Journal of Taibah University Medical Sciences最新文献

{"title":"Team-based learning as a catalyst for interdisciplinary competencies in dental education","authors":"Surahman M.Si , Dedi Kuswandi M.Pd , Riza Amalia M.Si , Adellia Wardatus Sholeha M.Pd","doi":"10.1016/j.jtumed.2024.09.007","DOIUrl":"10.1016/j.jtumed.2024.09.007","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 990-991"},"PeriodicalIF":1.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why candidates choose MHPE: Between limited opportunities and the perception of an easy program","authors":"Rizky A. Pohan M.Pd , M. Ramli Ph.D , Adi Atmoko Ph.D , Sa'dun Akbar Ph.D , Erfan Ramadhani M.Pd , Rikas Saputra M.Pd , Ririn D. Astuti M.Pd","doi":"10.1016/j.jtumed.2024.10.005","DOIUrl":"10.1016/j.jtumed.2024.10.005","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 1035-1036"},"PeriodicalIF":1.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity promotion through digital technology among older adults with type 2 diabetes mellitus: A scoping review","authors":"Tina Agnes MPT , Ullas U. Nayak MPT , Muralidhar M. Kulakarni MD , G. Arun Maiya PhD","doi":"10.1016/j.jtumed.2024.10.001","DOIUrl":"10.1016/j.jtumed.2024.10.001","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 1024-1034"},"PeriodicalIF":1.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Science of case reporting: Integrating CARE guidelines for enhanced clinical significance","authors":"Shifa Israr MBBS, Muhammad Usama MBBS, Muhammad Ikrama MBBS","doi":"10.1016/j.jtumed.2024.09.006","DOIUrl":"10.1016/j.jtumed.2024.09.006","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 936-937"},"PeriodicalIF":1.5,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health status of children with autism spectrum disorder in KSA: A systematic review and meta-analysis","authors":"Faris Y. Asiri MDP&PH , Marc Tennant PhD , Estie Kruger PhD","doi":"10.1016/j.jtumed.2024.09.005","DOIUrl":"10.1016/j.jtumed.2024.09.005","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 938-946"},"PeriodicalIF":1.5,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertonic saline achieves superior brain relaxation in tumor craniotomy: An updated systematic-network meta-analysis","authors":"Khairunnisai Tarimah MD ,&nbsp;Lalu B. Bramawangsa MD ,&nbsp;Christian J. Suhardi MD ,&nbsp;Elvan Wiyarta MD ,&nbsp;Dewi Y. Bisri MD","doi":"10.1016/j.jtumed.2024.09.001","DOIUrl":"10.1016/j.jtumed.2024.09.001","url":null,"abstract":"<div><h3>Background</h3><div>Brain tumor craniotomy requires relaxation of the brain through decreasing the intracranial pressure (ICP). Osmo-hyperosmolar therapy can be used to lower the ICP.</div></div><div><h3>Objectives</h3><div>This study was aimed at updating previous studies to determine the effects and safety of using hypertonic saline (HTS) and mannitol to decrease ICP in adult patients with brain tumors undergoing craniotomy.</div></div><div><h3>Methods</h3><div>To identify randomized controlled trials (RCTs) comparing HTS vs mannitol, we performed a systematic literature search according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, by examining records from 2013 to December of 2023 in five databases. The primary outcome was brain relaxation, and the secondary outcomes were cerebral perfusion pressure (CPP), urine output (UO), fluid input, mean arterial pressure (MAP), and plasma sodium. Conventional meta-analysis, Bayesian meta-insight analysis, trial-sequential analysis, and trial quality assessment were conducted.</div></div><div><h3>Results</h3><div>Eleven RCTs involving 593 participants were included in the meta-analysis. Use of HTS, compared with mannitol, was associated with significantly greater brain relaxation, and significantly lower UO and fluid input. HTS was also significantly associated with elevated MAP. Plasma sodium was significantly higher in the HTS group than the mannitol group. No significant difference in CPP was observed between groups. Trial sequential analysis indicated true significance for the brain relaxation outcomes. Bayesian analysis demonstrated the superiority of 3% HTS at 5 ml/kg in achieving brain relaxation, followed by 3% HTS at 5.3 ml/kg and 20% mannitol at 5 ml/kg.</div></div><div><h3>Conclusions</h3><div>HTS is superior to mannitol in achieving optimal brain relaxation, maintaining stable blood flow, and minimizing diuretic effects. However, use of HTS during tumor craniotomy procedures can increase plasma sodium levels. The optimal dose for achieving brain relaxation appears to be 3% HTS at 5 ml/kg body weight.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 961-973"},"PeriodicalIF":1.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of Scabiosa columbaria in Alzheimer's disease treatment: An in silico approach","authors":"Riyan A.P. Irsal M.Si ,&nbsp;Gusnia M. Gholam M.Si ,&nbsp;Maheswari A. Dwicesaria M.Si ,&nbsp;Tiyara F. Mansyah S.Si ,&nbsp;Fernanda Chairunisa M.Si","doi":"10.1016/j.jtumed.2024.09.003","DOIUrl":"10.1016/j.jtumed.2024.09.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Alzheimer's disease (AD) is posing an increasing global threat and currently lacks effective treatments. Therefore, this study was aimed at exploring phytochemicals in <em>Scabiosa columbaria</em> (<em>S. columbaria</em>) as inhibitors of acetylcholinesterase (AChE), β-site APP cleavage enzyme 1 (BACE1), and TNF-α converting enzyme (TACE) in AD. <em>S. columbaria</em> contains various bioactive compounds, such as chlorogenic acid, linalool, and catechins, which are known for their detoxification properties, capacity to resist and manage harmful moisture buildup, and therapeutic roles in COVID-19. Several studies have also shown that <em>S. columbaria</em> extract has strong antioxidant activity, and may potentially decrease neuroinflammation in AD. Therefore, this study investigated the interactions between <em>S. columbaria</em> phytochemicals and key enzymes associated with AD, thus providing opportunities for the development of new therapeutic candidates.</div></div><div><h3>Methods</h3><div>A total of 27 phytochemicals were evaluated for their inhibitory activity against AChE, BACE1, and TACE with YASARA Structure. ADMET profiles and toxicity were assessed. The top candidate compounds underwent 100 ns MD simulations.</div></div><div><h3>Results</h3><div>All ligands met Lipinski's rule and showed low toxicity. Catechins, compared with the known drug galantamine, showed higher inhibitory activity and interacted with additional active sites on AChE, thus suggesting potentially higher efficacy. Moreover, chlorogenic acid showed stronger inhibitory activity against TACE than the control drug (aryl-sulfonamide), thereby suggesting a different mechanism of action. MD simulation revealed that the formed complexes had good stability. However, further exploration is necessary.</div></div><div><h3>Conclusion</h3><div><em>S. columbaria</em> derivative compounds are promising drug candidates because of their properties, including the affinity of chlorogenic acid toward TACE and hydrogen bond enhancing ligand–receptor interactions. MD simulation indicated stable ligand–protein complexes, and the radius of gyration and MM-PBSA calculations revealed favorable binding and interaction energies. Our findings demonstrate the identified compounds' potential for further drug development.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 947-960"},"PeriodicalIF":1.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting to Gen Z: Innovative educational strategies in medical education","authors":"Riza Amalia M.Si. ,&nbsp;Ajeng Ayu Widiastuti M.A. ,&nbsp;Alwita Susanti S.ST ,&nbsp;Muhammad Sandy Al Fath M.Pd.","doi":"10.1016/j.jtumed.2024.08.029","DOIUrl":"10.1016/j.jtumed.2024.08.029","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 934-935"},"PeriodicalIF":1.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S165836122400101X/pdfft?md5=033dd46abc37f6d00a7e5f0731c4c9be&pid=1-s2.0-S165836122400101X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical arterial blood lactate as predictor of early neonatal outcome and evaluation of intrapartum asphyxia","authors":"Olufemi M. Badmus FWACS,&nbsp;Olaide R. Adenaya FWACS,&nbsp;Oluseyi A. Aderinwale FWACS,&nbsp;Bernard O. Ewuoso FWACS,&nbsp;Babatunde S. Awolaja FWACS,&nbsp;Adedoyin O. Ade-Onojobi FWACS","doi":"10.1016/j.jtumed.2024.08.027","DOIUrl":"10.1016/j.jtumed.2024.08.027","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 911-918"},"PeriodicalIF":1.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224000994/pdfft?md5=f658f180e4c2ff3ab8983f3d612f096c&pid=1-s2.0-S1658361224000994-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-lasting effects of post-traumatic stress disorder in Yazidi women living in Northern Iraqi camps","authors":"Kajeen H. Jasim MSc ,&nbsp;Suad Y. Alkass PhD ,&nbsp;Daniele S. Persike PhD","doi":"10.1016/j.jtumed.2024.08.028","DOIUrl":"10.1016/j.jtumed.2024.08.028","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"19 5","pages":"Pages 919-933"},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361224001008/pdfft?md5=2d4529c5938b117f32d7fc1ad4f8a3bb&pid=1-s2.0-S1658361224001008-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}