Journal of Taibah University Medical Sciences最新文献

{"title":"Expression of alpha-smooth muscle actin in salivary mucoepidermoid and adenoid cystic carcinomas: A comparative immunohistochemical study","authors":"Shatha A. Alsalman Ph.D Lecturer ,&nbsp;Israa M. Alsudani FIBMS professor ,&nbsp;Sultan L. Al-Janabi Medical Student","doi":"10.1016/j.jtumed.2025.09.006","DOIUrl":"10.1016/j.jtumed.2025.09.006","url":null,"abstract":"<div><h3>Background</h3><div>Alpha-smooth muscle actin (α-SMA) is crucial in fibrogenesis. Salivary gland tumor types exhibit varying degrees of α-SMA expression because myoepithelial cells play diverse roles in their formation. The present study compared the immunohistochemical expression of α-SMA in mucoepidermoid and adenoid cystic carcinoma according to the grades and variants.</div></div><div><h3>Methodology</h3><div>Sections of formalin-fixed, paraffin-embedded tissue blocks obtained from 50 cases of salivary gland carcinoma from 2011 to 2021 were stained using α-SMA monoclonal antibodies for immunohistochemical analysis.</div></div><div><h3>Results</h3><div>The mean α-SMA scores did not differ significantly among the three mucoepidermoid carcinoma histology levels. No notable variations in α-SMA expression were observed in the mucoepidermoid carcinoma cases analyzed. By contrast, high-grade adenoid cystic carcinoma cases had substantially higher α-SMA scores than cases with low or intermediate grades. The α-SMA scores did not differ significantly between the low and intermediate grades. Among the histological variants, more cases with highly significant α-SMA scores were found in solid types compared with tubular, cribriform, or combined types. Furthermore, patients with cribriform growth had significantly higher α-SMA scores than those with tubular tumor growth. Overall, the percentage of high reactivity (expression) (α-SMA score 4+) was significantly higher in adenoid cystic carcinoma cases than mucoepidermoid carcinoma cases.</div></div><div><h3>Conclusions</h3><div>These findings highlight the importance of α-SMA as a tumor marker for differentiating between mucoepidermoid and adenoid cystic carcinoma in terms of the tumor grading, histological variant, and expression.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 719-725"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimensional accuracy and degree of conversion of a novel self-polymerized acrylic resin modified with chlorhexidine–halloysite nanotubes: An in vitro controlled study","authors":"Nadia Al Ansari PhD ,&nbsp;Suhad Sadeq MSc ,&nbsp;Mushriq Abid PhD ,&nbsp;Hassan Abed PhD ,&nbsp;Rayan Sharka PhD","doi":"10.1016/j.jtumed.2025.10.003","DOIUrl":"10.1016/j.jtumed.2025.10.003","url":null,"abstract":"<div><h3>Objectives</h3><div>The integration of chlorhexidine-loaded halloysite nanotubes (CHX/HNTs) into acrylic-based orthodontic devices is a promising preventive measure to mitigate microbial proliferation under removable orthodontic appliances. The study was aimed at evaluating the physical properties of acrylic resin, particularly the degree of conversion (DC) and dimensional accuracy, after the integration of a novel CHX/HNT antimicrobial nanomaterial.</div></div><div><h3>Methods</h3><div>Fifty rectangular acrylic polymethyl methacrylate specimens were prepared with varying concentrations of CHX-HNTs. The degree of conversion was assessed using Fourier transform infrared spectroscopy. Dimensional accuracy was measured with digital caliper, which was used to assess the acrylic indentation dimensions before and after water immersion at multiple time points. Statistical comparisons were performed using one-way ANOVA, Tukey’s tests, and Bonferroni testing following repeated measures ANOVA.</div></div><div><h3>Results</h3><div>All experimental groups showed a significantly lower DC than the control group (<em>P</em> ≤ 0.05). No statistically significant differences in the mean dimensions of the control and modified acrylic resins were found at all concentrations of integrated CHX-HNT nanofillers before immersion in water. After water immersion, the control samples, compared with the CHX/HNT nanocomposite samples, showed statistically significant dimensional expansional differences (<em>P</em> ≤ 0.05) directly proportional to the immersion duration.</div></div><div><h3>Conclusions</h3><div>Incorporation of CHX/HNT nanofillers negatively affected the DC but enhanced the dimensional stability of PMMA acrylic resin for as long as 60 days.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 762-771"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the new characteristics of professionalism in nursing from the perspective of experts: A qualitative Study","authors":"Sakineh Parastesh PhD Student ,&nbsp;Mohammadali Hosseini PhD ,&nbsp;Farahnaz Mohammadi-Shahbolaghi PhD ,&nbsp;Sadat S.B. Maddah PhD ,&nbsp;Abbas Ebadi PhD","doi":"10.1016/j.jtumed.2025.09.003","DOIUrl":"10.1016/j.jtumed.2025.09.003","url":null,"abstract":"<div><h3>أهداف البحث</h3><div>أصبحت الاحترافية مؤخرا من أهم القضايا في مهنة التمريض. يرى الممرضون أن المشكلة الرئيسية التي تؤثر على الاحترافية هي إهمال رأي الخبراء في تحديد وتطوير مؤشرات الاحترافية في التمريض. تناولت هذه الدراسة خصائص الاحترافية في التمريض من وجهة نظر الخبراء.</div></div><div><h3>طرق البحث</h3><div>تُعد هذه الدراسة الجزء الثاني من تحليل مفاهيمي للاحترافية في التمريض (مقابلة شبه منظمة)، والذي أُجري باستخدام أسلوب تحليل المحتوى النوعي. شملت الدراسة 17 خبيرا من أعضاء هيئة التدريس في التمريض، وثلاثة مديري تمريض، ورئيسي تمريض، وممرضين سريريين ذوي خبرة، وطبيبين عامين، ومديري مستشفيات، والذين تم اختيارهم من ست جامعات للعلوم الطبية. تم اختيارهم باستخدام أسلوبي العينة الهادفة والتراكمية، وأُجريت معهم مقابلات. تم تحليل البيانات باستخدام أسلوب تحليل المحتوى الاستنتاجي والموجه.</div></div><div><h3>النتائج</h3><div>بعد تحليل البيانات، تم الحصول على 954 رمزا أوليا، و22 فئة فرعية، وتسع فئات رئيسية. شملت الفئات الرئيسية (خصائص الاحترافية في التمريض): \"المعرفة الأكاديمية المتخصصة\"، و\"السعي المستمر للكفاءة\"، و\"الالتزام بالمدونات والقيم الأخلاقية\"، و\"الالتزام المهني\"، و\"المساءلة\"، و\"الاستقلالية\"، و\"الدعوة\"، و\"التفاعل المهني\"، و\"الوعي الذاتي المهني\". يُعد إدراج فئة \"الوعي الذاتي المهني\" في مصفوفة مراجعة الأدبيات مساهمة مبتكرة لهذه الدراسة. وقد شكّلت هذه الإضافة أساسا لتطوير نموذج مفاهيمي جديد للاحترافية في التمريض.</div></div><div><h3>الاستنتاجات</h3><div>يمكن للإطار المفاهيمي الذي طُوّر في هذه الدراسة أن يُثري السياسات الهادفة إلى جذب الأفراد المؤهلين إلى مهنة التمريض. يُعد الفهم الواضح لسمات الاحترافية، وخاصة الوعي الذاتي المهني، أمرا أساسيا لدخول المهنة. ويمكن لهذا الوعي أن يُعزز المثابرة والرضا الوظيفي لدى الممرضين، بالإضافة إلى المساهمة في تحسين جودة الرعاية وتعزيز رضا العملاء.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 673-686"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The benefits and challenges of blockchain in healthcare supply chain management in KSA: A systematic review","authors":"Rakan B. Aldosari Msc ,&nbsp;Farah M. Kalmey PhD ,&nbsp;Abdullah T. Alanazi PhD ,&nbsp;Ashraf A. A'aqoulah PhD","doi":"10.1016/j.jtumed.2025.07.016","DOIUrl":"10.1016/j.jtumed.2025.07.016","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Blockchain is a cutting-edge innovation being applied to offer innovative solutions in various fields, including healthcare. The healthcare industry uses blockchain networks to store and distribute patient data across hospitals, physicians, diagnostic labs, and pharmaceutical firms. Blockchain applications are essential in the healthcare industry for identifying crucial fallacies that might be fatal. The effectiveness, security, and transparency in exchanging medical data may thus be improved in the healthcare industry. This technology may also aid medical institutions in procuring information and analysing patient data.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Aim&lt;/h3&gt;&lt;div&gt;To examine the published papers that discussed the ability of utilization and probable challenges of blockchain technology in KSA's healthcare supply chain management.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Until February 10, 2023, the prime databases: Pub Med, Science Direct, Scopus, Google Scholar, Web of science, Embase and The Cochrane Library were searched. Published studies (except case reports), commentaries, editorials, reviews, and meta-analysis reporting on the use of blockchain technology in healthcare supply chain management were included and a Preferred Reporting Items of systematic Reviews and Meta-analyses (PRISMA) flow diagram was used to present the process. To assess risk of bias and the quality of the included studies, the Joanna Briggs Institute's (JBI) critical evaluation tools were implemented.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 22 studies were included and most of them used blockchain in technology for ensuring transparency, security, and storage of electronic health or medical records. Patients benefited from seamless electronic health records provided by a multi-level blockchain eHealth system. It was observed that blockchain technology effectively addresses clinical trial misconduct, and its potential in this area is to boost data productivity for the healthcare sector. The distinctive data storage pattern of blockchain offers a high-security standard that potentially reduces concerns about data tampering. It provides flexibility, accountability, connection, and data access authentication. Blockchain helps the healthcare sector avoid certain risks and offers decentralized data protection. In our study, we observed that the most preferred network for integrating the healthcare authority, manufacturer, wholesaler, retailer, and service was Ethereum (ETH).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Healthcare policymakers should implement blockchain in Healthcare Supply Chain Management. Moreover, they need to be aware that the primary issues with blockchain technology in the healthcare industry are the lack of practical applications, the high rate of failed initiatives, and the requirement for collaboration between diverse stakeholders. However, there is a lack of studies on how to evaluate the acceptability and assist healthcare organis","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 612-621"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking and In-Silico pharmacokinetic analysis of 1,3-benzothiazole-2-amine derivatives as anticonvulsants","authors":"Ahmed Rufa’i MSc ,&nbsp;Abdullahi Y. Idris PhD ,&nbsp;Aliyu M. Musa PhD ,&nbsp;Halimatu S. Hassan PhD ,&nbsp;Asma’u H. Nasiru PhD ,&nbsp;Mohammed G. Magaji PhD","doi":"10.1016/j.jtumed.2025.08.002","DOIUrl":"10.1016/j.jtumed.2025.08.002","url":null,"abstract":"<div><h3>الأهداف</h3><div>تعتبر المشتقات التي تحمل مجموعة الثيازول من المواد الدوائية المهمة جدًا في الكيمياء الطبية نظرًا لخصائصها الدوائية الواسعة. البنزوثيازول هو سقالة مهمة مع مجموعة من النشاط البيولوجي والاستخدامات العلاجية، بما في ذلك خصائص مضادة للبكتيريا، ومضادة للملاريا، ومضادة للتشنجات، ومسكنة للألم، ومضادة للالتهابات، ومضادة لمرض السكري، ومضادة للسرطان. يقوم هذا العمل بتقييم السمات الدوائية الحركية الحاسوبية لـ 15 مشتقًا من 1،3-بنزوثيازول-2-أمين (نظائر) وتفاعلاتها مع هدفين أساسيين للصرع: حمض غاما أمينوبوتيريك-أمينوترانسفيراز (GABA-AT) وأيون الصوديوم المفتوح المنشط بروتينات القناة (Nav<em>Ms</em>).</div></div><div><h3>الطريقة</h3><div>تم تصميم وتحسين التركيب الكيميائي للمشتقات باستخدام برنامجي MarvinSketch و Spartan. تمت دراسة السمات الدوائية الحركية باستخدام خادم SwissADME. تم إجراء الالتحام الجزيئي باستخدام Autodock Vina وChimera وDiscovery Studio Visualizer</div></div><div><h3>النتائج</h3><div>فشلت أربعة نظائر (2، 5، 6، و7) في اختبار اختراق حاجز الدم الدماغي (BBB)، في حين أظهرت إحدى عشر من النظائر الخمسة عشر خصائص حركية دوائية جيدة. وأظهرت نتائج التحقق أن الإجراء المستخدم كان مناسبًا لتحليل الالتحام الجزيئي لنظائر الاختبار في المواقع النشطة للبروتينين المستهدفين. عند المقارنة مع الدواء المرجعي فيجاباترين (-5.2 كيلو كالوري/مول)، أظهرت سبعة نظائر (A₁، A₃، A₉، A₁₀، A₁₁، A₁₂، وA₁₄) تقارب ارتباط أعلى (-5.9، -5.8، -6.1، -5.9، -6.0، -6.1، و-6.6 كيلو كالوري/مول، على التوالي). ربط GABA-AT. فيما يتعلق بربط NavMs، أظهر A14 التناظري فقط تقاربًا للربط يبلغ 5.0 كيلو كالوري/مول، وهو ما كان مماثلاً لذلك الخاص بالدواء المرجعي، لاموتريجين.</div></div><div><h3>الاستنتاجات</h3><div>كشفت التحقيقات الحاسوبية عن مركبات بنزوثيازول ذات خصائص مضادة للتشنج عالية، مما يجعلها مرشحة مناسبة للتوليف والاختبار الدوائي.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 629-642"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health sector transformation in Saudi Arabia—The modern healthcare model: A qualitative study among healthcare leaders","authors":"Abeer Alharbi PhD ,&nbsp;Mohammed Aljuaid PhD ,&nbsp;Fahad A. Alamri MHA ,&nbsp;Shoroq N. Alosaimi MHA ,&nbsp;Sarah Aldeijy MHA","doi":"10.1016/j.jtumed.2025.08.006","DOIUrl":"10.1016/j.jtumed.2025.08.006","url":null,"abstract":"<div><h3>أهداف البحث</h3><div>هدفت هذه الدراسة إلى دراسة التغييرات في تقديم الرعاية الصحية في المملكة العربية السعودية وفقا لنموذج الرعاية الصحية الحديث، استنادا إلى وجهات نظر وتجارب قادة الرعاية الصحية، باستخدام نظرية التعقيد لفهم هذه التغييرات.</div></div><div><h3>طرق البحث</h3><div>استخدمت هذه الدراسة النوعية عينة هادفة من ثمانية مشاركين، والتي اعتُبرت كافية لتحديد المواضيع عبر البيانات. جُمعت البيانات من خلال مقابلات شبه مهيكلة بين أكتوبر 2024 وديسمبر 2024. تناولت الأسئلة تحديد خلفيات المشاركين وأدوارهم في المؤسسة؛ وعوامل تمكين وتحديات تطبيق نموذج الرعاية الصحية الحديث؛ والتغييرات التحولية الرئيسية في النظام الصحي؛ وآثار هذه التغييرات على السكان.</div></div><div><h3>النتائج</h3><div>تقدم هذه الدراسة خمسة محاور رئيسية ومحورا فرعيا واحدا مستمدا من تحليل شامل للبيانات. وشملت المحاور الرئيسية: تعزيز الصحة والوقاية من الأمراض؛ والحصول على الرعاية؛ والرعاية الافتراضية ورقمنة الرعاية الصحية؛ وكفاءة النظام وقيمته؛ والتغيير الثقافي. وكانت الرعاية الصحية الأولية والتكامل هي المحور الفرعي المنبثق عن المحور الرئيسي (الحصول على الرعاية).</div></div><div><h3>الاستنتاجات</h3><div>أشارت النتائج إلى أن نموذج الرعاية الصحية للأمهات، الذي يُركز على الوقاية، والحلول الرقمية، والرعاية الصحية الأولية، وتكافؤ الفرص، والانتقال السلس بين أنظمة الرعاية، قد أثر إيجابا على كفاءة النظام وقيمته. إضافة إلى ذلك، قد تواجه هذه التغييرات المستمرة في قطاع الرعاية الصحية العامة تحديات، لا سيما فيما يتعلق بالوعي العام ومقاومة التغيير.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 643-653"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting norovirus RdRp: A computational study on the inhibitory potential of ursolic acid and apigenin-7-O-glucoside","authors":"Mansoor Alsahag PhD","doi":"10.1016/j.jtumed.2025.09.007","DOIUrl":"10.1016/j.jtumed.2025.09.007","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Norovirus is a highly contagious pathogen responsible for significant global morbidity and mortality due to severe gastrointestinal illnesses, particularly in settings such as schools, hospitals, and cruise ships. Despite its impact on public health, no effective antiviral treatments or vaccines are currently available. This study seeks to identify natural compounds with inhibitory potential against the Norovirus RNA-dependent RNA polymerase (RdRp), an essential enzyme in viral replication. By focusing on phytochemicals, the research aims to propose novel, safe, and effective antiviral agents that could serve as alternatives to synthetic drugs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A comprehensive in silico approach was employed to screen and evaluate potential inhibitors of Norovirus RdRp. Candidate compounds were first assessed through pharmacokinetic (ADMET) analysis to evaluate their absorption, distribution, metabolism, excretion, and toxicity profiles, ensuring drug-likeness and safety. Toxicological profiling further confirmed the absence of harmful effects in the selected compounds. Molecular docking studies were performed to predict the binding affinities of natural compounds with the RdRp protein (PDB ID: 3ur0), identifying those with the strongest interactions. Molecular dynamics (MD) simulations were then conducted to assess the dynamic stability of the protein-ligand complexes under physiological conditions. Finally, MM-GBSA binding free energy calculations were used to quantitatively validate the strength and stability of the interactions between the compounds and the target protein.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The study identified two lead compounds, Ursolic Acid (CID_64945) and Apigenin-7-O-glucoside (CID_5280704), as potential inhibitors of Norovirus RdRp. Molecular docking studies revealed strong binding affinities, with Ursolic Acid showing a binding score of −8.8 kcal/mol and Apigenin-7-O-glucoside displaying a score of −8.7 kcal/mol. Pharmacokinetic and toxicological evaluations confirmed that both compounds exhibit excellent ADMET profiles, demonstrating favorable absorption, metabolic stability, and minimal toxicity, making them suitable for drug development. Molecular dynamics simulations validated the stability of interactions between the RdRp protein and the two lead compounds over time, with the protein-ligand complexes maintaining consistent and robust interactions throughout the simulation period. MM-GBSA calculations further supported the efficacy of these compounds, as they demonstrated stable and energetically favorable binding to the target protein. Both Ursolic Acid and Apigenin-7-O-glucoside are phytochemicals found in commonly available plants such as rosemary and holy basil, enhancing their accessibility and feasibility for therapeutic use.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study identifies Ursolic Acid and Apigenin-7-O-glucoside as promising natural inhibitors of","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 696-708"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic purchasing through online pharmacies: A mystery shopper study","authors":"Norah O. Abanmy PhD,&nbsp;Sarah A. Alshehri Pharm D,&nbsp;Renad A. Alsudais Pharm D","doi":"10.1016/j.jtumed.2025.09.002","DOIUrl":"10.1016/j.jtumed.2025.09.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The illegal sale of antibiotics through online pharmacies (OPs) can lead to misuse and poses major health risks, because drug quality and authenticity are not ensured. This study was aimed at investigating the extent of illegal online antibiotic sales from both local and international OPs.</div></div><div><h3>Material and <strong>Methods</strong></h3><div>A mystery shopper study was conducted on topical clindamycin, oral amoxicillin, and amoxicillin/clavulanic acid. A search term for each antibiotic in both English and Arabic was used to search Google, Bing, and Yahoo. The first 20 results were obtained, examined, and evaluated according to predetermined criteria. Purchasing was performed according to a systematic approach, to explore whether OPs would sell antibiotics without valid prescriptions, accept outdated prescription, or reject sales.</div></div><div><h3>Results and Discussion</h3><div>At the 60 OPs identified, 22 purchases were made, and ten products were successfully delivered, all from local OPs. Some international OPs requested Bitcoin payment and therefore appeared to be potential scam websites. A substantial number of OPs did not adhere to regulatory requirements, and 33.3 % (20 of 60) did not request prescriptions. Among those OPs, 45 % (9 of 20) were fake, and 45 % (9 of 20) sold topical clindamycin. Whereas 96.7 % of OPs provided contact details, only 13.3 % had quality certifications. Return policies were displayed by 85 % of OPs, and 88.3 % displayed drug information and related warnings, including adverse effects and interactions.</div></div><div><h3>Conclusion</h3><div>Our findings underscore the urgent need for stricter regulations and enhanced monitoring of OPs. However, searching of the dark web, which is known to have illegal marketplaces offering prescription drugs, particularly antibiotics, was not investigated.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 687-695"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imposter phenomenon; prevalence and associated factors among family medicine residents in Riyadh city, KSA","authors":"Abdulrahman Bamhair MD,&nbsp;Salem Alshahrani MD,&nbsp;Mohammed Alqahtani MD,&nbsp;Abdulelah Alotaibi MD,&nbsp;Omar Alghamdi MD, FMSB","doi":"10.1016/j.jtumed.2025.08.001","DOIUrl":"10.1016/j.jtumed.2025.08.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Imposter syndrome (IS) is a psychological phenomenon characterized by persistent self-doubt and fear of being exposed as incompetent despite clear evidence of competence. This study was aimed at determining the prevalence of IS, and identifying associated demographic predictors, among family medicine residents in Riyadh, KSA.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted among family medicine residents from multiple training centers in Riyadh using a self-administered questionnaire that included the Clance Impostor Phenomenon Scale (CIPS). Sociodemographic data were also collected.</div></div><div><h3>Results</h3><div>A total of 268 residents participated (mean age 26.1 ± 1.8 years; 63.4% males). The mean IS score was 50.8 ± 13.0 with a median of 51 (IQR 41–60). Over half (53.7%, n = 144) were in the moderate IS category, 23.1% (n = 62) reported few IS characteristics, 21.3% (n = 57) experienced frequent IS, and 1.9% (n = 5) had intense IS symptoms. Distribution of IS categories differed significantly across training centers (p &lt; 0.001). Marital status was associated with IS severity (p = 0.037), as married residents more often reported fewer IS characteristics (30.3%) compared with single residents (20.8%). Age (p = 0.684), gender (p = 0.714), and first-generation physician status (p = 0.461) showed no significant associations.</div></div><div><h3>Conclusion</h3><div>IS was highly prevalent among family medicine residents in Riyadh, with most experiencing moderate-to-frequent symptoms. Considering factors such as residency year and marital status, and providing robust psychosocial support, may help reduce IS severity. Future studies should use longitudinal designs to explore causal pathways and extend findings to other medical specialties and regions.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational emotive behavior therapy for preventing smoking initiation among school children: Addressing peer influence and social susceptibility","authors":"Sari Wardani Simarmata S.Pd., M.Pd.A ,&nbsp;Azizah Batubara M.Pd ,&nbsp;Dony Darma Sagita S.Pd., M.Pd., Kons ,&nbsp;Erwita Ika Violina M.Pd ,&nbsp;Akhmad Syaikhu M.Pd ,&nbsp;Juliana Simangunsong M.Th","doi":"10.1016/j.jtumed.2025.09.008","DOIUrl":"10.1016/j.jtumed.2025.09.008","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 726-727"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}