Journal of Taibah University Medical Sciences最新文献

{"title":"Exploring the potential of Scabiosa columbaria in Alzheimer's disease treatment: An in silico approach","authors":"Riyan A.P. Irsal M.Si ,&nbsp;Gusnia M. Gholam M.Si ,&nbsp;Maheswari A. Dwicesaria M.Si ,&nbsp;Tiyara F. Mansyah S.Si ,&nbsp;Fernanda Chairunisa M.Si","doi":"10.1016/j.jtumed.2024.09.003","DOIUrl":"10.1016/j.jtumed.2024.09.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Alzheimer's disease (AD) is posing an increasing global threat and currently lacks effective treatments. Therefore, this study was aimed at exploring phytochemicals in <em>Scabiosa columbaria</em> (<em>S. columbaria</em>) as inhibitors of acetylcholinesterase (AChE), β-site APP cleavage enzyme 1 (BACE1), and TNF-α converting enzyme (TACE) in AD. <em>S. columbaria</em> contains various bioactive compounds, such as chlorogenic acid, linalool, and catechins, which are known for their detoxification properties, capacity to resist and manage harmful moisture buildup, and therapeutic roles in COVID-19. Several studies have also shown that <em>S. columbaria</em> extract has strong antioxidant activity, and may potentially decrease neuroinflammation in AD. Therefore, this study investigated the interactions between <em>S. columbaria</em> phytochemicals and key enzymes associated with AD, thus providing opportunities for the development of new therapeutic candidates.</div></div><div><h3>Methods</h3><div>A total of 27 phytochemicals were evaluated for their inhibitory activity against AChE, BACE1, and TACE with YASARA Structure. ADMET profiles and toxicity were assessed. The top candidate compounds underwent 100 ns MD simulations.</div></div><div><h3>Results</h3><div>All ligands met Lipinski's rule and showed low toxicity. Catechins, compared with the known drug galantamine, showed higher inhibitory activity and interacted with additional active sites on AChE, thus suggesting potentially higher efficacy. Moreover, chlorogenic acid showed stronger inhibitory activity against TACE than the control drug (aryl-sulfonamide), thereby suggesting a different mechanism of action. MD simulation revealed that the formed complexes had good stability. However, further exploration is necessary.</div></div><div><h3>Conclusion</h3><div><em>S. columbaria</em> derivative compounds are promising drug candidates because of their properties, including the affinity of chlorogenic acid toward TACE and hydrogen bond enhancing ligand–receptor interactions. MD simulation indicated stable ligand–protein complexes, and the radius of gyration and MM-PBSA calculations revealed favorable binding and interaction energies. Our findings demonstrate the identified compounds' potential for further drug development.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 947-960"},"PeriodicalIF":1.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting to Gen Z: Innovative educational strategies in medical education","authors":"Riza Amalia M.Si. ,&nbsp;Ajeng Ayu Widiastuti M.A. ,&nbsp;Alwita Susanti S.ST ,&nbsp;Muhammad Sandy Al Fath M.Pd.","doi":"10.1016/j.jtumed.2024.08.029","DOIUrl":"10.1016/j.jtumed.2024.08.029","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 934-935"},"PeriodicalIF":1.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S165836122400101X/pdfft?md5=033dd46abc37f6d00a7e5f0731c4c9be&pid=1-s2.0-S165836122400101X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical arterial blood lactate as predictor of early neonatal outcome and evaluation of intrapartum asphyxia","authors":"Olufemi M. Badmus FWACS,&nbsp;Olaide R. Adenaya FWACS,&nbsp;Oluseyi A. Aderinwale FWACS,&nbsp;Bernard O. Ewuoso FWACS,&nbsp;Babatunde S. Awolaja FWACS,&nbsp;Adedoyin O. Ade-Onojobi FWACS","doi":"10.1016/j.jtumed.2024.08.027","DOIUrl":"10.1016/j.jtumed.2024.08.027","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 911-918"},"PeriodicalIF":1.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000994/pdfft?md5=f658f180e4c2ff3ab8983f3d612f096c&pid=1-s2.0-S1658361224000994-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-lasting effects of post-traumatic stress disorder in Yazidi women living in Northern Iraqi camps","authors":"Kajeen H. Jasim MSc ,&nbsp;Suad Y. Alkass PhD ,&nbsp;Daniele S. Persike PhD","doi":"10.1016/j.jtumed.2024.08.028","DOIUrl":"10.1016/j.jtumed.2024.08.028","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 919-933"},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224001008/pdfft?md5=2d4529c5938b117f32d7fc1ad4f8a3bb&pid=1-s2.0-S1658361224001008-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effects of a dasatinib-containing, self-emulsifying, drug delivery system on HT29 and SW420 human colorectal carcinoma cells, and MCF7 human breast adenocarcinoma cells","authors":"Rehab A. Baghdadi MD ,&nbsp;Ashraf N. Abdalla PhD ,&nbsp;Mohammed A.S. Abourehab PhD ,&nbsp;Alaa S. Tulbah PhD","doi":"10.1016/j.jtumed.2024.07.002","DOIUrl":"10.1016/j.jtumed.2024.07.002","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 4","pages":"Pages 806-815"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000647/pdfft?md5=5b4386f108c575f1c129e8c366b55b07&pid=1-s2.0-S1658361224000647-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conceptualization and establishment of value-based healthcare in Saudi Arabia: A scoping review","authors":"Bayan A. Hariri MSc ,&nbsp;Faisal M. Albagmi PhD ,&nbsp;Afnan A. Aljaffary PhD","doi":"10.1016/j.jtumed.2024.07.008","DOIUrl":"10.1016/j.jtumed.2024.07.008","url":null,"abstract":"<div><h3>Objectives</h3><p>Value-based healthcare (VBHC) represents a paradigm shift in healthcare delivery through optimizing patient outcomes relative to the costs of achieving those outcomes. This scoping review is aimed at revealing critical insights into the conceptualization and establishment of VBHC in the context of Saudi Arabia, a nation in a critical stage of healthcare transformation.</p></div><div><h3>Methods</h3><p>A scoping review was conducted by using online databases and official websites with a timeframe of 2017–2023. This review included 14 pieces of literature, comprising six research articles, six government documents, and two reports.</p></div><div><h3>Results</h3><p>The findings highlight increasing alignment with the definition of global VBHC principles, notably the emphasis on patient outcomes as a primary metric of healthcare value. Furthermore, financial reform has signaled a real move toward VBHC in the Kingdom, through a gradual shift from volume-based payments to value-based payments. However, the diverse interpretations and applications of VBHC across the examined literature indicate a promising stage of implementation characterized by evolving definitions and practices tailored to local needs and constraints.</p></div><div><h3>Conclusion</h3><p>This scoping review describes the current landscape of VBHC conceptualization and establishment, highlighting the substantial progress achieved and the future challenges.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 4","pages":"Pages 835-846"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000702/pdfft?md5=673e966d4a86bf0aeec940c7f5baea1a&pid=1-s2.0-S1658361224000702-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QSAR, molecular docking, and pharmacokinetic analysis of thiosemicarbazone-indole compounds targeting prostate cancer cells","authors":"Abdulrahman Ibrahim Kubo M.Sc ,&nbsp;Adamu Uzairu PhD ,&nbsp;Ibrahim Tijjani Babalola PhD ,&nbsp;Muhammad Tukur Ibrahim PhD ,&nbsp;Abdullahi Bello Umar PhD","doi":"10.1016/j.jtumed.2024.07.004","DOIUrl":"10.1016/j.jtumed.2024.07.004","url":null,"abstract":"<div><h3>Objectives</h3><p>By 2030, prostate cancer is estimated to account for 1.7 million new cases and 499,000 deaths. The objectives of this research were to create a model revealing the activity of thiosemicarbazone-indole compounds as anticancer agents against the PC3 cell line; perform docking analysis between the compounds and the target enzyme; and predict the pharmacokinetics and drug-likeness of the compounds under investigation.</p></div><div><h3>Methods</h3><p>The quantitative structureactivity relationship (QSAR) method was used to build the model; molecular docking between the compounds and the target enzyme was performed; and the drug-likeness and pharmacokinetics of the inhibiting compounds was examined.</p></div><div><h3>Results</h3><p>The genetic function algorithm-multilinear regression approach was used for building the QSAR model. Build model 1 had the best performance, with R² (coefficient of determination) = 0.972517, R_adj (adjusted R-squared) = 0.964665, (CRp²) = 0.780922, and LOF (leave-one-out cross-validation) = 0.076524, demonstrated strongly indicated by the molecular descriptors. SHBd, SsCH3, JGI2, and RDF60P were highly dependent on proliferative activity. Compounds ID 7 and 22 had the potential to act as androgen receptor inhibitors, as suggested by molecular docking studies between the drugs and their target enzymes. Compounds ID 7 and 22 exhibited binding scores of −8.5 kcal/mol and −8.8 kcal/mol, respectively. The approved maximum medication molecules for oral bioavailability included the molecules with IDs 7 and 22.</p></div><div><h3>Conclusion</h3><p>This research provides valuable insights into the relationships among molecular descriptors, potential inhibitors, and pharmacokinetic properties in the treatment of PC3. These findings may contribute to the understanding and potential development of new therapeutic options for prostate cancer patients.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 4","pages":"Pages 823-834"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000660/pdfft?md5=5fff1200c5d74138c26f1ce6ab9b148e&pid=1-s2.0-S1658361224000660-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of non-communicable diseases in Health Council of Gulf Cooperation (GCC) countries","authors":"Eyad Taha Alqadasi MPH ,&nbsp;Kanittha Chamroonsawasdi Ph.D. ,&nbsp;Kittipong Saejeng M.D. ,&nbsp;Mouaddh Abdulmalik Nagi Ph.D.","doi":"10.1016/j.jtumed.2024.07.009","DOIUrl":"10.1016/j.jtumed.2024.07.009","url":null,"abstract":"<div><h3>Objectives</h3><p>This study was aimed at comparing deaths, years of potential life loss (YPLL), and economic loss due to nine non-communicable diseases (NCDs) among Health Council of Gulf Cooperation (GCC) countries.</p></div><div><h3>Methods</h3><p>The number of deaths and life expectancy by age and sex in each country, obtained from the 2019 World Health Organization database, were used to calculate YPLL by disease and sex. Economic loss was estimated by combining the annual income adjusted for the present value multiplied by the YPLL for each disease by sex and country.</p></div><div><h3>Results</h3><p>The nine NCDs were responsible for 152,854 deaths, 3 million YPLL, and 23.9 billion US$ economic loss in GCC countries. The most common cause of death was ischemic heart disease, which caused 82,232 deaths (54% of the total), 1.6 million YPLL (54% of the total), and a 12.8 billion US$ economic loss (53% of the total). The least common cause of death was lung cancer, which caused 1,960 deaths, 37,287 YPLL, and a 317.6 million US$ economic loss. KSA was the most affected country among all GCC countries in terms of deaths (68,027), YPLL (1.4 million), and economic loss (14.3 billion US$). Notably, KSA had 45%, 49%, and 60% of the entire region's deaths, YPLL, and economic loss, respectively. In contrast, Qatar was the least affected country in terms of deaths and YPLL, and Yemen was the least affected country in terms of economic loss.</p></div><div><h3>Conclusion</h3><p>The burden of NCDs in GCC countries in terms of deaths, YPLL, and economic loss is substantial. Policymakers should pay greater attention to detecting, preventing, and controlling these NCDs and their risk factors.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 4","pages":"Pages 877-884"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000714/pdfft?md5=b248622ea2ff7fa76393f2a2dd7f829c&pid=1-s2.0-S1658361224000714-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive study of CCN4, VCAM-1, MMP-3, and GM-CSF as reliable markers for disease activity in rheumatoid arthritis","authors":"Ahmed T. Yasin ,&nbsp;Eman T. Ali Ph.D. ,&nbsp;Falah H. Shari Ph.D. ,&nbsp;Ali N. Mohammed M.B.CH.B D.R.M.R","doi":"10.1016/j.jtumed.2024.08.001","DOIUrl":"10.1016/j.jtumed.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><p>The involvement of Wnt-1-induced secreted protein-1 (WISP1/CCN4) in several inflammatory reaction has recently been proposed. Nevertheless, this protein's involvement in rheumatoid arthritis (RA) remains debated. Associations between poorly diagnosed RA and several classical markers derived from demography and biochemistry have been reported.</p></div><div><h3>Aim</h3><p>We sought to investigate the reliability and effectiveness of serum concentrations of CCN4, vascular cell adhesion molecule-1 (VCAM-1), matrix melloprotenase-3 (MMP-3), and granulocyte-macrophage colony-stimulating factor (GM-CSF) in monitoring and predicting RA and bone damage, and their correlation with RA disease course.</p></div><div><h3>Methods</h3><p>The study analyzed 128 patients with RA, comprising 68 newly diagnosed and 60 previously diagnosed patients, as well as 60 controls. Biomarker levels were measured with enzyme linked immuno-sorbent assays. Routine laboratory parameters such as serological, clinical, biochemical, and hematological parameters were additionally measured. Demography, anthropometry, and clinical symptom data were collected through interviews and a questionnaire. The joint disease activity score 28 (DAS28) was used to determine disease activity.</p></div><div><h3>Results</h3><p>Concentrations of four biomarkers were significantly higher in the RA group than the healthy controls. Elevated biomarker concentrations were also observed in patients with high, rather than moderate or low, DAS28-ESR activity status, except for monocyte count, hematocrit (%), and urea level. Furthermore, CCN4 level positively correlated with VCAM-1, MMP-3, and GM-CSF levels, DA-S28-CRP and DAS28-ESR. The levels of three predictive markers, CCN4, VCAM-1, and MMP-3, were elevated in non-treated patients, whereas GM-CSF level showed no difference. The highest area under the curve was 73.3% for CCN4, with 93.3% sensitivity and 64.7% specificity.</p></div><div><h3>Conclusion</h3><p>Our data suggest that CCN4 can be reliably used to indicate activity and therapeutic response associated with RA, thus facilitating earlier RA diagnosis.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 4","pages":"Pages 885-900"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000738/pdfft?md5=0fae54684f8496a974e5390a1e0703ab&pid=1-s2.0-S1658361224000738-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142039672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic properties of Pelargonium graveolens leaf extract and its green-synthesized gold nanoparticles (in vitro study)","authors":"Ahmed Y.M. Asker BDS,&nbsp;Aseel H.M.J. Al Haidar MSc","doi":"10.1016/j.jtumed.2024.08.002","DOIUrl":"10.1016/j.jtumed.2024.08.002","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 4","pages":"Pages 901-909"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S165836122400074X/pdfft?md5=3a054e23ef9c2a659cc4920b064a0745&pid=1-s2.0-S165836122400074X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142084362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}