Indian Journal of Surgical Oncology最新文献

{"title":"Double Jeopardy: Gastric Carcinoma Masquerading as Acute Limb Ischaemia.","authors":"Tammiraju Iragavarapu, Srinivas Ayyar, Ramnadh N V, Aakash Teja Dhurbesula","doi":"10.1007/s13193-025-02363-z","DOIUrl":"https://doi.org/10.1007/s13193-025-02363-z","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 3","pages":"703-707"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole exome sequencing of lung cancer in Indian patients reveals driver genes and novel mutations with therapeutic potential.","authors":"Wendy D'Souza, K N Lokesh, Naresh Mahajan, Radha Mishra, Usha Amirtham, L K Rajeev, Arun Kumar","doi":"10.1007/s13193-025-02359-9","DOIUrl":"https://doi.org/10.1007/s13193-025-02359-9","url":null,"abstract":"<p><p>Lung cancer remains a leading cause of cancer mortality in India, yet its genomic landscape remains understudied. To address this gap, we performed whole-exome sequencing (WES) on tumor and matched blood samples from 47 lung cancer patients [adenocarcinoma (ADC): 30; squamous cell carcinoma (SqCC): 10; and small cell lung cancer (SCLC): 7] to comprehensively analyze somatic mutations across all protein-coding genes. Our analysis revealed novel and recurrent alterations, with <i>MUC4</i> being the most recurrently mutated gene, and <i>TP53</i> emerging as the most frequently mutated across subtypes. Shared mutations included <i>MUC4, MUC16, TP53, KMT2C, CDC27,</i> and <i>UBXN11</i>, the latter not previously associated with lung cancer. ADC exhibited the highest mutational diversity, particularly in RTK/MAPK pathway genes (<i>EGFR, KRAS, BRAF, ERBB2, PIK3CG</i>). Notably, <i>EGFR</i> mutations were identified in 26.7% of ADC cases, including exon 19 deletions (5 cases), exon 21 missense mutations (2 cases), and exon 20 insertions (3 cases) and a novel <i>EGFR</i> exon 20 duplication (p.Ser768_Asp770dup). SqCC showed frequent mutations in <i>KMT2D, ARID2,</i> and <i>FBXW7</i>, suggesting a role for epigenetic dysregulation. One SqCC case harbored a rare <i>EGFR</i> p.Glu866Gly mutation. SCLC was enriched for <i>TP53</i> (43%) and <i>RB1</i> (14%) mutations, along with alterations in <i>FAT4</i> and <i>LRP1B.</i> Importantly, therapeutically actionable mutations were identified in 91.5% patients, including those with NCCN-recommended (25.5%) and FDA-approved off-label drug targets (68.1%). These findings underscore the value of WES in uncovering clinically relevant mutations and support the integration of genomic profiling into precision oncology strategies for Indian lung cancer patients.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-025-02359-9.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 3","pages":"631-643"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Treatment Patterns and Survival Outcomes in Periampullary Carcinoma: A Multicentric Retrospective Study from the Indian Subcontinent\".","authors":"Amit Sehrawat, Karthik Jayalingappa, Parmod Kumar, Soumya Surath Panda, Reetu Singhal, Sumit Subhadarshi Mohanty, Antara Sanyal, N Arumugam, Krishnakumar Rathnam, S V Saju, H S Raju, Sathya Natarajan, S Subhashree, M K Selvaraj, M Sajid, Amit Gupta, Deepak Sundriyal","doi":"10.1007/s13193-025-02356-y","DOIUrl":"https://doi.org/10.1007/s13193-025-02356-y","url":null,"abstract":"<p><p><i>Periampullary carcinoma (PA Ca)</i> management and outcome data from low and middle-income countries (LMICs) is limited. This multicentric retrospective study examines treatment patterns and outcomes of such patients in the Indian subcontinent. This study was conducted at four tertiary cancer centers in India from January 2019 to December 2023. Following ethical approval, patient data were retrieved to analyze treatment patterns and outcomes. Statistical analysis was performed using SPSS Statistics (Version 23.0). Comparative survival analysis with previous studies was conducted to contextualize findings. A total of <i>95 patients</i> were included, with a median age of 56 years, 56 males (59%) and 39 females (41%). The most common presenting symptoms were jaundice (69.7%) and abdominal pain (61.7%). Risk factors included alcohol consumption (17.8%) and smoking (15.7%), with diabetes (32.6%) and hypertension (24.2%) as common comorbidities. The most frequent tumor location was the ampulla (46.3%), followed by the head of the pancreas (34.7%), distal common bile duct (10.5%), and duodenum (8.4%). 78% had non-metastatic disease at presentation, while 22% had metastatic disease. Sixty-five patients underwent upfront surgery, achieving R0 resection in 97% of cases. The most common histological subtype was pancreatic adenocarcinoma (53%). Pathological T2 and T3 stages were observed in 46% and 40% of cases, respectively. In the R0 resection group, the median disease-free survival (DFS) was not reached, with 2-year DFS at 80.6%. and 3-year DFS at 62.7%. For R1 resection and metastatic disease, the median progression-free survival (PFS) was 17 months (95% CI: 8-26 months), with median overall survival (OS) not reached. To our knowledge, this is the first multicenter study from India providing real-world data on PA Ca management. Early-stage PA Ca in India demonstrates high resectability and favorable survival. Further research is imperative to refine PA Ca management strategies and optimize outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 3","pages":"527-534"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparable Effectiveness and Oncological Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Alone in Early-Stage Breast Cancer: A Comparison with Dual Tracers and Landmark Studies.","authors":"Chayanee Sae-Lim, Pattanan Bongkodmas, Sopark Manasnayakorn, Phuphat Vongwattanakit, Kasaya Tantiphlachiva, Voranaddha Vacharathit, Mawin Vongsaisuwon","doi":"10.1007/s13193-025-02342-4","DOIUrl":"https://doi.org/10.1007/s13193-025-02342-4","url":null,"abstract":"<p><p>Sentinel lymph node biopsy (SLNB) becomes the main axillary staging in early breast cancer, offering less morbidity without compromising oncological outcomes. However, resource limitations in developing countries challenge the usage of dual tracers for SLNB. Our study aimed to investigate the feasibility and oncological outcomes of SLNB using blue dye alone. The study included breast cancer patients who underwent SLNB using either isosulfan blue dye alone (S group) or dual agents (dye and radioisotope, D group) from May 2016 to May 2021 at a single institution. The SLN identification rate and oncological outcomes were compared between two groups and previous landmark studies. A total of 300 patients were enrolled in this study, with 272 (90.7%) in the S group and 28 (9.3%) in the D group. The SLN identification rate in the S group was 98.9%, comparable to the D group (100%, <i>p</i> = 0.745), regardless of total mastectomy or breast conserving surgery. Over a median follow-up of 64 months, rates of locoregional recurrence (1.1%, 3/270) and distant recurrence (3%, 8/270) were not significantly different between the two groups. The Kaplan-Meier curves demonstrated no significant differences in recurrence-free, breast cancer-specific, and overall survival between the S and D groups. Comparisons with results from landmark trials (ACOSOG Z0011, AMAROS, NSABP B-32) showed comparable SLN identification rates and oncological safety. Using blue dye alone for SLNB provides comparable effectiveness and survival outcomes in breast cancer patients, especially advantageous in developing countries with limited radioisotope availability.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 3","pages":"570-580"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Epithelioid Hemangioendothelioma: A Rare and Diagnostically Challenging Tumor in a Young Age.","authors":"Sunila Jain, Md Ali Osama, Neeraj Jain","doi":"10.1007/s13193-025-02358-w","DOIUrl":"https://doi.org/10.1007/s13193-025-02358-w","url":null,"abstract":"<p><p>Pulmonary epithelioid hemangioendothelioma (PEH) is a rare and unpredictable vascular tumor of the lung, often presenting with an uncertain prognosis. While it is generally considered to exhibit borderline malignancy, it can sometimes progress aggressively. Diagnosing PEH can be particularly difficult both clinically and histopathologically, as it often mimics a variety of neoplastic and inflammatory conditions, leading to delayed recognition and treatment. An increased level of clinical suspicion is essential for accurate diagnosis. We report a 23-year-old male initially misdiagnosed with empyema and tuberculosis, who presented with progressive respiratory symptoms. Imaging revealed bilateral pulmonary nodules and right lower lobe collapse. Diagnosis was confirmed through transbronchial cryobiopsy and immunohistochemistry, showing tumor cell positivity for CD31, CD34, and ERG. Despite treatment with cyclophosphamide and sorafenib, the patient's condition deteriorated rapidly, resulting in death. This case emphasizes the rarity and diagnostic challenges of PEH. A multidisciplinary approach combining histological evaluation and immunohistochemical testing is crucial for establishing the correct diagnosis.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 3","pages":"699-702"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Anatomical Relationship Between Intralobar Localization of Papillary Thyroid Carcinoma and Cervical Lymph Node Metastases.","authors":"Merve Kucuker, Behice Durgun","doi":"10.1007/s13193-025-02362-0","DOIUrl":"https://doi.org/10.1007/s13193-025-02362-0","url":null,"abstract":"<p><p>Papillary thyroid cancer (PTC) is the most prevalent form of differentiated thyroid carcinoma, known for its high survival rate and propensity for metastasizing to regional lymph nodes. Despite its generally favorable prognosis, the spread of PTC to cervical lymph nodes poses significant challenges in management and treatment.We aimed to investigate the anatomical relationship between intralobar localization of thyroid tumors and cervical lymph node metastases. The clinicopathological data of patients who presented to our hospital were retrospectively analyzed. A total of 103 patients (34 males, 69 females) diagnosed with papillary thyroid cancer and regional lymph node metastases at the time of diagnosis were included. Patients were categorized into four groups based on tumor localization: group 1 (right lobe), group 2 (left lobe), group 3 (isthmus), and group 4 (bilobar involvement). Tumor localization and cervical lymph node metastases (levels I-VII) were evaluated based on postoperative pathology, preoperative ultrasonography, and contrast-enhanced computed tomography (CT) findings. Fine-needle aspiration cytology (FNAC) was performed for suspicious lymph nodes. There was no difference between the groups in terms of tumor sizes. A statistically significant difference was found between ipsilateral metastases of the tumors in the lobes (<i>p</i> < 0.001). No significant difference was found between the metastasis rates to the central region lymph nodes among groups. The metastases to the right cervical level III of the tumors located in the upper half of the right lobe were significantly higher than the other regions. Preoperative regional lymph node staging in thyroid carcinoma is crucial for determining the extent of surgery. Our study supports applying more selective lymph node dissection, especially for the central and ipsilateral cervical region. The risk of contralateral cervical metastasis is low for routine comprehensive surgery.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 3","pages":"654-661"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Outcomes after Total Mesorectal Excision for Rectal Cancer - A Single Institution Experience.","authors":"Suresh Kumar, S Navin Noushad, Ajay Sharma, Viswanathan M P, Selva Kumar Ganesan","doi":"10.1007/s13193-025-02341-5","DOIUrl":"https://doi.org/10.1007/s13193-025-02341-5","url":null,"abstract":"<p><p>Over the past four decades, advancements in multimodality treatments have significantly improved the prognosis of rectal cancer, with the 5 year tumor related survival rate increasing from 60 to 79% and local recurrences rates dropping from 14.3% to 5.3%. This study evaluated the oncological outcomes of total mesorectal excision (TME), including local recurrence and survival rates, along with factors influencing survival in South Indian population. A Total of 190 patients who underwent TME for rectal adenocarcinoma in our centre from 2015 to 2024 were included. Disease free survival and overall survival were assessed using the Kaplan-Meier method. Univariate analysis with log rank test was done on to identify high risk groups based on established risk factors. With a median follow up of 55 months, local recurrence occurred in four (2.7%) patients and distant recurrence occurred in 18 patients (12%). The overall survival rate was 89.4%, with 100% for stage I disease, 94% for stage II, and 73.8% for stage III disease. The disease free survival rate was 87.7%. Univariate analysis identified age under 50 yrs (<i>p</i> = 0.04), baseline CEA levels of above 4 ng/mL (<i>P</i> = 0.001), higher grade (<i>P</i> = 0.04) and patients unable to complete adjuvant chemotherapy (<i>P</i> = 0.03) as significant predictors of poorer overall survival. This study has demonstrates that low local recurrence rates and favourable overall survival can be achieved through multimodality treatment for rectal cancer. Elevated baseline CEA levels, higher tumor grade, and patients unable to complete adjuvant chemotherapy are associated with poorer prognosis.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 3","pages":"535-541"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Short-term Outcomes of Pancreatic Resections from a Low Volume Centre in a Tier II City in India.","authors":"Amita Sekhar Padhy, Rajyalakshmi Puvvada, Rigved Nittala, Vishnu S Menon, Sidaksingh R Arora, Mounika Basani","doi":"10.1007/s13193-025-02325-5","DOIUrl":"https://doi.org/10.1007/s13193-025-02325-5","url":null,"abstract":"<p><p>Pancreatic cancer surgery represents the holy grail of hepatobiliary surgery and is the only option of curative treatment for malignancies involving this particular organ. This study aims to analyse the short-term outcomes of across the spectrum of surgeries performed for pancreatic neoplasms at a low volume hepatobiliary centre in eastern India. This is a retrospective study from our centre, from 1st January 2019 to 31st October 2024. Patients were identified from a prospectively maintained surgical database and electronic medical records, and data was collected from Electronic Medical Records. We identified 41 patients who underwent surgical resections during the study period. Median age was 56 years. Pre-operative biliary drainage was required in 24 (58.5%) cases. Pancreatico-duodenectomies represented with majority of cases (87.8%), followed by distal pancreas resections (2.4%), total pancreatectomy (2.4%) and ampullectomy (2.4%). Minimally invasive approach was attempted in 2 patients (4.9%). Post-operative complications and their incidences were post-operative pancreatic fistula (POPF) 26.8%, chyle leak 9.7%, biliary leaks 7.3%, delayed gastric emptying 19.4%, post pancreatectomy haemorrhage 4.8%, bowel-related complications 7.3, and surgical site infection 9.8%. Significant post-operative morbidity occurred in 24.4% of cases. Perioperative mortality rate was 7.3%. Although a low volume centre, our results are comparable to published literature for low volume centres, though worse than high volume centres. Safe outcomes are achievable at low volume centres with trained and dedicated surgeons, anaesthesiologists and proper patient selection.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"312-320"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Preference for Non-Operative Treatment Strategy in Locally Advanced Rectal Cancers: A Cross-Sectional Survey.","authors":"Surendran Veeraiah, Revathy Sudhakar, Jagan Murugan, Pradeep Jayakumar, A S Ramakrishnan","doi":"10.1007/s13193-025-02390-w","DOIUrl":"https://doi.org/10.1007/s13193-025-02390-w","url":null,"abstract":"<p><strong>Introduction: </strong>Surgical resection remains the standard treatment in the management of rectal cancer. Omitting surgery in carefully selected patients who achieve a clinical complete response after neoadjuvant radiotherapy is stated to provide acceptable oncological outcomes. This survey aimed to understand the preference of patients with rectal cancer towards non-operative management (NOM).</p><p><strong>Method: </strong>A prospective cross-sectional study was conducted among patients diagnosed with locally advanced mid- or lower-third rectal cancer. A structured interview schedule was used to assess the willingness for the trial under various conditions associated with an imaginary scenario of NOM after a complete response to an intensive neoadjuvant treatment. Psychological parameters were collected using Fear of Progression (FOP)-12, Life Orientation Test-Revised, and Multidimensional Health Locus of Control-Form C (MHLC-C). The data was analyzed using descriptive statistics.</p><p><strong>Results: </strong>Of the 59 patients included, 37.3% expressed an overall willingness for NOM. While 91.5% expressed willingness for the NOM if there were no increased side effects of neoadjuvant treatment, 44.1% reported willingness with even 10% increased side effects, 54.2% with the suggested intensive follow-up schedule, and 10.2% if there was a 25% chance of tumour regrowth. In total, 74.6% and 16.9% consented if the cure rate with NOM was similar to and less than surgery, respectively. Overall, 50% had significant FOP, and 79.7% had low optimism. Comparatively higher MHLC-C score (M = 22.29; SD = 4.33) indicates that the majority of the patients attribute events to luck or fate.</p><p><strong>Conclusion: </strong>We observed that only one-third of patients in this study preferred a NOM to radical surgery; the decision was mainly driven by FOP and fear of increased side effects of neoadjuvant treatment. Detailed counselling of the patients about the treatment modality and NOM strategy is essential before considering any patient for an intentional watch-and-wait approach.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-025-02390-w.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"454-461"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for perineal wound infection after abdominoperineal resection of rectal cancer.","authors":"Pham Hoang Ha, Me Quoc Vong, Pham Quang Thai","doi":"10.1007/s13193-025-02478-3","DOIUrl":"https://doi.org/10.1007/s13193-025-02478-3","url":null,"abstract":"<p><strong>Introduction: </strong>Perineal wound infection following abdominoperineal resection for rectal cancer is a common postoperative complication. Identifying factors associated with perineal wound infection can help reduce morbidity. This study aimed to identify risk factors for perineal wound infection following abdominoperineal resection for rectal cancer.</p><p><strong>Methods: </strong>This was a retrospective cross-sectional study involving 70 patients with rectal cancer who underwent abdominoperineal resection at Viet Duc University Hospital between January 1, 2015, and December 31, 2022. Patients were categorized into two groups based on the presence or absence of perineal wound infection. Potential risk factors were compared between the two groups, including: age, BMI, presence of diabetes mellitus, preoperative chemoradiotherapy, preoperative laboratory indices (hemoglobin, albumin, white blood cell count), tumor diameter, tumor stage, and operative time.</p><p><strong>Results: </strong>Perineal wound infection occurred in 38 out of 70 patients (54.3%). Univariate analysis revealed that undernutrition, indicated by BMI < 18.5 kg/m² (<i>p</i> = 0.047), and preoperative hypoalbuminemia (albumin < 35 g/L) (<i>p</i> = 0.004), were significantly associated with an increased risk of perineal wound infection. Multivariate analysis identified diabetes mellitus (<i>p</i> = 0.02) and preoperative hypoalbuminemia (<i>p</i> = 0.02) as independent risk factors for perineal wound infection following abdominoperineal resection for rectal cancer.</p><p><strong>Conclusion: </strong>Univariate analysis indicated that malnutrition (BMI < 18.5 kg/m²) and preoperative hypoalbuminemia (albumin < 35 g/L) were significantly associated with perineal wound infection. Multivariate analysis identified diabetes mellitus and preoperative hypoalbuminemia as independent risk factors that increased the likelihood of perineal wound infection following abdominoperineal resection for rectal cancer.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"469-474"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}