visits: (1) uninterrupted sitting (SIT); (2) sitting interrupted by 3 min of walking every hour (LIT); and (3) sitting interrupted by 3 min of stair climbing every hour (MIT). Carotid (CA) and superficial femoral artery (SFA) diameter, velocity, shear rate and blood flow were measured with Duplex ultrasound at 50 MHz at three time points (hours 0, 2 and 4), and executive function was assessed with the computer based Eriksen Flanker task every hour.</p></div><div><h3>Results</h3><p>The decreases in reaction time (−30.59%) and accuracy (−10.56%) during SIT conditions were statistically significant, and less of a decrease was observed under LIT and MIT conditions. No significant differences in CA and SFA function were observed with LIT and MIT interventions.</p></div><div><h3>Conclusion</h3><p>Physical activity breaks of varying intensity during prolonged sitting improve reaction time. However, the vascular benefits of physical activity breaks should be confirmed in the future through long term studies in natural environment.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/87/main.PMC10040888.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological evaluation of the effects of bone morphogenetic protein 9 and angiopoietin 1 on bone healing","authors":"Enas Fadhil PhD ,&nbsp;Rasha H. Dosh PhD ,&nbsp;Zena J. Wally PhD ,&nbsp;Julfikar Haider PhD","doi":"10.1016/j.jtumed.2023.02.005","DOIUrl":"10.1016/j.jtumed.2023.02.005","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/59/main.PMC9982621.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9100767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uses of simulation-based education for anesthesiology training, certification and recertification: A scoping review","authors":"Baraa O. Tayeb MBBS, MS, D.ABA, ABHPM, CHSE ,&nbsp;Firas A. Shubbak Md, CJB, SFPA, DIU ,&nbsp;Khaled S. Doais MBBS, SBAI, ABAI, SFCA ,&nbsp;Ahad N. Yamani MBBS ,&nbsp;Daniah G. Dhaifallah MBBS ,&nbsp;Eyad F. Alsayed MBBS, GBAI ,&nbsp;Malik J. Addas MBBS ,&nbsp;Abdulaziz M. Boker MBBS, Med, FRCPC","doi":"10.1016/j.jtumed.2023.03.015","DOIUrl":"10.1016/j.jtumed.2023.03.015","url":null,"abstract":"<div><h3>Objectives</h3><p>To conduct a comprehensive scoping review focusing on published anesthesiology-specific training based on simulation to assess up-to-date uses of simulation-based education in anesthesiology training. Our goal was to establish a solid ground for building standardized and accredited curricula for simulation-based education in the specialty of anesthesia in the near future.</p></div><div><h3>Methods</h3><p>We searched the PubMed, CINAHL and EMBASE databases on May 10, 2021 for relevant articles. We followed the five-stage scoping review methodology: identifying a research question, identifying relevant studies, study selection, charting the data, and synthesis of results.</p></div><div><h3>Results</h3><p>Our initial electronic search identified 5609 potential articles. After abstract screening and removing duplicates, 636 articles were evaluated in full text for inclusion or exclusion. Based on this strategy, 283 articles were included in this review. We mapped the current practice of simulation in training and certification across different anesthesiology subspecialties.</p></div><div><h3>Conclusions</h3><p>Significant effort has been placed into the use of simulation for training, certification, and recertification in anesthesiology. Future effort to develop simulation-based training that can be generalized to trainees in this specialty, similar to other fields such as aviation and space sciences, will enhance the standardization of training and hence patient safety.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42192737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}