Journal of Taibah University Medical Sciences最新文献

{"title":"Integration of genomic nursing in nursing education curriculum in Indonesia: A perspective","authors":"Henri Setiawan BSN, RN, MSi.Med , Andan Firmansyah BSN, RN, MN , Ayu E. Purwati S.ST., M.Kes","doi":"10.1016/j.jtumed.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.12.001","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002597/pdfft?md5=1293c19ee89893a079902c81a9a896a1&pid=1-s2.0-S1658361223002597-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138839485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT and the future of medical education: Correspondence","authors":"Hinpetch Daungsupawong Ph.D , Viroj Wiwanitkit Ph.D","doi":"10.1016/j.jtumed.2023.11.007","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.11.007","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002226/pdfft?md5=b2025e56dd4a84f16da225338caeeac0&pid=1-s2.0-S1658361223002226-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138769669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-directed learning and clinical competence: The mediating role of the clinical learning environment","authors":"Parvaneh Vasli Ph.D. ,&nbsp;Hanieh Asadiparvar-Masouleh B.A.","doi":"10.1016/j.jtumed.2023.11.004","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.11.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Recognizing the factors affecting clinical competence among internship nursing students is crucial. This study was aimed at determining the effects of self-directed learning on internship nursing students’ clinical competence under the mediating role of the clinical learning environment.</p></div><div><h3>Methods</h3><p>This cross-sectional research was performed on 300 internship nursing students selected by convenience sampling with a structural equation modeling (SEM) approach. Data were collected in one stage with three tools: the Self-Directed Learning Readiness Scale for Nursing Education, Education Environment Measure, and Clinical Competence Questionnaire. Data analysis was performed in SPSS version 21 and Smart-PLS version 3 with partial least squares-SEM. Measurement and structural model data were assessed with a significance threshold of p &lt; 0.05.</p></div><div><h3>Results</h3><p>A total of 20.5 % of the variance in clinical competence was explained by self-directed and clinical learning environments. Self-directed learning had a significant positive effect on clinical competence (path coefficient = 0.14, 95 % CI: 0.02, 0.26; p = 0.027), and on the clinical learning environment (path coefficient = 0.41, 95 % CI: 0.31, 0.52; p &lt; 0.001). A relationship was observed between the clinical learning environment and clinical competence (path coefficient = 0.38, 95 % CI: 0.25, 0.50; p &lt; 0.001). The indirect effect of self-directed learning on clinical competence was positive and significant (path coefficient = 0.11, 95 % CI: 0.07, 0.17; p &lt; 0.001). Self-directed learning had a significant total effect on clinical competence (path coefficient = 0.30, 95 % CI: 0.19, 0.40; p &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>According to the results, we recommend that nursing education managers and instructors consider plans to enhance self-directed learning among nursing students and improve the clinical learning environment.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002196/pdfft?md5=0be700f7daee138b008ca11d33664437&pid=1-s2.0-S1658361223002196-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138769691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of stingless bee (Kelulut) honey versus conventional gel dressing in diabetic wound bed preparation: A randomized controlled trial","authors":"Mohamad A. Rosli MS (Plastic Surgery) ,&nbsp;Nur A. Mohd Nasir PhD ,&nbsp;Mohd Z. Mustafa PhD ,&nbsp;Muhammad A. Othman MD ,&nbsp;Zaidi Zakaria MMed (Surgery) ,&nbsp;Ahmad S. Halim FCCP","doi":"10.1016/j.jtumed.2023.11.003","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.11.003","url":null,"abstract":"<div><h3>Purpose</h3><p>Kelulut honey contains trehalulose and has high antioxidant content, such as phenolic and flavonoid substances, which can promote wound healing. This study evaluated the effectiveness of Kelulut honey in diabetic wound healing compared to a commercially available conventional gel dressing (Intrasite gel).</p></div><div><h3>Methods</h3><p>A prospective, randomized, single-blinded control trial was performed on eligible diabetic patients with full-thickness cavity wounds. Patients’ demographics, size and site of wounds, and baseline routine blood investigations were recorded. The wounds were dressed every other day with Kelulut honey for the intervention group or gel for the control group. The wound size reduction and granulation tissue formation percentage were calculated every 6 days for 1 month.</p></div><div><h3>Results</h3><p>Seventy-one patients were randomized. After 30 days of follow-up, 62 participants were available for analysis: 30 from the control group and 32 from the treatment group. The control group had increased granulation tissue at baseline and more wounds on the lower limb and posterior trunk. Both groups showed an increasing mean and median percentage of wound epithelialization and granulation tissue over time, with significantly higher values at every timepoint in the honey group (p &lt; 0.05). However, repeated measures analysis of variance and analysis of covariance revealed no significant interaction effect between the different treatments and time, with F (2.02, 121.28) = 0.88, p = 0.417 and F (1.60, 93.95) = 0.79, p = 0.431, respectively.</p></div><div><h3>Conclusion</h3><p>This study revealed that Kelulut honey was comparable to and as effective as the conventional gel in treating diabetic wounds in terms of promoting epithelialization and granulation tissue formation.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002159/pdfft?md5=82e0c549471ba64878c9ebee4c486ac1&pid=1-s2.0-S1658361223002159-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138466711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2,4-disubstituted 6-fluoroquinolines as potent antiplasmodial agents: QSAR, homology modeling, molecular docking and ADMET studies","authors":"Gideon A. Shallangwa PhD ,&nbsp;Aliyu W. Mahmud MSc ,&nbsp;Adamu Uzairu PhD ,&nbsp;Muhmmad T. Ibrahim PhD","doi":"10.1016/j.jtumed.2023.11.006","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.11.006","url":null,"abstract":"<div><h3>Objective</h3><p>This work was designed to study 2,4-disubstituted 6-fluoroquinolines as antiplasmodial agents by using <em>in silico</em> techniques, to aid in the design of novel analogs with high potency against malaria and high inhibition of <em>Plasmodium falciparum</em> translation elongation factor 2 (<em>Pf</em>eEF2), a novel drug target.</p></div><div><h3>Methods</h3><p>Quantitative structure-activity relationships (QSAR) of 2,4-disubstituted 6-fluoroquinolines were studied with the genetic function approximation technique in Material Studio software. The 3D structure of <em>Pf</em>eEF2 was modeled in the SWISS-MODEL workspace through homology modeling. A molecular docking study of the modeled <em>Pf</em>eEF2 and 2,4-disubstituted 6-fluoroquinolines was conducted with Autodock Vina in Pyrx software. Furthermore, the <em>in silico</em> pharmacokinetic properties of selected compounds were investigated.</p></div><div><h3>Results</h3><p>A robust, reliable and predictive QSAR model was developed that related the chemical structures of 2,4-disubstituted 6-fluoroquinolines to their antiplasmodium activities. The model had an internal squared correlation coefficient R² of 0.921, adjusted squared correlation coefficient R²_adj of 0.878, leave-one-out cross-validation coefficient Q²_cv of 0.801 and predictive squared correlation coefficient R²_pred of 0.901. The antiplasmodium activity of 6-fluoroquinolines was found to depend on the n5Ring, GGI9, TDB7u, TDB8u and RDF75i physicochemical properties: n5Ring, TDB8u and RDF75i were positively associated, whereas GGI9 and TDB7u were negatively associated, with the antiplasmodium activity of the compounds. Stable complexes formed between the compounds and modeled <em>Pf</em>eEF2, with binding affinity ranging from −8.200 to −10.700 kcal/mol. Compounds 5, 11, 16, 22 and 24 had better binding affinities than quinoline-4-carboxamide (DDD107498), as well as good pharmacokinetic properties, and therefore may be better inhibitors of this novel target.</p></div><div><h3>Conclusion</h3><p>QSAR and docking studies provided insight into designing novel 2,4-disubstituted 6-fluoroquinolines with high antiplasmodial activity and good structural properties for inhibiting a novel antimalarial drug target.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002214/pdfft?md5=fb294449945290ff0ca42bd3fae83d03&pid=1-s2.0-S1658361223002214-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138769668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speckle tracking echocardiography for diagnosis of right ventricular failure in children with totally corrected tetralogy of Fallot in Sulaimani, Iraq","authors":"Niaz M. Kamal Ph.D. Community Health Medicine ,&nbsp;Aso F. Salih MBChB, DCHFIBMS Higher diploma in pediatric cardiology ,&nbsp;Bushra M. Ali FICMS/Family Medicine","doi":"10.1016/j.jtumed.2023.11.005","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.11.005","url":null,"abstract":"<div><h3>أهداف البحث</h3><p>هدفت الدراسة إلى استخدام \"تخطيط صدى القلب بتتبع البقع\" كتقنية جديدة لتشخيص فشل البطين الأيمن لدى الأطفال مع التصحيح الكامل لجراحة رباعية فالوت.</p></div><div><h3>طريقة البحث</h3><p>أجريت دراسة شبه تجريبية في مستشفى قلب الأطفال والمستشفى عالي الجودة في السليمانية لمدة تسعة أشهر. تم تسجيل 150 طفلا تتراوح أعمارهم بين 3 و13 عاما في حالة رباعية فالوت التي تم إصلاحها بالكامل للتحقيق في حمى الوادي المتصدع. تم تقدير حجم العينة اعتمادا على معدل انتشار رباعية فالوت بنسبة 7% إلى 10% من مجمل أمراض القلب التاجية. قياسات تخطيط صدى القلب التقليدية، بما في ذلك الكسر القذفي للبطين الأيمن، والانحراف الانقباضي للمستوى الحلقي ثلاثي الشرفات، ومؤشر أداء عضلة القلب، وحجم البطين الأيمن الانقباضي والانبساطي. بالإضافة إلى ذلك، تتبع البقع للإجهاد الإقليمي والطولي ومعدل الإجهاد في المنظر القمي المكون من 4 غرف. يتضمن تشخيص حمى الوادي المتصدع تخطيط كهربية القلب لقياس ثلاث عوامل: تشتت الموجة \"بي\"، وتشتت الموجة \"تي\"، ومدة \"كيو آر اس\".</p></div><div><h3>النتائج</h3><p>أظهر الأطفال الذين تم إصلاح رباعية فالوت والذين تم تشخيص إصابتهم بحمى الوادي المتصدع من خلال تخطيط صدى القلب التقليدي انحرافا انقباضيا غير طبيعي في المستوى الحلقي ثلاثي الشرفات قدره 1.3 ± 0.11 سم، وجزء القذف البطيني الأيمن 35.5 ± 6.72، ونهاية انقباضية للبطين الأيمن 69.8 ± 15.13 مل، ونهاية انقباضية والحجم الانبساطي 110.1 ± 14.13 مل، مؤشر أداء عضلة القلب 0.60 ± 0.12 ، و أقصى ضغط لجهاز التنفس الصناعي 52.4 ± 14.08. مقارنة بالأطفال ذوي وظيفة البطين الأيمن الطبيعية. كشف تطبيق تتبع البقع في تشخيص حمى الوادي المتصدع عن انخفاض معدل الإجهاد والإجهاد الطولي (-12.1 ± 2.3 و-0.9 ± 0.3) في الأطفال المصابين بحمى الوادي المتصدع. علاوة على ذلك، كانت هناك ارتباطات إيجابية ملحوظة بين سلالة البطين الأيمن الطولية والانحراف الانقباضي للمستوى الحلقي ثلاثي الشرفات (ص = 0.656) وكذلك الكسر القذفي (ص = 0.675) بينما تظهر الارتباطات السلبية مع حجم البطين الأيمن الانبساطي (ص = -0.684)، حجم نهاية الانقباضي للبطين الأيمن ( ص = -0.718)، مؤشر أداء عضلة القلب ( ص = -0.735)، و أقصى ضغط لجهاز التنفس الصناعي ( ص = -0.767).</p></div><div><h3>الاستنتاجات</h3><p>يعد تطبيق تتبع البقع مع \"معدل الإجهاد والانفعال\" البطيني الأيمن الطولي لتقدير وظيفة البطين الأيمن في رباعية فالوت التي تم إصلاحها طريقة جديدة ومتقدمة تعمل على تحسين تشخيص تشوهات عضلة القلب الإقليمية وسرعة حركة عضلة القلب بشكل كبير مقارنة بالصدى التقليدي.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002202/pdfft?md5=2322ee6dcc505a3d2bce743a9a0681ce&pid=1-s2.0-S1658361223002202-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138467504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymethylmethacrylate-hydroxyapatite antibacterial and antifungal activity against oral bacteria: An in vitro study","authors":"Tania Saskianti Ph.D ,&nbsp;Karina K. Wardhani BDS ,&nbsp;Naura Fadhila BDS ,&nbsp;Soegeng Wahluyo Ph.D ,&nbsp;Ardianti M. Dewi DDS ,&nbsp;Alexander P. Nugraha Ph.D ,&nbsp;Diah S. Ernawati Ph.D ,&nbsp;Masami Kanawa Ph.D","doi":"10.1016/j.jtumed.2023.11.001","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.11.001","url":null,"abstract":"<div><h3>Objective</h3><p>Reconstruction of alveolar bone defects resulting from aging, trauma, ablative surgery or pathology, remains a significant clinical challenge. The objective of this study was to investigate the antibacterial and antifungal activities of mixed polymethylmethacrylate-hydroxyapatite (PMMA-HA) against oral microorganisms. Our findings could provide valuable insights into the prospective application of PMMA-HA as a synthetic bone graft material to manage alveolar bone defects <em>via</em> tissue engineering.</p></div><div><h3>Methods</h3><p>HA powder was obtained from the Center for Ceramics in Indonesia and PMMA granules were obtained from HiMedia Laboratories; these were prepared in 20:80, 30:70, and 40:60 ratios. The antibacterial diffusion method was then performed against <em>Staphylococcus</em> <em>aureus</em>, <em>Aggregatibacter actinomycetemcomitans</em>, <em>Porphyromonas gingivalis</em>, and <em>Fusobacterium nucleatum</em>, while the antifungal diffusion method was used to test against <em>Candida albicans</em>. Standardized protocols were used for microbial culturing and inhibition zones were measured with digital calipers. Statistical analyses included one-way ANOVA and Kruskal–Wallis tests, supplemented by post-hoc Tukey HSD tests.</p></div><div><h3>Results</h3><p>A PMMA-HA scaffold with a 20:80 ratio demonstrated the highest antibacterial activity against <em>S. aureus</em>, <em>A. actinomycetemcomitans</em>, <em>P. gingivalis</em>, and <em>F. nucleatum</em>. This was followed by the 30:70 and 40:60 ratios in terms of antibacterial activity. Statistical significance was achieved with p &lt; 0.05 in comparison to controls. However, none of the PMMA-HA ratios showed antifungal activity against <em>C. albicans</em>.</p></div><div><h3>Conclusion</h3><p>PMMA-HA scaffolds have significant activity against bacteria, but not against fungi.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002135/pdfft?md5=3ea35c4a46cd05e04418f2729de902af&pid=1-s2.0-S1658361223002135-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138436350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the editor criticizing our recently published work","authors":"Mai E. Abbass Ph.D. ,&nbsp;Alaa M. El-Moatasem Ph.D.","doi":"10.1016/j.jtumed.2023.11.002","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.11.002","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002147/pdfft?md5=0710bce1614d54386ffe751380db5a68&pid=1-s2.0-S1658361223002147-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134657001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern sedative agents and techniques used in dentistry for patients with special needs: A review","authors":"Ruijia Yang BDS ,&nbsp;Rusin Zhao BDS ,&nbsp;Fatima Chaudry BDS ,&nbsp;Tao Wang BDS ,&nbsp;Paul Brunton PhD ,&nbsp;Zohaib Khurshid MRES ,&nbsp;Jithendra Ratnayake PhD","doi":"10.1016/j.jtumed.2023.10.004","DOIUrl":"https://doi.org/10.1016/j.jtumed.2023.10.004","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223001531/pdfft?md5=70cd6f6ca9c1bda01e254c247257f8cf&pid=1-s2.0-S1658361223001531-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134832906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immunomodulatory activity of Orthosiphon aristatus against atopic dermatitis: Evidence-based on network pharmacology and molecular simulations","authors":"Thigita A. Pandaleke M.D. ,&nbsp;Kusworini Handono Ph.D. ,&nbsp;Dhelya Widasmara Ph.D. ,&nbsp;Hani Susianti Ph.D.","doi":"10.1016/j.jtumed.2023.10.005","DOIUrl":"10.1016/j.jtumed.2023.10.005","url":null,"abstract":"<div><h3>Objectives</h3><p>To explore the potential activity of <em>Orthosiphon aristatus</em> (OA) against atopic dermatitis (AD).</p></div><div><h3>Methods</h3><p>Phytocompounds from OA were identified through chromatography analysis, then continued to target identification and functional annotation to explore the potential target of OA. Then, network pharmacology from annotated proteins determined protein targets for OA phytocompounds. Protein with highest rank according to the betweenness and closeness algorithm then continued to molecular docking and validated through molecular dynamics analysis.</p></div><div><h3>Results</h3><p>Chromatography data analysis revealed thirty-six compounds, predominantly classified as carboxylic acid, fatty acyls, and polyphenols. Upon identifying these compounds, network biology-based target identification revealed their potential bioactivity in modulating inflammation in AD. Tumour Necrosis Factor-alpha (TNF-α) and Prostaglandin G/H synthase 2 (PTGS2) emerged as the most probable targets based on hub centrality in the protein–protein interaction network. Later, molecular docking analyses highlighted sixteen compounds with good inhibitory activity against these two proteins. Notably, molecular dynamics simulation revealed that three compounds out of the previous sixteen potential compounds were more likely to act as the TNF-α and PTGS2 inhibitor as well as their native inhibitor. Those compounds are (1R,9R)-5-Cyclohexyl-11- (propylsulfonyl)-7,11- diazatricyclo[7.3.1.02,7]trideca- 2,4-dien-6-one, also known as ZINC8297940, as the best TNF-α inhibitor along with dl-Leucineamide and Benazol P as the potential inhibitor of PTGS2.</p></div><div><h3>Conclusions</h3><p>These findings suggest that OA may exert therapeutic effects against AD by controlling inflammation through TNF-α and PTGS2 signalling pathways.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223001543/pdfft?md5=3c17ea4d77f531e7511379a30f858621&pid=1-s2.0-S1658361223001543-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135411935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}