Indian Journal of Surgical Oncology最新文献

{"title":"Elucidating Cytomorphological Features of Eccrine Porocarcinoma on The Forehead Presenting Without Pre-existing Poroma in an Adult Male: A Rarity Unveiled with a Comprehensive Review of Literature.","authors":"Shaivy Malik, Mukul Singh, Adil Aziz Khan","doi":"10.1007/s13193-024-02130-6","DOIUrl":"10.1007/s13193-024-02130-6","url":null,"abstract":"<p><p>Eccrine porocarcinoma (EPC), a rare and aggressive skin adnexal malignancy, presents significant diagnostic and management challenges due to its low incidence and clinical resemblance to other skin lesions. The case report highlights its rarity, propensity for aggressive behavior, and the importance of prompt diagnosis for effective management. A 50-year-old male presented with a rapidly enlarging swelling on his forehead, clinically resembling to any other skin lesion. Fine needle aspiration biopsy (FNAB) revealed atypical basaloid cells suggestive of porocarcinoma, confirmed by histopathological examination and immunohistochemistry. The case emphasized the diverse clinical presentation and the utility of FNAB in early diagnosis. This case underscores the comprehensive understanding of EPC, including its clinical, cytological, histopathological, and immunohistological features. It also emphasizes the key cytological features and its role in early diagnosis.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"443-449"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Atypical Teratoid Rhabdoid Tumor of Central Nervous System: A Case Series with Review of Literature.","authors":"Jyoti Verma, Neelima Gupta, Sushila Jaiswal, Awdhesh Kumar Jaiswal","doi":"10.1007/s13193-024-02115-5","DOIUrl":"10.1007/s13193-024-02115-5","url":null,"abstract":"<p><p>Atypical teratoid rhabdoid tumor (AT/RT) of the central nervous system (CNS) is the rare, aggressive malignant neoplasm of infancy and early childhood and relatively rare in adults. Patients with ATRT typically follow a dismal course. Because of its rarity and rapid course and poor prognosis, there has been no consensus as to the optimal treatment of this tumor. We herein report a series of nine cases collected from the year 2015 to 2021 in a regional tertiary care center in North India. We retrospectively collected histologically diagnosed ATRT cases and obtained demographic and clinical data from the databases. We retrieved the archived slides and tissue blocks for analysis and found nine diagnosed cases of ATRT. The median age of presentation was 3 years (ranging from 0.9 to 13 years) and showed male preponderance (male to female ratio of 2:1). The mean duration of symptoms was 3.5 months with headache and vomiting being the commonest symptoms. The tumors showed heterogenous immunohistochemical expression. Patients with AT/RT underwent multimodal treatment comprising surgical resection, radiotherapy, and chemotherapy based on the patient's age and tumor site and its resectability. The mean overall survival was 15.1 months (range, 1.5-30 months). ATRT is a rare neoplasm with a highly variable clinical course and poor prognosis. It portends poor outcomes in spite of a multimodal approach to treatment; hence, there is a dire need to help combat this enigmatic tumor.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"611-620"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgically Treated Clear Cell Sarcomas - What Influences Outcomes?","authors":"Harsha S S Tadala, Ashish Gulia, Ajay Puri, Bharat Rekhi, Siddhartha Laskar","doi":"10.1007/s13193-024-02108-4","DOIUrl":"https://doi.org/10.1007/s13193-024-02108-4","url":null,"abstract":"<p><p>Clear cell sarcoma (CCS) also called as melanoma of soft parts is a rare malignant soft-tissue tumor with melanocytic differentiation, primarily located in deep soft tissue and has preference for lymph node and pulmonary metastasis. Metastatic patients have poor oncologic prognosis and so far, no adjuvant treatment seems to be effective in these cases. All cases were retrieved from our prospectively maintained surgical database. Twenty-nine patients (14 males,15 females) with a mean age of 34 years (13-69 years) were operated between 2004 and 2020. Overall survival and recurrence free survival were evaluated. At mean follow-up of 45 months, out of 29 cases, 2 lost to follow-up, 6 patients had nodal metastasis, 3 had lung metastasis, one had both at presentation, 15 patients had died due to disease and 12 are alive. Nodal metastasis rate was 24% (7/29). Positive margin is observed in 6 (19%). 24 patients had recurrence of which 6 had both local and distant. The 5-year OS, LRFS, DRFS were 53%, 56%, 35% respectively at 5 years. Survival rates were significantly poor in patients with metastasis at presentation, 66% vs. 25% (<i>p</i> = 0.016). CCS is an aggressive soft tissue malignancy with high propensity for metastasis. The overall survival of CCS is poor. Metastasis at presentation negatively impacts on survival. Distant recurrences, especially nodal recurrences are not uncommon and complete surgical resection of all recurrences if possible is advisable. Research to develop new chemotherapeutic agents and targeted therapies may help improve the prognosis of CCS.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"627-632"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Safety and Efficacy: Laparoscopic vs. Open Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma: A Meta-analysis of Randomized Control Trials.","authors":"Hussain Sohail Rangwala, Hareer Fatima, Mirha Ali, Burhanuddin Sohail Rangwala","doi":"10.1007/s13193-024-02132-4","DOIUrl":"10.1007/s13193-024-02132-4","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) has an estimated 5-year survival rate of 11% and remains a formidable challenge. Despite evolving pancreaticoduodenectomy techniques, the pinnacle status of laparoscopic surgery persists. Technological advancements since Gagner and Pomp's 1994 breakthrough have expanded its reach, yet it remains complex. Although safety reports exist, large-scale studies establishing the viability of laparoscopic surgery for PDAC are scarce. This study aimed to provide an up-to-date meta-analysis, scrutinizing all relevant trials, especially recently published ones, to discern differences between laparoscopic and open pancreaticoduodenectomy procedures. This meta-analysis, following the PRISMA guidelines, systematically searched the PubMed and Cochrane Library databases for randomized controlled trials on pancreaticoduodenectomy up to November 25, 2023. Data extraction, quality assessment, and statistical analysis, including primary and secondary outcomes, were conducted using rigorous methodology. The study employed Review Manager 5.4 for analysis, with significance set at <i>P</i> < 0.05. This meta-analysis, comprising five randomized controlled trials (laparoscopic, 605; open, 601; total, 1206), utilized the Cochrane Risk of Bias 2 tool, revealing minimal bias. Primary outcome analysis indicated a shorter hospital stay with laparoscopic pancreaticoduodenectomy (S.M.D. =  - 0.18, 95% CI - 0.63 - 0.28, <i>P</i> = 0.45) and reduced blood loss (S.M.D. =  - 1.96, 95% CI - 3.05, 0.88, <i>P</i> = 0.0004), but increased operative time (S.M.D. = 1.74, 95% CI 0.95 to 2.53, <i>P</i> < 0.0001). The secondary outcomes showed no significant differences in morbidity, mortality, resection, fistula, gastric emptying, hemorrhage, bile leak, reoperation, readmission, and surgical site infection between the two procedures. Laparoscopic pancreaticoduodenectomy (LPD) offers marginal benefits over open pancreaticoduodenectomy (OPD), including reduced blood loss and shorter hospital stays. However, LPD requires a significantly longer operative time, and no substantial differences have been observed in terms of mortality or other complications. Additional studies with lower heterogeneity are needed to thoroughly evaluate the comparative effectiveness and safety of LPD and OPD.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"432-442"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Indian Perspective on the Management of Adolescent Ovarian Cancer.","authors":"P Rema","doi":"10.1007/s13193-024-02120-8","DOIUrl":"10.1007/s13193-024-02120-8","url":null,"abstract":"<p><p>Malignant ovarian tumours often go unrecognised or improperly treated in adolescents. The treatment of adolescents with ovarian cancer requires a tailored approach aiming at a cure for the disease while at the same time considering the adverse reproductive and long-term side effects. Most of the discussions of cancer treatment do not include discussions on post-treatment reproductive functions, considering the dilemma of counselling fertility preservation to a girl who has not reached adulthood. The surgical treatment should aim at fertility preservation by retaining the uterus and remaining ovarian function with comprehensive staging to rule out occult disease. Adjuvant chemotherapy is administered taking into account the spread and aggressiveness of the tumour. There are no specific Indian guidelines for the treatment of adolescent ovarian cancers. Early identification of symptoms and multidisciplinary management can improve the survival rate and quality of life.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"421-426"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Influence of Accuracy and Precision of Measurements of Long Bone Tumors in Imaging Studies-A Retrospective Study in Musculoskeletal Oncology.","authors":"G K Rangarajan, R Krishnakumar, D Devakumar, M Karthigaiselvi, Anand Raja, Chandrakumar Krishnan","doi":"10.1007/s13193-023-01714-y","DOIUrl":"10.1007/s13193-023-01714-y","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s13193-022-01699-0.].</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":" ","pages":"723"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43860019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second Primary Malignancies - a Retrospective Analysis from a Regional Cancer Centre of South India.","authors":"Sakthi Usha Devi J, Balamurugan T D, Prasanna Srinivasa Rao H, Ajay Kumar A","doi":"10.1007/s13193-023-01762-4","DOIUrl":"10.1007/s13193-023-01762-4","url":null,"abstract":"<p><p>The early diagnosis and aggressive treatment in patients diagnosed with a cancer led them to lead a life with a good survival rate. This in turn leads to increase in the number of second primary malignancies. Our article aims to report the prevalence and survival of both synchronous and metachronous second primary malignancies and challenges in treatment by reviewing our retrospective data. A hospital based gathering of retrospective data of the patients diagnosed with second primary malignancies over 9 years from January 2014 to June 2022. Patient details with regards to age, sex, distribution of primary sites, histopathology reports, synchronous or metachronous, treatment details are recorded (Patients fulfilling IARC Definition and Warren Gates criteria). A total of 86 patients were analysed in the retrospective data of whom females contribute the most - 74.4% (<i>n</i> = 64). Metachronous type of tumours - 68.6% (<i>n</i> = 59) are common than synchronous tumours. Overall, patients with breast cancer are more vulnerable for second primary malignancies accounting for 31% and second primary were prone to occur in the ovary followed by cervix. The median survival following first primary tumour diagnosis was 44 months and that of the second primary tumour was 11 months. With advanced screening procedures and evolving treatments, the incidence of second primary malignancies is steadily increasing and the outcomes are poorer since there are no proper set guidelines. More awareness, research and studies are needed to investigate in the treatment of second primary malignancies.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"1 1","pages":"456-464"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43911113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Truly Inevitable-Our Perspective on the Complications After Surgery for Rectal Cancer.","authors":"Kumar Vinchurkar, Manoj Togale, Preeti Maste, Saurin Chaudhary, Imtiaz Ahmed, Sapna Krishnamurthy, Rohan Bhise, Jyoti Mane, Praveen Kumbar","doi":"10.1007/s13193-024-02125-3","DOIUrl":"10.1007/s13193-024-02125-3","url":null,"abstract":"<p><p>Rectal cancer is one of the most common malignancies in the GI tract. Although recent technology and treatments are available today, complications are still there. The focus of this study is to draw attention towards the important complications and their management options in rectal cancer surgeries. Retrospective study of 57 patients diagnosed and operated with rectal cancer between 2012 and 2022 using questionnaire data. 21.05% developed complications following surgery for rectal cancer including SSI, LARS, anastomosis leak, and stomal stenosis. LARS was seen in 26.31% out of the 19 patients involved in the study (LAR + ULAR) of which 80% had minor LARS scores and 20% had major LARS scores. In LARS, 80% had received long-term chemoradiotherapy in a neoadjuvant setting. The study revealed a rising trend of rectal cancer in young individuals (35.08%). Complications are an inevitable part of rectal cancer surgery even with recent technology. Use of long-course radiotherapy in neoadjuvant settings and LAR and ULAR may improve sphincter preservation with the risk of increasing incidence of low anterior resection syndrome, and anastomosis leak should be used cautiously with proper patient selection.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"667-675"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncologic and Aesthetic Outcomes of Matrix Rotation Mammoplasty in Management of Upper Inner Quadrant Breast Cancer: A Single Centre Experience.","authors":"Emad Hamed, Ashraf Khater, Ahmed Atef, Amr Hossam","doi":"10.1007/s13193-024-02058-x","DOIUrl":"10.1007/s13193-024-02058-x","url":null,"abstract":"<p><p>Oncoplastic techniques in breast cancer therapy allow for extending the indications of breast-conservative surgery plus improving cosmetic outcomes. Breast tumours located at the upper inner quadrant particularly represent a challenge for conservative surgery due to the scarcity of breast tissue and the risk of skin involvement. We present a \"matrix rotation advancement\" flap for breast-conserving surgery in patients with breast tumours at this location. This retrospective observational study analyzed 15 patients who underwent breast-conserving surgery with matrix rotation mammaplasty. All patients were treated in our tertiary oncology centre. The median age at diagnosis was 49 years. The average initial tumour size was 5.2 cm, and the mean excised breast weight was 105 g. Patients required neither symmetrization nor repositioning of the nipple-areola complex. Only two patients had a minor complication (wound dehiscence). During follow-up, no local recurrences were reported. We conclude that the matrix rotation flap is a safe and effective technique to treat tumours at this difficult location. It provides adequate oncological margins, accepted cosmetic results, and contralateral symmetry, with complication rates like those of standard conservative surgery.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 1","pages":"228-233"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triumph Over Butchery: Guest Editorial for Indian Journal of Surgical Oncology.","authors":"Aradhya Nigam, Ashok R Shaha","doi":"10.1007/s13193-024-02150-2","DOIUrl":"10.1007/s13193-024-02150-2","url":null,"abstract":"<p><p>While once considered \"butchery,\" thyroid cancer surgery is now considered a safe surgery in the setting of the increasing incidence of thyroid nodules. Several changes in the approach to patients and advancements in technology have paved the way for the technical feasibility of thyroid surgery. International guidelines have enabled a personalized, and less invasive approach to patients and thus reducing the morbidity attributed tumors from potential injury to the recurrent laryngeal nerve or long-term thyroid hormone replacement- particularly for papillary microcarcinomas. Morbidity from hypocalcemia and nerve injury have further been improved by advancements including parathyroid localizing technology, nerve monitoring, molecular testing, and improved diagnostic imaging. As we continue to improve our understanding of the thyroid, so will the outcomes of patients who undergo thyroid cancer surgery. Advancements in the safety and feasibility of thyroid surgery remind us of the statement made by William Halsted: \"thyroid surgery is a supreme triumph of the surgeon's heart.\"</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 1","pages":"5-7"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}