Journal of Taibah University Medical Sciences最新文献

{"title":"Nephroprotective Effect of L-Carvone on a Mouse Model of LPS-Induced Sepsis-Associated Renal Injury via Regulation of TLR4/NF-κB/AP-1/IRF-3 and Nrf2/iNOS Molecular Signaling Cascades","authors":"Saja M. Shareef PhD (Pharmacology and Toxicology) ,&nbsp;Sarmed H. Kathem PhD (Pharmacology and Toxicology) ,&nbsp;Hayder Ridha-Salman PhD (Pharmacology)","doi":"10.1016/j.jtumed.2025.12.008","DOIUrl":"10.1016/j.jtumed.2025.12.008","url":null,"abstract":"<div><h3>Background</h3><div>LPS-evoked endotoxemia triggers systemic inflammation and can cause multi-organ damage, with the kidneys being particularly vulnerable. L-carvone is a natural monoterpene with strong antimicrobial, cytoprotective, and immunomodulatory benefits.</div></div><div><h3>Objective</h3><div>This study was aimed at exploring the influence of L-carvone on LPS-aggravated sepsis-associated renal impairment in mice.</div></div><div><h3>Methods</h3><div>A total of 32 male albino-type mice were randomly divided into six groups: untreated control group, sepsis model group (LPS 10 mg/kg single dose), vehicle group (oral corn oil for 5 days before LPS injection), and three intervention groups orally pre-treated with low (25), moderate (50), or high (100) mg/kg doses of L-carvone for 5 continuous days before LPS challenge.</div></div><div><h3>Results</h3><div>L-carvone markedly decreased levels of KIM-1, BUN, and creatinine, and reversed renal histological aberrations. It downregulated TLR4, NF-κB, AP-1, IRF-3, and iNOS renal expression, while upregulating Nrf2 transcription in a dose-dependent manner, thus decreasing interleukin (IL)-1β and TNF-α concentrations. L-carvone further ameliorated pro-apoptotic Bax levels, increased anti-apoptotic Bcl-2, inhibited MDA production, and enhanced SOD activity.</div></div><div><h3>Conclusion</h3><div>L-carvone effectively mitigates sepsis-related renal impairment by counteracting inflammatory, oxidative, and apoptotic mechanisms, thus supporting its translational therapeutic promise.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"21 1","pages":"Pages 49-66"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of gold nanoparticles and apricot seeds on bone healing in New Zealand rabbits","authors":"Zena J. Wally PhD ,&nbsp;Bushra H. Al-Maula PhD ,&nbsp;Sahar G. AL-Kazzaz PhD ,&nbsp;Rasha H. Dosh PhD ,&nbsp;Wasna'a M. Abdulridh PhD ,&nbsp;Suhad J. Hamed Al-Nasrawi PhD ,&nbsp;Julfikar Haider PhD","doi":"10.1016/j.jtumed.2025.11.006","DOIUrl":"10.1016/j.jtumed.2025.11.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Suboptimal osseointegration of implant materials is linked to oxidative stress and compromised bone regeneration. Gold nanoparticles (Au NPs) function as anti-inflammatory and osteogenic agents, promoting bone growth by reducing cell damage and enhancing cellular activity. Apricot seeds contain amygdalin, a natural antioxidant and osteogenic substance. This study aimed to evaluate the impacts of Au NPs and apricot seed extract on bone healing in a rabbit model.</div></div><div><h3>Methods</h3><div>Twelve adult male New Zealand white rabbits were assigned to three groups: untreated (control), Au NPs treated, and apricot seed treated groups. Six holes were surgically drilled in the tibiae (right/left) of each animal. Each hole was injected with 0.3 mL of Au NPs or apricot seed liquid extract. Histological analysis was performed after 7 and 14 days of healing using hematoxylin and eosin (H&amp;E)-stained bone samples, which were cut around the holes in all test animals. Light microscopy and S-EYE 2.0 software were used to count blood vessels, osteoblasts, osteocytes, and bone marrow spaces.</div></div><div><h3>Results</h3><div>Local application of apricot seeds and Au NPs decreased vascularization and bone marrow spaces, and stimulated bone-forming cells, where Au NPs were more effective. Treatment with Au NPs significantly lowered the number of blood vessels after 14 days to the smallest value (2.6 ± 0.96) recorded under all treatments. By day 14, the numbers of osteoblasts (45.1 ± 4.36) and osteocytes (60.0 ± 7.71) were significantly higher under treatment by Au NPs compared with the control.</div></div><div><h3>Conclusion</h3><div>Au NPs and the natural agent apricot seed extract enhanced osteoblasts and osteocytes in a rabbit model, and could potentially promote bone regeneration. However, these observations should be interpreted cautiously considering the limitations of this study, such as its retrospective design and single-center sample. These findings are an essential preliminary clinical step required to justify future human studies.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"21 1","pages":"Pages 78-90"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lunar synchronization of hemostasis and immunity validates prophetic timing of hijama therapy: A multicenter study from Yemen","authors":"Naif T. Ali PhD ,&nbsp;Radfan S. Abdullah PhD ,&nbsp;Ibrahim Ahmed Bsc ,&nbsp;Othman Mohammed Bsc ,&nbsp;Akram Jamal Bsc ,&nbsp;Fawaz Ahmed Bsc ,&nbsp;Bushra Dahan Bsc ,&nbsp;Alawy Adel Bsc ,&nbsp;Tofaha Abdullah Bsc ,&nbsp;Monther Saleh Bsc ,&nbsp;Shadia Hamid Bsc ,&nbsp;Naif Mohammed Bsc ,&nbsp;Khawla Mohammed Bsc ,&nbsp;Yaqoub Khalid Bsc ,&nbsp;Sabran Nabil Bsc ,&nbsp;Abdulmajeed Abdualkareem Bsc","doi":"10.1016/j.jtumed.2025.12.004","DOIUrl":"10.1016/j.jtumed.2025.12.004","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"21 1","pages":"Pages 33-40"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From rivalry to synergy: Calibration of PBL and TBL for medical learning outcomes","authors":"Akhmad Syaikhu M.Pd. ,&nbsp;Dony D. Sagita S.Pd., M.Pd., Kons ,&nbsp;Mudayat M.Pd","doi":"10.1016/j.jtumed.2025.11.003","DOIUrl":"10.1016/j.jtumed.2025.11.003","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 6","pages":"Pages 833-834"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of spirulina supplementation on growth parameters in malnourished children: A systematic review and meta-analysis","authors":"Ima Sukmawati MPH ,&nbsp;Heri Ariyanto M.Kep ,&nbsp;Heni Heryani M.KM ,&nbsp;Sri W. Sundari M.Keb ,&nbsp;Miftahul Falah PhD ,&nbsp;Dika Rhousnaka BSN ,&nbsp;Yuyun Rahayu M.Kep ,&nbsp;Fitri Arofiati PhD ,&nbsp;Anna L. Yusuf M.Farm ,&nbsp;Sri Susilawati M.Keb ,&nbsp;Henri Setiawan PhD","doi":"10.1016/j.jtumed.2025.10.008","DOIUrl":"10.1016/j.jtumed.2025.10.008","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effectiveness of spirulina supplementation in improving growth parameter outcomes among malnourished children.</div></div><div><h3>Methods</h3><div>This study followed a systematic review and meta-analysis design. The inclusion criteria were experimental spirulina supplementation studies in children with chronic malnutrition, which were published in English between 2006 and 2025. Studies involving adult participants, and literature reviews, systematic reviews, and comprehensive reviews were excluded. A comprehensive search was conducted across five electronic databases: PubMed, Scopus, Wiley, ProQuest, and Emerald Insight. The quality of the included studies was assessed with the Joanna Briggs Institute Critical Appraisal Checklist. Data were quantitatively synthesized in Review Manager version 5.4. This review was prospectively registered in PROSPERO (CRD420251069286).</div></div><div><h3>Results</h3><div>Seven studies in 1335 participants met the inclusion criteria. The meta-analysis indicated significant increases in weight (SMD = 0.33, 95 % CI [0.22, 0.45], <em>p</em> &lt; 0.00001, I² = 95 %) and MUAC (SMD = 0.71, 95 % CI [0.31, 1.11], <em>p</em> = 0.0005, I² = 67 %), but no significant effect on height (SMD = −0.25, 95 % CI [−1.36, 0.85], <em>p</em> = 0.65, I² = 98 %), among children receiving spirulina supplementation.</div></div><div><h3>Conclusion</h3><div>Spirulina supplementation was found to have significant positive effects on weight and MUAC in children with chronic malnutrition, but no significant improvement in height. These findings support spirulina's potential role as a complementary intervention in nutritional programs targeting undernourished children.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 6","pages":"Pages 809-819"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of breast reconstruction on quality of life among women after mastectomy","authors":"Anthony M. Ban PhD candidate ,&nbsp;Branka V. Ličanin PhD candidate","doi":"10.1016/j.jtumed.2025.11.010","DOIUrl":"10.1016/j.jtumed.2025.11.010","url":null,"abstract":"<div><h3>أهداف البحث</h3><div>تُعدّ إعادة بناء الثدي بعد الاستئصال جزءًا مهمًا من إعادة التأهيل للنساء الناجيات من سرطان الثدي، رغم أنها لا تُعدّ جزءًا إلزاميًا من الخطة العلاجية. هدفت هذه الدراسة إلى تقييم تأثير إعادة بناء الثدي على جوانب متعددة من جودة الحياة، بما في ذلك الرفاه الجسدي والانفعالي والاجتماعي، ومدى إسهامها في رضا المريضات بشكل عام.</div></div><div><h3>طرق البحث</h3><div>أُجريت دراسة مقطعية شملت 100 امرأة خضعن لإعادة بناء الثدي خلال السنوات السبع الماضية. استُخدم مقياس \"ليكرت\" خماسي الدرجات المطوّر خصيصًا لقياس تصوّر المريضات للراحة الجسدية، والرفاه النفسي، وتقدير الذات، والتفاعل الاجتماعي. تم تحليل البيانات باستخدام طرائق إحصائية وصفية واستدلالية.</div></div><div><h3>النتائج</h3><div>أظهرت النتائج تحسّنًا ملموسًا في جودة الحياة لدى النساء اللاتي خضعن لإعادة بناء الثدي. لوحظت فروق ذات دلالة إحصائية في جوانب الراحة الجسدية، والاستقرار الانفعالي، والثقة بالنفس. كما أبلغت المشاركات عن تحسن في التفاعل الاجتماعي، وزيادة في الرضا عن الحياة. وتشير هذه النتائج إلى أن إعادة بناء الثدي لا تسهم في التعافي الجسدي فحسب، بل تدعم أيضًا الاندماج النفسي والاجتماعي بعد الاستئصال.</div></div><div><h3>الاستنتاجات</h3><div>تُظهر إعادة بناء الثدي بعد الاستئصال أثرًا إيجابيًا على جودة حياة النساء من خلال تحسين الحالة الجسدية، والاستقرار النفسي، والوظائف الاجتماعية. وتبرز هذه النتائج أهمية اعتبار إعادة بناء الثدي جزءًا أساسيًا من برامج إعادة التأهيل بعد استئصال الثدي. وتوصى الدراسات المستقبلية بالتركيز على تطوير بروتوكولات إعادة التأهيل وتعزيز أنظمة الدعم الشامل لتحسين نتائج المريضات ورفاههن.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 6","pages":"Pages 875-889"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open versus laparoscopic techniques for incisional hernia repair: A systematic review and meta-analysis of randomized controlled trials","authors":"Thamer H. Alghamdi MD ,&nbsp;Yara A. Alghamdi ,&nbsp;Fadya Y. Alghamdi ,&nbsp;Lujain M. Alzahrani ,&nbsp;Joud S. Alghamdi ,&nbsp;Ghadi M. Alghamdi ,&nbsp;Naif A. Alharthi","doi":"10.1016/j.jtumed.2025.10.004","DOIUrl":"10.1016/j.jtumed.2025.10.004","url":null,"abstract":"<div><h3>Background</h3><div>The choice between open and laparoscopic techniques for incisional hernia repair remains debated in surgical practice. This systematic review and meta-analysis was aimed at comparing the clinical outcomes of open versus laparoscopic incisional hernia repair in adults, with a focus on postoperative complications, recurrence, recovery, and patient satisfaction.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Randomized controlled trials (RCTs) comparing open and laparoscopic repair of incisional hernias were included. The main outcomes were postoperative complications (wound infection, hematoma, seroma, ileus, and sepsis), recurrence rates, time to recovery, and quality of life. A total of 726 patients from studies conducted in Europe and the United States were included: 365 in the open surgery group and 361 in the laparoscopic group.</div></div><div><h3>Results</h3><div>The meta-analysis revealed no statistically significant differences between techniques regarding overall postoperative complications, recurrence rates, or quality-of-life scores. Although the rate of wound infection and the incidence of ileus were slightly lower in the laparoscopic group than the open surgery group, the differences were not statistically significant. Additionally, the recurrence rates were ‏comparable between approaches (risk ratio = 1.00, 95 % CI: 0.64–1.57). However, seroma formation exhibited significant heterogeneity across studies. ‏Laparoscopic repair was associated with faster recovery and better long-term quality of life, particularly physical and emotional well-being.</div></div><div><h3>Conclusion</h3><div>This systematic review and meta-analysis demonstrated no significant differences in primary clinical outcomes between open and laparoscopic incisional hernia repair techniques. Both approaches had comparable complication and recurrence rates. However, laparoscopic repair might provide advantages of faster recovery and improved postoperative quality of life, and therefore is a viable alternative to open repair for suitable candidates. Further studies with larger sample sizes and standardized protocols are necessary to confirm these findings.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 6","pages":"Pages 773-783"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: “Quality of Life among patients with epilepsy in the western region of KSA: A cross-sectional study”","authors":"Shyam Sundar Sah MD ,&nbsp;Abhishek Kumbhalwar PhD","doi":"10.1016/j.jtumed.2025.11.002","DOIUrl":"10.1016/j.jtumed.2025.11.002","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 6","pages":"Pages 831-832"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the absence of LMP1-XhoI deletion in nasopharyngeal carcinoma patients: A genetic perspective","authors":"Yaqeen Rjoub MSc ,&nbsp;Mai Abusalah PhD ,&nbsp;Aseel Al-Hussein MSc ,&nbsp;Khaled Al-Qaoud PhD ,&nbsp;Anwar Rjoop MD ,&nbsp;Yasmin AlSaidat MD ,&nbsp;Moayad A. Rjoub MD ,&nbsp;Manal Abusalah MSc ,&nbsp;Naveed Ahmed PhD","doi":"10.1016/j.jtumed.2025.11.009","DOIUrl":"10.1016/j.jtumed.2025.11.009","url":null,"abstract":"<div><h3>Background</h3><div>Nasopharyngeal carcinoma (NPC) is the most common type of head and neck cancer, and its development is closely linked to Epstein–Barr virus (EBV). Notably, changes in the viral Latent Membrane Protein 1 (LMP-1) gene, such as the absence of the Xhol restriction site, contribute to its oncogenic properties. This study was to explore the connection between the XhoI site and NPC progression, with the goal of enhancing early diagnosis and treatment strategies.</div></div><div><h3>Methods</h3><div>Formalin-fixed paraffin-embedded (FFPE) tissues from NPC patients were collected, and using restriction fragment length polymorphism (RFLP-PCR), variants of the EBV LMP-1 XhoI gene were identified, followed by amplification of the BamHI-W gene.</div></div><div><h3>Results</h3><div>EBV DNA was detected in all NPC tissue samples via amplification of the BamHI-W region, confirming widespread EBV association in the Jordanian cohort. Wild-type (WT) XhoI variant was identified in 82.86 % of NPC cases, whereas no samples exhibited the mutant-type (MT) XhoI variant, as substantiated by Sanger Sequencing of representative cases. Statistical analysis revealed no significant correlation between the presence of WT XhoI and variables such as patient sex, age, tissue origin, NPC subtype, or disease stage. Notably, most samples from stage III/IV harbored the WT XhoI variant. Overall, BamHI-W gene detection proved to be a more consistent molecular marker than LMP-1 XhoI in this population, and no relationship was established between LMP-1 XhoI mutation and NPC development</div></div><div><h3>Conclusion</h3><div>These findings primarily highlight the epidemiological association between EBV and NPC in Jordanian patients, rather than demonstrating immediate clinical applicability for screening or early diagnosis. The absence of the LMP-1 XhoI deletion in this cohort underscores significant geographic and ethnic heterogeneity in the prevalence of this genetic alteration among NPC patients.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 6","pages":"Pages 865-874"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of immediate-release versus extended-release metformin on glycemic control and insulin resistance in Saudi patients with type 2 diabetes: A prospective cohort study","authors":"Hisham S. Alshadfan MSc ,&nbsp;Hyder O. Mirghani MD ,&nbsp;Tariq K. Alrasheed MD ,&nbsp;Muhammad N.H. Abdullah PhD","doi":"10.1016/j.jtumed.2025.11.005","DOIUrl":"10.1016/j.jtumed.2025.11.005","url":null,"abstract":"<div><h3>أهداف البحث</h3><div>يُعَدّ الميتفورمين العلاج الأوّل لداء السكري من النوع الثاني، ويتوافر في شكلين دوائيين هما سريع المفعول (IR) وممتد المفعول (XR)، مع ندرة البيانات التي تقارن بين تأثيرهما على ضبط سكر الدم ومقاومة الإنسولين لدى المرضى السعوديين. تهدف هذه الدراسة إلى تقييم تأثير ميتفورمين سريع المفعول مقابل ممتد المفعول على الهيموغلوبين الغليكوزيلاتي (HbA1c)، وسكر الدم الصائم (FBG)، والإنسولين الصائم (FSI)، ومقاومة الإنسولين (HOMA-IR) لدى مرضى سعوديين تم تشخيصهم حديثًا بداء السكري من النوع الثاني.</div></div><div><h3>طرق البحث</h3><div>أُجريت دراسة أترابية مستقبلية لمدة 6 أشهر في مركز سعودي للسكري، شملت 119 مريضًا بالغًا تم تشخيصهم حديثًا بداء السكري من النوع الثاني (62 مريضًا يتلقون الميتفورمين سريع المفعول، و57 يتلقون الميتفورمين ممتد المفعول). جرى قياس HbA1c وFBG وFSI وحساب HOMA-IR عند خط الأساس وبعد 6 أشهر من المتابعة. تم تحليل التغيرات داخل كل مجموعة، ثم مقارنة النتائج بين المجموعتين باستخدام الاختبارات الإحصائية المناسبة مع ضبط الفروق في القيم الأساسية.</div></div><div><h3>النتائج</h3><div>حَسَّن الشكلان الدوائيان ضبط سكر الدم بصورة ذات دلالة إحصائية مقارنة بخط الأساس. انخفض متوسط HbA1c من 7.3% إلى نحو 6.5% في مجموعة الميتفورمين ممتد المفعول، مقابل انخفاض من نحو 7.6% إلى 7.2% في مجموعة الميتفورمين سريع المفعول، مع تحقيق الميتفورمين ممتد المفعول انخفاضًا أكبر في المتوسط المعدَّل لـ HbA1c بنسبة 31% مقارنة بسريع المفعول (p&lt;0.05). تحسّن FBG في كلتا المجموعتين دون وجود فرق معنوي بينهما (p=0.111). وعلى الرغم من التفوق في خفض مؤشرات ضبط السكر مع الميتفورمين ممتد المفعول، فقد تحسنت مستويات الإنسولين الصائم (FSI) ومقاومة الإنسولين (HOMA-IR) بشكل ملحوظ في كلتا المجموعتين دون فروق معنوية بينهما (p&gt;0.05).</div></div><div><h3>الاستنتاجات</h3><div>أظهر الميتفورمين ممتد المفعول خفضًا أفضل في مؤشرات ضبط سكر الدم على المدى البعيد مقارنة بالميتفورمين سريع المفعول لدى المرضى السعوديين المشخَّصين حديثًا بداء السكري من النوع الثاني، في حين حقق الشكﻼن الدوائيان تحسنًا متقاربًا في مستويات الإنسولين ومقاومة الإنسولين. قد تعكس الفاعلية المحسَّنة للميتفورمين ممتد المفعول في ضبط سكر الدم دور الالتزام الأفضل بالعلاج وآلية الإطلاق المستمر للدواء.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 6","pages":"Pages 835-845"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}